Amino acid dipepetide frequency for Wenzhou sobemo-like virus 4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.944AlaAla: 1.944 ± 0.206
1.944AlaCys: 1.944 ± 0.206
0.972AlaAsp: 0.972 ± 0.817
4.859AlaGlu: 4.859 ± 1.63
0.972AlaPhe: 0.972 ± 0.612
1.944AlaGly: 1.944 ± 0.206
1.944AlaHis: 1.944 ± 0.206
0.972AlaIle: 0.972 ± 0.612
4.859AlaLys: 4.859 ± 0.201
7.775AlaLeu: 7.775 ± 0.822
6.803AlaMet: 6.803 ± 2.853
3.887AlaAsn: 3.887 ± 1.84
3.887AlaPro: 3.887 ± 1.018
2.915AlaGln: 2.915 ± 1.023
3.887AlaArg: 3.887 ± 0.411
2.915AlaSer: 2.915 ± 1.835
1.944AlaThr: 1.944 ± 1.224
6.803AlaVal: 6.803 ± 1.434
3.887AlaTrp: 3.887 ± 3.269
0.972AlaTyr: 0.972 ± 0.817
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.972CysAsp: 0.972 ± 0.817
0.0CysGlu: 0.0 ± 0.0
2.915CysPhe: 2.915 ± 0.406
2.915CysGly: 2.915 ± 0.406
0.0CysHis: 0.0 ± 0.0
0.972CysIle: 0.972 ± 0.612
0.972CysLys: 0.972 ± 0.612
1.944CysLeu: 1.944 ± 1.635
0.972CysMet: 0.972 ± 0.817
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
2.915CysGln: 2.915 ± 0.406
1.944CysArg: 1.944 ± 0.206
0.972CysSer: 0.972 ± 0.817
0.972CysThr: 0.972 ± 0.612
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
2.915CysTyr: 2.915 ± 1.023
0.0CysXaa: 0.0 ± 0.0
Asp
4.859AspAla: 4.859 ± 1.228
0.0AspCys: 0.0 ± 0.0
2.915AspAsp: 2.915 ± 1.023
4.859AspGlu: 4.859 ± 1.63
0.972AspPhe: 0.972 ± 0.612
6.803AspGly: 6.803 ± 1.434
0.0AspHis: 0.0 ± 0.0
1.944AspIle: 1.944 ± 1.635
1.944AspLys: 1.944 ± 1.224
2.915AspLeu: 2.915 ± 1.023
0.972AspMet: 0.972 ± 0.817
0.0AspAsn: 0.0 ± 0.0
3.887AspPro: 3.887 ± 0.411
0.0AspGln: 0.0 ± 0.0
2.915AspArg: 2.915 ± 2.452
3.887AspSer: 3.887 ± 1.018
2.915AspThr: 2.915 ± 2.452
0.972AspVal: 0.972 ± 0.612
0.972AspTrp: 0.972 ± 0.817
1.944AspTyr: 1.944 ± 1.224
0.0AspXaa: 0.0 ± 0.0
Glu
3.887GluAla: 3.887 ± 0.411
0.972GluCys: 0.972 ± 0.612
3.887GluAsp: 3.887 ± 0.411
3.887GluGlu: 3.887 ± 1.018
5.831GluPhe: 5.831 ± 0.617
1.944GluGly: 1.944 ± 1.224
3.887GluHis: 3.887 ± 2.447
3.887GluIle: 3.887 ± 0.411
0.972GluLys: 0.972 ± 0.612
8.746GluLeu: 8.746 ± 1.219
0.0GluMet: 0.0 ± 0.0
1.944GluAsn: 1.944 ± 0.206
4.859GluPro: 4.859 ± 1.228
0.0GluGln: 0.0 ± 0.0
1.944GluArg: 1.944 ± 0.206
1.944GluSer: 1.944 ± 1.224
2.915GluThr: 2.915 ± 1.023
1.944GluVal: 1.944 ± 1.224
2.915GluTrp: 2.915 ± 0.406
0.972GluTyr: 0.972 ± 0.817
0.0GluXaa: 0.0 ± 0.0
Phe
2.915PheAla: 2.915 ± 2.452
0.972PheCys: 0.972 ± 0.817
4.859PheAsp: 4.859 ± 4.087
3.887PheGlu: 3.887 ± 0.411
0.0PhePhe: 0.0 ± 0.0
5.831PheGly: 5.831 ± 0.812
0.0PheHis: 0.0 ± 0.0
0.0PheIle: 0.0 ± 0.0
0.972PheLys: 0.972 ± 0.817
2.915PheLeu: 2.915 ± 0.406
0.972PheMet: 0.972 ± 0.612
2.915PheAsn: 2.915 ± 1.023
0.0PhePro: 0.0 ± 0.0
2.915PheGln: 2.915 ± 1.835
1.944PheArg: 1.944 ± 1.635
2.915PheSer: 2.915 ± 0.406
0.0PheThr: 0.0 ± 0.0
4.859PheVal: 4.859 ± 0.201
0.972PheTrp: 0.972 ± 0.612
0.0PheTyr: 0.0 ± 0.0
0.0PheXaa: 0.0 ± 0.0
Gly
4.859GlyAla: 4.859 ± 1.63
0.972GlyCys: 0.972 ± 0.817
2.915GlyAsp: 2.915 ± 0.406
3.887GlyGlu: 3.887 ± 1.84
4.859GlyPhe: 4.859 ± 1.63
2.915GlyGly: 2.915 ± 0.406
0.0GlyHis: 0.0 ± 0.0
2.915GlyIle: 2.915 ± 1.023
1.944GlyLys: 1.944 ± 0.206
5.831GlyLeu: 5.831 ± 0.812
0.972GlyMet: 0.972 ± 0.612
3.887GlyAsn: 3.887 ± 1.018
2.915GlyPro: 2.915 ± 0.406
1.944GlyGln: 1.944 ± 1.224
3.887GlyArg: 3.887 ± 1.018
3.887GlySer: 3.887 ± 1.018
6.803GlyThr: 6.803 ± 0.005
2.915GlyVal: 2.915 ± 0.406
2.915GlyTrp: 2.915 ± 2.452
3.887GlyTyr: 3.887 ± 0.411
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.972HisCys: 0.972 ± 0.817
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
1.944HisGly: 1.944 ± 1.224
0.0HisHis: 0.0 ± 0.0
0.972HisIle: 0.972 ± 0.612
0.972HisLys: 0.972 ± 0.817
3.887HisLeu: 3.887 ± 1.018
1.944HisMet: 1.944 ± 0.977
0.0HisAsn: 0.0 ± 0.0
1.944HisPro: 1.944 ± 1.224
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
0.972HisSer: 0.972 ± 0.612
1.944HisThr: 1.944 ± 0.206
3.887HisVal: 3.887 ± 0.411
0.972HisTrp: 0.972 ± 0.817
0.972HisTyr: 0.972 ± 0.817
0.0HisXaa: 0.0 ± 0.0
Ile
1.944IleAla: 1.944 ± 1.635
0.0IleCys: 0.0 ± 0.0
2.915IleAsp: 2.915 ± 2.452
2.915IleGlu: 2.915 ± 0.406
2.915IlePhe: 2.915 ± 0.406
3.887IleGly: 3.887 ± 0.411
0.0IleHis: 0.0 ± 0.0
1.944IleIle: 1.944 ± 1.224
4.859IleLys: 4.859 ± 1.63
7.775IleLeu: 7.775 ± 0.822
1.944IleMet: 1.944 ± 0.206
0.972IleAsn: 0.972 ± 0.612
0.972IlePro: 0.972 ± 0.817
1.944IleGln: 1.944 ± 0.206
0.0IleArg: 0.0 ± 0.0
1.944IleSer: 1.944 ± 0.206
3.887IleThr: 3.887 ± 0.411
3.887IleVal: 3.887 ± 2.447
1.944IleTrp: 1.944 ± 1.224
3.887IleTyr: 3.887 ± 2.447
0.0IleXaa: 0.0 ± 0.0
Lys
4.859LysAla: 4.859 ± 1.63
0.0LysCys: 0.0 ± 0.0
0.972LysAsp: 0.972 ± 0.612
3.887LysGlu: 3.887 ± 1.018
0.972LysPhe: 0.972 ± 0.817
5.831LysGly: 5.831 ± 0.812
2.915LysHis: 2.915 ± 1.023
2.915LysIle: 2.915 ± 0.406
4.859LysLys: 4.859 ± 1.63
8.746LysLeu: 8.746 ± 0.21
0.972LysMet: 0.972 ± 0.817
3.887LysAsn: 3.887 ± 2.447
0.972LysPro: 0.972 ± 0.612
5.831LysGln: 5.831 ± 2.046
2.915LysArg: 2.915 ± 1.023
2.915LysSer: 2.915 ± 0.406
2.915LysThr: 2.915 ± 0.406
6.803LysVal: 6.803 ± 1.424
0.0LysTrp: 0.0 ± 0.0
2.915LysTyr: 2.915 ± 1.835
0.0LysXaa: 0.0 ± 0.0
Leu
3.887LeuAla: 3.887 ± 2.447
1.944LeuCys: 1.944 ± 1.224
4.859LeuAsp: 4.859 ± 0.201
3.887LeuGlu: 3.887 ± 0.411
4.859LeuPhe: 4.859 ± 2.658
7.775LeuGly: 7.775 ± 0.822
2.915LeuHis: 2.915 ± 1.023
9.718LeuIle: 9.718 ± 1.028
8.746LeuLys: 8.746 ± 1.64
8.746LeuLeu: 8.746 ± 0.21
0.972LeuMet: 0.972 ± 0.817
2.915LeuAsn: 2.915 ± 0.406
5.831LeuPro: 5.831 ± 2.046
2.915LeuGln: 2.915 ± 1.835
5.831LeuArg: 5.831 ± 0.617
3.887LeuSer: 3.887 ± 0.411
4.859LeuThr: 4.859 ± 2.658
4.859LeuVal: 4.859 ± 0.201
0.972LeuTrp: 0.972 ± 0.817
4.859LeuTyr: 4.859 ± 0.201
0.0LeuXaa: 0.0 ± 0.0
Met
3.887MetAla: 3.887 ± 1.018
0.0MetCys: 0.0 ± 0.0
0.972MetAsp: 0.972 ± 0.612
1.944MetGlu: 1.944 ± 1.224
0.0MetPhe: 0.0 ± 0.0
1.944MetGly: 1.944 ± 1.224
1.944MetHis: 1.944 ± 1.224
0.972MetIle: 0.972 ± 0.612
1.944MetLys: 1.944 ± 1.635
1.944MetLeu: 1.944 ± 0.206
0.972MetMet: 0.972 ± 0.817
1.944MetAsn: 1.944 ± 1.635
2.915MetPro: 2.915 ± 0.406
0.0MetGln: 0.0 ± 0.0
0.0MetArg: 0.0 ± 0.0
2.915MetSer: 2.915 ± 1.023
1.944MetThr: 1.944 ± 1.224
4.859MetVal: 4.859 ± 3.059
0.0MetTrp: 0.0 ± 0.0
1.944MetTyr: 1.944 ± 0.206
0.0MetXaa: 0.0 ± 0.0
Asn
2.915AsnAla: 2.915 ± 2.452
0.972AsnCys: 0.972 ± 0.817
0.972AsnAsp: 0.972 ± 0.612
1.944AsnGlu: 1.944 ± 1.635
0.0AsnPhe: 0.0 ± 0.0
2.915AsnGly: 2.915 ± 0.406
0.972AsnHis: 0.972 ± 0.612
0.972AsnIle: 0.972 ± 0.612
5.831AsnLys: 5.831 ± 0.617
4.859AsnLeu: 4.859 ± 1.228
0.972AsnMet: 0.972 ± 0.612
1.944AsnAsn: 1.944 ± 0.206
3.887AsnPro: 3.887 ± 1.018
0.972AsnGln: 0.972 ± 0.817
0.972AsnArg: 0.972 ± 0.612
2.915AsnSer: 2.915 ± 1.023
0.0AsnThr: 0.0 ± 0.0
4.859AsnVal: 4.859 ± 1.63
0.0AsnTrp: 0.0 ± 0.0
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
2.915ProAla: 2.915 ± 1.023
0.972ProCys: 0.972 ± 0.817
2.915ProAsp: 2.915 ± 1.023
2.915ProGlu: 2.915 ± 1.023
1.944ProPhe: 1.944 ± 0.206
1.944ProGly: 1.944 ± 0.206
0.972ProHis: 0.972 ± 0.817
0.972ProIle: 0.972 ± 0.612
0.972ProLys: 0.972 ± 0.612
1.944ProLeu: 1.944 ± 1.224
1.944ProMet: 1.944 ± 0.206
2.915ProAsn: 2.915 ± 0.406
2.915ProPro: 2.915 ± 1.023
1.944ProGln: 1.944 ± 0.206
3.887ProArg: 3.887 ± 1.84
4.859ProSer: 4.859 ± 3.059
2.915ProThr: 2.915 ± 0.406
4.859ProVal: 4.859 ± 2.658
0.0ProTrp: 0.0 ± 0.0
1.944ProTyr: 1.944 ± 0.206
0.0ProXaa: 0.0 ± 0.0
Gln
1.944GlnAla: 1.944 ± 1.224
0.972GlnCys: 0.972 ± 0.612
0.972GlnAsp: 0.972 ± 0.817
1.944GlnGlu: 1.944 ± 1.635
0.972GlnPhe: 0.972 ± 0.612
1.944GlnGly: 1.944 ± 1.635
2.915GlnHis: 2.915 ± 1.023
1.944GlnIle: 1.944 ± 0.206
6.803GlnLys: 6.803 ± 0.005
2.915GlnLeu: 2.915 ± 1.023
0.972GlnMet: 0.972 ± 0.612
0.0GlnAsn: 0.0 ± 0.0
1.944GlnPro: 1.944 ± 1.635
4.859GlnGln: 4.859 ± 3.059
2.915GlnArg: 2.915 ± 0.406
3.887GlnSer: 3.887 ± 1.018
5.831GlnThr: 5.831 ± 0.812
1.944GlnVal: 1.944 ± 0.206
0.0GlnTrp: 0.0 ± 0.0
0.972GlnTyr: 0.972 ± 0.817
0.0GlnXaa: 0.0 ± 0.0
Arg
4.859ArgAla: 4.859 ± 1.228
0.972ArgCys: 0.972 ± 0.817
1.944ArgAsp: 1.944 ± 1.224
4.859ArgGlu: 4.859 ± 1.63
4.859ArgPhe: 4.859 ± 2.658
1.944ArgGly: 1.944 ± 0.206
0.0ArgHis: 0.0 ± 0.0
2.915ArgIle: 2.915 ± 1.023
1.944ArgLys: 1.944 ± 1.224
3.887ArgLeu: 3.887 ± 1.84
0.972ArgMet: 0.972 ± 0.397
1.944ArgAsn: 1.944 ± 0.206
0.972ArgPro: 0.972 ± 0.817
3.887ArgGln: 3.887 ± 1.84
1.944ArgArg: 1.944 ± 1.224
4.859ArgSer: 4.859 ± 1.228
4.859ArgThr: 4.859 ± 1.63
4.859ArgVal: 4.859 ± 1.228
0.0ArgTrp: 0.0 ± 0.0
0.972ArgTyr: 0.972 ± 0.612
0.0ArgXaa: 0.0 ± 0.0
Ser
7.775SerAla: 7.775 ± 2.251
0.0SerCys: 0.0 ± 0.0
0.972SerAsp: 0.972 ± 0.612
1.944SerGlu: 1.944 ± 0.206
2.915SerPhe: 2.915 ± 0.406
3.887SerGly: 3.887 ± 1.018
0.0SerHis: 0.0 ± 0.0
4.859SerIle: 4.859 ± 1.63
3.887SerLys: 3.887 ± 2.447
6.803SerLeu: 6.803 ± 1.434
0.972SerMet: 0.972 ± 0.612
1.944SerAsn: 1.944 ± 0.206
2.915SerPro: 2.915 ± 0.406
0.972SerGln: 0.972 ± 0.817
2.915SerArg: 2.915 ± 1.835
1.944SerSer: 1.944 ± 1.224
5.831SerThr: 5.831 ± 0.812
2.915SerVal: 2.915 ± 1.835
0.972SerTrp: 0.972 ± 0.817
2.915SerTyr: 2.915 ± 1.023
0.0SerXaa: 0.0 ± 0.0
Thr
5.831ThrAla: 5.831 ± 0.812
2.915ThrCys: 2.915 ± 0.406
1.944ThrAsp: 1.944 ± 0.206
3.887ThrGlu: 3.887 ± 2.447
1.944ThrPhe: 1.944 ± 1.635
0.972ThrGly: 0.972 ± 0.612
0.0ThrHis: 0.0 ± 0.0
2.915ThrIle: 2.915 ± 0.406
4.859ThrLys: 4.859 ± 1.63
3.887ThrLeu: 3.887 ± 0.411
1.944ThrMet: 1.944 ± 1.224
1.944ThrAsn: 1.944 ± 1.635
2.915ThrPro: 2.915 ± 1.023
4.859ThrGln: 4.859 ± 1.63
1.944ThrArg: 1.944 ± 1.635
1.944ThrSer: 1.944 ± 0.206
0.972ThrThr: 0.972 ± 0.612
8.746ThrVal: 8.746 ± 0.21
0.0ThrTrp: 0.0 ± 0.0
2.915ThrTyr: 2.915 ± 0.406
0.0ThrXaa: 0.0 ± 0.0
Val
3.887ValAla: 3.887 ± 1.018
4.859ValCys: 4.859 ± 0.201
6.803ValAsp: 6.803 ± 1.424
3.887ValGlu: 3.887 ± 1.018
1.944ValPhe: 1.944 ± 1.635
3.887ValGly: 3.887 ± 1.018
0.0ValHis: 0.0 ± 0.0
3.887ValIle: 3.887 ± 2.447
5.831ValLys: 5.831 ± 0.617
2.915ValLeu: 2.915 ± 0.406
6.803ValMet: 6.803 ± 1.424
5.831ValAsn: 5.831 ± 0.617
1.944ValPro: 1.944 ± 0.206
5.831ValGln: 5.831 ± 2.046
9.718ValArg: 9.718 ± 0.401
4.859ValSer: 4.859 ± 0.201
3.887ValThr: 3.887 ± 2.447
2.915ValVal: 2.915 ± 1.835
0.0ValTrp: 0.0 ± 0.0
1.944ValTyr: 1.944 ± 1.224
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
1.944TrpAsp: 1.944 ± 1.635
0.0TrpGlu: 0.0 ± 0.0
0.972TrpPhe: 0.972 ± 0.817
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
2.915TrpIle: 2.915 ± 1.023
0.972TrpLys: 0.972 ± 0.612
2.915TrpLeu: 2.915 ± 1.023
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.972TrpGln: 0.972 ± 0.817
2.915TrpArg: 2.915 ± 1.023
0.972TrpSer: 0.972 ± 0.817
0.972TrpThr: 0.972 ± 0.817
2.915TrpVal: 2.915 ± 0.406
0.972TrpTrp: 0.972 ± 0.817
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.915TyrAla: 2.915 ± 1.835
1.944TyrCys: 1.944 ± 0.206
0.972TyrAsp: 0.972 ± 0.612
1.944TyrGlu: 1.944 ± 0.206
0.0TyrPhe: 0.0 ± 0.0
3.887TyrGly: 3.887 ± 0.411
2.915TyrHis: 2.915 ± 1.835
1.944TyrIle: 1.944 ± 0.206
1.944TyrLys: 1.944 ± 1.224
3.887TyrLeu: 3.887 ± 1.84
0.0TyrMet: 0.0 ± 0.0
0.0TyrAsn: 0.0 ± 0.0
0.972TyrPro: 0.972 ± 0.817
0.972TyrGln: 0.972 ± 0.817
1.944TyrArg: 1.944 ± 0.206
1.944TyrSer: 1.944 ± 0.206
0.972TyrThr: 0.972 ± 0.612
5.831TyrVal: 5.831 ± 0.812
1.944TyrTrp: 1.944 ± 0.206
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (1030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski