Amino acid dipepetide frequency for Mariprofundus erugo

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.279AlaAla: 13.279 ± 0.275	1.379AlaCys: 1.379 ± 0.049	6.43AlaAsp: 6.43 ± 0.094	6.668AlaGlu: 6.668 ± 0.119	3.434AlaPhe: 3.434 ± 0.064	9.42AlaGly: 9.42 ± 0.155	2.417AlaHis: 2.417 ± 0.058	6.299AlaIle: 6.299 ± 0.089	3.055AlaLys: 3.055 ± 0.064	11.087AlaLeu: 11.087 ± 0.142	3.789AlaMet: 3.789 ± 0.071	2.884AlaAsn: 2.884 ± 0.065	3.631AlaPro: 3.631 ± 0.083	3.31AlaGln: 3.31 ± 0.083	6.529AlaArg: 6.529 ± 0.096	6.28AlaSer: 6.28 ± 0.106	5.288AlaThr: 5.288 ± 0.116	7.779AlaVal: 7.779 ± 0.133	1.363AlaTrp: 1.363 ± 0.049	2.304AlaTyr: 2.304 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.907CysAla: 0.907 ± 0.036	0.213CysCys: 0.213 ± 0.017	0.709CysAsp: 0.709 ± 0.032	0.626CysGlu: 0.626 ± 0.031	0.489CysPhe: 0.489 ± 0.025	1.128CysGly: 1.128 ± 0.037	0.458CysHis: 0.458 ± 0.025	0.669CysIle: 0.669 ± 0.034	0.381CysLys: 0.381 ± 0.023	1.057CysLeu: 1.057 ± 0.04	0.389CysMet: 0.389 ± 0.023	0.336CysAsn: 0.336 ± 0.021	0.562CysPro: 0.562 ± 0.028	0.396CysGln: 0.396 ± 0.021	0.819CysArg: 0.819 ± 0.035	0.748CysSer: 0.748 ± 0.034	0.533CysThr: 0.533 ± 0.028	0.645CysVal: 0.645 ± 0.028	0.189CysTrp: 0.189 ± 0.016	0.324CysTyr: 0.324 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	6.497AspAla: 6.497 ± 0.106	0.617AspCys: 0.617 ± 0.025	3.151AspAsp: 3.151 ± 0.08	4.084AspGlu: 4.084 ± 0.076	2.143AspPhe: 2.143 ± 0.054	4.63AspGly: 4.63 ± 0.082	1.635AspHis: 1.635 ± 0.043	3.818AspIle: 3.818 ± 0.071	2.096AspLys: 2.096 ± 0.056	4.964AspLeu: 4.964 ± 0.077	1.664AspMet: 1.664 ± 0.046	1.413AspAsn: 1.413 ± 0.05	2.34AspPro: 2.34 ± 0.057	2.245AspGln: 2.245 ± 0.051	3.288AspArg: 3.288 ± 0.064	2.791AspSer: 2.791 ± 0.06	2.424AspThr: 2.424 ± 0.067	4.075AspVal: 4.075 ± 0.075	0.746AspTrp: 0.746 ± 0.031	1.625AspTyr: 1.625 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	6.77GluAla: 6.77 ± 0.152	0.506GluCys: 0.506 ± 0.023	2.576GluAsp: 2.576 ± 0.061	3.685GluGlu: 3.685 ± 0.088	1.871GluPhe: 1.871 ± 0.047	3.74GluGly: 3.74 ± 0.07	1.805GluHis: 1.805 ± 0.048	3.587GluIle: 3.587 ± 0.069	3.02GluLys: 3.02 ± 0.068	6.584GluLeu: 6.584 ± 0.101	1.987GluMet: 1.987 ± 0.048	1.713GluAsn: 1.713 ± 0.042	2.301GluPro: 2.301 ± 0.056	3.584GluGln: 3.584 ± 0.077	4.203GluArg: 4.203 ± 0.084	3.549GluSer: 3.549 ± 0.07	2.849GluThr: 2.849 ± 0.063	4.196GluVal: 4.196 ± 0.09	0.823GluTrp: 0.823 ± 0.036	1.454GluTyr: 1.454 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.559PheAla: 3.559 ± 0.07	0.472PheCys: 0.472 ± 0.021	2.606PheAsp: 2.606 ± 0.063	2.206PheGlu: 2.206 ± 0.055	1.43PhePhe: 1.43 ± 0.048	2.92PheGly: 2.92 ± 0.063	0.947PheHis: 0.947 ± 0.032	1.981PheIle: 1.981 ± 0.052	1.072PheLys: 1.072 ± 0.036	3.007PheLeu: 3.007 ± 0.066	0.938PheMet: 0.938 ± 0.034	1.273PheAsn: 1.273 ± 0.039	1.475PhePro: 1.475 ± 0.041	1.026PheGln: 1.026 ± 0.039	2.171PheArg: 2.171 ± 0.053	2.705PheSer: 2.705 ± 0.057	2.016PheThr: 2.016 ± 0.051	2.322PheVal: 2.322 ± 0.065	0.463PheTrp: 0.463 ± 0.025	1.019PheTyr: 1.019 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	6.421GlyAla: 6.421 ± 0.146	1.137GlyCys: 1.137 ± 0.04	4.13GlyAsp: 4.13 ± 0.071	4.821GlyGlu: 4.821 ± 0.091	3.007GlyPhe: 3.007 ± 0.056	5.725GlyGly: 5.725 ± 0.104	2.325GlyHis: 2.325 ± 0.059	4.952GlyIle: 4.952 ± 0.084	3.793GlyLys: 3.793 ± 0.075	7.494GlyLeu: 7.494 ± 0.099	2.824GlyMet: 2.824 ± 0.059	2.372GlyAsn: 2.372 ± 0.067	1.979GlyPro: 1.979 ± 0.055	2.773GlyGln: 2.773 ± 0.059	4.66GlyArg: 4.66 ± 0.075	4.562GlySer: 4.562 ± 0.068	3.574GlyThr: 3.574 ± 0.084	5.516GlyVal: 5.516 ± 0.098	1.254GlyTrp: 1.254 ± 0.055	2.434GlyTyr: 2.434 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	2.95HisAla: 2.95 ± 0.061	0.345HisCys: 0.345 ± 0.022	1.517HisAsp: 1.517 ± 0.047	1.576HisGlu: 1.576 ± 0.036	1.028HisPhe: 1.028 ± 0.036	2.454HisGly: 2.454 ± 0.057	1.032HisHis: 1.032 ± 0.04	1.755HisIle: 1.755 ± 0.044	0.783HisLys: 0.783 ± 0.028	2.686HisLeu: 2.686 ± 0.059	0.774HisMet: 0.774 ± 0.029	0.696HisAsn: 0.696 ± 0.026	1.593HisPro: 1.593 ± 0.049	1.174HisGln: 1.174 ± 0.034	1.702HisArg: 1.702 ± 0.044	1.413HisSer: 1.413 ± 0.043	1.264HisThr: 1.264 ± 0.039	1.838HisVal: 1.838 ± 0.047	0.401HisTrp: 0.401 ± 0.027	0.831HisTyr: 0.831 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.682IleAla: 6.682 ± 0.091	0.74IleCys: 0.74 ± 0.029	3.775IleAsp: 3.775 ± 0.068	4.186IleGlu: 4.186 ± 0.08	1.801IlePhe: 1.801 ± 0.052	4.685IleGly: 4.685 ± 0.079	1.613IleHis: 1.613 ± 0.045	3.107IleIle: 3.107 ± 0.071	2.018IleLys: 2.018 ± 0.055	4.869IleLeu: 4.869 ± 0.076	1.348IleMet: 1.348 ± 0.045	2.039IleAsn: 2.039 ± 0.051	2.644IlePro: 2.644 ± 0.054	1.875IleGln: 1.875 ± 0.045	4.191IleArg: 4.191 ± 0.069	4.029IleSer: 4.029 ± 0.079	3.276IleThr: 3.276 ± 0.065	3.967IleVal: 3.967 ± 0.077	0.648IleTrp: 0.648 ± 0.029	1.449IleTyr: 1.449 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	3.911LysAla: 3.911 ± 0.128	0.254LysCys: 0.254 ± 0.021	1.651LysAsp: 1.651 ± 0.048	2.34LysGlu: 2.34 ± 0.059	0.927LysPhe: 0.927 ± 0.039	2.693LysGly: 2.693 ± 0.052	0.896LysHis: 0.896 ± 0.032	2.034LysIle: 2.034 ± 0.05	2.026LysLys: 2.026 ± 0.06	3.794LysLeu: 3.794 ± 0.072	1.151LysMet: 1.151 ± 0.041	1.211LysAsn: 1.211 ± 0.039	1.982LysPro: 1.982 ± 0.05	2.031LysGln: 2.031 ± 0.06	2.524LysArg: 2.524 ± 0.058	2.381LysSer: 2.381 ± 0.052	1.857LysThr: 1.857 ± 0.054	2.612LysVal: 2.612 ± 0.065	0.331LysTrp: 0.331 ± 0.021	0.832LysTyr: 0.832 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	12.027LeuAla: 12.027 ± 0.149	1.181LeuCys: 1.181 ± 0.04	5.797LeuAsp: 5.797 ± 0.093	5.668LeuGlu: 5.668 ± 0.09	4.08LeuPhe: 4.08 ± 0.078	6.857LeuGly: 6.857 ± 0.091	2.891LeuHis: 2.891 ± 0.063	5.936LeuIle: 5.936 ± 0.089	4.315LeuLys: 4.315 ± 0.072	12.565LeuLeu: 12.565 ± 0.197	2.978LeuMet: 2.978 ± 0.072	3.346LeuAsn: 3.346 ± 0.062	5.318LeuPro: 5.318 ± 0.087	4.529LeuGln: 4.529 ± 0.08	5.973LeuArg: 5.973 ± 0.083	6.696LeuSer: 6.696 ± 0.096	5.31LeuThr: 5.31 ± 0.087	6.518LeuVal: 6.518 ± 0.104	1.212LeuTrp: 1.212 ± 0.037	2.368LeuTyr: 2.368 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	3.31MetAla: 3.31 ± 0.069	0.236MetCys: 0.236 ± 0.018	1.615MetAsp: 1.615 ± 0.044	1.545MetGlu: 1.545 ± 0.043	0.892MetPhe: 0.892 ± 0.037	1.999MetGly: 1.999 ± 0.051	0.844MetHis: 0.844 ± 0.033	1.846MetIle: 1.846 ± 0.046	1.315MetLys: 1.315 ± 0.036	3.594MetLeu: 3.594 ± 0.069	1.033MetMet: 1.033 ± 0.033	1.154MetAsn: 1.154 ± 0.039	1.61MetPro: 1.61 ± 0.044	1.653MetGln: 1.653 ± 0.04	1.999MetArg: 1.999 ± 0.049	1.824MetSer: 1.824 ± 0.045	1.689MetThr: 1.689 ± 0.056	2.134MetVal: 2.134 ± 0.053	0.247MetTrp: 0.247 ± 0.017	0.497MetTyr: 0.497 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	2.712AsnAla: 2.712 ± 0.055	0.304AsnCys: 0.304 ± 0.018	1.628AsnAsp: 1.628 ± 0.047	1.535AsnGlu: 1.535 ± 0.046	0.939AsnPhe: 0.939 ± 0.036	2.463AsnGly: 2.463 ± 0.065	0.899AsnHis: 0.899 ± 0.035	1.989AsnIle: 1.989 ± 0.052	1.083AsnLys: 1.083 ± 0.044	2.921AsnLeu: 2.921 ± 0.054	0.895AsnMet: 0.895 ± 0.033	1.125AsnAsn: 1.125 ± 0.038	1.748AsnPro: 1.748 ± 0.051	1.11AsnGln: 1.11 ± 0.037	2.15AsnArg: 2.15 ± 0.052	1.687AsnSer: 1.687 ± 0.047	1.434AsnThr: 1.434 ± 0.041	1.773AsnVal: 1.773 ± 0.058	0.421AsnTrp: 0.421 ± 0.025	0.756AsnTyr: 0.756 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.182ProAla: 5.182 ± 0.103	0.447ProCys: 0.447 ± 0.025	3.252ProAsp: 3.252 ± 0.072	3.366ProGlu: 3.366 ± 0.079	1.853ProPhe: 1.853 ± 0.048	3.265ProGly: 3.265 ± 0.068	0.986ProHis: 0.986 ± 0.04	1.891ProIle: 1.891 ± 0.042	1.263ProLys: 1.263 ± 0.037	4.545ProLeu: 4.545 ± 0.084	1.134ProMet: 1.134 ± 0.035	0.953ProAsn: 0.953 ± 0.034	1.665ProPro: 1.665 ± 0.052	1.497ProGln: 1.497 ± 0.043	1.869ProArg: 1.869 ± 0.051	2.137ProSer: 2.137 ± 0.05	1.657ProThr: 1.657 ± 0.042	4.186ProVal: 4.186 ± 0.079	0.628ProTrp: 0.628 ± 0.031	1.17ProTyr: 1.17 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.924GlnAla: 4.924 ± 0.104	0.417GlnCys: 0.417 ± 0.023	1.605GlnAsp: 1.605 ± 0.046	2.093GlnGlu: 2.093 ± 0.057	1.195GlnPhe: 1.195 ± 0.04	2.761GlnGly: 2.761 ± 0.059	1.203GlnHis: 1.203 ± 0.041	2.006GlnIle: 2.006 ± 0.046	1.62GlnLys: 1.62 ± 0.072	5.067GlnLeu: 5.067 ± 0.09	1.281GlnMet: 1.281 ± 0.033	0.936GlnAsn: 0.936 ± 0.034	2.001GlnPro: 2.001 ± 0.049	3.066GlnGln: 3.066 ± 0.081	2.732GlnArg: 2.732 ± 0.063	2.352GlnSer: 2.352 ± 0.058	1.856GlnThr: 1.856 ± 0.04	2.817GlnVal: 2.817 ± 0.057	0.637GlnTrp: 0.637 ± 0.028	0.882GlnTyr: 0.882 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	5.225ArgAla: 5.225 ± 0.079	0.751ArgCys: 0.751 ± 0.027	3.477ArgAsp: 3.477 ± 0.067	4.061ArgGlu: 4.061 ± 0.086	2.596ArgPhe: 2.596 ± 0.056	3.63ArgGly: 3.63 ± 0.069	1.995ArgHis: 1.995 ± 0.054	4.094ArgIle: 4.094 ± 0.07	2.687ArgLys: 2.687 ± 0.064	7.475ArgLeu: 7.475 ± 0.118	2.271ArgMet: 2.271 ± 0.052	1.963ArgAsn: 1.963 ± 0.049	2.334ArgPro: 2.334 ± 0.051	3.26ArgGln: 3.26 ± 0.075	4.028ArgArg: 4.028 ± 0.088	3.4ArgSer: 3.4 ± 0.065	2.505ArgThr: 2.505 ± 0.055	4.104ArgVal: 4.104 ± 0.07	0.883ArgTrp: 0.883 ± 0.033	1.89ArgTyr: 1.89 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.802SerAla: 5.802 ± 0.104	0.747SerCys: 0.747 ± 0.034	3.488SerAsp: 3.488 ± 0.068	3.638SerGlu: 3.638 ± 0.078	2.312SerPhe: 2.312 ± 0.056	5.621SerGly: 5.621 ± 0.089	1.668SerHis: 1.668 ± 0.043	3.372SerIle: 3.372 ± 0.066	2.005SerLys: 2.005 ± 0.058	6.236SerLeu: 6.236 ± 0.105	1.946SerMet: 1.946 ± 0.05	1.653SerAsn: 1.653 ± 0.049	2.471SerPro: 2.471 ± 0.053	2.127SerGln: 2.127 ± 0.063	3.768SerArg: 3.768 ± 0.062	3.645SerSer: 3.645 ± 0.086	2.741SerThr: 2.741 ± 0.056	4.12SerVal: 4.12 ± 0.072	0.827SerTrp: 0.827 ± 0.031	1.482SerTyr: 1.482 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	5.453ThrAla: 5.453 ± 0.114	0.516ThrCys: 0.516 ± 0.026	2.709ThrAsp: 2.709 ± 0.063	2.442ThrGlu: 2.442 ± 0.056	1.683ThrPhe: 1.683 ± 0.051	4.63ThrGly: 4.63 ± 0.086	1.263ThrHis: 1.263 ± 0.039	3.009ThrIle: 3.009 ± 0.072	1.2ThrLys: 1.2 ± 0.039	5.549ThrLeu: 5.549 ± 0.093	1.314ThrMet: 1.314 ± 0.042	1.17ThrAsn: 1.17 ± 0.049	2.768ThrPro: 2.768 ± 0.056	1.408ThrGln: 1.408 ± 0.047	2.759ThrArg: 2.759 ± 0.056	2.664ThrSer: 2.664 ± 0.067	2.74ThrThr: 2.74 ± 0.075	3.583ThrVal: 3.583 ± 0.085	0.497ThrTrp: 0.497 ± 0.023	1.059ThrTyr: 1.059 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	7.698ValAla: 7.698 ± 0.128	0.81ValCys: 0.81 ± 0.029	4.203ValAsp: 4.203 ± 0.078	4.433ValGlu: 4.433 ± 0.084	2.345ValPhe: 2.345 ± 0.049	4.423ValGly: 4.423 ± 0.088	1.693ValHis: 1.693 ± 0.048	4.583ValIle: 4.583 ± 0.085	2.396ValLys: 2.396 ± 0.062	7.16ValLeu: 7.16 ± 0.099	2.198ValMet: 2.198 ± 0.052	2.264ValAsn: 2.264 ± 0.054	2.804ValPro: 2.804 ± 0.058	2.265ValGln: 2.265 ± 0.052	4.433ValArg: 4.433 ± 0.075	4.458ValSer: 4.458 ± 0.072	3.866ValThr: 3.866 ± 0.099	5.412ValVal: 5.412 ± 0.104	0.774ValTrp: 0.774 ± 0.034	1.678ValTyr: 1.678 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.85TrpAla: 0.85 ± 0.032	0.159TrpCys: 0.159 ± 0.014	0.537TrpAsp: 0.537 ± 0.028	0.515TrpGlu: 0.515 ± 0.028	0.551TrpPhe: 0.551 ± 0.029	0.706TrpGly: 0.706 ± 0.03	0.468TrpHis: 0.468 ± 0.022	0.712TrpIle: 0.712 ± 0.03	0.491TrpLys: 0.491 ± 0.026	2.076TrpLeu: 2.076 ± 0.061	0.478TrpMet: 0.478 ± 0.024	0.341TrpAsn: 0.341 ± 0.019	0.549TrpPro: 0.549 ± 0.026	0.987TrpGln: 0.987 ± 0.041	0.869TrpArg: 0.869 ± 0.039	0.817TrpSer: 0.817 ± 0.03	0.42TrpThr: 0.42 ± 0.023	0.818TrpVal: 0.818 ± 0.043	0.225TrpTrp: 0.225 ± 0.016	0.343TrpTyr: 0.343 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.467TyrAla: 2.467 ± 0.054	0.349TyrCys: 0.349 ± 0.022	1.389TyrAsp: 1.389 ± 0.05	1.317TyrGlu: 1.317 ± 0.037	1.034TyrPhe: 1.034 ± 0.034	2.004TyrGly: 2.004 ± 0.051	0.771TyrHis: 0.771 ± 0.034	1.3TyrIle: 1.3 ± 0.041	0.818TyrLys: 0.818 ± 0.037	2.836TyrLeu: 2.836 ± 0.063	0.645TyrMet: 0.645 ± 0.029	0.732TyrAsn: 0.732 ± 0.03	1.17TyrPro: 1.17 ± 0.041	1.135TyrGln: 1.135 ± 0.038	1.963TyrArg: 1.963 ± 0.045	1.529TyrSer: 1.529 ± 0.044	1.115TyrThr: 1.115 ± 0.038	1.48TyrVal: 1.48 ± 0.039	0.343TyrTrp: 0.343 ± 0.019	0.715TyrTyr: 0.715 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2574 proteins (852991 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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