Amino acid dipepetide frequency for Bovine ephemeral fever virus (strain BB7721) (BEFV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.04AlaAla: 1.04 ± 0.75
0.624AlaCys: 0.624 ± 0.24
1.248AlaAsp: 1.248 ± 0.386
1.04AlaGlu: 1.04 ± 0.329
1.04AlaPhe: 1.04 ± 0.44
1.248AlaGly: 1.248 ± 0.678
1.248AlaHis: 1.248 ± 0.658
3.536AlaIle: 3.536 ± 0.613
1.872AlaLys: 1.872 ± 0.542
2.288AlaLeu: 2.288 ± 0.756
0.832AlaMet: 0.832 ± 0.493
2.288AlaAsn: 2.288 ± 0.578
1.248AlaPro: 1.248 ± 0.749
0.832AlaGln: 0.832 ± 0.441
1.04AlaArg: 1.04 ± 0.44
2.08AlaSer: 2.08 ± 0.472
0.624AlaThr: 0.624 ± 0.369
2.08AlaVal: 2.08 ± 0.785
0.416AlaTrp: 0.416 ± 0.349
1.248AlaTyr: 1.248 ± 0.706
0.0AlaXaa: 0.0 ± 0.0
Cys
0.208CysAla: 0.208 ± 0.252
0.0CysCys: 0.0 ± 0.0
0.624CysAsp: 0.624 ± 0.24
0.624CysGlu: 0.624 ± 0.24
0.416CysPhe: 0.416 ± 0.183
1.456CysGly: 1.456 ± 0.47
0.832CysHis: 0.832 ± 0.512
0.624CysIle: 0.624 ± 0.263
1.04CysLys: 1.04 ± 0.638
2.912CysLeu: 2.912 ± 0.837
0.0CysMet: 0.0 ± 0.23
1.456CysAsn: 1.456 ± 0.376
0.624CysPro: 0.624 ± 0.469
0.832CysGln: 0.832 ± 0.357
1.04CysArg: 1.04 ± 0.469
1.248CysSer: 1.248 ± 0.569
1.456CysThr: 1.456 ± 0.551
0.624CysVal: 0.624 ± 0.319
0.832CysTrp: 0.832 ± 0.492
0.832CysTyr: 0.832 ± 0.348
0.0CysXaa: 0.0 ± 0.0
Asp
2.288AspAla: 2.288 ± 0.866
0.832AspCys: 0.832 ± 0.344
3.536AspAsp: 3.536 ± 1.744
4.576AspGlu: 4.576 ± 0.912
2.08AspPhe: 2.08 ± 0.513
2.912AspGly: 2.912 ± 0.782
1.248AspHis: 1.248 ± 0.665
3.328AspIle: 3.328 ± 0.827
4.992AspLys: 4.992 ± 1.247
7.072AspLeu: 7.072 ± 1.22
2.288AspMet: 2.288 ± 0.685
2.912AspAsn: 2.912 ± 0.784
1.248AspPro: 1.248 ± 0.479
2.912AspGln: 2.912 ± 0.41
1.664AspArg: 1.664 ± 0.544
3.328AspSer: 3.328 ± 0.877
0.832AspThr: 0.832 ± 0.718
3.328AspVal: 3.328 ± 1.056
1.248AspTrp: 1.248 ± 0.475
3.536AspTyr: 3.536 ± 0.621
0.0AspXaa: 0.0 ± 0.0
Glu
0.832GluAla: 0.832 ± 0.474
1.04GluCys: 1.04 ± 0.374
6.864GluAsp: 6.864 ± 1.345
7.696GluGlu: 7.696 ± 1.343
4.784GluPhe: 4.784 ± 0.594
4.576GluGly: 4.576 ± 0.73
1.248GluHis: 1.248 ± 0.68
7.488GluIle: 7.488 ± 1.633
6.864GluLys: 6.864 ± 1.066
8.735GluLeu: 8.735 ± 1.025
1.456GluMet: 1.456 ± 0.491
4.16GluAsn: 4.16 ± 0.749
1.664GluPro: 1.664 ± 0.446
1.04GluGln: 1.04 ± 0.436
3.744GluArg: 3.744 ± 0.575
6.448GluSer: 6.448 ± 0.896
1.872GluThr: 1.872 ± 0.542
3.744GluVal: 3.744 ± 0.543
0.624GluTrp: 0.624 ± 0.263
3.328GluTyr: 3.328 ± 0.807
0.0GluXaa: 0.0 ± 0.0
Phe
0.624PheAla: 0.624 ± 0.327
1.248PheCys: 1.248 ± 0.634
2.08PheAsp: 2.08 ± 0.433
3.12PheGlu: 3.12 ± 0.736
2.912PhePhe: 2.912 ± 1.07
3.328PheGly: 3.328 ± 1.115
0.208PheHis: 0.208 ± 0.316
2.912PheIle: 2.912 ± 0.654
4.16PheLys: 4.16 ± 0.456
4.16PheLeu: 4.16 ± 0.999
0.832PheMet: 0.832 ± 0.396
1.664PheAsn: 1.664 ± 0.632
0.832PhePro: 0.832 ± 0.492
1.872PheGln: 1.872 ± 0.592
1.872PheArg: 1.872 ± 0.699
1.872PheSer: 1.872 ± 0.704
2.704PheThr: 2.704 ± 0.853
2.496PheVal: 2.496 ± 0.753
0.832PheTrp: 0.832 ± 0.586
1.248PheTyr: 1.248 ± 0.374
0.0PheXaa: 0.0 ± 0.0
Gly
1.456GlyAla: 1.456 ± 0.36
1.248GlyCys: 1.248 ± 0.709
3.12GlyAsp: 3.12 ± 0.931
5.616GlyGlu: 5.616 ± 0.977
2.288GlyPhe: 2.288 ± 0.834
3.536GlyGly: 3.536 ± 0.985
2.08GlyHis: 2.08 ± 0.707
3.744GlyIle: 3.744 ± 0.449
4.576GlyLys: 4.576 ± 1.314
6.656GlyLeu: 6.656 ± 1.582
1.664GlyMet: 1.664 ± 0.505
2.288GlyAsn: 2.288 ± 0.641
0.624GlyPro: 0.624 ± 0.276
0.832GlyGln: 0.832 ± 0.357
3.12GlyArg: 3.12 ± 1.064
3.744GlySer: 3.744 ± 0.832
3.12GlyThr: 3.12 ± 0.886
2.496GlyVal: 2.496 ± 0.544
0.832GlyTrp: 0.832 ± 0.344
1.664GlyTyr: 1.664 ± 0.566
0.0GlyXaa: 0.0 ± 0.0
His
0.832HisAla: 0.832 ± 0.476
0.208HisCys: 0.208 ± 0.192
0.832HisAsp: 0.832 ± 0.318
1.664HisGlu: 1.664 ± 0.631
1.04HisPhe: 1.04 ± 0.642
1.456HisGly: 1.456 ± 0.379
0.832HisHis: 0.832 ± 0.344
1.664HisIle: 1.664 ± 0.516
1.872HisLys: 1.872 ± 0.578
2.704HisLeu: 2.704 ± 0.461
0.832HisMet: 0.832 ± 0.367
1.456HisAsn: 1.456 ± 0.554
1.456HisPro: 1.456 ± 0.438
0.208HisGln: 0.208 ± 0.305
1.664HisArg: 1.664 ± 0.286
1.456HisSer: 1.456 ± 0.409
0.624HisThr: 0.624 ± 0.525
1.04HisVal: 1.04 ± 0.606
0.416HisTrp: 0.416 ± 0.183
1.456HisTyr: 1.456 ± 0.47
0.0HisXaa: 0.0 ± 0.0
Ile
1.664IleAla: 1.664 ± 0.517
2.288IleCys: 2.288 ± 0.719
4.576IleAsp: 4.576 ± 0.552
5.616IleGlu: 5.616 ± 0.926
2.704IlePhe: 2.704 ± 0.479
2.912IleGly: 2.912 ± 0.742
1.664IleHis: 1.664 ± 0.628
8.527IleIle: 8.527 ± 1.337
11.647IleLys: 11.647 ± 1.566
6.656IleLeu: 6.656 ± 1.03
1.248IleMet: 1.248 ± 0.482
8.319IleAsn: 8.319 ± 1.363
2.912IlePro: 2.912 ± 0.626
2.496IleGln: 2.496 ± 0.476
5.408IleArg: 5.408 ± 0.76
5.616IleSer: 5.616 ± 0.643
2.496IleThr: 2.496 ± 0.801
3.328IleVal: 3.328 ± 0.487
1.04IleTrp: 1.04 ± 0.292
4.16IleTyr: 4.16 ± 1.161
0.0IleXaa: 0.0 ± 0.0
Lys
3.12LysAla: 3.12 ± 0.713
2.288LysCys: 2.288 ± 0.646
3.952LysAsp: 3.952 ± 0.566
6.656LysGlu: 6.656 ± 1.157
3.12LysPhe: 3.12 ± 0.72
6.24LysGly: 6.24 ± 1.023
2.08LysHis: 2.08 ± 0.371
7.696LysIle: 7.696 ± 1.056
7.488LysLys: 7.488 ± 0.92
7.696LysLeu: 7.696 ± 2.063
1.456LysMet: 1.456 ± 0.284
6.656LysAsn: 6.656 ± 0.923
3.952LysPro: 3.952 ± 0.776
2.496LysGln: 2.496 ± 0.727
5.824LysArg: 5.824 ± 1.259
7.28LysSer: 7.28 ± 0.836
3.744LysThr: 3.744 ± 0.981
2.912LysVal: 2.912 ± 0.844
0.624LysTrp: 0.624 ± 0.276
2.496LysTyr: 2.496 ± 1.101
0.0LysXaa: 0.0 ± 0.0
Leu
3.952LeuAla: 3.952 ± 0.524
1.456LeuCys: 1.456 ± 0.681
7.696LeuAsp: 7.696 ± 1.475
9.359LeuGlu: 9.359 ± 1.47
3.536LeuPhe: 3.536 ± 0.731
4.992LeuGly: 4.992 ± 1.024
2.496LeuHis: 2.496 ± 0.46
8.527LeuIle: 8.527 ± 1.305
6.448LeuLys: 6.448 ± 0.971
7.072LeuLeu: 7.072 ± 1.45
3.328LeuMet: 3.328 ± 0.961
6.448LeuAsn: 6.448 ± 1.28
2.704LeuPro: 2.704 ± 0.493
3.952LeuGln: 3.952 ± 0.606
6.24LeuArg: 6.24 ± 1.944
6.24LeuSer: 6.24 ± 0.936
4.992LeuThr: 4.992 ± 0.909
4.16LeuVal: 4.16 ± 0.914
1.04LeuTrp: 1.04 ± 0.513
2.912LeuTyr: 2.912 ± 0.827
0.0LeuXaa: 0.0 ± 0.0
Met
0.832MetAla: 0.832 ± 0.368
0.624MetCys: 0.624 ± 0.276
1.664MetAsp: 1.664 ± 0.516
2.496MetGlu: 2.496 ± 1.057
1.456MetPhe: 1.456 ± 0.496
1.248MetGly: 1.248 ± 0.447
0.208MetHis: 0.208 ± 0.192
1.872MetIle: 1.872 ± 0.713
2.08MetLys: 2.08 ± 0.648
2.08MetLeu: 2.08 ± 1.013
1.664MetMet: 1.664 ± 0.603
1.664MetAsn: 1.664 ± 0.402
1.456MetPro: 1.456 ± 0.395
0.416MetGln: 0.416 ± 0.29
1.04MetArg: 1.04 ± 0.537
2.288MetSer: 2.288 ± 0.437
1.664MetThr: 1.664 ± 0.48
1.872MetVal: 1.872 ± 0.627
0.0MetTrp: 0.0 ± 0.0
0.208MetTyr: 0.208 ± 0.247
0.0MetXaa: 0.0 ± 0.0
Asn
1.248AsnAla: 1.248 ± 0.683
1.456AsnCys: 1.456 ± 0.372
4.16AsnAsp: 4.16 ± 0.948
2.704AsnGlu: 2.704 ± 0.309
3.328AsnPhe: 3.328 ± 0.852
3.536AsnGly: 3.536 ± 0.886
1.872AsnHis: 1.872 ± 0.655
6.032AsnIle: 6.032 ± 0.715
6.864AsnLys: 6.864 ± 1.074
8.319AsnLeu: 8.319 ± 1.171
1.872AsnMet: 1.872 ± 0.417
4.992AsnAsn: 4.992 ± 0.605
2.288AsnPro: 2.288 ± 0.691
4.16AsnGln: 4.16 ± 0.852
2.08AsnArg: 2.08 ± 0.414
2.912AsnSer: 2.912 ± 0.735
2.704AsnThr: 2.704 ± 0.651
2.912AsnVal: 2.912 ± 0.972
2.08AsnTrp: 2.08 ± 0.79
3.536AsnTyr: 3.536 ± 1.052
0.0AsnXaa: 0.0 ± 0.0
Pro
1.664ProAla: 1.664 ± 0.476
0.416ProCys: 0.416 ± 0.183
1.872ProAsp: 1.872 ± 0.502
2.288ProGlu: 2.288 ± 0.574
1.04ProPhe: 1.04 ± 0.345
0.832ProGly: 0.832 ± 0.482
1.04ProHis: 1.04 ± 0.302
3.12ProIle: 3.12 ± 1.649
2.496ProLys: 2.496 ± 0.524
2.288ProLeu: 2.288 ± 0.615
1.04ProMet: 1.04 ± 0.488
1.456ProAsn: 1.456 ± 0.441
1.664ProPro: 1.664 ± 0.824
1.04ProGln: 1.04 ± 0.575
0.832ProArg: 0.832 ± 0.348
2.08ProSer: 2.08 ± 0.61
2.288ProThr: 2.288 ± 0.703
2.288ProVal: 2.288 ± 0.689
0.624ProTrp: 0.624 ± 0.329
2.08ProTyr: 2.08 ± 0.554
0.0ProXaa: 0.0 ± 0.0
Gln
1.248GlnAla: 1.248 ± 0.469
0.624GlnCys: 0.624 ± 0.319
1.664GlnAsp: 1.664 ± 0.581
3.328GlnGlu: 3.328 ± 0.77
1.456GlnPhe: 1.456 ± 0.54
1.456GlnGly: 1.456 ± 0.484
0.416GlnHis: 0.416 ± 0.358
2.912GlnIle: 2.912 ± 0.525
2.496GlnLys: 2.496 ± 0.802
2.496GlnLeu: 2.496 ± 0.732
0.416GlnMet: 0.416 ± 0.246
3.328GlnAsn: 3.328 ± 1.277
0.624GlnPro: 0.624 ± 0.276
0.624GlnGln: 0.624 ± 0.369
1.456GlnArg: 1.456 ± 0.398
2.288GlnSer: 2.288 ± 1.117
2.08GlnThr: 2.08 ± 0.513
0.832GlnVal: 0.832 ± 0.472
0.0GlnTrp: 0.0 ± 0.0
0.624GlnTyr: 0.624 ± 0.243
0.0GlnXaa: 0.0 ± 0.0
Arg
1.456ArgAla: 1.456 ± 0.683
1.04ArgCys: 1.04 ± 0.478
2.08ArgAsp: 2.08 ± 0.689
5.616ArgGlu: 5.616 ± 0.968
3.328ArgPhe: 3.328 ± 0.499
3.952ArgGly: 3.952 ± 1.009
0.416ArgHis: 0.416 ± 0.246
3.744ArgIle: 3.744 ± 1.05
2.912ArgLys: 2.912 ± 1.033
4.16ArgLeu: 4.16 ± 0.786
1.04ArgMet: 1.04 ± 0.723
3.952ArgAsn: 3.952 ± 0.764
2.08ArgPro: 2.08 ± 0.661
0.624ArgGln: 0.624 ± 0.243
2.704ArgArg: 2.704 ± 0.7
3.744ArgSer: 3.744 ± 0.674
2.288ArgThr: 2.288 ± 0.567
3.328ArgVal: 3.328 ± 0.745
1.248ArgTrp: 1.248 ± 0.58
1.664ArgTyr: 1.664 ± 0.501
0.0ArgXaa: 0.0 ± 0.0
Ser
1.664SerAla: 1.664 ± 0.485
1.04SerCys: 1.04 ± 0.26
3.536SerAsp: 3.536 ± 0.603
5.2SerGlu: 5.2 ± 0.619
2.704SerPhe: 2.704 ± 0.95
3.536SerGly: 3.536 ± 0.754
2.496SerHis: 2.496 ± 0.421
5.824SerIle: 5.824 ± 0.572
5.408SerLys: 5.408 ± 1.219
6.864SerLeu: 6.864 ± 1.995
2.288SerMet: 2.288 ± 0.95
5.408SerAsn: 5.408 ± 1.219
1.456SerPro: 1.456 ± 0.447
2.496SerGln: 2.496 ± 0.942
2.912SerArg: 2.912 ± 0.929
6.864SerSer: 6.864 ± 1.053
3.744SerThr: 3.744 ± 0.962
2.288SerVal: 2.288 ± 0.743
2.08SerTrp: 2.08 ± 0.542
3.328SerTyr: 3.328 ± 1.812
0.0SerXaa: 0.0 ± 0.0
Thr
1.04ThrAla: 1.04 ± 0.695
0.0ThrCys: 0.0 ± 0.0
2.08ThrAsp: 2.08 ± 0.733
3.12ThrGlu: 3.12 ± 0.587
0.624ThrPhe: 0.624 ± 0.263
2.704ThrGly: 2.704 ± 0.374
0.624ThrHis: 0.624 ± 0.288
3.744ThrIle: 3.744 ± 0.594
3.328ThrLys: 3.328 ± 0.801
3.744ThrLeu: 3.744 ± 1.09
1.04ThrMet: 1.04 ± 0.486
3.328ThrAsn: 3.328 ± 0.799
1.04ThrPro: 1.04 ± 0.294
0.208ThrGln: 0.208 ± 0.123
2.08ThrArg: 2.08 ± 0.662
4.16ThrSer: 4.16 ± 0.712
1.872ThrThr: 1.872 ± 0.664
3.952ThrVal: 3.952 ± 0.678
1.664ThrTrp: 1.664 ± 0.504
2.496ThrTyr: 2.496 ± 0.774
0.0ThrXaa: 0.0 ± 0.0
Val
1.248ValAla: 1.248 ± 0.747
0.416ValCys: 0.416 ± 0.246
1.872ValAsp: 1.872 ± 0.554
2.912ValGlu: 2.912 ± 0.647
1.456ValPhe: 1.456 ± 0.509
2.704ValGly: 2.704 ± 0.535
0.832ValHis: 0.832 ± 0.57
4.368ValIle: 4.368 ± 0.964
5.616ValLys: 5.616 ± 1.419
4.784ValLeu: 4.784 ± 0.923
2.08ValMet: 2.08 ± 0.484
3.12ValAsn: 3.12 ± 0.72
2.288ValPro: 2.288 ± 0.534
0.832ValGln: 0.832 ± 0.398
2.704ValArg: 2.704 ± 0.794
3.744ValSer: 3.744 ± 0.546
2.496ValThr: 2.496 ± 0.532
1.456ValVal: 1.456 ± 0.834
1.248ValTrp: 1.248 ± 0.494
1.04ValTyr: 1.04 ± 0.821
0.0ValXaa: 0.0 ± 0.0
Trp
0.416TrpAla: 0.416 ± 0.361
0.624TrpCys: 0.624 ± 0.246
0.624TrpAsp: 0.624 ± 0.369
1.872TrpGlu: 1.872 ± 0.657
0.832TrpPhe: 0.832 ± 0.255
1.04TrpGly: 1.04 ± 0.335
0.208TrpHis: 0.208 ± 0.123
2.704TrpIle: 2.704 ± 0.424
1.456TrpLys: 1.456 ± 0.531
1.04TrpLeu: 1.04 ± 0.815
0.208TrpMet: 0.208 ± 0.123
2.08TrpAsn: 2.08 ± 0.34
0.416TrpPro: 0.416 ± 0.246
0.416TrpGln: 0.416 ± 0.183
0.416TrpArg: 0.416 ± 0.183
1.664TrpSer: 1.664 ± 0.668
0.208TrpThr: 0.208 ± 0.192
0.832TrpVal: 0.832 ± 0.42
0.416TrpTrp: 0.416 ± 0.356
0.832TrpTyr: 0.832 ± 0.457
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.04TyrAla: 1.04 ± 0.38
0.416TyrCys: 0.416 ± 0.312
2.08TyrAsp: 2.08 ± 0.736
2.704TyrGlu: 2.704 ± 0.679
0.832TyrPhe: 0.832 ± 0.344
1.04TyrGly: 1.04 ± 0.306
1.664TyrHis: 1.664 ± 0.618
2.912TyrIle: 2.912 ± 1.357
4.16TyrLys: 4.16 ± 0.782
5.824TyrLeu: 5.824 ± 1.197
1.04TyrMet: 1.04 ± 0.633
2.08TyrAsn: 2.08 ± 1.153
1.872TyrPro: 1.872 ± 0.703
2.08TyrGln: 2.08 ± 0.615
3.536TyrArg: 3.536 ± 0.507
2.08TyrSer: 2.08 ± 0.375
1.04TyrThr: 1.04 ± 0.26
1.248TyrVal: 1.248 ± 0.612
1.04TyrTrp: 1.04 ± 0.699
1.872TyrTyr: 1.872 ± 0.55
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (4809 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski