Amino acid dipepetide frequency for Podoviridae sp. ctbd591

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.015AlaAla: 4.015 ± 0.962
0.382AlaCys: 0.382 ± 0.335
3.441AlaAsp: 3.441 ± 0.653
2.868AlaGlu: 2.868 ± 0.634
3.441AlaPhe: 3.441 ± 0.943
3.632AlaGly: 3.632 ± 1.093
1.338AlaHis: 1.338 ± 0.894
4.206AlaIle: 4.206 ± 1.124
3.059AlaLys: 3.059 ± 0.855
4.588AlaLeu: 4.588 ± 1.187
1.529AlaMet: 1.529 ± 0.498
4.397AlaAsn: 4.397 ± 1.022
0.765AlaPro: 0.765 ± 0.335
1.912AlaGln: 1.912 ± 0.576
2.294AlaArg: 2.294 ± 0.721
4.015AlaSer: 4.015 ± 1.093
4.206AlaThr: 4.206 ± 1.579
3.632AlaVal: 3.632 ± 1.105
0.765AlaTrp: 0.765 ± 0.538
2.103AlaTyr: 2.103 ± 0.447
0.0AlaXaa: 0.0 ± 0.0
Cys
0.574CysAla: 0.574 ± 0.392
0.574CysCys: 0.574 ± 0.243
0.191CysAsp: 0.191 ± 0.182
2.485CysGlu: 2.485 ± 0.675
0.574CysPhe: 0.574 ± 0.313
1.338CysGly: 1.338 ± 0.555
0.191CysHis: 0.191 ± 0.145
0.574CysIle: 0.574 ± 0.435
0.0CysLys: 0.0 ± 0.0
0.382CysLeu: 0.382 ± 0.29
0.0CysMet: 0.0 ± 0.0
1.721CysAsn: 1.721 ± 0.581
0.765CysPro: 0.765 ± 0.464
0.191CysGln: 0.191 ± 0.182
1.912CysArg: 1.912 ± 1.214
1.338CysSer: 1.338 ± 0.817
0.574CysThr: 0.574 ± 0.392
1.147CysVal: 1.147 ± 0.618
0.191CysTrp: 0.191 ± 0.182
0.956CysTyr: 0.956 ± 0.28
0.0CysXaa: 0.0 ± 0.0
Asp
4.97AspAla: 4.97 ± 1.483
0.765AspCys: 0.765 ± 0.462
3.823AspAsp: 3.823 ± 0.908
3.25AspGlu: 3.25 ± 0.699
2.485AspPhe: 2.485 ± 0.734
4.779AspGly: 4.779 ± 0.842
0.765AspHis: 0.765 ± 0.468
5.735AspIle: 5.735 ± 1.103
2.868AspLys: 2.868 ± 0.758
2.294AspLeu: 2.294 ± 0.571
0.765AspMet: 0.765 ± 0.475
4.779AspAsn: 4.779 ± 1.18
0.765AspPro: 0.765 ± 0.375
0.382AspGln: 0.382 ± 0.324
2.103AspArg: 2.103 ± 0.577
4.97AspSer: 4.97 ± 0.855
4.779AspThr: 4.779 ± 1.17
5.926AspVal: 5.926 ± 0.859
0.956AspTrp: 0.956 ± 0.548
2.294AspTyr: 2.294 ± 0.848
0.0AspXaa: 0.0 ± 0.0
Glu
4.206GluAla: 4.206 ± 0.803
1.338GluCys: 1.338 ± 0.504
3.632GluAsp: 3.632 ± 0.98
3.059GluGlu: 3.059 ± 0.871
2.485GluPhe: 2.485 ± 1.07
2.103GluGly: 2.103 ± 0.593
0.765GluHis: 0.765 ± 0.298
5.926GluIle: 5.926 ± 1.666
3.441GluLys: 3.441 ± 0.585
4.97GluLeu: 4.97 ± 1.035
2.676GluMet: 2.676 ± 0.869
7.456GluAsn: 7.456 ± 1.596
1.912GluPro: 1.912 ± 0.543
1.529GluGln: 1.529 ± 0.488
3.25GluArg: 3.25 ± 0.898
4.779GluSer: 4.779 ± 0.782
7.264GluThr: 7.264 ± 1.794
2.294GluVal: 2.294 ± 0.784
0.574GluTrp: 0.574 ± 0.283
3.059GluTyr: 3.059 ± 1.093
0.0GluXaa: 0.0 ± 0.0
Phe
1.338PheAla: 1.338 ± 0.46
0.574PheCys: 0.574 ± 0.386
2.294PheAsp: 2.294 ± 0.615
1.529PheGlu: 1.529 ± 0.92
2.294PhePhe: 2.294 ± 0.633
3.25PheGly: 3.25 ± 0.926
0.574PheHis: 0.574 ± 0.352
3.823PheIle: 3.823 ± 1.143
2.676PheLys: 2.676 ± 0.886
3.441PheLeu: 3.441 ± 1.312
0.956PheMet: 0.956 ± 0.41
4.397PheAsn: 4.397 ± 0.853
1.912PhePro: 1.912 ± 0.563
1.147PheGln: 1.147 ± 0.719
1.912PheArg: 1.912 ± 0.457
3.823PheSer: 3.823 ± 1.112
3.25PheThr: 3.25 ± 1.041
3.059PheVal: 3.059 ± 1.224
0.574PheTrp: 0.574 ± 0.349
1.529PheTyr: 1.529 ± 0.56
0.0PheXaa: 0.0 ± 0.0
Gly
3.25GlyAla: 3.25 ± 0.971
2.485GlyCys: 2.485 ± 1.21
4.97GlyAsp: 4.97 ± 1.298
4.206GlyGlu: 4.206 ± 0.749
2.676GlyPhe: 2.676 ± 0.487
5.162GlyGly: 5.162 ± 0.761
0.574GlyHis: 0.574 ± 0.426
3.632GlyIle: 3.632 ± 1.099
3.823GlyLys: 3.823 ± 0.827
3.25GlyLeu: 3.25 ± 0.645
1.529GlyMet: 1.529 ± 0.713
5.353GlyAsn: 5.353 ± 0.821
1.721GlyPro: 1.721 ± 0.663
1.147GlyGln: 1.147 ± 0.433
2.103GlyArg: 2.103 ± 0.536
3.441GlySer: 3.441 ± 1.142
3.823GlyThr: 3.823 ± 1.356
5.735GlyVal: 5.735 ± 0.831
0.956GlyTrp: 0.956 ± 0.339
3.25GlyTyr: 3.25 ± 0.772
0.0GlyXaa: 0.0 ± 0.0
His
0.765HisAla: 0.765 ± 0.456
0.382HisCys: 0.382 ± 0.27
0.191HisAsp: 0.191 ± 0.182
0.382HisGlu: 0.382 ± 0.264
0.765HisPhe: 0.765 ± 0.448
0.382HisGly: 0.382 ± 0.27
0.382HisHis: 0.382 ± 0.401
1.147HisIle: 1.147 ± 0.38
0.191HisLys: 0.191 ± 0.182
0.574HisLeu: 0.574 ± 0.479
0.191HisMet: 0.191 ± 0.2
1.529HisAsn: 1.529 ± 0.463
0.191HisPro: 0.191 ± 0.182
0.382HisGln: 0.382 ± 0.3
0.765HisArg: 0.765 ± 0.426
1.147HisSer: 1.147 ± 0.449
0.574HisThr: 0.574 ± 0.362
1.529HisVal: 1.529 ± 0.347
0.191HisTrp: 0.191 ± 0.182
1.147HisTyr: 1.147 ± 0.699
0.0HisXaa: 0.0 ± 0.0
Ile
4.015IleAla: 4.015 ± 1.002
0.191IleCys: 0.191 ± 0.199
6.882IleAsp: 6.882 ± 0.85
7.073IleGlu: 7.073 ± 1.251
2.103IlePhe: 2.103 ± 0.635
3.441IleGly: 3.441 ± 0.661
0.765IleHis: 0.765 ± 0.444
5.162IleIle: 5.162 ± 0.835
5.735IleLys: 5.735 ± 1.342
4.015IleLeu: 4.015 ± 1.069
1.529IleMet: 1.529 ± 0.575
7.073IleAsn: 7.073 ± 1.245
2.676IlePro: 2.676 ± 0.756
3.25IleGln: 3.25 ± 1.216
4.015IleArg: 4.015 ± 1.273
7.456IleSer: 7.456 ± 1.215
5.926IleThr: 5.926 ± 1.322
3.441IleVal: 3.441 ± 1.113
0.765IleTrp: 0.765 ± 0.373
3.823IleTyr: 3.823 ± 0.875
0.0IleXaa: 0.0 ± 0.0
Lys
3.632LysAla: 3.632 ± 1.426
0.956LysCys: 0.956 ± 0.405
3.25LysAsp: 3.25 ± 0.615
5.162LysGlu: 5.162 ± 1.559
2.294LysPhe: 2.294 ± 0.814
2.485LysGly: 2.485 ± 0.931
0.956LysHis: 0.956 ± 0.375
5.544LysIle: 5.544 ± 0.97
3.441LysLys: 3.441 ± 0.894
5.353LysLeu: 5.353 ± 1.484
0.765LysMet: 0.765 ± 0.315
4.779LysAsn: 4.779 ± 1.2
1.912LysPro: 1.912 ± 0.571
1.912LysGln: 1.912 ± 0.457
3.632LysArg: 3.632 ± 1.301
6.117LysSer: 6.117 ± 1.418
5.926LysThr: 5.926 ± 1.103
2.294LysVal: 2.294 ± 0.738
0.574LysTrp: 0.574 ± 0.327
2.868LysTyr: 2.868 ± 1.044
0.0LysXaa: 0.0 ± 0.0
Leu
2.676LeuAla: 2.676 ± 0.96
1.338LeuCys: 1.338 ± 0.745
3.059LeuAsp: 3.059 ± 0.634
6.309LeuGlu: 6.309 ± 1.019
3.059LeuPhe: 3.059 ± 1.877
3.632LeuGly: 3.632 ± 0.904
0.956LeuHis: 0.956 ± 0.532
4.206LeuIle: 4.206 ± 0.911
4.397LeuLys: 4.397 ± 1.046
5.544LeuLeu: 5.544 ± 2.042
1.529LeuMet: 1.529 ± 0.571
4.779LeuAsn: 4.779 ± 1.157
4.588LeuPro: 4.588 ± 1.012
2.485LeuGln: 2.485 ± 1.203
2.103LeuArg: 2.103 ± 0.937
6.309LeuSer: 6.309 ± 1.322
4.779LeuThr: 4.779 ± 0.953
4.206LeuVal: 4.206 ± 0.957
0.191LeuTrp: 0.191 ± 0.225
2.676LeuTyr: 2.676 ± 0.647
0.0LeuXaa: 0.0 ± 0.0
Met
0.956MetAla: 0.956 ± 0.415
0.574MetCys: 0.574 ± 0.345
0.765MetAsp: 0.765 ± 0.477
0.956MetGlu: 0.956 ± 0.37
1.721MetPhe: 1.721 ± 0.507
1.721MetGly: 1.721 ± 0.59
0.191MetHis: 0.191 ± 0.18
1.338MetIle: 1.338 ± 0.427
1.147MetLys: 1.147 ± 0.716
1.721MetLeu: 1.721 ± 0.434
0.382MetMet: 0.382 ± 0.324
1.721MetAsn: 1.721 ± 0.751
1.912MetPro: 1.912 ± 0.518
0.765MetGln: 0.765 ± 0.45
0.765MetArg: 0.765 ± 0.429
2.103MetSer: 2.103 ± 0.494
1.338MetThr: 1.338 ± 0.427
0.956MetVal: 0.956 ± 0.42
0.191MetTrp: 0.191 ± 0.18
1.338MetTyr: 1.338 ± 0.351
0.0MetXaa: 0.0 ± 0.0
Asn
4.015AsnAla: 4.015 ± 1.004
1.912AsnCys: 1.912 ± 0.552
3.441AsnAsp: 3.441 ± 0.828
6.882AsnGlu: 6.882 ± 1.646
2.103AsnPhe: 2.103 ± 0.868
6.309AsnGly: 6.309 ± 1.218
1.338AsnHis: 1.338 ± 0.484
5.735AsnIle: 5.735 ± 1.324
8.794AsnLys: 8.794 ± 1.501
3.632AsnLeu: 3.632 ± 0.932
2.868AsnMet: 2.868 ± 0.752
4.206AsnAsn: 4.206 ± 1.171
4.397AsnPro: 4.397 ± 1.357
2.676AsnGln: 2.676 ± 1.001
2.103AsnArg: 2.103 ± 0.606
5.544AsnSer: 5.544 ± 1.202
5.544AsnThr: 5.544 ± 2.149
3.823AsnVal: 3.823 ± 0.935
0.191AsnTrp: 0.191 ± 0.182
4.588AsnTyr: 4.588 ± 1.269
0.0AsnXaa: 0.0 ± 0.0
Pro
2.103ProAla: 2.103 ± 0.597
0.191ProCys: 0.191 ± 0.199
1.721ProAsp: 1.721 ± 0.466
2.294ProGlu: 2.294 ± 0.59
2.103ProPhe: 2.103 ± 0.91
2.103ProGly: 2.103 ± 0.549
0.191ProHis: 0.191 ± 0.182
3.059ProIle: 3.059 ± 0.736
1.529ProLys: 1.529 ± 0.416
2.868ProLeu: 2.868 ± 0.998
0.765ProMet: 0.765 ± 0.372
2.676ProAsn: 2.676 ± 0.776
1.147ProPro: 1.147 ± 0.544
0.956ProGln: 0.956 ± 0.468
0.765ProArg: 0.765 ± 0.363
1.912ProSer: 1.912 ± 0.533
1.147ProThr: 1.147 ± 0.544
2.676ProVal: 2.676 ± 0.608
0.382ProTrp: 0.382 ± 0.267
2.868ProTyr: 2.868 ± 0.476
0.0ProXaa: 0.0 ± 0.0
Gln
1.338GlnAla: 1.338 ± 0.574
0.191GlnCys: 0.191 ± 0.231
0.956GlnAsp: 0.956 ± 0.403
1.529GlnGlu: 1.529 ± 0.658
1.721GlnPhe: 1.721 ± 0.711
1.912GlnGly: 1.912 ± 0.667
0.382GlnHis: 0.382 ± 0.296
2.485GlnIle: 2.485 ± 0.765
2.103GlnLys: 2.103 ± 0.602
2.868GlnLeu: 2.868 ± 0.834
0.191GlnMet: 0.191 ± 0.145
1.912GlnAsn: 1.912 ± 0.923
0.574GlnPro: 0.574 ± 0.251
0.956GlnGln: 0.956 ± 0.582
0.574GlnArg: 0.574 ± 0.352
3.059GlnSer: 3.059 ± 0.995
2.294GlnThr: 2.294 ± 0.785
1.529GlnVal: 1.529 ± 0.721
0.382GlnTrp: 0.382 ± 0.267
1.721GlnTyr: 1.721 ± 0.615
0.0GlnXaa: 0.0 ± 0.0
Arg
2.294ArgAla: 2.294 ± 0.885
0.382ArgCys: 0.382 ± 0.336
2.294ArgAsp: 2.294 ± 0.773
2.294ArgGlu: 2.294 ± 0.942
2.103ArgPhe: 2.103 ± 0.859
2.676ArgGly: 2.676 ± 0.883
0.765ArgHis: 0.765 ± 0.457
3.059ArgIle: 3.059 ± 1.109
3.632ArgLys: 3.632 ± 1.024
4.779ArgLeu: 4.779 ± 1.322
0.956ArgMet: 0.956 ± 0.457
2.294ArgAsn: 2.294 ± 0.487
0.765ArgPro: 0.765 ± 0.308
1.338ArgGln: 1.338 ± 0.472
1.912ArgArg: 1.912 ± 0.82
1.338ArgSer: 1.338 ± 0.562
2.294ArgThr: 2.294 ± 0.932
2.485ArgVal: 2.485 ± 0.594
0.574ArgTrp: 0.574 ± 0.312
1.912ArgTyr: 1.912 ± 0.749
0.0ArgXaa: 0.0 ± 0.0
Ser
5.926SerAla: 5.926 ± 1.442
0.574SerCys: 0.574 ± 0.435
4.779SerAsp: 4.779 ± 0.655
5.162SerGlu: 5.162 ± 1.011
3.25SerPhe: 3.25 ± 0.715
6.5SerGly: 6.5 ± 1.66
0.956SerHis: 0.956 ± 0.355
7.264SerIle: 7.264 ± 1.458
5.353SerLys: 5.353 ± 0.936
5.162SerLeu: 5.162 ± 0.902
2.485SerMet: 2.485 ± 0.683
6.882SerAsn: 6.882 ± 1.657
1.721SerPro: 1.721 ± 0.67
1.529SerGln: 1.529 ± 0.551
2.294SerArg: 2.294 ± 0.932
4.015SerSer: 4.015 ± 0.878
4.206SerThr: 4.206 ± 1.297
5.353SerVal: 5.353 ± 0.57
0.574SerTrp: 0.574 ± 0.301
1.912SerTyr: 1.912 ± 0.659
0.0SerXaa: 0.0 ± 0.0
Thr
3.441ThrAla: 3.441 ± 1.319
0.574ThrCys: 0.574 ± 0.235
4.588ThrAsp: 4.588 ± 0.744
5.162ThrGlu: 5.162 ± 1.892
3.632ThrPhe: 3.632 ± 0.89
5.162ThrGly: 5.162 ± 1.861
0.382ThrHis: 0.382 ± 0.196
7.264ThrIle: 7.264 ± 0.928
4.015ThrLys: 4.015 ± 1.394
4.588ThrLeu: 4.588 ± 0.788
1.147ThrMet: 1.147 ± 0.426
4.015ThrAsn: 4.015 ± 0.836
3.632ThrPro: 3.632 ± 0.75
2.485ThrGln: 2.485 ± 0.774
2.868ThrArg: 2.868 ± 0.515
4.206ThrSer: 4.206 ± 1.346
7.073ThrThr: 7.073 ± 2.657
3.441ThrVal: 3.441 ± 0.853
1.147ThrTrp: 1.147 ± 0.538
2.676ThrTyr: 2.676 ± 0.554
0.0ThrXaa: 0.0 ± 0.0
Val
4.015ValAla: 4.015 ± 1.356
0.574ValCys: 0.574 ± 0.421
6.309ValAsp: 6.309 ± 0.691
4.397ValGlu: 4.397 ± 1.114
2.103ValPhe: 2.103 ± 0.519
3.632ValGly: 3.632 ± 0.7
0.574ValHis: 0.574 ± 0.241
4.779ValIle: 4.779 ± 1.036
4.015ValLys: 4.015 ± 0.861
4.779ValLeu: 4.779 ± 1.097
0.574ValMet: 0.574 ± 0.292
5.353ValAsn: 5.353 ± 1.015
1.338ValPro: 1.338 ± 0.386
1.721ValGln: 1.721 ± 0.524
2.294ValArg: 2.294 ± 0.595
5.162ValSer: 5.162 ± 1.649
3.823ValThr: 3.823 ± 0.824
3.059ValVal: 3.059 ± 0.639
0.382ValTrp: 0.382 ± 0.267
2.103ValTyr: 2.103 ± 0.695
0.0ValXaa: 0.0 ± 0.0
Trp
0.956TrpAla: 0.956 ± 0.567
0.382TrpCys: 0.382 ± 0.414
0.382TrpAsp: 0.382 ± 0.264
0.0TrpGlu: 0.0 ± 0.0
0.382TrpPhe: 0.382 ± 0.264
0.191TrpGly: 0.191 ± 0.145
0.382TrpHis: 0.382 ± 0.245
0.574TrpIle: 0.574 ± 0.398
0.191TrpLys: 0.191 ± 0.219
0.765TrpLeu: 0.765 ± 0.386
0.191TrpMet: 0.191 ± 0.182
0.956TrpAsn: 0.956 ± 0.411
0.0TrpPro: 0.0 ± 0.0
0.574TrpGln: 0.574 ± 0.333
0.191TrpArg: 0.191 ± 0.231
1.529TrpSer: 1.529 ± 0.649
0.382TrpThr: 0.382 ± 0.317
1.147TrpVal: 1.147 ± 0.535
0.191TrpTrp: 0.191 ± 0.182
0.765TrpTyr: 0.765 ± 0.442
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.103TyrAla: 2.103 ± 0.94
1.338TyrCys: 1.338 ± 0.417
2.485TyrAsp: 2.485 ± 0.424
1.721TyrGlu: 1.721 ± 0.569
3.059TyrPhe: 3.059 ± 0.709
2.676TyrGly: 2.676 ± 0.535
0.382TyrHis: 0.382 ± 0.311
3.823TyrIle: 3.823 ± 1.185
3.441TyrLys: 3.441 ± 1.032
3.25TyrLeu: 3.25 ± 0.862
1.338TyrMet: 1.338 ± 0.354
3.823TyrAsn: 3.823 ± 1.068
0.765TyrPro: 0.765 ± 0.293
1.338TyrGln: 1.338 ± 0.599
2.294TyrArg: 2.294 ± 0.717
3.823TyrSer: 3.823 ± 0.909
2.294TyrThr: 2.294 ± 0.676
3.25TyrVal: 3.25 ± 1.137
0.382TyrTrp: 0.382 ± 0.414
2.294TyrTyr: 2.294 ± 0.633
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 17 proteins (5232 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski