Amino acid dipepetide frequency for Glaciecola punicea ACAM 611

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.469AlaAla: 7.469 ± 0.11
1.065AlaCys: 1.065 ± 0.035
4.442AlaAsp: 4.442 ± 0.069
4.106AlaGlu: 4.106 ± 0.078
3.853AlaPhe: 3.853 ± 0.065
6.1AlaGly: 6.1 ± 0.102
1.879AlaHis: 1.879 ± 0.048
6.46AlaIle: 6.46 ± 0.098
5.35AlaLys: 5.35 ± 0.091
10.051AlaLeu: 10.051 ± 0.131
2.504AlaMet: 2.504 ± 0.051
4.334AlaAsn: 4.334 ± 0.082
2.952AlaPro: 2.952 ± 0.063
4.842AlaGln: 4.842 ± 0.093
3.739AlaArg: 3.739 ± 0.069
6.169AlaSer: 6.169 ± 0.091
4.423AlaThr: 4.423 ± 0.081
5.781AlaVal: 5.781 ± 0.098
0.886AlaTrp: 0.886 ± 0.036
2.595AlaTyr: 2.595 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.949CysAla: 0.949 ± 0.035
0.148CysCys: 0.148 ± 0.014
0.64CysAsp: 0.64 ± 0.031
0.589CysGlu: 0.589 ± 0.028
0.485CysPhe: 0.485 ± 0.022
0.775CysGly: 0.775 ± 0.03
0.293CysHis: 0.293 ± 0.018
0.802CysIle: 0.802 ± 0.033
0.522CysLys: 0.522 ± 0.024
1.009CysLeu: 1.009 ± 0.035
0.246CysMet: 0.246 ± 0.018
0.383CysAsn: 0.383 ± 0.019
0.428CysPro: 0.428 ± 0.024
0.398CysGln: 0.398 ± 0.022
0.426CysArg: 0.426 ± 0.023
0.693CysSer: 0.693 ± 0.027
0.489CysThr: 0.489 ± 0.027
0.734CysVal: 0.734 ± 0.03
0.103CysTrp: 0.103 ± 0.012
0.318CysTyr: 0.318 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.72AspAla: 4.72 ± 0.07
0.522AspCys: 0.522 ± 0.027
3.038AspAsp: 3.038 ± 0.067
3.638AspGlu: 3.638 ± 0.079
2.637AspPhe: 2.637 ± 0.057
3.592AspGly: 3.592 ± 0.069
0.981AspHis: 0.981 ± 0.04
4.606AspIle: 4.606 ± 0.072
3.255AspLys: 3.255 ± 0.066
5.193AspLeu: 5.193 ± 0.079
1.514AspMet: 1.514 ± 0.046
2.483AspAsn: 2.483 ± 0.064
2.034AspPro: 2.034 ± 0.053
1.563AspGln: 1.563 ± 0.04
2.008AspArg: 2.008 ± 0.043
3.297AspSer: 3.297 ± 0.068
2.919AspThr: 2.919 ± 0.069
3.912AspVal: 3.912 ± 0.072
0.757AspTrp: 0.757 ± 0.03
2.08AspTyr: 2.08 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
4.797GluAla: 4.797 ± 0.082
0.438GluCys: 0.438 ± 0.023
2.603GluAsp: 2.603 ± 0.065
2.936GluGlu: 2.936 ± 0.067
2.426GluPhe: 2.426 ± 0.057
3.194GluGly: 3.194 ± 0.074
1.407GluHis: 1.407 ± 0.041
3.863GluIle: 3.863 ± 0.064
3.591GluLys: 3.591 ± 0.075
5.989GluLeu: 5.989 ± 0.108
1.51GluMet: 1.51 ± 0.041
2.869GluAsn: 2.869 ± 0.06
1.77GluPro: 1.77 ± 0.044
3.198GluGln: 3.198 ± 0.072
2.807GluArg: 2.807 ± 0.06
3.216GluSer: 3.216 ± 0.064
2.776GluThr: 2.776 ± 0.054
3.916GluVal: 3.916 ± 0.074
0.523GluTrp: 0.523 ± 0.026
1.781GluTyr: 1.781 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
4.018PheAla: 4.018 ± 0.08
0.489PheCys: 0.489 ± 0.024
2.963PheAsp: 2.963 ± 0.068
2.731PheGlu: 2.731 ± 0.06
1.919PhePhe: 1.919 ± 0.051
3.264PheGly: 3.264 ± 0.074
0.728PheHis: 0.728 ± 0.029
3.091PheIle: 3.091 ± 0.07
2.004PheLys: 2.004 ± 0.053
3.549PheLeu: 3.549 ± 0.066
1.181PheMet: 1.181 ± 0.035
2.143PheAsn: 2.143 ± 0.05
1.355PhePro: 1.355 ± 0.037
1.154PheGln: 1.154 ± 0.037
1.53PheArg: 1.53 ± 0.044
3.468PheSer: 3.468 ± 0.066
2.892PheThr: 2.892 ± 0.057
3.033PheVal: 3.033 ± 0.062
0.463PheTrp: 0.463 ± 0.027
1.389PheTyr: 1.389 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
5.604GlyAla: 5.604 ± 0.085
0.834GlyCys: 0.834 ± 0.027
3.588GlyAsp: 3.588 ± 0.076
3.91GlyGlu: 3.91 ± 0.071
3.468GlyPhe: 3.468 ± 0.072
4.817GlyGly: 4.817 ± 0.098
1.496GlyHis: 1.496 ± 0.044
4.893GlyIle: 4.893 ± 0.089
4.193GlyLys: 4.193 ± 0.088
6.862GlyLeu: 6.862 ± 0.096
1.846GlyMet: 1.846 ± 0.048
2.799GlyAsn: 2.799 ± 0.063
1.852GlyPro: 1.852 ± 0.048
2.507GlyGln: 2.507 ± 0.047
2.913GlyArg: 2.913 ± 0.064
4.156GlySer: 4.156 ± 0.065
3.328GlyThr: 3.328 ± 0.072
4.84GlyVal: 4.84 ± 0.079
0.776GlyTrp: 0.776 ± 0.035
2.228GlyTyr: 2.228 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
1.825HisAla: 1.825 ± 0.049
0.345HisCys: 0.345 ± 0.021
1.035HisAsp: 1.035 ± 0.04
1.173HisGlu: 1.173 ± 0.034
1.069HisPhe: 1.069 ± 0.038
1.435HisGly: 1.435 ± 0.039
0.57HisHis: 0.57 ± 0.027
1.556HisIle: 1.556 ± 0.045
1.373HisLys: 1.373 ± 0.043
2.19HisLeu: 2.19 ± 0.048
0.523HisMet: 0.523 ± 0.024
0.987HisAsn: 0.987 ± 0.035
1.047HisPro: 1.047 ± 0.042
0.938HisGln: 0.938 ± 0.035
0.984HisArg: 0.984 ± 0.038
1.499HisSer: 1.499 ± 0.052
1.212HisThr: 1.212 ± 0.045
1.317HisVal: 1.317 ± 0.044
0.33HisTrp: 0.33 ± 0.018
0.811HisTyr: 0.811 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.924IleAla: 6.924 ± 0.1
0.805IleCys: 0.805 ± 0.033
4.659IleAsp: 4.659 ± 0.073
4.749IleGlu: 4.749 ± 0.083
2.575IlePhe: 2.575 ± 0.065
4.943IleGly: 4.943 ± 0.093
1.281IleHis: 1.281 ± 0.04
4.33IleIle: 4.33 ± 0.077
3.919IleLys: 3.919 ± 0.087
5.609IleLeu: 5.609 ± 0.1
1.546IleMet: 1.546 ± 0.046
3.696IleAsn: 3.696 ± 0.062
2.631IlePro: 2.631 ± 0.056
2.349IleGln: 2.349 ± 0.052
2.75IleArg: 2.75 ± 0.056
5.124IleSer: 5.124 ± 0.083
3.872IleThr: 3.872 ± 0.066
4.798IleVal: 4.798 ± 0.083
0.596IleTrp: 0.596 ± 0.03
1.885IleTyr: 1.885 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
4.982LysAla: 4.982 ± 0.089
0.422LysCys: 0.422 ± 0.023
2.953LysAsp: 2.953 ± 0.058
3.147LysGlu: 3.147 ± 0.069
1.752LysPhe: 1.752 ± 0.038
3.395LysGly: 3.395 ± 0.072
1.486LysHis: 1.486 ± 0.039
3.438LysIle: 3.438 ± 0.066
3.285LysLys: 3.285 ± 0.072
5.402LysLeu: 5.402 ± 0.083
1.497LysMet: 1.497 ± 0.045
2.5LysAsn: 2.5 ± 0.066
2.364LysPro: 2.364 ± 0.051
3.156LysGln: 3.156 ± 0.065
3.003LysArg: 3.003 ± 0.06
3.463LysSer: 3.463 ± 0.07
3.234LysThr: 3.234 ± 0.059
4.012LysVal: 4.012 ± 0.073
0.623LysTrp: 0.623 ± 0.028
1.522LysTyr: 1.522 ± 0.044
0.0LysXaa: 0.0 ± 0.0
Leu
9.79LeuAla: 9.79 ± 0.122
1.184LeuCys: 1.184 ± 0.034
5.42LeuAsp: 5.42 ± 0.083
5.312LeuGlu: 5.312 ± 0.083
4.202LeuPhe: 4.202 ± 0.077
6.808LeuGly: 6.808 ± 0.105
2.279LeuHis: 2.279 ± 0.05
6.56LeuIle: 6.56 ± 0.114
5.021LeuLys: 5.021 ± 0.094
10.345LeuLeu: 10.345 ± 0.139
2.543LeuMet: 2.543 ± 0.062
4.775LeuAsn: 4.775 ± 0.089
4.572LeuPro: 4.572 ± 0.08
3.96LeuGln: 3.96 ± 0.076
4.363LeuArg: 4.363 ± 0.074
8.317LeuSer: 8.317 ± 0.109
5.435LeuThr: 5.435 ± 0.083
6.87LeuVal: 6.87 ± 0.099
0.87LeuTrp: 0.87 ± 0.029
2.682LeuTyr: 2.682 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
2.446MetAla: 2.446 ± 0.05
0.233MetCys: 0.233 ± 0.016
1.128MetAsp: 1.128 ± 0.042
0.995MetGlu: 0.995 ± 0.037
0.936MetPhe: 0.936 ± 0.033
1.719MetGly: 1.719 ± 0.046
0.652MetHis: 0.652 ± 0.026
1.457MetIle: 1.457 ± 0.044
1.412MetLys: 1.412 ± 0.036
3.03MetLeu: 3.03 ± 0.063
0.657MetMet: 0.657 ± 0.028
1.123MetAsn: 1.123 ± 0.035
1.368MetPro: 1.368 ± 0.043
1.474MetGln: 1.474 ± 0.044
1.304MetArg: 1.304 ± 0.04
2.022MetSer: 2.022 ± 0.049
1.478MetThr: 1.478 ± 0.04
1.662MetVal: 1.662 ± 0.043
0.238MetTrp: 0.238 ± 0.016
0.569MetTyr: 0.569 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
4.186AsnAla: 4.186 ± 0.075
0.451AsnCys: 0.451 ± 0.023
2.651AsnAsp: 2.651 ± 0.055
2.774AsnGlu: 2.774 ± 0.064
1.832AsnPhe: 1.832 ± 0.049
3.025AsnGly: 3.025 ± 0.061
0.907AsnHis: 0.907 ± 0.035
3.689AsnIle: 3.689 ± 0.075
2.887AsnLys: 2.887 ± 0.063
4.169AsnLeu: 4.169 ± 0.067
1.252AsnMet: 1.252 ± 0.034
2.461AsnAsn: 2.461 ± 0.059
2.06AsnPro: 2.06 ± 0.046
1.869AsnGln: 1.869 ± 0.048
1.877AsnArg: 1.877 ± 0.045
2.924AsnSer: 2.924 ± 0.069
2.85AsnThr: 2.85 ± 0.056
3.029AsnVal: 3.029 ± 0.057
0.582AsnTrp: 0.582 ± 0.026
1.425AsnTyr: 1.425 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
2.957ProAla: 2.957 ± 0.058
0.344ProCys: 0.344 ± 0.019
2.243ProAsp: 2.243 ± 0.051
2.474ProGlu: 2.474 ± 0.061
1.787ProPhe: 1.787 ± 0.052
2.272ProGly: 2.272 ± 0.058
0.809ProHis: 0.809 ± 0.032
2.697ProIle: 2.697 ± 0.061
2.084ProLys: 2.084 ± 0.055
3.88ProLeu: 3.88 ± 0.074
1.026ProMet: 1.026 ± 0.034
1.947ProAsn: 1.947 ± 0.048
1.198ProPro: 1.198 ± 0.04
1.744ProGln: 1.744 ± 0.046
1.345ProArg: 1.345 ± 0.044
2.848ProSer: 2.848 ± 0.057
1.995ProThr: 1.995 ± 0.051
2.771ProVal: 2.771 ± 0.055
0.429ProTrp: 0.429 ± 0.026
1.129ProTyr: 1.129 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.425GlnAla: 4.425 ± 0.079
0.362GlnCys: 0.362 ± 0.022
2.15GlnAsp: 2.15 ± 0.056
2.448GlnGlu: 2.448 ± 0.057
1.731GlnPhe: 1.731 ± 0.04
2.85GlnGly: 2.85 ± 0.056
1.257GlnHis: 1.257 ± 0.048
2.75GlnIle: 2.75 ± 0.052
2.24GlnLys: 2.24 ± 0.053
4.455GlnLeu: 4.455 ± 0.09
1.066GlnMet: 1.066 ± 0.035
1.903GlnAsn: 1.903 ± 0.053
1.359GlnPro: 1.359 ± 0.043
2.988GlnGln: 2.988 ± 0.069
2.236GlnArg: 2.236 ± 0.051
3.006GlnSer: 3.006 ± 0.062
2.381GlnThr: 2.381 ± 0.054
2.938GlnVal: 2.938 ± 0.057
0.626GlnTrp: 0.626 ± 0.025
1.422GlnTyr: 1.422 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
3.571ArgAla: 3.571 ± 0.067
0.369ArgCys: 0.369 ± 0.02
2.29ArgAsp: 2.29 ± 0.05
2.551ArgGlu: 2.551 ± 0.057
2.2ArgPhe: 2.2 ± 0.049
2.611ArgGly: 2.611 ± 0.054
0.995ArgHis: 0.995 ± 0.025
3.125ArgIle: 3.125 ± 0.057
2.367ArgLys: 2.367 ± 0.048
4.608ArgLeu: 4.608 ± 0.077
1.171ArgMet: 1.171 ± 0.038
1.892ArgAsn: 1.892 ± 0.047
1.565ArgPro: 1.565 ± 0.043
2.026ArgGln: 2.026 ± 0.05
2.1ArgArg: 2.1 ± 0.054
2.626ArgSer: 2.626 ± 0.058
2.075ArgThr: 2.075 ± 0.046
3.106ArgVal: 3.106 ± 0.07
0.519ArgTrp: 0.519 ± 0.026
1.61ArgTyr: 1.61 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
6.416SerAla: 6.416 ± 0.09
0.581SerCys: 0.581 ± 0.023
3.834SerAsp: 3.834 ± 0.068
3.72SerGlu: 3.72 ± 0.061
3.096SerPhe: 3.096 ± 0.064
4.954SerGly: 4.954 ± 0.076
1.548SerHis: 1.548 ± 0.046
4.86SerIle: 4.86 ± 0.092
3.652SerLys: 3.652 ± 0.072
7.274SerLeu: 7.274 ± 0.088
1.777SerMet: 1.777 ± 0.044
3.063SerAsn: 3.063 ± 0.061
2.606SerPro: 2.606 ± 0.062
3.17SerGln: 3.17 ± 0.069
2.857SerArg: 2.857 ± 0.063
4.83SerSer: 4.83 ± 0.093
3.644SerThr: 3.644 ± 0.07
4.833SerVal: 4.833 ± 0.077
0.705SerTrp: 0.705 ± 0.028
1.97SerTyr: 1.97 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
4.406ThrAla: 4.406 ± 0.08
0.541ThrCys: 0.541 ± 0.024
2.738ThrAsp: 2.738 ± 0.058
2.396ThrGlu: 2.396 ± 0.052
2.269ThrPhe: 2.269 ± 0.05
4.08ThrGly: 4.08 ± 0.079
1.299ThrHis: 1.299 ± 0.036
3.561ThrIle: 3.561 ± 0.065
2.768ThrLys: 2.768 ± 0.062
6.095ThrLeu: 6.095 ± 0.082
1.24ThrMet: 1.24 ± 0.041
2.4ThrAsn: 2.4 ± 0.059
2.591ThrPro: 2.591 ± 0.058
2.799ThrGln: 2.799 ± 0.06
2.304ThrArg: 2.304 ± 0.047
3.659ThrSer: 3.659 ± 0.072
2.807ThrThr: 2.807 ± 0.056
3.582ThrVal: 3.582 ± 0.07
0.566ThrTrp: 0.566 ± 0.033
1.494ThrTyr: 1.494 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
6.088ValAla: 6.088 ± 0.081
0.756ValCys: 0.756 ± 0.031
4.198ValAsp: 4.198 ± 0.071
3.783ValGlu: 3.783 ± 0.069
3.085ValPhe: 3.085 ± 0.061
4.492ValGly: 4.492 ± 0.083
1.341ValHis: 1.341 ± 0.042
4.778ValIle: 4.778 ± 0.08
3.665ValLys: 3.665 ± 0.068
6.899ValLeu: 6.899 ± 0.1
1.853ValMet: 1.853 ± 0.049
3.513ValAsn: 3.513 ± 0.06
2.58ValPro: 2.58 ± 0.058
2.269ValGln: 2.269 ± 0.052
2.799ValArg: 2.799 ± 0.063
5.285ValSer: 5.285 ± 0.075
3.686ValThr: 3.686 ± 0.082
5.089ValVal: 5.089 ± 0.1
0.676ValTrp: 0.676 ± 0.027
1.996ValTyr: 1.996 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.751TrpAla: 0.751 ± 0.035
0.11TrpCys: 0.11 ± 0.011
0.571TrpAsp: 0.571 ± 0.027
0.507TrpGlu: 0.507 ± 0.025
0.534TrpPhe: 0.534 ± 0.026
0.618TrpGly: 0.618 ± 0.03
0.322TrpHis: 0.322 ± 0.02
0.665TrpIle: 0.665 ± 0.029
0.36TrpLys: 0.36 ± 0.022
1.461TrpLeu: 1.461 ± 0.05
0.275TrpMet: 0.275 ± 0.018
0.374TrpAsn: 0.374 ± 0.019
0.429TrpPro: 0.429 ± 0.022
0.802TrpGln: 0.802 ± 0.033
0.637TrpArg: 0.637 ± 0.028
0.657TrpSer: 0.657 ± 0.03
0.505TrpThr: 0.505 ± 0.028
0.715TrpVal: 0.715 ± 0.029
0.167TrpTrp: 0.167 ± 0.013
0.382TrpTyr: 0.382 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.675TyrAla: 2.675 ± 0.05
0.429TyrCys: 0.429 ± 0.021
1.606TyrAsp: 1.606 ± 0.043
1.67TyrGlu: 1.67 ± 0.049
1.51TyrPhe: 1.51 ± 0.038
1.965TyrGly: 1.965 ± 0.05
0.688TyrHis: 0.688 ± 0.03
1.862TyrIle: 1.862 ± 0.044
1.684TyrLys: 1.684 ± 0.039
3.238TyrLeu: 3.238 ± 0.064
0.671TyrMet: 0.671 ± 0.032
1.257TyrAsn: 1.257 ± 0.042
1.217TyrPro: 1.217 ± 0.04
1.389TyrGln: 1.389 ± 0.038
1.395TyrArg: 1.395 ± 0.043
2.133TyrSer: 2.133 ± 0.049
1.595TyrThr: 1.595 ± 0.049
1.895TyrVal: 1.895 ± 0.048
0.407TyrTrp: 0.407 ± 0.02
1.027TyrTyr: 1.027 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2883 proteins (882842 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski