Amino acid dipepetide frequency for Pseudoflavonifractor sp. An184

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.965AlaAla: 11.965 ± 0.143	1.394AlaCys: 1.394 ± 0.043	5.181AlaAsp: 5.181 ± 0.087	6.162AlaGlu: 6.162 ± 0.092	3.298AlaPhe: 3.298 ± 0.071	8.043AlaGly: 8.043 ± 0.104	1.488AlaHis: 1.488 ± 0.034	4.721AlaIle: 4.721 ± 0.074	3.796AlaLys: 3.796 ± 0.074	10.574AlaLeu: 10.574 ± 0.142	2.751AlaMet: 2.751 ± 0.054	2.242AlaAsn: 2.242 ± 0.051	3.698AlaPro: 3.698 ± 0.067	4.314AlaGln: 4.314 ± 0.076	5.082AlaArg: 5.082 ± 0.088	4.427AlaSer: 4.427 ± 0.082	3.456AlaThr: 3.456 ± 0.077	7.854AlaVal: 7.854 ± 0.099	1.013AlaTrp: 1.013 ± 0.032	2.749AlaTyr: 2.749 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	1.464CysAla: 1.464 ± 0.039	0.314CysCys: 0.314 ± 0.017	0.775CysAsp: 0.775 ± 0.027	0.74CysGlu: 0.74 ± 0.031	0.567CysPhe: 0.567 ± 0.026	1.705CysGly: 1.705 ± 0.045	0.309CysHis: 0.309 ± 0.02	0.75CysIle: 0.75 ± 0.028	0.522CysLys: 0.522 ± 0.025	1.458CysLeu: 1.458 ± 0.042	0.372CysMet: 0.372 ± 0.019	0.408CysAsn: 0.408 ± 0.018	0.777CysPro: 0.777 ± 0.029	0.499CysGln: 0.499 ± 0.023	1.107CysArg: 1.107 ± 0.034	0.854CysSer: 0.854 ± 0.028	0.805CysThr: 0.805 ± 0.03	1.043CysVal: 1.043 ± 0.038	0.197CysTrp: 0.197 ± 0.014	0.522CysTyr: 0.522 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.719AspAla: 4.719 ± 0.065	0.835AspCys: 0.835 ± 0.032	2.561AspAsp: 2.561 ± 0.087	3.754AspGlu: 3.754 ± 0.075	2.458AspPhe: 2.458 ± 0.047	5.09AspGly: 5.09 ± 0.087	1.091AspHis: 1.091 ± 0.03	3.037AspIle: 3.037 ± 0.064	2.292AspLys: 2.292 ± 0.055	5.555AspLeu: 5.555 ± 0.081	1.478AspMet: 1.478 ± 0.039	1.577AspAsn: 1.577 ± 0.039	2.834AspPro: 2.834 ± 0.055	2.169AspGln: 2.169 ± 0.046	3.493AspArg: 3.493 ± 0.066	2.912AspSer: 2.912 ± 0.063	2.982AspThr: 2.982 ± 0.068	3.677AspVal: 3.677 ± 0.067	0.798AspTrp: 0.798 ± 0.031	2.46AspTyr: 2.46 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	6.497GluAla: 6.497 ± 0.089	0.737GluCys: 0.737 ± 0.027	4.263GluAsp: 4.263 ± 0.066	6.37GluGlu: 6.37 ± 0.098	2.192GluPhe: 2.192 ± 0.052	5.026GluGly: 5.026 ± 0.07	1.526GluHis: 1.526 ± 0.044	3.905GluIle: 3.905 ± 0.07	3.964GluLys: 3.964 ± 0.081	7.403GluLeu: 7.403 ± 0.101	1.856GluMet: 1.856 ± 0.047	2.813GluAsn: 2.813 ± 0.062	2.527GluPro: 2.527 ± 0.057	3.432GluGln: 3.432 ± 0.064	4.642GluArg: 4.642 ± 0.101	2.895GluSer: 2.895 ± 0.06	3.553GluThr: 3.553 ± 0.065	4.196GluVal: 4.196 ± 0.078	0.621GluTrp: 0.621 ± 0.025	2.367GluTyr: 2.367 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	3.195PheAla: 3.195 ± 0.058	0.724PheCys: 0.724 ± 0.028	2.237PheAsp: 2.237 ± 0.056	2.011PheGlu: 2.011 ± 0.054	1.631PhePhe: 1.631 ± 0.043	3.056PheGly: 3.056 ± 0.059	0.873PheHis: 0.873 ± 0.028	1.739PheIle: 1.739 ± 0.048	1.084PheLys: 1.084 ± 0.035	4.165PheLeu: 4.165 ± 0.085	0.782PheMet: 0.782 ± 0.03	1.084PheAsn: 1.084 ± 0.036	1.638PhePro: 1.638 ± 0.047	1.758PheGln: 1.758 ± 0.046	2.055PheArg: 2.055 ± 0.047	2.743PheSer: 2.743 ± 0.06	2.323PheThr: 2.323 ± 0.057	2.333PheVal: 2.333 ± 0.046	0.511PheTrp: 0.511 ± 0.025	1.47PheTyr: 1.47 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	6.806GlyAla: 6.806 ± 0.105	1.293GlyCys: 1.293 ± 0.049	4.074GlyAsp: 4.074 ± 0.068	5.833GlyGlu: 5.833 ± 0.095	2.916GlyPhe: 2.916 ± 0.056	6.616GlyGly: 6.616 ± 0.114	1.409GlyHis: 1.409 ± 0.041	4.311GlyIle: 4.311 ± 0.067	4.085GlyLys: 4.085 ± 0.068	7.566GlyLeu: 7.566 ± 0.104	2.396GlyMet: 2.396 ± 0.054	2.417GlyAsn: 2.417 ± 0.058	2.31GlyPro: 2.31 ± 0.058	2.822GlyGln: 2.822 ± 0.054	4.83GlyArg: 4.83 ± 0.073	4.468GlySer: 4.468 ± 0.075	4.694GlyThr: 4.694 ± 0.092	6.0GlyVal: 6.0 ± 0.077	1.083GlyTrp: 1.083 ± 0.032	3.123GlyTyr: 3.123 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.34HisAla: 1.34 ± 0.044	0.364HisCys: 0.364 ± 0.02	0.892HisAsp: 0.892 ± 0.027	0.926HisGlu: 0.926 ± 0.033	0.806HisPhe: 0.806 ± 0.027	1.499HisGly: 1.499 ± 0.041	0.42HisHis: 0.42 ± 0.025	1.238HisIle: 1.238 ± 0.039	0.761HisLys: 0.761 ± 0.031	1.781HisLeu: 1.781 ± 0.045	0.466HisMet: 0.466 ± 0.023	0.627HisAsn: 0.627 ± 0.028	1.169HisPro: 1.169 ± 0.037	0.706HisGln: 0.706 ± 0.027	1.124HisArg: 1.124 ± 0.035	0.952HisSer: 0.952 ± 0.032	1.054HisThr: 1.054 ± 0.037	1.112HisVal: 1.112 ± 0.036	0.252HisTrp: 0.252 ± 0.017	0.698HisTyr: 0.698 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	4.835IleAla: 4.835 ± 0.076	0.933IleCys: 0.933 ± 0.03	2.833IleAsp: 2.833 ± 0.058	2.85IleGlu: 2.85 ± 0.062	2.055IlePhe: 2.055 ± 0.055	3.755IleGly: 3.755 ± 0.066	1.066IleHis: 1.066 ± 0.037	2.593IleIle: 2.593 ± 0.065	1.954IleLys: 1.954 ± 0.049	5.758IleLeu: 5.758 ± 0.089	1.182IleMet: 1.182 ± 0.042	1.641IleAsn: 1.641 ± 0.045	2.899IlePro: 2.899 ± 0.057	2.455IleGln: 2.455 ± 0.054	3.313IleArg: 3.313 ± 0.062	3.396IleSer: 3.396 ± 0.065	3.231IleThr: 3.231 ± 0.07	3.525IleVal: 3.525 ± 0.056	0.587IleTrp: 0.587 ± 0.027	1.791IleTyr: 1.791 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.066LysAla: 4.066 ± 0.081	0.47LysCys: 0.47 ± 0.023	2.32LysAsp: 2.32 ± 0.054	3.539LysGlu: 3.539 ± 0.068	1.245LysPhe: 1.245 ± 0.034	3.014LysGly: 3.014 ± 0.057	0.779LysHis: 0.779 ± 0.026	2.5LysIle: 2.5 ± 0.061	3.091LysLys: 3.091 ± 0.064	4.467LysLeu: 4.467 ± 0.074	1.173LysMet: 1.173 ± 0.034	1.787LysAsn: 1.787 ± 0.041	1.794LysPro: 1.794 ± 0.054	1.715LysGln: 1.715 ± 0.054	2.712LysArg: 2.712 ± 0.051	2.224LysSer: 2.224 ± 0.048	2.642LysThr: 2.642 ± 0.059	2.956LysVal: 2.956 ± 0.062	0.444LysTrp: 0.444 ± 0.02	1.537LysTyr: 1.537 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	9.85LeuAla: 9.85 ± 0.14	1.919LeuCys: 1.919 ± 0.05	6.262LeuAsp: 6.262 ± 0.084	7.535LeuGlu: 7.535 ± 0.108	3.963LeuPhe: 3.963 ± 0.079	7.269LeuGly: 7.269 ± 0.112	1.764LeuHis: 1.764 ± 0.041	4.853LeuIle: 4.853 ± 0.077	4.354LeuLys: 4.354 ± 0.077	10.939LeuLeu: 10.939 ± 0.158	2.684LeuMet: 2.684 ± 0.059	3.145LeuAsn: 3.145 ± 0.058	5.106LeuPro: 5.106 ± 0.083	3.115LeuGln: 3.115 ± 0.062	6.114LeuArg: 6.114 ± 0.102	7.225LeuSer: 7.225 ± 0.088	6.368LeuThr: 6.368 ± 0.088	6.512LeuVal: 6.512 ± 0.097	1.196LeuTrp: 1.196 ± 0.04	3.393LeuTyr: 3.393 ± 0.073	0.0LeuXaa: 0.0 ± 0.0
Met	2.72MetAla: 2.72 ± 0.052	0.277MetCys: 0.277 ± 0.018	1.828MetAsp: 1.828 ± 0.043	2.289MetGlu: 2.289 ± 0.045	0.784MetPhe: 0.784 ± 0.032	2.108MetGly: 2.108 ± 0.054	0.329MetHis: 0.329 ± 0.018	1.261MetIle: 1.261 ± 0.041	1.668MetLys: 1.668 ± 0.041	2.485MetLeu: 2.485 ± 0.047	0.693MetMet: 0.693 ± 0.029	1.06MetAsn: 1.06 ± 0.033	1.115MetPro: 1.115 ± 0.032	0.76MetGln: 0.76 ± 0.028	1.381MetArg: 1.381 ± 0.04	1.549MetSer: 1.549 ± 0.038	1.604MetThr: 1.604 ± 0.038	1.885MetVal: 1.885 ± 0.042	0.197MetTrp: 0.197 ± 0.013	0.6MetTyr: 0.6 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.737AsnAla: 2.737 ± 0.057	0.49AsnCys: 0.49 ± 0.024	1.476AsnAsp: 1.476 ± 0.04	1.752AsnGlu: 1.752 ± 0.05	1.152AsnPhe: 1.152 ± 0.041	2.82AsnGly: 2.82 ± 0.076	0.641AsnHis: 0.641 ± 0.024	1.982AsnIle: 1.982 ± 0.042	1.249AsnLys: 1.249 ± 0.043	3.323AsnLeu: 3.323 ± 0.059	0.843AsnMet: 0.843 ± 0.032	1.051AsnAsn: 1.051 ± 0.039	1.767AsnPro: 1.767 ± 0.049	1.255AsnGln: 1.255 ± 0.039	1.875AsnArg: 1.875 ± 0.043	1.676AsnSer: 1.676 ± 0.05	1.764AsnThr: 1.764 ± 0.051	2.002AsnVal: 2.002 ± 0.046	0.398AsnTrp: 0.398 ± 0.021	1.268AsnTyr: 1.268 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	4.461ProAla: 4.461 ± 0.091	0.521ProCys: 0.521 ± 0.026	3.006ProAsp: 3.006 ± 0.061	4.49ProGlu: 4.49 ± 0.079	1.604ProPhe: 1.604 ± 0.045	3.507ProGly: 3.507 ± 0.063	0.757ProHis: 0.757 ± 0.03	2.107ProIle: 2.107 ± 0.046	1.829ProLys: 1.829 ± 0.05	3.888ProLeu: 3.888 ± 0.07	1.164ProMet: 1.164 ± 0.038	1.377ProAsn: 1.377 ± 0.039	1.692ProPro: 1.692 ± 0.05	1.665ProGln: 1.665 ± 0.043	1.98ProArg: 1.98 ± 0.051	2.292ProSer: 2.292 ± 0.051	1.96ProThr: 1.96 ± 0.055	3.494ProVal: 3.494 ± 0.06	0.503ProTrp: 0.503 ± 0.024	1.458ProTyr: 1.458 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.164GlnAla: 4.164 ± 0.088	0.421GlnCys: 0.421 ± 0.02	1.966GlnAsp: 1.966 ± 0.044	3.352GlnGlu: 3.352 ± 0.065	1.276GlnPhe: 1.276 ± 0.039	2.766GlnGly: 2.766 ± 0.053	0.584GlnHis: 0.584 ± 0.027	2.226GlnIle: 2.226 ± 0.047	2.025GlnLys: 2.025 ± 0.049	3.783GlnLeu: 3.783 ± 0.069	1.133GlnMet: 1.133 ± 0.032	1.438GlnAsn: 1.438 ± 0.039	1.466GlnPro: 1.466 ± 0.041	1.57GlnGln: 1.57 ± 0.052	2.347GlnArg: 2.347 ± 0.055	2.033GlnSer: 2.033 ± 0.047	2.056GlnThr: 2.056 ± 0.058	3.027GlnVal: 3.027 ± 0.058	0.475GlnTrp: 0.475 ± 0.019	1.454GlnTyr: 1.454 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	4.966ArgAla: 4.966 ± 0.072	0.916ArgCys: 0.916 ± 0.035	3.195ArgAsp: 3.195 ± 0.062	5.1ArgGlu: 5.1 ± 0.085	2.242ArgPhe: 2.242 ± 0.047	3.831ArgGly: 3.831 ± 0.079	1.084ArgHis: 1.084 ± 0.035	3.039ArgIle: 3.039 ± 0.057	2.963ArgLys: 2.963 ± 0.056	6.07ArgLeu: 6.07 ± 0.084	1.773ArgMet: 1.773 ± 0.041	1.803ArgAsn: 1.803 ± 0.046	2.521ArgPro: 2.521 ± 0.058	2.55ArgGln: 2.55 ± 0.059	4.727ArgArg: 4.727 ± 0.096	3.043ArgSer: 3.043 ± 0.054	3.125ArgThr: 3.125 ± 0.06	3.627ArgVal: 3.627 ± 0.064	0.816ArgTrp: 0.816 ± 0.031	2.252ArgTyr: 2.252 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	5.263SerAla: 5.263 ± 0.083	0.762SerCys: 0.762 ± 0.029	2.913SerAsp: 2.913 ± 0.06	3.079SerGlu: 3.079 ± 0.054	2.369SerPhe: 2.369 ± 0.049	5.547SerGly: 5.547 ± 0.093	1.052SerHis: 1.052 ± 0.033	3.052SerIle: 3.052 ± 0.063	2.149SerLys: 2.149 ± 0.042	5.635SerLeu: 5.635 ± 0.082	1.539SerMet: 1.539 ± 0.036	1.658SerAsn: 1.658 ± 0.045	2.505SerPro: 2.505 ± 0.054	2.249SerGln: 2.249 ± 0.05	3.278SerArg: 3.278 ± 0.058	3.422SerSer: 3.422 ± 0.086	2.799SerThr: 2.799 ± 0.057	4.01SerVal: 4.01 ± 0.07	0.677SerTrp: 0.677 ± 0.027	1.959SerTyr: 1.959 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.609ThrAla: 5.609 ± 0.086	0.676ThrCys: 0.676 ± 0.028	2.936ThrAsp: 2.936 ± 0.066	3.055ThrGlu: 3.055 ± 0.059	2.072ThrPhe: 2.072 ± 0.051	4.993ThrGly: 4.993 ± 0.081	0.944ThrHis: 0.944 ± 0.034	3.19ThrIle: 3.19 ± 0.069	1.923ThrLys: 1.923 ± 0.051	5.728ThrLeu: 5.728 ± 0.088	1.424ThrMet: 1.424 ± 0.033	1.446ThrAsn: 1.446 ± 0.051	2.907ThrPro: 2.907 ± 0.053	2.002ThrGln: 2.002 ± 0.042	2.636ThrArg: 2.636 ± 0.057	2.604ThrSer: 2.604 ± 0.059	2.742ThrThr: 2.742 ± 0.071	5.024ThrVal: 5.024 ± 0.091	0.633ThrTrp: 0.633 ± 0.025	1.846ThrTyr: 1.846 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	5.628ValAla: 5.628 ± 0.092	1.321ValCys: 1.321 ± 0.034	4.118ValAsp: 4.118 ± 0.077	4.779ValGlu: 4.779 ± 0.078	2.831ValPhe: 2.831 ± 0.056	4.757ValGly: 4.757 ± 0.083	1.13ValHis: 1.13 ± 0.034	3.745ValIle: 3.745 ± 0.069	3.006ValLys: 3.006 ± 0.061	7.951ValLeu: 7.951 ± 0.116	1.817ValMet: 1.817 ± 0.045	2.303ValAsn: 2.303 ± 0.048	3.162ValPro: 3.162 ± 0.046	2.403ValGln: 2.403 ± 0.047	3.94ValArg: 3.94 ± 0.068	4.627ValSer: 4.627 ± 0.068	4.437ValThr: 4.437 ± 0.092	5.157ValVal: 5.157 ± 0.083	0.854ValTrp: 0.854 ± 0.03	2.353ValTyr: 2.353 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.997TrpAla: 0.997 ± 0.034	0.206TrpCys: 0.206 ± 0.015	0.703TrpAsp: 0.703 ± 0.029	0.909TrpGlu: 0.909 ± 0.034	0.528TrpPhe: 0.528 ± 0.023	0.879TrpGly: 0.879 ± 0.031	0.202TrpHis: 0.202 ± 0.013	0.53TrpIle: 0.53 ± 0.022	0.565TrpLys: 0.565 ± 0.025	1.276TrpLeu: 1.276 ± 0.045	0.355TrpMet: 0.355 ± 0.02	0.459TrpAsn: 0.459 ± 0.024	0.383TrpPro: 0.383 ± 0.021	0.481TrpGln: 0.481 ± 0.021	0.767TrpArg: 0.767 ± 0.03	0.678TrpSer: 0.678 ± 0.027	0.622TrpThr: 0.622 ± 0.025	0.68TrpVal: 0.68 ± 0.025	0.15TrpTrp: 0.15 ± 0.013	0.441TrpTyr: 0.441 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.927TyrAla: 2.927 ± 0.053	0.616TyrCys: 0.616 ± 0.026	2.236TyrAsp: 2.236 ± 0.052	2.259TyrGlu: 2.259 ± 0.048	1.425TyrPhe: 1.425 ± 0.041	2.775TyrGly: 2.775 ± 0.057	0.739TyrHis: 0.739 ± 0.028	1.872TyrIle: 1.872 ± 0.046	1.196TyrLys: 1.196 ± 0.037	3.761TyrLeu: 3.761 ± 0.06	0.708TyrMet: 0.708 ± 0.027	1.187TyrAsn: 1.187 ± 0.04	1.484TyrPro: 1.484 ± 0.036	1.643TyrGln: 1.643 ± 0.038	2.237TyrArg: 2.237 ± 0.051	1.896TyrSer: 1.896 ± 0.053	2.171TyrThr: 2.171 ± 0.062	2.203TyrVal: 2.203 ± 0.057	0.406TyrTrp: 0.406 ± 0.023	1.445TyrTyr: 1.445 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3242 proteins (982754 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---