Amino acid dipepetide frequency for Novosphingobium kunmingense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.964AlaAla: 19.964 ± 0.236	1.143AlaCys: 1.143 ± 0.037	7.858AlaAsp: 7.858 ± 0.094	7.903AlaGlu: 7.903 ± 0.115	4.343AlaPhe: 4.343 ± 0.067	11.838AlaGly: 11.838 ± 0.128	2.233AlaHis: 2.233 ± 0.053	6.661AlaIle: 6.661 ± 0.081	4.068AlaLys: 4.068 ± 0.075	14.837AlaLeu: 14.837 ± 0.152	4.069AlaMet: 4.069 ± 0.062	3.236AlaAsn: 3.236 ± 0.064	6.375AlaPro: 6.375 ± 0.1	4.547AlaGln: 4.547 ± 0.069	10.184AlaArg: 10.184 ± 0.134	6.801AlaSer: 6.801 ± 0.095	6.427AlaThr: 6.427 ± 0.087	9.192AlaVal: 9.192 ± 0.111	1.81AlaTrp: 1.81 ± 0.048	2.535AlaTyr: 2.535 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.1CysAla: 1.1 ± 0.03	0.106CysCys: 0.106 ± 0.01	0.6CysAsp: 0.6 ± 0.023	0.443CysGlu: 0.443 ± 0.021	0.294CysPhe: 0.294 ± 0.018	0.923CysGly: 0.923 ± 0.033	0.196CysHis: 0.196 ± 0.014	0.337CysIle: 0.337 ± 0.018	0.204CysLys: 0.204 ± 0.015	0.772CysLeu: 0.772 ± 0.025	0.143CysMet: 0.143 ± 0.012	0.235CysAsn: 0.235 ± 0.015	0.488CysPro: 0.488 ± 0.023	0.23CysGln: 0.23 ± 0.015	0.601CysArg: 0.601 ± 0.024	0.476CysSer: 0.476 ± 0.024	0.408CysThr: 0.408 ± 0.021	0.574CysVal: 0.574 ± 0.026	0.129CysTrp: 0.129 ± 0.011	0.183CysTyr: 0.183 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.776AspAla: 7.776 ± 0.1	0.555AspCys: 0.555 ± 0.025	3.487AspAsp: 3.487 ± 0.07	3.504AspGlu: 3.504 ± 0.073	2.228AspPhe: 2.228 ± 0.042	5.876AspGly: 5.876 ± 0.083	1.293AspHis: 1.293 ± 0.036	2.591AspIle: 2.591 ± 0.05	1.899AspLys: 1.899 ± 0.043	6.116AspLeu: 6.116 ± 0.076	1.376AspMet: 1.376 ± 0.037	1.423AspAsn: 1.423 ± 0.045	3.974AspPro: 3.974 ± 0.077	1.839AspGln: 1.839 ± 0.048	4.83AspArg: 4.83 ± 0.075	2.554AspSer: 2.554 ± 0.065	2.694AspThr: 2.694 ± 0.064	3.869AspVal: 3.869 ± 0.058	1.264AspTrp: 1.264 ± 0.035	1.562AspTyr: 1.562 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	8.154GluAla: 8.154 ± 0.11	0.386GluCys: 0.386 ± 0.017	2.755GluAsp: 2.755 ± 0.058	2.719GluGlu: 2.719 ± 0.067	1.567GluPhe: 1.567 ± 0.047	4.474GluGly: 4.474 ± 0.059	1.092GluHis: 1.092 ± 0.034	2.682GluIle: 2.682 ± 0.051	1.711GluLys: 1.711 ± 0.045	5.189GluLeu: 5.189 ± 0.083	1.319GluMet: 1.319 ± 0.035	1.292GluAsn: 1.292 ± 0.034	2.619GluPro: 2.619 ± 0.054	2.009GluGln: 2.009 ± 0.047	4.783GluArg: 4.783 ± 0.087	2.122GluSer: 2.122 ± 0.046	2.935GluThr: 2.935 ± 0.053	3.779GluVal: 3.779 ± 0.078	0.787GluTrp: 0.787 ± 0.028	0.989GluTyr: 0.989 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	5.174PheAla: 5.174 ± 0.069	0.344PheCys: 0.344 ± 0.016	2.699PheAsp: 2.699 ± 0.055	2.006PheGlu: 2.006 ± 0.044	1.233PhePhe: 1.233 ± 0.041	3.713PheGly: 3.713 ± 0.064	0.685PheHis: 0.685 ± 0.031	1.332PheIle: 1.332 ± 0.043	0.924PheLys: 0.924 ± 0.029	2.976PheLeu: 2.976 ± 0.065	0.706PheMet: 0.706 ± 0.027	1.058PheAsn: 1.058 ± 0.044	1.527PhePro: 1.527 ± 0.039	0.886PheGln: 0.886 ± 0.03	2.085PheArg: 2.085 ± 0.046	1.945PheSer: 1.945 ± 0.046	2.011PheThr: 2.011 ± 0.055	2.693PheVal: 2.693 ± 0.052	0.547PheTrp: 0.547 ± 0.027	0.891PheTyr: 0.891 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.341GlyAla: 10.341 ± 0.113	0.843GlyCys: 0.843 ± 0.031	5.093GlyAsp: 5.093 ± 0.086	4.949GlyGlu: 4.949 ± 0.072	3.643GlyPhe: 3.643 ± 0.063	8.289GlyGly: 8.289 ± 0.129	1.794GlyHis: 1.794 ± 0.044	4.358GlyIle: 4.358 ± 0.067	3.474GlyLys: 3.474 ± 0.068	9.054GlyLeu: 9.054 ± 0.099	2.386GlyMet: 2.386 ± 0.043	2.488GlyAsn: 2.488 ± 0.069	3.736GlyPro: 3.736 ± 0.061	3.341GlyGln: 3.341 ± 0.056	6.181GlyArg: 6.181 ± 0.084	5.038GlySer: 5.038 ± 0.078	5.186GlyThr: 5.186 ± 0.083	6.182GlyVal: 6.182 ± 0.091	1.635GlyTrp: 1.635 ± 0.041	2.328GlyTyr: 2.328 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.449HisAla: 2.449 ± 0.056	0.251HisCys: 0.251 ± 0.015	1.22HisAsp: 1.22 ± 0.034	0.942HisGlu: 0.942 ± 0.031	0.824HisPhe: 0.824 ± 0.024	1.945HisGly: 1.945 ± 0.045	0.522HisHis: 0.522 ± 0.027	0.809HisIle: 0.809 ± 0.032	0.468HisLys: 0.468 ± 0.022	1.939HisLeu: 1.939 ± 0.042	0.429HisMet: 0.429 ± 0.022	0.475HisAsn: 0.475 ± 0.019	1.234HisPro: 1.234 ± 0.036	0.561HisGln: 0.561 ± 0.023	1.45HisArg: 1.45 ± 0.038	0.922HisSer: 0.922 ± 0.03	0.744HisThr: 0.744 ± 0.025	1.391HisVal: 1.391 ± 0.038	0.346HisTrp: 0.346 ± 0.019	0.529HisTyr: 0.529 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.498IleAla: 7.498 ± 0.089	0.457IleCys: 0.457 ± 0.022	3.998IleAsp: 3.998 ± 0.065	3.423IleGlu: 3.423 ± 0.062	1.31IlePhe: 1.31 ± 0.034	4.851IleGly: 4.851 ± 0.08	0.862IleHis: 0.862 ± 0.027	1.666IleIle: 1.666 ± 0.046	1.332IleLys: 1.332 ± 0.042	3.548IleLeu: 3.548 ± 0.06	0.822IleMet: 0.822 ± 0.033	1.332IleAsn: 1.332 ± 0.037	2.054IlePro: 2.054 ± 0.049	1.073IleGln: 1.073 ± 0.033	2.874IleArg: 2.874 ± 0.057	2.313IleSer: 2.313 ± 0.05	2.44IleThr: 2.44 ± 0.057	3.911IleVal: 3.911 ± 0.063	0.532IleTrp: 0.532 ± 0.021	0.941IleTyr: 0.941 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.37LysAla: 4.37 ± 0.071	0.154LysCys: 0.154 ± 0.011	1.673LysAsp: 1.673 ± 0.049	1.188LysGlu: 1.188 ± 0.04	0.834LysPhe: 0.834 ± 0.03	2.751LysGly: 2.751 ± 0.051	0.507LysHis: 0.507 ± 0.024	1.37LysIle: 1.37 ± 0.041	0.952LysLys: 0.952 ± 0.03	3.04LysLeu: 3.04 ± 0.058	0.695LysMet: 0.695 ± 0.027	0.683LysAsn: 0.683 ± 0.029	1.955LysPro: 1.955 ± 0.042	0.861LysGln: 0.861 ± 0.033	2.205LysArg: 2.205 ± 0.05	1.506LysSer: 1.506 ± 0.039	1.616LysThr: 1.616 ± 0.049	2.326LysVal: 2.326 ± 0.056	0.408LysTrp: 0.408 ± 0.021	0.599LysTyr: 0.599 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	15.401LeuAla: 15.401 ± 0.187	0.839LeuCys: 0.839 ± 0.031	6.322LeuAsp: 6.322 ± 0.086	4.744LeuGlu: 4.744 ± 0.074	3.534LeuPhe: 3.534 ± 0.065	8.766LeuGly: 8.766 ± 0.088	1.813LeuHis: 1.813 ± 0.048	4.662LeuIle: 4.662 ± 0.09	3.011LeuLys: 3.011 ± 0.06	9.138LeuLeu: 9.138 ± 0.13	2.045LeuMet: 2.045 ± 0.046	2.389LeuAsn: 2.389 ± 0.053	5.696LeuPro: 5.696 ± 0.093	2.478LeuGln: 2.478 ± 0.052	6.911LeuArg: 6.911 ± 0.096	5.817LeuSer: 5.817 ± 0.082	5.72LeuThr: 5.72 ± 0.091	7.682LeuVal: 7.682 ± 0.095	1.277LeuTrp: 1.277 ± 0.039	1.96LeuTyr: 1.96 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.353MetAla: 3.353 ± 0.057	0.156MetCys: 0.156 ± 0.013	1.212MetAsp: 1.212 ± 0.034	0.998MetGlu: 0.998 ± 0.032	0.593MetPhe: 0.593 ± 0.024	1.929MetGly: 1.929 ± 0.04	0.444MetHis: 0.444 ± 0.02	1.259MetIle: 1.259 ± 0.039	0.879MetLys: 0.879 ± 0.028	2.443MetLeu: 2.443 ± 0.049	0.572MetMet: 0.572 ± 0.025	0.681MetAsn: 0.681 ± 0.027	1.484MetPro: 1.484 ± 0.035	0.757MetGln: 0.757 ± 0.026	1.64MetArg: 1.64 ± 0.043	1.374MetSer: 1.374 ± 0.036	1.758MetThr: 1.758 ± 0.04	1.674MetVal: 1.674 ± 0.038	0.211MetTrp: 0.211 ± 0.016	0.239MetTyr: 0.239 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.3AsnAla: 3.3 ± 0.071	0.262AsnCys: 0.262 ± 0.017	1.422AsnAsp: 1.422 ± 0.055	1.118AsnGlu: 1.118 ± 0.028	0.948AsnPhe: 0.948 ± 0.038	2.33AsnGly: 2.33 ± 0.064	0.508AsnHis: 0.508 ± 0.021	1.091AsnIle: 1.091 ± 0.034	0.592AsnLys: 0.592 ± 0.026	2.6AsnLeu: 2.6 ± 0.054	0.545AsnMet: 0.545 ± 0.021	0.655AsnAsn: 0.655 ± 0.033	1.837AsnPro: 1.837 ± 0.042	0.788AsnGln: 0.788 ± 0.028	1.896AsnArg: 1.896 ± 0.036	1.222AsnSer: 1.222 ± 0.042	1.219AsnThr: 1.219 ± 0.048	1.866AsnVal: 1.866 ± 0.045	0.423AsnTrp: 0.423 ± 0.021	0.678AsnTyr: 0.678 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	7.253ProAla: 7.253 ± 0.106	0.326ProCys: 0.326 ± 0.017	3.877ProAsp: 3.877 ± 0.067	3.296ProGlu: 3.296 ± 0.06	1.928ProPhe: 1.928 ± 0.042	5.058ProGly: 5.058 ± 0.076	1.048ProHis: 1.048 ± 0.03	2.244ProIle: 2.244 ± 0.048	1.419ProLys: 1.419 ± 0.039	5.176ProLeu: 5.176 ± 0.079	1.149ProMet: 1.149 ± 0.029	1.228ProAsn: 1.228 ± 0.037	2.689ProPro: 2.689 ± 0.064	1.683ProGln: 1.683 ± 0.042	3.334ProArg: 3.334 ± 0.062	2.802ProSer: 2.802 ± 0.055	2.39ProThr: 2.39 ± 0.048	4.517ProVal: 4.517 ± 0.071	0.699ProTrp: 0.699 ± 0.028	1.045ProTyr: 1.045 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.281GlnAla: 4.281 ± 0.071	0.226GlnCys: 0.226 ± 0.015	1.525GlnAsp: 1.525 ± 0.036	1.162GlnGlu: 1.162 ± 0.035	1.159GlnPhe: 1.159 ± 0.03	2.649GlnGly: 2.649 ± 0.046	0.607GlnHis: 0.607 ± 0.026	1.711GlnIle: 1.711 ± 0.041	0.882GlnLys: 0.882 ± 0.028	3.11GlnLeu: 3.11 ± 0.056	0.768GlnMet: 0.768 ± 0.025	0.703GlnAsn: 0.703 ± 0.025	1.803GlnPro: 1.803 ± 0.038	1.161GlnGln: 1.161 ± 0.034	2.521GlnArg: 2.521 ± 0.044	1.632GlnSer: 1.632 ± 0.042	1.658GlnThr: 1.658 ± 0.044	2.512GlnVal: 2.512 ± 0.046	0.455GlnTrp: 0.455 ± 0.021	0.614GlnTyr: 0.614 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.645ArgAla: 8.645 ± 0.108	0.505ArgCys: 0.505 ± 0.02	4.339ArgAsp: 4.339 ± 0.073	4.05ArgGlu: 4.05 ± 0.069	3.11ArgPhe: 3.11 ± 0.049	5.131ArgGly: 5.131 ± 0.078	1.694ArgHis: 1.694 ± 0.041	3.982ArgIle: 3.982 ± 0.067	2.181ArgLys: 2.181 ± 0.047	8.243ArgLeu: 8.243 ± 0.123	1.888ArgMet: 1.888 ± 0.046	1.765ArgAsn: 1.765 ± 0.043	3.678ArgPro: 3.678 ± 0.061	2.548ArgGln: 2.548 ± 0.051	5.596ArgArg: 5.596 ± 0.083	3.783ArgSer: 3.783 ± 0.054	3.508ArgThr: 3.508 ± 0.058	4.793ArgVal: 4.793 ± 0.079	1.197ArgTrp: 1.197 ± 0.032	1.741ArgTyr: 1.741 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.566SerAla: 6.566 ± 0.082	0.417SerCys: 0.417 ± 0.019	3.116SerAsp: 3.116 ± 0.052	2.624SerGlu: 2.624 ± 0.051	2.041SerPhe: 2.041 ± 0.044	5.588SerGly: 5.588 ± 0.084	1.003SerHis: 1.003 ± 0.032	2.35SerIle: 2.35 ± 0.053	1.371SerLys: 1.371 ± 0.04	5.242SerLeu: 5.242 ± 0.073	1.112SerMet: 1.112 ± 0.03	1.316SerAsn: 1.316 ± 0.038	2.869SerPro: 2.869 ± 0.055	1.621SerGln: 1.621 ± 0.037	3.582SerArg: 3.582 ± 0.065	2.693SerSer: 2.693 ± 0.06	2.521SerThr: 2.521 ± 0.056	3.654SerVal: 3.654 ± 0.068	0.796SerTrp: 0.796 ± 0.027	1.329SerTyr: 1.329 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.534ThrAla: 6.534 ± 0.088	0.447ThrCys: 0.447 ± 0.021	2.868ThrAsp: 2.868 ± 0.067	2.33ThrGlu: 2.33 ± 0.055	1.952ThrPhe: 1.952 ± 0.049	5.456ThrGly: 5.456 ± 0.103	0.892ThrHis: 0.892 ± 0.028	2.851ThrIle: 2.851 ± 0.055	1.236ThrLys: 1.236 ± 0.033	5.701ThrLeu: 5.701 ± 0.087	1.181ThrMet: 1.181 ± 0.031	1.245ThrAsn: 1.245 ± 0.039	3.158ThrPro: 3.158 ± 0.062	1.425ThrGln: 1.425 ± 0.039	3.528ThrArg: 3.528 ± 0.055	2.685ThrSer: 2.685 ± 0.067	2.719ThrThr: 2.719 ± 0.064	4.269ThrVal: 4.269 ± 0.075	0.736ThrTrp: 0.736 ± 0.025	1.234ThrTyr: 1.234 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	9.683ValAla: 9.683 ± 0.116	0.628ValCys: 0.628 ± 0.022	4.372ValAsp: 4.372 ± 0.074	4.307ValGlu: 4.307 ± 0.064	2.446ValPhe: 2.446 ± 0.05	5.595ValGly: 5.595 ± 0.09	1.379ValHis: 1.379 ± 0.036	3.817ValIle: 3.817 ± 0.065	2.05ValLys: 2.05 ± 0.052	7.116ValLeu: 7.116 ± 0.098	1.707ValMet: 1.707 ± 0.039	2.006ValAsn: 2.006 ± 0.046	4.161ValPro: 4.161 ± 0.065	1.964ValGln: 1.964 ± 0.044	5.074ValArg: 5.074 ± 0.074	4.026ValSer: 4.026 ± 0.064	4.579ValThr: 4.579 ± 0.086	5.41ValVal: 5.41 ± 0.086	0.965ValTrp: 0.965 ± 0.035	1.38ValTyr: 1.38 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.498TrpAla: 1.498 ± 0.042	0.164TrpCys: 0.164 ± 0.012	0.788TrpAsp: 0.788 ± 0.031	0.581TrpGlu: 0.581 ± 0.021	0.573TrpPhe: 0.573 ± 0.025	1.021TrpGly: 1.021 ± 0.028	0.382TrpHis: 0.382 ± 0.018	0.726TrpIle: 0.726 ± 0.025	0.474TrpLys: 0.474 ± 0.024	1.886TrpLeu: 1.886 ± 0.055	0.361TrpMet: 0.361 ± 0.019	0.448TrpAsn: 0.448 ± 0.021	0.757TrpPro: 0.757 ± 0.027	0.709TrpGln: 0.709 ± 0.03	1.324TrpArg: 1.324 ± 0.038	0.896TrpSer: 0.896 ± 0.027	0.867TrpThr: 0.867 ± 0.031	0.798TrpVal: 0.798 ± 0.027	0.248TrpTrp: 0.248 ± 0.017	0.315TrpTyr: 0.315 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.688TyrAla: 2.688 ± 0.05	0.23TyrCys: 0.23 ± 0.015	1.483TyrAsp: 1.483 ± 0.039	1.076TyrGlu: 1.076 ± 0.034	0.871TyrPhe: 0.871 ± 0.032	2.153TyrGly: 2.153 ± 0.053	0.495TyrHis: 0.495 ± 0.021	0.74TyrIle: 0.74 ± 0.025	0.565TyrLys: 0.565 ± 0.027	2.077TyrLeu: 2.077 ± 0.05	0.384TyrMet: 0.384 ± 0.019	0.646TyrAsn: 0.646 ± 0.03	1.068TyrPro: 1.068 ± 0.032	0.661TyrGln: 0.661 ± 0.026	1.778TyrArg: 1.778 ± 0.048	1.205TyrSer: 1.205 ± 0.037	1.047TyrThr: 1.047 ± 0.043	1.571TyrVal: 1.571 ± 0.04	0.351TyrTrp: 0.351 ± 0.019	0.646TyrTyr: 0.646 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3342 proteins (1082236 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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