Amino acid dipepetide frequency for Paludibacter jiangxiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.953AlaAla: 5.953 ± 0.088
0.856AlaCys: 0.856 ± 0.032
4.17AlaAsp: 4.17 ± 0.068
4.085AlaGlu: 4.085 ± 0.075
3.434AlaPhe: 3.434 ± 0.056
5.623AlaGly: 5.623 ± 0.097
1.224AlaHis: 1.224 ± 0.035
5.293AlaIle: 5.293 ± 0.086
4.911AlaLys: 4.911 ± 0.073
6.79AlaLeu: 6.79 ± 0.088
1.788AlaMet: 1.788 ± 0.044
3.725AlaAsn: 3.725 ± 0.077
2.62AlaPro: 2.62 ± 0.077
2.954AlaGln: 2.954 ± 0.063
2.621AlaArg: 2.621 ± 0.053
4.899AlaSer: 4.899 ± 0.087
4.497AlaThr: 4.497 ± 0.098
5.013AlaVal: 5.013 ± 0.074
0.887AlaTrp: 0.887 ± 0.035
2.912AlaTyr: 2.912 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.699CysAla: 0.699 ± 0.028
0.176CysCys: 0.176 ± 0.014
0.6CysAsp: 0.6 ± 0.029
0.518CysGlu: 0.518 ± 0.023
0.587CysPhe: 0.587 ± 0.022
0.91CysGly: 0.91 ± 0.034
0.255CysHis: 0.255 ± 0.016
0.778CysIle: 0.778 ± 0.032
0.684CysLys: 0.684 ± 0.026
0.944CysLeu: 0.944 ± 0.031
0.236CysMet: 0.236 ± 0.014
0.617CysAsn: 0.617 ± 0.025
0.49CysPro: 0.49 ± 0.025
0.32CysGln: 0.32 ± 0.018
0.496CysArg: 0.496 ± 0.025
0.856CysSer: 0.856 ± 0.034
0.634CysThr: 0.634 ± 0.025
0.721CysVal: 0.721 ± 0.024
0.181CysTrp: 0.181 ± 0.037
0.457CysTyr: 0.457 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
4.082AspAla: 4.082 ± 0.062
0.553AspCys: 0.553 ± 0.025
2.367AspAsp: 2.367 ± 0.057
3.208AspGlu: 3.208 ± 0.064
2.956AspPhe: 2.956 ± 0.049
3.914AspGly: 3.914 ± 0.097
0.868AspHis: 0.868 ± 0.025
3.782AspIle: 3.782 ± 0.058
3.959AspLys: 3.959 ± 0.077
4.552AspLeu: 4.552 ± 0.067
1.31AspMet: 1.31 ± 0.034
2.879AspAsn: 2.879 ± 0.054
2.06AspPro: 2.06 ± 0.05
1.573AspGln: 1.573 ± 0.045
2.083AspArg: 2.083 ± 0.044
3.192AspSer: 3.192 ± 0.059
2.541AspThr: 2.541 ± 0.052
3.479AspVal: 3.479 ± 0.065
0.792AspTrp: 0.792 ± 0.028
2.512AspTyr: 2.512 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
4.348GluAla: 4.348 ± 0.078
0.465GluCys: 0.465 ± 0.023
2.392GluAsp: 2.392 ± 0.053
3.648GluGlu: 3.648 ± 0.092
2.335GluPhe: 2.335 ± 0.05
3.317GluGly: 3.317 ± 0.057
1.064GluHis: 1.064 ± 0.032
4.219GluIle: 4.219 ± 0.078
4.705GluLys: 4.705 ± 0.079
5.233GluLeu: 5.233 ± 0.089
1.683GluMet: 1.683 ± 0.044
3.339GluAsn: 3.339 ± 0.069
1.691GluPro: 1.691 ± 0.046
2.271GluGln: 2.271 ± 0.053
2.397GluArg: 2.397 ± 0.051
2.965GluSer: 2.965 ± 0.063
3.089GluThr: 3.089 ± 0.061
3.587GluVal: 3.587 ± 0.066
0.771GluTrp: 0.771 ± 0.031
2.23GluTyr: 2.23 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.666PheAla: 3.666 ± 0.067
0.69PheCys: 0.69 ± 0.023
2.997PheAsp: 2.997 ± 0.062
2.501PheGlu: 2.501 ± 0.047
2.335PhePhe: 2.335 ± 0.059
3.564PheGly: 3.564 ± 0.065
0.858PheHis: 0.858 ± 0.028
3.057PheIle: 3.057 ± 0.059
2.548PheLys: 2.548 ± 0.049
4.164PheLeu: 4.164 ± 0.079
1.105PheMet: 1.105 ± 0.032
2.587PheAsn: 2.587 ± 0.056
1.801PhePro: 1.801 ± 0.043
1.361PheGln: 1.361 ± 0.042
2.018PheArg: 2.018 ± 0.047
3.76PheSer: 3.76 ± 0.055
2.947PheThr: 2.947 ± 0.065
3.277PheVal: 3.277 ± 0.062
0.619PheTrp: 0.619 ± 0.027
2.017PheTyr: 2.017 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
4.809GlyAla: 4.809 ± 0.104
0.88GlyCys: 0.88 ± 0.039
3.407GlyAsp: 3.407 ± 0.069
3.4GlyGlu: 3.4 ± 0.064
3.372GlyPhe: 3.372 ± 0.064
4.935GlyGly: 4.935 ± 0.119
1.299GlyHis: 1.299 ± 0.038
5.297GlyIle: 5.297 ± 0.066
5.345GlyLys: 5.345 ± 0.086
5.831GlyLeu: 5.831 ± 0.08
1.922GlyMet: 1.922 ± 0.049
3.835GlyAsn: 3.835 ± 0.071
1.428GlyPro: 1.428 ± 0.041
2.142GlyGln: 2.142 ± 0.049
2.543GlyArg: 2.543 ± 0.06
4.71GlySer: 4.71 ± 0.105
4.605GlyThr: 4.605 ± 0.118
4.912GlyVal: 4.912 ± 0.075
1.068GlyTrp: 1.068 ± 0.047
3.202GlyTyr: 3.202 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
1.137HisAla: 1.137 ± 0.032
0.263HisCys: 0.263 ± 0.015
0.925HisAsp: 0.925 ± 0.03
0.942HisGlu: 0.942 ± 0.035
1.092HisPhe: 1.092 ± 0.038
1.204HisGly: 1.204 ± 0.04
0.495HisHis: 0.495 ± 0.023
1.34HisIle: 1.34 ± 0.034
1.076HisLys: 1.076 ± 0.035
1.859HisLeu: 1.859 ± 0.049
0.364HisMet: 0.364 ± 0.02
0.972HisAsn: 0.972 ± 0.031
1.106HisPro: 1.106 ± 0.032
0.617HisGln: 0.617 ± 0.021
0.761HisArg: 0.761 ± 0.03
1.148HisSer: 1.148 ± 0.036
1.01HisThr: 1.01 ± 0.034
1.082HisVal: 1.082 ± 0.031
0.272HisTrp: 0.272 ± 0.016
0.884HisTyr: 0.884 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.825IleAla: 5.825 ± 0.078
0.907IleCys: 0.907 ± 0.035
4.281IleAsp: 4.281 ± 0.07
4.367IleGlu: 4.367 ± 0.075
3.03IlePhe: 3.03 ± 0.061
4.733IleGly: 4.733 ± 0.064
1.294IleHis: 1.294 ± 0.042
4.627IleIle: 4.627 ± 0.087
4.314IleLys: 4.314 ± 0.077
5.811IleLeu: 5.811 ± 0.092
1.319IleMet: 1.319 ± 0.037
3.774IleAsn: 3.774 ± 0.067
3.175IlePro: 3.175 ± 0.061
2.131IleGln: 2.131 ± 0.051
3.044IleArg: 3.044 ± 0.056
5.126IleSer: 5.126 ± 0.097
4.518IleThr: 4.518 ± 0.089
4.595IleVal: 4.595 ± 0.078
0.725IleTrp: 0.725 ± 0.031
2.54IleTyr: 2.54 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
5.33LysAla: 5.33 ± 0.08
0.501LysCys: 0.501 ± 0.024
3.64LysAsp: 3.64 ± 0.073
4.754LysGlu: 4.754 ± 0.077
2.394LysPhe: 2.394 ± 0.048
4.48LysGly: 4.48 ± 0.067
1.258LysHis: 1.258 ± 0.034
4.847LysIle: 4.847 ± 0.085
4.984LysLys: 4.984 ± 0.077
5.644LysLeu: 5.644 ± 0.08
2.131LysMet: 2.131 ± 0.048
3.863LysAsn: 3.863 ± 0.059
2.547LysPro: 2.547 ± 0.055
2.814LysGln: 2.814 ± 0.059
2.751LysArg: 2.751 ± 0.059
3.95LysSer: 3.95 ± 0.061
4.188LysThr: 4.188 ± 0.073
4.371LysVal: 4.371 ± 0.058
0.862LysTrp: 0.862 ± 0.033
2.776LysTyr: 2.776 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
6.449LeuAla: 6.449 ± 0.091
1.118LeuCys: 1.118 ± 0.037
4.263LeuAsp: 4.263 ± 0.07
4.36LeuGlu: 4.36 ± 0.077
4.847LeuPhe: 4.847 ± 0.079
5.6LeuGly: 5.6 ± 0.078
1.85LeuHis: 1.85 ± 0.044
5.972LeuIle: 5.972 ± 0.102
6.492LeuLys: 6.492 ± 0.083
9.042LeuLeu: 9.042 ± 0.121
2.187LeuMet: 2.187 ± 0.046
4.82LeuAsn: 4.82 ± 0.086
3.991LeuPro: 3.991 ± 0.065
3.489LeuGln: 3.489 ± 0.066
3.662LeuArg: 3.662 ± 0.065
6.837LeuSer: 6.837 ± 0.102
5.516LeuThr: 5.516 ± 0.075
5.212LeuVal: 5.212 ± 0.082
1.028LeuTrp: 1.028 ± 0.034
3.409LeuTyr: 3.409 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
1.894MetAla: 1.894 ± 0.042
0.211MetCys: 0.211 ± 0.015
1.152MetAsp: 1.152 ± 0.037
1.373MetGlu: 1.373 ± 0.037
0.958MetPhe: 0.958 ± 0.029
1.644MetGly: 1.644 ± 0.042
0.492MetHis: 0.492 ± 0.022
1.601MetIle: 1.601 ± 0.037
2.176MetLys: 2.176 ± 0.05
2.236MetLeu: 2.236 ± 0.048
0.713MetMet: 0.713 ± 0.028
1.43MetAsn: 1.43 ± 0.037
1.122MetPro: 1.122 ± 0.035
1.072MetGln: 1.072 ± 0.032
1.12MetArg: 1.12 ± 0.032
1.527MetSer: 1.527 ± 0.037
1.428MetThr: 1.428 ± 0.041
1.539MetVal: 1.539 ± 0.042
0.253MetTrp: 0.253 ± 0.015
0.735MetTyr: 0.735 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.913AsnAla: 3.913 ± 0.071
0.589AsnCys: 0.589 ± 0.024
2.897AsnAsp: 2.897 ± 0.055
2.864AsnGlu: 2.864 ± 0.063
2.466AsnPhe: 2.466 ± 0.052
4.403AsnGly: 4.403 ± 0.1
1.039AsnHis: 1.039 ± 0.033
4.013AsnIle: 4.013 ± 0.073
3.484AsnLys: 3.484 ± 0.062
4.494AsnLeu: 4.494 ± 0.076
1.217AsnMet: 1.217 ± 0.034
3.045AsnAsn: 3.045 ± 0.066
2.75AsnPro: 2.75 ± 0.058
1.887AsnGln: 1.887 ± 0.041
2.259AsnArg: 2.259 ± 0.049
3.459AsnSer: 3.459 ± 0.066
3.083AsnThr: 3.083 ± 0.079
3.441AsnVal: 3.441 ± 0.057
0.73AsnTrp: 0.73 ± 0.03
2.579AsnTyr: 2.579 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
3.206ProAla: 3.206 ± 0.062
0.361ProCys: 0.361 ± 0.024
2.633ProAsp: 2.633 ± 0.051
2.981ProGlu: 2.981 ± 0.063
1.946ProPhe: 1.946 ± 0.046
2.434ProGly: 2.434 ± 0.051
0.721ProHis: 0.721 ± 0.028
2.287ProIle: 2.287 ± 0.046
2.241ProLys: 2.241 ± 0.049
3.296ProLeu: 3.296 ± 0.062
0.841ProMet: 0.841 ± 0.025
1.912ProAsn: 1.912 ± 0.042
0.924ProPro: 0.924 ± 0.037
1.487ProGln: 1.487 ± 0.036
1.184ProArg: 1.184 ± 0.031
2.634ProSer: 2.634 ± 0.056
2.31ProThr: 2.31 ± 0.076
3.398ProVal: 3.398 ± 0.069
0.481ProTrp: 0.481 ± 0.022
1.642ProTyr: 1.642 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
2.459GlnAla: 2.459 ± 0.049
0.311GlnCys: 0.311 ± 0.02
1.427GlnAsp: 1.427 ± 0.04
1.874GlnGlu: 1.874 ± 0.047
1.645GlnPhe: 1.645 ± 0.034
2.03GlnGly: 2.03 ± 0.048
0.697GlnHis: 0.697 ± 0.025
2.548GlnIle: 2.548 ± 0.057
2.762GlnLys: 2.762 ± 0.062
3.631GlnLeu: 3.631 ± 0.067
1.016GlnMet: 1.016 ± 0.034
2.035GlnAsn: 2.035 ± 0.049
1.445GlnPro: 1.445 ± 0.039
1.796GlnGln: 1.796 ± 0.05
1.547GlnArg: 1.547 ± 0.04
2.304GlnSer: 2.304 ± 0.047
2.267GlnThr: 2.267 ± 0.049
2.05GlnVal: 2.05 ± 0.046
0.519GlnTrp: 0.519 ± 0.022
1.525GlnTyr: 1.525 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
2.428ArgAla: 2.428 ± 0.052
0.413ArgCys: 0.413 ± 0.02
1.907ArgAsp: 1.907 ± 0.042
2.282ArgGlu: 2.282 ± 0.056
2.258ArgPhe: 2.258 ± 0.047
2.22ArgGly: 2.22 ± 0.051
0.765ArgHis: 0.765 ± 0.03
3.071ArgIle: 3.071 ± 0.054
2.869ArgLys: 2.869 ± 0.059
3.903ArgLeu: 3.903 ± 0.068
1.216ArgMet: 1.216 ± 0.034
2.193ArgAsn: 2.193 ± 0.051
1.508ArgPro: 1.508 ± 0.038
1.65ArgGln: 1.65 ± 0.037
1.655ArgArg: 1.655 ± 0.043
2.256ArgSer: 2.256 ± 0.051
2.159ArgThr: 2.159 ± 0.054
2.436ArgVal: 2.436 ± 0.05
0.559ArgTrp: 0.559 ± 0.026
1.879ArgTyr: 1.879 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
4.738SerAla: 4.738 ± 0.093
0.802SerCys: 0.802 ± 0.026
3.646SerAsp: 3.646 ± 0.076
3.336SerGlu: 3.336 ± 0.06
3.607SerPhe: 3.607 ± 0.067
5.233SerGly: 5.233 ± 0.121
1.21SerHis: 1.21 ± 0.033
4.825SerIle: 4.825 ± 0.075
4.071SerLys: 4.071 ± 0.062
6.355SerLeu: 6.355 ± 0.081
1.432SerMet: 1.432 ± 0.035
3.44SerAsn: 3.44 ± 0.074
2.567SerPro: 2.567 ± 0.06
2.205SerGln: 2.205 ± 0.047
2.404SerArg: 2.404 ± 0.054
4.68SerSer: 4.68 ± 0.099
3.888SerThr: 3.888 ± 0.08
4.924SerVal: 4.924 ± 0.08
0.821SerTrp: 0.821 ± 0.03
2.958SerTyr: 2.958 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
4.648ThrAla: 4.648 ± 0.124
0.524ThrCys: 0.524 ± 0.025
3.407ThrAsp: 3.407 ± 0.066
2.958ThrGlu: 2.958 ± 0.068
2.791ThrPhe: 2.791 ± 0.059
4.767ThrGly: 4.767 ± 0.108
1.034ThrHis: 1.034 ± 0.034
4.542ThrIle: 4.542 ± 0.09
3.315ThrLys: 3.315 ± 0.058
5.565ThrLeu: 5.565 ± 0.076
1.239ThrMet: 1.239 ± 0.029
3.025ThrAsn: 3.025 ± 0.07
2.949ThrPro: 2.949 ± 0.083
1.85ThrGln: 1.85 ± 0.048
2.032ThrArg: 2.032 ± 0.055
4.041ThrSer: 4.041 ± 0.119
3.997ThrThr: 3.997 ± 0.143
4.305ThrVal: 4.305 ± 0.1
0.679ThrTrp: 0.679 ± 0.032
2.535ThrTyr: 2.535 ± 0.077
0.0ThrXaa: 0.0 ± 0.0
Val
5.081ValAla: 5.081 ± 0.077
0.846ValCys: 0.846 ± 0.03
3.65ValAsp: 3.65 ± 0.067
3.683ValGlu: 3.683 ± 0.074
2.972ValPhe: 2.972 ± 0.051
4.187ValGly: 4.187 ± 0.068
1.061ValHis: 1.061 ± 0.037
4.648ValIle: 4.648 ± 0.062
4.459ValLys: 4.459 ± 0.073
5.783ValLeu: 5.783 ± 0.076
1.663ValMet: 1.663 ± 0.04
3.686ValAsn: 3.686 ± 0.067
2.599ValPro: 2.599 ± 0.049
2.056ValGln: 2.056 ± 0.047
2.638ValArg: 2.638 ± 0.054
4.896ValSer: 4.896 ± 0.085
4.27ValThr: 4.27 ± 0.109
5.064ValVal: 5.064 ± 0.077
0.789ValTrp: 0.789 ± 0.029
2.555ValTyr: 2.555 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.786TrpAla: 0.786 ± 0.033
0.164TrpCys: 0.164 ± 0.012
0.673TrpAsp: 0.673 ± 0.028
0.665TrpGlu: 0.665 ± 0.025
0.579TrpPhe: 0.579 ± 0.025
0.954TrpGly: 0.954 ± 0.034
0.259TrpHis: 0.259 ± 0.016
0.841TrpIle: 0.841 ± 0.034
0.97TrpLys: 0.97 ± 0.034
1.181TrpLeu: 1.181 ± 0.04
0.406TrpMet: 0.406 ± 0.019
0.854TrpAsn: 0.854 ± 0.035
0.31TrpPro: 0.31 ± 0.019
0.607TrpGln: 0.607 ± 0.023
0.51TrpArg: 0.51 ± 0.025
0.895TrpSer: 0.895 ± 0.042
0.723TrpThr: 0.723 ± 0.034
0.737TrpVal: 0.737 ± 0.031
0.209TrpTrp: 0.209 ± 0.014
0.513TrpTyr: 0.513 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.804TyrAla: 2.804 ± 0.069
0.532TyrCys: 0.532 ± 0.026
2.228TyrAsp: 2.228 ± 0.05
1.948TyrGlu: 1.948 ± 0.046
2.265TyrPhe: 2.265 ± 0.049
2.79TyrGly: 2.79 ± 0.064
0.807TyrHis: 0.807 ± 0.029
2.55TyrIle: 2.55 ± 0.048
2.723TyrLys: 2.723 ± 0.054
3.827TyrLeu: 3.827 ± 0.068
0.89TyrMet: 0.89 ± 0.029
2.584TyrAsn: 2.584 ± 0.056
1.834TyrPro: 1.834 ± 0.045
1.604TyrGln: 1.604 ± 0.039
1.902TyrArg: 1.902 ± 0.046
3.012TyrSer: 3.012 ± 0.054
2.532TyrThr: 2.532 ± 0.081
2.44TyrVal: 2.44 ± 0.048
0.588TyrTrp: 0.588 ± 0.031
2.09TyrTyr: 2.09 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2945 proteins (1080957 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski