Amino acid dipepetide frequency for Luteimicrobium subarcticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.658AlaAla: 22.658 ± 0.254
0.832AlaCys: 0.832 ± 0.028
9.503AlaAsp: 9.503 ± 0.116
6.741AlaGlu: 6.741 ± 0.093
3.43AlaPhe: 3.43 ± 0.06
13.718AlaGly: 13.718 ± 0.139
2.789AlaHis: 2.789 ± 0.053
3.572AlaIle: 3.572 ± 0.069
2.271AlaLys: 2.271 ± 0.064
14.509AlaLeu: 14.509 ± 0.156
2.225AlaMet: 2.225 ± 0.044
1.87AlaAsn: 1.87 ± 0.043
7.873AlaPro: 7.873 ± 0.118
3.948AlaGln: 3.948 ± 0.065
10.979AlaArg: 10.979 ± 0.146
7.686AlaSer: 7.686 ± 0.094
9.077AlaThr: 9.077 ± 0.118
13.524AlaVal: 13.524 ± 0.137
2.233AlaTrp: 2.233 ± 0.048
2.476AlaTyr: 2.476 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.734CysAla: 0.734 ± 0.028
0.053CysCys: 0.053 ± 0.008
0.357CysAsp: 0.357 ± 0.025
0.257CysGlu: 0.257 ± 0.015
0.166CysPhe: 0.166 ± 0.013
0.634CysGly: 0.634 ± 0.024
0.121CysHis: 0.121 ± 0.01
0.126CysIle: 0.126 ± 0.012
0.071CysLys: 0.071 ± 0.008
0.465CysLeu: 0.465 ± 0.021
0.073CysMet: 0.073 ± 0.008
0.086CysAsn: 0.086 ± 0.009
0.358CysPro: 0.358 ± 0.021
0.131CysGln: 0.131 ± 0.012
0.388CysArg: 0.388 ± 0.018
0.38CysSer: 0.38 ± 0.022
0.417CysThr: 0.417 ± 0.027
0.556CysVal: 0.556 ± 0.024
0.082CysTrp: 0.082 ± 0.009
0.131CysTyr: 0.131 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
10.734AspAla: 10.734 ± 0.126
0.274AspCys: 0.274 ± 0.017
5.928AspAsp: 5.928 ± 0.085
4.098AspGlu: 4.098 ± 0.071
1.335AspPhe: 1.335 ± 0.04
7.534AspGly: 7.534 ± 0.105
1.37AspHis: 1.37 ± 0.035
1.4AspIle: 1.4 ± 0.046
0.992AspLys: 0.992 ± 0.034
7.226AspLeu: 7.226 ± 0.088
0.719AspMet: 0.719 ± 0.024
0.827AspAsn: 0.827 ± 0.032
4.846AspPro: 4.846 ± 0.082
1.566AspGln: 1.566 ± 0.041
4.751AspArg: 4.751 ± 0.087
2.2AspSer: 2.2 ± 0.053
3.271AspThr: 3.271 ± 0.06
7.773AspVal: 7.773 ± 0.098
0.868AspTrp: 0.868 ± 0.029
1.07AspTyr: 1.07 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
5.895GluAla: 5.895 ± 0.086
0.221GluCys: 0.221 ± 0.015
2.727GluAsp: 2.727 ± 0.059
2.089GluGlu: 2.089 ± 0.059
0.979GluPhe: 0.979 ± 0.036
3.461GluGly: 3.461 ± 0.065
1.548GluHis: 1.548 ± 0.039
1.986GluIle: 1.986 ± 0.049
0.992GluLys: 0.992 ± 0.039
5.503GluLeu: 5.503 ± 0.091
0.67GluMet: 0.67 ± 0.028
0.855GluAsn: 0.855 ± 0.034
2.992GluPro: 2.992 ± 0.054
1.866GluGln: 1.866 ± 0.049
4.856GluArg: 4.856 ± 0.092
2.138GluSer: 2.138 ± 0.041
2.576GluThr: 2.576 ± 0.048
4.648GluVal: 4.648 ± 0.079
0.608GluTrp: 0.608 ± 0.021
0.904GluTyr: 0.904 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
3.438PheAla: 3.438 ± 0.051
0.182PheCys: 0.182 ± 0.013
2.001PheAsp: 2.001 ± 0.044
1.349PheGlu: 1.349 ± 0.038
0.771PhePhe: 0.771 ± 0.031
2.755PheGly: 2.755 ± 0.06
0.509PheHis: 0.509 ± 0.021
0.529PheIle: 0.529 ± 0.023
0.389PheLys: 0.389 ± 0.021
2.32PheLeu: 2.32 ± 0.056
0.312PheMet: 0.312 ± 0.016
0.452PheAsn: 0.452 ± 0.022
1.181PhePro: 1.181 ± 0.03
0.639PheGln: 0.639 ± 0.027
1.578PheArg: 1.578 ± 0.042
1.335PheSer: 1.335 ± 0.04
1.86PheThr: 1.86 ± 0.049
2.832PheVal: 2.832 ± 0.054
0.397PheTrp: 0.397 ± 0.019
0.525PheTyr: 0.525 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
12.442GlyAla: 12.442 ± 0.127
0.608GlyCys: 0.608 ± 0.027
5.648GlyAsp: 5.648 ± 0.084
4.241GlyGlu: 4.241 ± 0.063
2.68GlyPhe: 2.68 ± 0.057
8.586GlyGly: 8.586 ± 0.133
2.048GlyHis: 2.048 ± 0.042
3.218GlyIle: 3.218 ± 0.055
2.042GlyLys: 2.042 ± 0.055
9.141GlyLeu: 9.141 ± 0.106
1.743GlyMet: 1.743 ± 0.04
1.51GlyAsn: 1.51 ± 0.048
4.936GlyPro: 4.936 ± 0.071
2.337GlyGln: 2.337 ± 0.06
7.229GlyArg: 7.229 ± 0.103
5.961GlySer: 5.961 ± 0.086
7.469GlyThr: 7.469 ± 0.115
9.091GlyVal: 9.091 ± 0.1
1.795GlyTrp: 1.795 ± 0.039
2.064GlyTyr: 2.064 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.821HisAla: 2.821 ± 0.063
0.12HisCys: 0.12 ± 0.011
1.697HisAsp: 1.697 ± 0.041
1.122HisGlu: 1.122 ± 0.035
0.42HisPhe: 0.42 ± 0.02
2.333HisGly: 2.333 ± 0.051
0.617HisHis: 0.617 ± 0.026
0.354HisIle: 0.354 ± 0.019
0.261HisLys: 0.261 ± 0.017
2.274HisLeu: 2.274 ± 0.048
0.227HisMet: 0.227 ± 0.016
0.323HisAsn: 0.323 ± 0.016
1.495HisPro: 1.495 ± 0.04
0.494HisGln: 0.494 ± 0.023
1.753HisArg: 1.753 ± 0.039
0.784HisSer: 0.784 ± 0.027
1.065HisThr: 1.065 ± 0.033
2.254HisVal: 2.254 ± 0.048
0.257HisTrp: 0.257 ± 0.016
0.371HisTyr: 0.371 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
3.897IleAla: 3.897 ± 0.072
0.151IleCys: 0.151 ± 0.012
2.195IleAsp: 2.195 ± 0.054
1.607IleGlu: 1.607 ± 0.046
0.66IlePhe: 0.66 ± 0.029
2.862IleGly: 2.862 ± 0.055
0.451IleHis: 0.451 ± 0.017
0.739IleIle: 0.739 ± 0.032
0.575IleLys: 0.575 ± 0.026
2.231IleLeu: 2.231 ± 0.06
0.386IleMet: 0.386 ± 0.019
0.536IleAsn: 0.536 ± 0.02
1.433IlePro: 1.433 ± 0.036
0.62IleGln: 0.62 ± 0.025
1.598IleArg: 1.598 ± 0.039
1.355IleSer: 1.355 ± 0.039
1.94IleThr: 1.94 ± 0.049
2.895IleVal: 2.895 ± 0.058
0.304IleTrp: 0.304 ± 0.018
0.419IleTyr: 0.419 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
2.185LysAla: 2.185 ± 0.064
0.073LysCys: 0.073 ± 0.009
1.138LysAsp: 1.138 ± 0.038
0.761LysGlu: 0.761 ± 0.032
0.366LysPhe: 0.366 ± 0.019
1.492LysGly: 1.492 ± 0.045
0.392LysHis: 0.392 ± 0.018
0.724LysIle: 0.724 ± 0.032
0.664LysLys: 0.664 ± 0.036
1.339LysLeu: 1.339 ± 0.04
0.257LysMet: 0.257 ± 0.015
0.464LysAsn: 0.464 ± 0.025
1.014LysPro: 1.014 ± 0.038
0.523LysGln: 0.523 ± 0.02
0.986LysArg: 0.986 ± 0.038
1.033LysSer: 1.033 ± 0.037
1.177LysThr: 1.177 ± 0.046
1.782LysVal: 1.782 ± 0.053
0.18LysTrp: 0.18 ± 0.013
0.403LysTyr: 0.403 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
15.681LeuAla: 15.681 ± 0.169
0.598LeuCys: 0.598 ± 0.021
7.584LeuAsp: 7.584 ± 0.087
4.394LeuGlu: 4.394 ± 0.069
2.363LeuPhe: 2.363 ± 0.056
9.631LeuGly: 9.631 ± 0.117
1.969LeuHis: 1.969 ± 0.048
1.885LeuIle: 1.885 ± 0.05
1.316LeuLys: 1.316 ± 0.041
9.938LeuLeu: 9.938 ± 0.164
1.172LeuMet: 1.172 ± 0.031
1.276LeuAsn: 1.276 ± 0.037
5.748LeuPro: 5.748 ± 0.076
2.113LeuGln: 2.113 ± 0.046
7.794LeuArg: 7.794 ± 0.104
4.667LeuSer: 4.667 ± 0.075
6.403LeuThr: 6.403 ± 0.087
11.606LeuVal: 11.606 ± 0.138
1.273LeuTrp: 1.273 ± 0.04
1.507LeuTyr: 1.507 ± 0.036
0.0LeuXaa: 0.0 ± 0.0
Met
1.687MetAla: 1.687 ± 0.04
0.089MetCys: 0.089 ± 0.009
0.733MetAsp: 0.733 ± 0.026
0.446MetGlu: 0.446 ± 0.021
0.386MetPhe: 0.386 ± 0.018
0.964MetGly: 0.964 ± 0.034
0.263MetHis: 0.263 ± 0.016
0.533MetIle: 0.533 ± 0.023
0.293MetLys: 0.293 ± 0.017
1.488MetLeu: 1.488 ± 0.039
0.194MetMet: 0.194 ± 0.014
0.325MetAsn: 0.325 ± 0.015
0.938MetPro: 0.938 ± 0.031
0.345MetGln: 0.345 ± 0.017
1.076MetArg: 1.076 ± 0.031
1.262MetSer: 1.262 ± 0.036
1.653MetThr: 1.653 ± 0.039
1.152MetVal: 1.152 ± 0.034
0.168MetTrp: 0.168 ± 0.013
0.21MetTyr: 0.21 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
1.948AsnAla: 1.948 ± 0.052
0.074AsnCys: 0.074 ± 0.007
0.931AsnAsp: 0.931 ± 0.037
0.639AsnGlu: 0.639 ± 0.031
0.434AsnPhe: 0.434 ± 0.02
1.567AsnGly: 1.567 ± 0.046
0.323AsnHis: 0.323 ± 0.016
0.543AsnIle: 0.543 ± 0.023
0.345AsnLys: 0.345 ± 0.02
1.566AsnLeu: 1.566 ± 0.04
0.215AsnMet: 0.215 ± 0.015
0.356AsnAsn: 0.356 ± 0.022
1.239AsnPro: 1.239 ± 0.033
0.417AsnGln: 0.417 ± 0.022
0.956AsnArg: 0.956 ± 0.033
0.653AsnSer: 0.653 ± 0.029
0.973AsnThr: 0.973 ± 0.041
1.553AsnVal: 1.553 ± 0.046
0.206AsnTrp: 0.206 ± 0.014
0.378AsnTyr: 0.378 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
8.791ProAla: 8.791 ± 0.122
0.229ProCys: 0.229 ± 0.02
5.089ProAsp: 5.089 ± 0.068
3.302ProGlu: 3.302 ± 0.061
1.545ProPhe: 1.545 ± 0.043
6.253ProGly: 6.253 ± 0.09
1.177ProHis: 1.177 ± 0.034
1.125ProIle: 1.125 ± 0.038
0.826ProLys: 0.826 ± 0.032
4.732ProLeu: 4.732 ± 0.061
0.742ProMet: 0.742 ± 0.023
0.755ProAsn: 0.755 ± 0.024
2.927ProPro: 2.927 ± 0.078
1.484ProGln: 1.484 ± 0.041
4.002ProArg: 4.002 ± 0.073
3.601ProSer: 3.601 ± 0.06
4.441ProThr: 4.441 ± 0.104
6.029ProVal: 6.029 ± 0.075
0.918ProTrp: 0.918 ± 0.03
1.044ProTyr: 1.044 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.257GlnAla: 3.257 ± 0.058
0.141GlnCys: 0.141 ± 0.011
1.61GlnAsp: 1.61 ± 0.04
1.11GlnGlu: 1.11 ± 0.032
0.626GlnPhe: 0.626 ± 0.027
2.196GlnGly: 2.196 ± 0.051
0.704GlnHis: 0.704 ± 0.025
0.918GlnIle: 0.918 ± 0.034
0.515GlnLys: 0.515 ± 0.023
2.485GlnLeu: 2.485 ± 0.05
0.388GlnMet: 0.388 ± 0.017
0.471GlnAsn: 0.471 ± 0.024
1.491GlnPro: 1.491 ± 0.039
1.099GlnGln: 1.099 ± 0.039
2.186GlnArg: 2.186 ± 0.051
1.183GlnSer: 1.183 ± 0.036
1.465GlnThr: 1.465 ± 0.045
3.005GlnVal: 3.005 ± 0.054
0.464GlnTrp: 0.464 ± 0.022
0.56GlnTyr: 0.56 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
10.302ArgAla: 10.302 ± 0.134
0.386ArgCys: 0.386 ± 0.019
4.769ArgAsp: 4.769 ± 0.076
3.906ArgGlu: 3.906 ± 0.075
2.072ArgPhe: 2.072 ± 0.043
5.963ArgGly: 5.963 ± 0.088
1.716ArgHis: 1.716 ± 0.036
2.365ArgIle: 2.365 ± 0.048
1.103ArgLys: 1.103 ± 0.036
7.647ArgLeu: 7.647 ± 0.1
1.322ArgMet: 1.322 ± 0.036
1.058ArgAsn: 1.058 ± 0.033
4.556ArgPro: 4.556 ± 0.079
1.8ArgGln: 1.8 ± 0.044
7.57ArgArg: 7.57 ± 0.121
4.209ArgSer: 4.209 ± 0.072
5.451ArgThr: 5.451 ± 0.076
6.868ArgVal: 6.868 ± 0.084
1.434ArgTrp: 1.434 ± 0.039
1.666ArgTyr: 1.666 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
7.147SerAla: 7.147 ± 0.096
0.308SerCys: 0.308 ± 0.017
3.337SerAsp: 3.337 ± 0.063
2.036SerGlu: 2.036 ± 0.045
1.561SerPhe: 1.561 ± 0.038
6.013SerGly: 6.013 ± 0.095
0.947SerHis: 0.947 ± 0.028
1.497SerIle: 1.497 ± 0.042
0.972SerLys: 0.972 ± 0.033
4.686SerLeu: 4.686 ± 0.064
0.951SerMet: 0.951 ± 0.031
0.847SerAsn: 0.847 ± 0.035
3.16SerPro: 3.16 ± 0.066
1.357SerGln: 1.357 ± 0.04
3.607SerArg: 3.607 ± 0.064
3.732SerSer: 3.732 ± 0.09
4.255SerThr: 4.255 ± 0.089
4.919SerVal: 4.919 ± 0.074
1.007SerTrp: 1.007 ± 0.032
1.194SerTyr: 1.194 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
9.065ThrAla: 9.065 ± 0.122
0.426ThrCys: 0.426 ± 0.022
4.113ThrAsp: 4.113 ± 0.076
2.666ThrGlu: 2.666 ± 0.052
2.092ThrPhe: 2.092 ± 0.049
6.848ThrGly: 6.848 ± 0.094
1.251ThrHis: 1.251 ± 0.032
2.059ThrIle: 2.059 ± 0.047
1.188ThrLys: 1.188 ± 0.042
6.403ThrLeu: 6.403 ± 0.088
0.844ThrMet: 0.844 ± 0.028
1.127ThrAsn: 1.127 ± 0.047
4.779ThrPro: 4.779 ± 0.099
1.677ThrGln: 1.677 ± 0.048
4.052ThrArg: 4.052 ± 0.063
4.271ThrSer: 4.271 ± 0.083
5.741ThrThr: 5.741 ± 0.117
7.611ThrVal: 7.611 ± 0.112
1.18ThrTrp: 1.18 ± 0.035
1.493ThrTyr: 1.493 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
15.081ValAla: 15.081 ± 0.148
0.577ValCys: 0.577 ± 0.024
7.106ValAsp: 7.106 ± 0.093
5.209ValGlu: 5.209 ± 0.073
2.371ValPhe: 2.371 ± 0.052
8.946ValGly: 8.946 ± 0.106
2.146ValHis: 2.146 ± 0.042
2.438ValIle: 2.438 ± 0.053
1.523ValLys: 1.523 ± 0.052
11.284ValLeu: 11.284 ± 0.14
1.308ValMet: 1.308 ± 0.034
1.481ValAsn: 1.481 ± 0.04
6.341ValPro: 6.341 ± 0.081
2.344ValGln: 2.344 ± 0.045
7.971ValArg: 7.971 ± 0.101
4.958ValSer: 4.958 ± 0.067
7.277ValThr: 7.277 ± 0.143
13.661ValVal: 13.661 ± 0.163
1.342ValTrp: 1.342 ± 0.04
1.62ValTyr: 1.62 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
1.756TrpAla: 1.756 ± 0.046
0.131TrpCys: 0.131 ± 0.011
0.951TrpAsp: 0.951 ± 0.031
0.617TrpGlu: 0.617 ± 0.024
0.534TrpPhe: 0.534 ± 0.022
1.13TrpGly: 1.13 ± 0.037
0.372TrpHis: 0.372 ± 0.017
0.476TrpIle: 0.476 ± 0.022
0.274TrpLys: 0.274 ± 0.017
1.637TrpLeu: 1.637 ± 0.048
0.262TrpMet: 0.262 ± 0.014
0.352TrpAsn: 0.352 ± 0.018
0.713TrpPro: 0.713 ± 0.025
0.54TrpGln: 0.54 ± 0.023
1.283TrpArg: 1.283 ± 0.04
1.14TrpSer: 1.14 ± 0.033
1.167TrpThr: 1.167 ± 0.036
1.36TrpVal: 1.36 ± 0.038
0.452TrpTrp: 0.452 ± 0.025
0.343TrpTyr: 0.343 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.396TyrAla: 2.396 ± 0.05
0.109TyrCys: 0.109 ± 0.009
1.362TyrAsp: 1.362 ± 0.045
0.924TyrGlu: 0.924 ± 0.031
0.566TyrPhe: 0.566 ± 0.023
1.904TyrGly: 1.904 ± 0.042
0.328TyrHis: 0.328 ± 0.018
0.37TyrIle: 0.37 ± 0.017
0.34TyrLys: 0.34 ± 0.021
2.044TyrLeu: 2.044 ± 0.05
0.194TyrMet: 0.194 ± 0.013
0.346TyrAsn: 0.346 ± 0.018
0.993TyrPro: 0.993 ± 0.035
0.573TyrGln: 0.573 ± 0.025
1.549TyrArg: 1.549 ± 0.045
0.986TyrSer: 0.986 ± 0.032
1.208TyrThr: 1.208 ± 0.043
1.865TyrVal: 1.865 ± 0.045
0.322TyrTrp: 0.322 ± 0.019
0.454TyrTyr: 0.454 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3150 proteins (1102968 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski