Amino acid dipepetide frequency for Cronobacter phage Dev-CD-23823

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.467AlaAla: 14.467 ± 1.829
0.923AlaCys: 0.923 ± 0.289
6.849AlaAsp: 6.849 ± 0.836
7.772AlaGlu: 7.772 ± 0.729
3.771AlaPhe: 3.771 ± 0.601
7.311AlaGly: 7.311 ± 0.944
1.924AlaHis: 1.924 ± 0.38
4.771AlaIle: 4.771 ± 0.586
6.079AlaLys: 6.079 ± 0.686
7.695AlaLeu: 7.695 ± 0.773
3.232AlaMet: 3.232 ± 0.541
4.155AlaAsn: 4.155 ± 0.658
3.232AlaPro: 3.232 ± 0.481
4.694AlaGln: 4.694 ± 1.018
4.771AlaArg: 4.771 ± 0.62
4.54AlaSer: 4.54 ± 0.613
5.541AlaThr: 5.541 ± 0.571
6.926AlaVal: 6.926 ± 0.721
1.385AlaTrp: 1.385 ± 0.259
3.001AlaTyr: 3.001 ± 0.505
0.0AlaXaa: 0.0 ± 0.0
Cys
0.539CysAla: 0.539 ± 0.173
0.077CysCys: 0.077 ± 0.062
0.539CysAsp: 0.539 ± 0.186
0.462CysGlu: 0.462 ± 0.176
0.308CysPhe: 0.308 ± 0.125
0.462CysGly: 0.462 ± 0.183
0.308CysHis: 0.308 ± 0.151
0.385CysIle: 0.385 ± 0.184
0.385CysLys: 0.385 ± 0.192
1.385CysLeu: 1.385 ± 0.356
0.308CysMet: 0.308 ± 0.165
0.462CysAsn: 0.462 ± 0.202
0.616CysPro: 0.616 ± 0.241
0.539CysGln: 0.539 ± 0.183
0.462CysArg: 0.462 ± 0.212
0.154CysSer: 0.154 ± 0.101
0.539CysThr: 0.539 ± 0.224
1.0CysVal: 1.0 ± 0.274
0.154CysTrp: 0.154 ± 0.106
0.846CysTyr: 0.846 ± 0.226
0.0CysXaa: 0.0 ± 0.0
Asp
6.156AspAla: 6.156 ± 0.571
0.693AspCys: 0.693 ± 0.223
3.386AspAsp: 3.386 ± 0.512
4.232AspGlu: 4.232 ± 0.507
2.616AspPhe: 2.616 ± 0.434
5.233AspGly: 5.233 ± 0.634
0.539AspHis: 0.539 ± 0.215
3.617AspIle: 3.617 ± 0.411
4.463AspLys: 4.463 ± 0.535
4.463AspLeu: 4.463 ± 0.464
2.309AspMet: 2.309 ± 0.384
2.924AspAsn: 2.924 ± 0.538
2.539AspPro: 2.539 ± 0.319
2.309AspGln: 2.309 ± 0.447
2.539AspArg: 2.539 ± 0.373
3.001AspSer: 3.001 ± 0.629
3.232AspThr: 3.232 ± 0.371
4.771AspVal: 4.771 ± 0.786
0.77AspTrp: 0.77 ± 0.259
2.616AspTyr: 2.616 ± 0.403
0.0AspXaa: 0.0 ± 0.0
Glu
7.157GluAla: 7.157 ± 0.872
0.616GluCys: 0.616 ± 0.219
3.463GluAsp: 3.463 ± 0.561
4.925GluGlu: 4.925 ± 0.647
1.847GluPhe: 1.847 ± 0.475
4.54GluGly: 4.54 ± 0.573
1.616GluHis: 1.616 ± 0.493
2.462GluIle: 2.462 ± 0.496
3.848GluLys: 3.848 ± 0.515
5.925GluLeu: 5.925 ± 0.667
1.924GluMet: 1.924 ± 0.378
2.616GluAsn: 2.616 ± 0.473
1.847GluPro: 1.847 ± 0.34
4.309GluGln: 4.309 ± 0.691
3.694GluArg: 3.694 ± 0.525
2.924GluSer: 2.924 ± 0.483
2.693GluThr: 2.693 ± 0.372
4.386GluVal: 4.386 ± 0.617
1.385GluTrp: 1.385 ± 0.328
2.309GluTyr: 2.309 ± 0.498
0.0GluXaa: 0.0 ± 0.0
Phe
2.309PheAla: 2.309 ± 0.385
0.385PheCys: 0.385 ± 0.148
3.078PheAsp: 3.078 ± 0.572
1.693PheGlu: 1.693 ± 0.377
1.077PhePhe: 1.077 ± 0.23
2.924PheGly: 2.924 ± 0.341
0.77PheHis: 0.77 ± 0.256
2.001PheIle: 2.001 ± 0.425
2.616PheLys: 2.616 ± 0.385
2.616PheLeu: 2.616 ± 0.289
1.077PheMet: 1.077 ± 0.239
1.385PheAsn: 1.385 ± 0.267
1.462PhePro: 1.462 ± 0.4
2.078PheGln: 2.078 ± 0.379
1.847PheArg: 1.847 ± 0.335
1.924PheSer: 1.924 ± 0.39
2.001PheThr: 2.001 ± 0.351
1.616PheVal: 1.616 ± 0.292
0.539PheTrp: 0.539 ± 0.183
1.077PheTyr: 1.077 ± 0.26
0.0PheXaa: 0.0 ± 0.0
Gly
6.464GlyAla: 6.464 ± 0.838
1.231GlyCys: 1.231 ± 0.462
5.31GlyAsp: 5.31 ± 0.526
3.617GlyGlu: 3.617 ± 0.467
2.462GlyPhe: 2.462 ± 0.432
6.233GlyGly: 6.233 ± 0.846
1.385GlyHis: 1.385 ± 0.436
4.078GlyIle: 4.078 ± 0.572
4.925GlyLys: 4.925 ± 0.658
6.079GlyLeu: 6.079 ± 0.736
1.693GlyMet: 1.693 ± 0.332
2.462GlyAsn: 2.462 ± 0.312
1.462GlyPro: 1.462 ± 0.337
3.617GlyGln: 3.617 ± 0.621
3.925GlyArg: 3.925 ± 0.514
5.541GlySer: 5.541 ± 0.615
5.618GlyThr: 5.618 ± 0.657
5.233GlyVal: 5.233 ± 0.619
1.308GlyTrp: 1.308 ± 0.261
3.078GlyTyr: 3.078 ± 0.472
0.0GlyXaa: 0.0 ± 0.0
His
1.154HisAla: 1.154 ± 0.384
0.231HisCys: 0.231 ± 0.128
1.616HisAsp: 1.616 ± 0.414
1.308HisGlu: 1.308 ± 0.453
1.0HisPhe: 1.0 ± 0.297
1.385HisGly: 1.385 ± 0.419
0.462HisHis: 0.462 ± 0.212
0.77HisIle: 0.77 ± 0.185
1.231HisLys: 1.231 ± 0.345
1.231HisLeu: 1.231 ± 0.297
0.846HisMet: 0.846 ± 0.241
0.77HisAsn: 0.77 ± 0.233
0.923HisPro: 0.923 ± 0.231
0.308HisGln: 0.308 ± 0.141
1.231HisArg: 1.231 ± 0.345
1.0HisSer: 1.0 ± 0.298
1.0HisThr: 1.0 ± 0.195
1.231HisVal: 1.231 ± 0.295
0.154HisTrp: 0.154 ± 0.097
0.77HisTyr: 0.77 ± 0.254
0.0HisXaa: 0.0 ± 0.0
Ile
4.694IleAla: 4.694 ± 0.377
0.231IleCys: 0.231 ± 0.141
2.847IleAsp: 2.847 ± 0.428
3.386IleGlu: 3.386 ± 0.52
2.001IlePhe: 2.001 ± 0.339
3.309IleGly: 3.309 ± 0.423
1.539IleHis: 1.539 ± 0.318
2.078IleIle: 2.078 ± 0.467
3.386IleLys: 3.386 ± 0.531
3.309IleLeu: 3.309 ± 0.489
1.154IleMet: 1.154 ± 0.356
2.309IleAsn: 2.309 ± 0.41
2.309IlePro: 2.309 ± 0.451
1.539IleGln: 1.539 ± 0.291
3.001IleArg: 3.001 ± 0.46
2.386IleSer: 2.386 ± 0.453
3.925IleThr: 3.925 ± 0.647
2.232IleVal: 2.232 ± 0.594
0.846IleTrp: 0.846 ± 0.25
1.77IleTyr: 1.77 ± 0.302
0.0IleXaa: 0.0 ± 0.0
Lys
6.772LysAla: 6.772 ± 0.592
0.154LysCys: 0.154 ± 0.084
4.771LysAsp: 4.771 ± 0.625
4.54LysGlu: 4.54 ± 0.547
2.616LysPhe: 2.616 ± 0.328
4.617LysGly: 4.617 ± 0.544
1.0LysHis: 1.0 ± 0.246
2.001LysIle: 2.001 ± 0.342
3.617LysLys: 3.617 ± 0.496
6.233LysLeu: 6.233 ± 0.806
2.001LysMet: 2.001 ± 0.415
1.616LysAsn: 1.616 ± 0.34
2.924LysPro: 2.924 ± 0.512
2.616LysGln: 2.616 ± 0.5
4.078LysArg: 4.078 ± 0.509
2.309LysSer: 2.309 ± 0.386
2.847LysThr: 2.847 ± 0.358
4.309LysVal: 4.309 ± 0.552
0.616LysTrp: 0.616 ± 0.215
2.155LysTyr: 2.155 ± 0.297
0.0LysXaa: 0.0 ± 0.0
Leu
8.927LeuAla: 8.927 ± 0.894
0.846LeuCys: 0.846 ± 0.282
4.925LeuAsp: 4.925 ± 0.555
4.694LeuGlu: 4.694 ± 0.6
2.078LeuPhe: 2.078 ± 0.389
6.156LeuGly: 6.156 ± 0.612
1.0LeuHis: 1.0 ± 0.213
3.386LeuIle: 3.386 ± 0.593
5.464LeuLys: 5.464 ± 0.726
5.848LeuLeu: 5.848 ± 0.73
2.232LeuMet: 2.232 ± 0.335
4.002LeuAsn: 4.002 ± 0.416
4.848LeuPro: 4.848 ± 0.478
4.232LeuGln: 4.232 ± 0.507
4.309LeuArg: 4.309 ± 0.618
4.925LeuSer: 4.925 ± 0.655
5.771LeuThr: 5.771 ± 0.753
4.386LeuVal: 4.386 ± 0.639
0.846LeuTrp: 0.846 ± 0.254
2.462LeuTyr: 2.462 ± 0.429
0.0LeuXaa: 0.0 ± 0.0
Met
3.925MetAla: 3.925 ± 0.664
0.308MetCys: 0.308 ± 0.169
1.847MetAsp: 1.847 ± 0.356
1.231MetGlu: 1.231 ± 0.248
1.308MetPhe: 1.308 ± 0.316
1.77MetGly: 1.77 ± 0.51
0.693MetHis: 0.693 ± 0.203
1.154MetIle: 1.154 ± 0.27
1.616MetLys: 1.616 ± 0.408
2.77MetLeu: 2.77 ± 0.49
0.693MetMet: 0.693 ± 0.228
1.847MetAsn: 1.847 ± 0.492
1.385MetPro: 1.385 ± 0.315
1.924MetGln: 1.924 ± 0.369
1.693MetArg: 1.693 ± 0.377
2.078MetSer: 2.078 ± 0.433
0.846MetThr: 0.846 ± 0.275
1.693MetVal: 1.693 ± 0.398
0.77MetTrp: 0.77 ± 0.245
0.77MetTyr: 0.77 ± 0.221
0.0MetXaa: 0.0 ± 0.0
Asn
5.079AsnAla: 5.079 ± 0.778
0.693AsnCys: 0.693 ± 0.31
2.232AsnAsp: 2.232 ± 0.345
2.386AsnGlu: 2.386 ± 0.335
1.385AsnPhe: 1.385 ± 0.361
3.925AsnGly: 3.925 ± 0.519
0.308AsnHis: 0.308 ± 0.151
2.539AsnIle: 2.539 ± 0.437
2.616AsnLys: 2.616 ± 0.65
3.078AsnLeu: 3.078 ± 0.442
1.924AsnMet: 1.924 ± 0.323
1.462AsnAsn: 1.462 ± 0.347
1.924AsnPro: 1.924 ± 0.29
1.616AsnGln: 1.616 ± 0.307
2.232AsnArg: 2.232 ± 0.464
1.847AsnSer: 1.847 ± 0.302
2.77AsnThr: 2.77 ± 0.378
2.539AsnVal: 2.539 ± 0.492
0.385AsnTrp: 0.385 ± 0.165
1.154AsnTyr: 1.154 ± 0.217
0.0AsnXaa: 0.0 ± 0.0
Pro
3.848ProAla: 3.848 ± 0.549
0.385ProCys: 0.385 ± 0.157
2.155ProAsp: 2.155 ± 0.334
4.463ProGlu: 4.463 ± 0.766
0.846ProPhe: 0.846 ± 0.224
2.77ProGly: 2.77 ± 0.473
0.616ProHis: 0.616 ± 0.21
2.232ProIle: 2.232 ± 0.406
1.847ProLys: 1.847 ± 0.361
3.078ProLeu: 3.078 ± 0.392
1.077ProMet: 1.077 ± 0.335
1.77ProAsn: 1.77 ± 0.439
1.539ProPro: 1.539 ± 0.418
1.77ProGln: 1.77 ± 0.266
1.231ProArg: 1.231 ± 0.287
2.155ProSer: 2.155 ± 0.333
2.155ProThr: 2.155 ± 0.325
3.155ProVal: 3.155 ± 0.497
0.462ProTrp: 0.462 ± 0.207
1.77ProTyr: 1.77 ± 0.357
0.0ProXaa: 0.0 ± 0.0
Gln
6.002GlnAla: 6.002 ± 0.829
0.154GlnCys: 0.154 ± 0.101
1.924GlnAsp: 1.924 ± 0.464
2.462GlnGlu: 2.462 ± 0.464
1.462GlnPhe: 1.462 ± 0.29
4.002GlnGly: 4.002 ± 0.484
1.077GlnHis: 1.077 ± 0.294
2.616GlnIle: 2.616 ± 0.453
2.693GlnLys: 2.693 ± 0.475
3.309GlnLeu: 3.309 ± 0.494
1.847GlnMet: 1.847 ± 0.377
1.385GlnAsn: 1.385 ± 0.417
1.385GlnPro: 1.385 ± 0.312
3.309GlnGln: 3.309 ± 0.607
2.616GlnArg: 2.616 ± 0.426
2.232GlnSer: 2.232 ± 0.374
2.078GlnThr: 2.078 ± 0.458
4.002GlnVal: 4.002 ± 0.687
0.693GlnTrp: 0.693 ± 0.208
2.232GlnTyr: 2.232 ± 0.363
0.0GlnXaa: 0.0 ± 0.0
Arg
4.463ArgAla: 4.463 ± 0.559
0.693ArgCys: 0.693 ± 0.205
3.54ArgAsp: 3.54 ± 0.456
3.309ArgGlu: 3.309 ± 0.409
2.77ArgPhe: 2.77 ± 0.447
3.463ArgGly: 3.463 ± 0.645
1.308ArgHis: 1.308 ± 0.27
2.693ArgIle: 2.693 ± 0.542
3.617ArgLys: 3.617 ± 0.607
4.078ArgLeu: 4.078 ± 0.519
1.77ArgMet: 1.77 ± 0.384
3.463ArgAsn: 3.463 ± 0.589
1.77ArgPro: 1.77 ± 0.401
2.77ArgGln: 2.77 ± 0.411
3.771ArgArg: 3.771 ± 0.41
2.847ArgSer: 2.847 ± 0.393
2.924ArgThr: 2.924 ± 0.426
3.232ArgVal: 3.232 ± 0.424
0.923ArgTrp: 0.923 ± 0.327
2.462ArgTyr: 2.462 ± 0.255
0.0ArgXaa: 0.0 ± 0.0
Ser
5.464SerAla: 5.464 ± 0.521
0.462SerCys: 0.462 ± 0.181
3.309SerAsp: 3.309 ± 0.739
2.924SerGlu: 2.924 ± 0.457
1.385SerPhe: 1.385 ± 0.438
4.155SerGly: 4.155 ± 0.55
1.0SerHis: 1.0 ± 0.244
2.693SerIle: 2.693 ± 0.398
2.847SerLys: 2.847 ± 0.478
4.848SerLeu: 4.848 ± 0.499
1.308SerMet: 1.308 ± 0.269
1.693SerAsn: 1.693 ± 0.458
2.232SerPro: 2.232 ± 0.39
2.078SerGln: 2.078 ± 0.418
3.771SerArg: 3.771 ± 0.546
2.078SerSer: 2.078 ± 0.313
3.078SerThr: 3.078 ± 0.573
3.617SerVal: 3.617 ± 0.436
1.0SerTrp: 1.0 ± 0.207
1.616SerTyr: 1.616 ± 0.339
0.0SerXaa: 0.0 ± 0.0
Thr
5.694ThrAla: 5.694 ± 0.566
0.308ThrCys: 0.308 ± 0.156
3.54ThrAsp: 3.54 ± 0.588
3.694ThrGlu: 3.694 ± 0.477
1.616ThrPhe: 1.616 ± 0.334
4.925ThrGly: 4.925 ± 0.519
0.846ThrHis: 0.846 ± 0.246
2.77ThrIle: 2.77 ± 0.57
3.232ThrLys: 3.232 ± 0.475
5.156ThrLeu: 5.156 ± 0.567
1.462ThrMet: 1.462 ± 0.323
2.386ThrAsn: 2.386 ± 0.533
2.77ThrPro: 2.77 ± 0.452
1.462ThrGln: 1.462 ± 0.373
2.924ThrArg: 2.924 ± 0.427
3.386ThrSer: 3.386 ± 0.621
2.078ThrThr: 2.078 ± 0.342
3.694ThrVal: 3.694 ± 0.572
1.077ThrTrp: 1.077 ± 0.253
2.386ThrTyr: 2.386 ± 0.486
0.0ThrXaa: 0.0 ± 0.0
Val
5.694ValAla: 5.694 ± 0.546
0.539ValCys: 0.539 ± 0.185
3.617ValAsp: 3.617 ± 0.485
4.463ValGlu: 4.463 ± 0.58
1.539ValPhe: 1.539 ± 0.354
4.694ValGly: 4.694 ± 0.639
1.077ValHis: 1.077 ± 0.324
3.386ValIle: 3.386 ± 0.539
4.309ValLys: 4.309 ± 0.658
5.387ValLeu: 5.387 ± 0.528
2.386ValMet: 2.386 ± 0.426
3.232ValAsn: 3.232 ± 0.398
2.232ValPro: 2.232 ± 0.342
3.771ValGln: 3.771 ± 0.449
5.079ValArg: 5.079 ± 0.658
3.617ValSer: 3.617 ± 0.407
4.002ValThr: 4.002 ± 0.688
4.848ValVal: 4.848 ± 0.638
0.462ValTrp: 0.462 ± 0.169
2.462ValTyr: 2.462 ± 0.378
0.0ValXaa: 0.0 ± 0.0
Trp
1.077TrpAla: 1.077 ± 0.247
0.308TrpCys: 0.308 ± 0.124
0.693TrpAsp: 0.693 ± 0.201
1.0TrpGlu: 1.0 ± 0.293
1.154TrpPhe: 1.154 ± 0.25
0.923TrpGly: 0.923 ± 0.342
0.308TrpHis: 0.308 ± 0.121
0.308TrpIle: 0.308 ± 0.174
0.846TrpLys: 0.846 ± 0.209
2.001TrpLeu: 2.001 ± 0.533
0.308TrpMet: 0.308 ± 0.135
0.462TrpAsn: 0.462 ± 0.207
0.385TrpPro: 0.385 ± 0.182
0.462TrpGln: 0.462 ± 0.209
0.616TrpArg: 0.616 ± 0.243
0.923TrpSer: 0.923 ± 0.247
0.693TrpThr: 0.693 ± 0.213
1.231TrpVal: 1.231 ± 0.293
0.77TrpTrp: 0.77 ± 0.284
0.385TrpTyr: 0.385 ± 0.221
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.155TyrAla: 3.155 ± 0.354
0.693TyrCys: 0.693 ± 0.284
2.77TyrAsp: 2.77 ± 0.501
1.924TyrGlu: 1.924 ± 0.375
1.231TyrPhe: 1.231 ± 0.29
3.001TyrGly: 3.001 ± 0.525
0.846TyrHis: 0.846 ± 0.204
2.309TyrIle: 2.309 ± 0.379
2.155TyrLys: 2.155 ± 0.386
2.847TyrLeu: 2.847 ± 0.393
0.693TyrMet: 0.693 ± 0.297
1.693TyrAsn: 1.693 ± 0.437
1.539TyrPro: 1.539 ± 0.364
2.078TyrGln: 2.078 ± 0.353
2.078TyrArg: 2.078 ± 0.424
1.693TyrSer: 1.693 ± 0.369
1.616TyrThr: 1.616 ± 0.427
2.693TyrVal: 2.693 ± 0.508
0.308TyrTrp: 0.308 ± 0.152
0.923TyrTyr: 0.923 ± 0.215
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 48 proteins (12996 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski