Amino acid dipepetide frequency for Sphingomonas rubra

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.603AlaAla: 23.603 ± 0.26	1.126AlaCys: 1.126 ± 0.039	8.716AlaAsp: 8.716 ± 0.095	8.146AlaGlu: 8.146 ± 0.115	4.248AlaPhe: 4.248 ± 0.077	12.971AlaGly: 12.971 ± 0.147	2.466AlaHis: 2.466 ± 0.055	6.842AlaIle: 6.842 ± 0.104	3.721AlaLys: 3.721 ± 0.093	14.654AlaLeu: 14.654 ± 0.173	3.955AlaMet: 3.955 ± 0.078	2.902AlaAsn: 2.902 ± 0.063	7.036AlaPro: 7.036 ± 0.104	4.219AlaGln: 4.219 ± 0.079	11.379AlaArg: 11.379 ± 0.144	6.329AlaSer: 6.329 ± 0.092	8.146AlaThr: 8.146 ± 0.116	10.102AlaVal: 10.102 ± 0.128	1.9AlaTrp: 1.9 ± 0.055	2.6AlaTyr: 2.6 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.941CysAla: 0.941 ± 0.031	0.065CysCys: 0.065 ± 0.009	0.47CysAsp: 0.47 ± 0.022	0.332CysGlu: 0.332 ± 0.018	0.251CysPhe: 0.251 ± 0.016	0.793CysGly: 0.793 ± 0.03	0.167CysHis: 0.167 ± 0.014	0.282CysIle: 0.282 ± 0.017	0.108CysLys: 0.108 ± 0.011	0.616CysLeu: 0.616 ± 0.025	0.13CysMet: 0.13 ± 0.012	0.172CysAsn: 0.172 ± 0.015	0.403CysPro: 0.403 ± 0.019	0.147CysGln: 0.147 ± 0.012	0.592CysArg: 0.592 ± 0.027	0.336CysSer: 0.336 ± 0.025	0.379CysThr: 0.379 ± 0.02	0.539CysVal: 0.539 ± 0.025	0.114CysTrp: 0.114 ± 0.013	0.159CysTyr: 0.159 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.913AspAla: 8.913 ± 0.105	0.388AspCys: 0.388 ± 0.018	3.632AspAsp: 3.632 ± 0.063	3.552AspGlu: 3.552 ± 0.063	1.95AspPhe: 1.95 ± 0.044	6.061AspGly: 6.061 ± 0.081	1.374AspHis: 1.374 ± 0.043	2.288AspIle: 2.288 ± 0.049	1.489AspLys: 1.489 ± 0.045	5.935AspLeu: 5.935 ± 0.092	1.205AspMet: 1.205 ± 0.043	1.157AspAsn: 1.157 ± 0.038	3.936AspPro: 3.936 ± 0.061	1.92AspGln: 1.92 ± 0.048	5.675AspArg: 5.675 ± 0.079	1.823AspSer: 1.823 ± 0.047	2.909AspThr: 2.909 ± 0.059	4.362AspVal: 4.362 ± 0.079	1.105AspTrp: 1.105 ± 0.036	1.495AspTyr: 1.495 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	7.822GluAla: 7.822 ± 0.112	0.27GluCys: 0.27 ± 0.016	2.403GluAsp: 2.403 ± 0.052	2.731GluGlu: 2.731 ± 0.075	1.265GluPhe: 1.265 ± 0.038	4.318GluGly: 4.318 ± 0.071	1.105GluHis: 1.105 ± 0.034	2.349GluIle: 2.349 ± 0.054	1.497GluLys: 1.497 ± 0.045	4.755GluLeu: 4.755 ± 0.082	1.267GluMet: 1.267 ± 0.041	1.122GluAsn: 1.122 ± 0.034	2.699GluPro: 2.699 ± 0.065	1.992GluGln: 1.992 ± 0.046	5.386GluArg: 5.386 ± 0.081	1.724GluSer: 1.724 ± 0.044	2.923GluThr: 2.923 ± 0.059	3.852GluVal: 3.852 ± 0.072	0.749GluTrp: 0.749 ± 0.024	0.896GluTyr: 0.896 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.943PheAla: 4.943 ± 0.082	0.282PheCys: 0.282 ± 0.016	2.542PheAsp: 2.542 ± 0.054	1.728PheGlu: 1.728 ± 0.041	1.216PhePhe: 1.216 ± 0.044	3.474PheGly: 3.474 ± 0.075	0.66PheHis: 0.66 ± 0.026	1.067PheIle: 1.067 ± 0.034	0.676PheLys: 0.676 ± 0.028	2.949PheLeu: 2.949 ± 0.063	0.608PheMet: 0.608 ± 0.026	0.86PheAsn: 0.86 ± 0.035	1.414PhePro: 1.414 ± 0.042	0.884PheGln: 0.884 ± 0.033	2.248PheArg: 2.248 ± 0.054	1.645PheSer: 1.645 ± 0.045	1.974PheThr: 1.974 ± 0.053	2.731PheVal: 2.731 ± 0.055	0.457PheTrp: 0.457 ± 0.022	0.8PheTyr: 0.8 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.902GlyAla: 10.902 ± 0.128	0.794GlyCys: 0.794 ± 0.028	5.309GlyAsp: 5.309 ± 0.071	5.123GlyGlu: 5.123 ± 0.078	3.52GlyPhe: 3.52 ± 0.064	8.712GlyGly: 8.712 ± 0.143	1.845GlyHis: 1.845 ± 0.047	4.345GlyIle: 4.345 ± 0.069	2.71GlyLys: 2.71 ± 0.061	8.698GlyLeu: 8.698 ± 0.108	2.267GlyMet: 2.267 ± 0.055	2.025GlyAsn: 2.025 ± 0.056	3.657GlyPro: 3.657 ± 0.066	3.054GlyGln: 3.054 ± 0.061	7.58GlyArg: 7.58 ± 0.1	4.707GlySer: 4.707 ± 0.069	5.465GlyThr: 5.465 ± 0.099	6.802GlyVal: 6.802 ± 0.094	1.736GlyTrp: 1.736 ± 0.045	2.298GlyTyr: 2.298 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.661HisAla: 2.661 ± 0.052	0.184HisCys: 0.184 ± 0.016	1.317HisAsp: 1.317 ± 0.038	0.934HisGlu: 0.934 ± 0.03	0.673HisPhe: 0.673 ± 0.029	1.984HisGly: 1.984 ± 0.045	0.605HisHis: 0.605 ± 0.027	0.634HisIle: 0.634 ± 0.03	0.345HisLys: 0.345 ± 0.018	2.008HisLeu: 2.008 ± 0.051	0.384HisMet: 0.384 ± 0.018	0.378HisAsn: 0.378 ± 0.022	1.333HisPro: 1.333 ± 0.04	0.529HisGln: 0.529 ± 0.021	1.63HisArg: 1.63 ± 0.046	0.728HisSer: 0.728 ± 0.024	0.664HisThr: 0.664 ± 0.028	1.512HisVal: 1.512 ± 0.046	0.337HisTrp: 0.337 ± 0.019	0.494HisTyr: 0.494 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.452IleAla: 7.452 ± 0.104	0.301IleCys: 0.301 ± 0.019	3.865IleAsp: 3.865 ± 0.063	2.917IleGlu: 2.917 ± 0.056	1.16IlePhe: 1.16 ± 0.039	5.019IleGly: 5.019 ± 0.073	0.729IleHis: 0.729 ± 0.031	1.417IleIle: 1.417 ± 0.047	0.959IleLys: 0.959 ± 0.031	3.36IleLeu: 3.36 ± 0.067	0.679IleMet: 0.679 ± 0.029	1.06IleAsn: 1.06 ± 0.031	1.901IlePro: 1.901 ± 0.049	0.935IleGln: 0.935 ± 0.035	2.956IleArg: 2.956 ± 0.047	1.778IleSer: 1.778 ± 0.052	2.143IleThr: 2.143 ± 0.05	4.302IleVal: 4.302 ± 0.068	0.453IleTrp: 0.453 ± 0.02	0.792IleTyr: 0.792 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.476LysAla: 3.476 ± 0.077	0.099LysCys: 0.099 ± 0.011	1.258LysAsp: 1.258 ± 0.042	1.034LysGlu: 1.034 ± 0.038	0.598LysPhe: 0.598 ± 0.03	2.226LysGly: 2.226 ± 0.058	0.416LysHis: 0.416 ± 0.02	1.045LysIle: 1.045 ± 0.036	0.905LysLys: 0.905 ± 0.044	2.737LysLeu: 2.737 ± 0.062	0.644LysMet: 0.644 ± 0.028	0.595LysAsn: 0.595 ± 0.027	1.717LysPro: 1.717 ± 0.043	0.791LysGln: 0.791 ± 0.027	2.08LysArg: 2.08 ± 0.049	1.206LysSer: 1.206 ± 0.043	1.378LysThr: 1.378 ± 0.044	1.881LysVal: 1.881 ± 0.058	0.291LysTrp: 0.291 ± 0.02	0.485LysTyr: 0.485 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	15.577LeuAla: 15.577 ± 0.178	0.675LeuCys: 0.675 ± 0.028	6.491LeuAsp: 6.491 ± 0.093	4.056LeuGlu: 4.056 ± 0.078	3.589LeuPhe: 3.589 ± 0.072	8.62LeuGly: 8.62 ± 0.1	1.848LeuHis: 1.848 ± 0.049	4.172LeuIle: 4.172 ± 0.072	2.544LeuLys: 2.544 ± 0.06	9.702LeuLeu: 9.702 ± 0.139	1.918LeuMet: 1.918 ± 0.042	2.086LeuAsn: 2.086 ± 0.052	5.82LeuPro: 5.82 ± 0.086	2.275LeuGln: 2.275 ± 0.047	6.996LeuArg: 6.996 ± 0.088	5.568LeuSer: 5.568 ± 0.081	5.506LeuThr: 5.506 ± 0.074	8.138LeuVal: 8.138 ± 0.123	1.21LeuTrp: 1.21 ± 0.038	1.863LeuTyr: 1.863 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.161MetAla: 3.161 ± 0.065	0.127MetCys: 0.127 ± 0.012	1.031MetAsp: 1.031 ± 0.034	0.898MetGlu: 0.898 ± 0.039	0.57MetPhe: 0.57 ± 0.024	1.738MetGly: 1.738 ± 0.051	0.377MetHis: 0.377 ± 0.02	1.213MetIle: 1.213 ± 0.038	0.817MetLys: 0.817 ± 0.034	2.377MetLeu: 2.377 ± 0.049	0.572MetMet: 0.572 ± 0.022	0.655MetAsn: 0.655 ± 0.027	1.387MetPro: 1.387 ± 0.05	0.616MetGln: 0.616 ± 0.027	1.781MetArg: 1.781 ± 0.045	1.21MetSer: 1.21 ± 0.036	1.892MetThr: 1.892 ± 0.051	1.603MetVal: 1.603 ± 0.037	0.198MetTrp: 0.198 ± 0.015	0.263MetTyr: 0.263 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.971AsnAla: 2.971 ± 0.061	0.21AsnCys: 0.21 ± 0.016	1.345AsnAsp: 1.345 ± 0.033	0.951AsnGlu: 0.951 ± 0.034	0.777AsnPhe: 0.777 ± 0.03	2.157AsnGly: 2.157 ± 0.059	0.414AsnHis: 0.414 ± 0.023	1.013AsnIle: 1.013 ± 0.035	0.606AsnLys: 0.606 ± 0.03	2.17AsnLeu: 2.17 ± 0.055	0.461AsnMet: 0.461 ± 0.022	0.649AsnAsn: 0.649 ± 0.03	1.508AsnPro: 1.508 ± 0.042	0.663AsnGln: 0.663 ± 0.028	1.702AsnArg: 1.702 ± 0.051	0.943AsnSer: 0.943 ± 0.037	1.09AsnThr: 1.09 ± 0.039	1.718AsnVal: 1.718 ± 0.047	0.342AsnTrp: 0.342 ± 0.019	0.548AsnTyr: 0.548 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	8.338ProAla: 8.338 ± 0.118	0.303ProCys: 0.303 ± 0.02	3.871ProAsp: 3.871 ± 0.072	3.053ProGlu: 3.053 ± 0.06	1.844ProPhe: 1.844 ± 0.045	4.993ProGly: 4.993 ± 0.083	1.038ProHis: 1.038 ± 0.036	2.334ProIle: 2.334 ± 0.057	1.275ProLys: 1.275 ± 0.04	5.165ProLeu: 5.165 ± 0.08	1.129ProMet: 1.129 ± 0.036	1.149ProAsn: 1.149 ± 0.037	3.156ProPro: 3.156 ± 0.089	1.478ProGln: 1.478 ± 0.041	3.545ProArg: 3.545 ± 0.072	2.672ProSer: 2.672 ± 0.063	3.065ProThr: 3.065 ± 0.068	4.637ProVal: 4.637 ± 0.08	0.681ProTrp: 0.681 ± 0.028	1.106ProTyr: 1.106 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.135GlnAla: 4.135 ± 0.074	0.193GlnCys: 0.193 ± 0.016	1.249GlnAsp: 1.249 ± 0.038	1.132GlnGlu: 1.132 ± 0.035	0.993GlnPhe: 0.993 ± 0.032	2.585GlnGly: 2.585 ± 0.056	0.568GlnHis: 0.568 ± 0.025	1.333GlnIle: 1.333 ± 0.041	0.698GlnLys: 0.698 ± 0.029	2.99GlnLeu: 2.99 ± 0.053	0.683GlnMet: 0.683 ± 0.029	0.674GlnAsn: 0.674 ± 0.03	1.808GlnPro: 1.808 ± 0.045	1.135GlnGln: 1.135 ± 0.037	2.575GlnArg: 2.575 ± 0.049	1.367GlnSer: 1.367 ± 0.042	1.537GlnThr: 1.537 ± 0.047	2.492GlnVal: 2.492 ± 0.053	0.39GlnTrp: 0.39 ± 0.02	0.575GlnTyr: 0.575 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	10.531ArgAla: 10.531 ± 0.131	0.51ArgCys: 0.51 ± 0.022	4.851ArgAsp: 4.851 ± 0.077	4.058ArgGlu: 4.058 ± 0.083	3.352ArgPhe: 3.352 ± 0.065	6.041ArgGly: 6.041 ± 0.086	1.783ArgHis: 1.783 ± 0.055	3.931ArgIle: 3.931 ± 0.061	1.563ArgLys: 1.563 ± 0.046	8.81ArgLeu: 8.81 ± 0.116	2.008ArgMet: 2.008 ± 0.051	1.629ArgAsn: 1.629 ± 0.038	4.28ArgPro: 4.28 ± 0.089	2.553ArgGln: 2.553 ± 0.058	6.987ArgArg: 6.987 ± 0.105	3.747ArgSer: 3.747 ± 0.068	4.104ArgThr: 4.104 ± 0.065	5.918ArgVal: 5.918 ± 0.08	1.437ArgTrp: 1.437 ± 0.045	1.947ArgTyr: 1.947 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.785SerAla: 5.785 ± 0.078	0.333SerCys: 0.333 ± 0.019	2.658SerAsp: 2.658 ± 0.053	1.982SerGlu: 1.982 ± 0.045	1.885SerPhe: 1.885 ± 0.052	4.797SerGly: 4.797 ± 0.072	0.804SerHis: 0.804 ± 0.027	2.307SerIle: 2.307 ± 0.052	1.117SerLys: 1.117 ± 0.037	4.659SerLeu: 4.659 ± 0.073	1.074SerMet: 1.074 ± 0.033	1.164SerAsn: 1.164 ± 0.039	2.837SerPro: 2.837 ± 0.059	1.227SerGln: 1.227 ± 0.038	3.403SerArg: 3.403 ± 0.064	2.346SerSer: 2.346 ± 0.058	2.637SerThr: 2.637 ± 0.058	3.503SerVal: 3.503 ± 0.065	0.726SerTrp: 0.726 ± 0.026	1.183SerTyr: 1.183 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	7.304ThrAla: 7.304 ± 0.081	0.337ThrCys: 0.337 ± 0.019	3.093ThrAsp: 3.093 ± 0.06	2.195ThrGlu: 2.195 ± 0.046	1.764ThrPhe: 1.764 ± 0.054	5.701ThrGly: 5.701 ± 0.085	0.945ThrHis: 0.945 ± 0.036	3.004ThrIle: 3.004 ± 0.06	1.222ThrLys: 1.222 ± 0.037	6.284ThrLeu: 6.284 ± 0.083	1.253ThrMet: 1.253 ± 0.034	1.187ThrAsn: 1.187 ± 0.039	3.783ThrPro: 3.783 ± 0.069	1.409ThrGln: 1.409 ± 0.04	4.135ThrArg: 4.135 ± 0.073	2.575ThrSer: 2.575 ± 0.054	3.123ThrThr: 3.123 ± 0.077	4.7ThrVal: 4.7 ± 0.081	0.65ThrTrp: 0.65 ± 0.028	1.165ThrTyr: 1.165 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	12.177ValAla: 12.177 ± 0.138	0.476ValCys: 0.476 ± 0.021	4.884ValAsp: 4.884 ± 0.073	4.711ValGlu: 4.711 ± 0.078	2.237ValPhe: 2.237 ± 0.049	6.319ValGly: 6.319 ± 0.087	1.423ValHis: 1.423 ± 0.038	3.377ValIle: 3.377 ± 0.057	1.754ValLys: 1.754 ± 0.052	7.084ValLeu: 7.084 ± 0.086	1.56ValMet: 1.56 ± 0.037	1.864ValAsn: 1.864 ± 0.053	4.42ValPro: 4.42 ± 0.068	2.029ValGln: 2.029 ± 0.054	5.921ValArg: 5.921 ± 0.076	3.812ValSer: 3.812 ± 0.077	4.95ValThr: 4.95 ± 0.078	6.532ValVal: 6.532 ± 0.091	0.9ValTrp: 0.9 ± 0.032	1.34ValTyr: 1.34 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	1.464TrpAla: 1.464 ± 0.039	0.123TrpCys: 0.123 ± 0.011	0.736TrpAsp: 0.736 ± 0.025	0.542TrpGlu: 0.542 ± 0.025	0.555TrpPhe: 0.555 ± 0.028	0.944TrpGly: 0.944 ± 0.034	0.334TrpHis: 0.334 ± 0.018	0.628TrpIle: 0.628 ± 0.028	0.386TrpLys: 0.386 ± 0.021	1.673TrpLeu: 1.673 ± 0.045	0.337TrpMet: 0.337 ± 0.02	0.397TrpAsn: 0.397 ± 0.019	0.753TrpPro: 0.753 ± 0.029	0.582TrpGln: 0.582 ± 0.023	1.533TrpArg: 1.533 ± 0.04	0.923TrpSer: 0.923 ± 0.036	0.959TrpThr: 0.959 ± 0.032	0.84TrpVal: 0.84 ± 0.032	0.33TrpTrp: 0.33 ± 0.022	0.281TrpTyr: 0.281 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.906TyrAla: 2.906 ± 0.058	0.199TyrCys: 0.199 ± 0.016	1.451TyrAsp: 1.451 ± 0.041	1.049TyrGlu: 1.049 ± 0.035	0.711TyrPhe: 0.711 ± 0.027	2.096TyrGly: 2.096 ± 0.055	0.429TyrHis: 0.429 ± 0.02	0.598TyrIle: 0.598 ± 0.028	0.471TyrLys: 0.471 ± 0.024	2.028TyrLeu: 2.028 ± 0.049	0.349TyrMet: 0.349 ± 0.021	0.51TyrAsn: 0.51 ± 0.022	0.982TyrPro: 0.982 ± 0.029	0.675TyrGln: 0.675 ± 0.03	1.935TyrArg: 1.935 ± 0.043	0.989TyrSer: 0.989 ± 0.036	0.985TyrThr: 0.985 ± 0.034	1.607TyrVal: 1.607 ± 0.044	0.318TyrTrp: 0.318 ± 0.021	0.578TyrTyr: 0.578 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3070 proteins (947806 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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