Amino acid dipepetide frequency for Monoglobus pectinilyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.182AlaAla: 6.182 ± 0.116
0.792AlaCys: 0.792 ± 0.033
4.469AlaAsp: 4.469 ± 0.089
5.629AlaGlu: 5.629 ± 0.093
2.544AlaPhe: 2.544 ± 0.057
4.968AlaGly: 4.968 ± 0.099
0.941AlaHis: 0.941 ± 0.037
4.573AlaIle: 4.573 ± 0.082
4.703AlaLys: 4.703 ± 0.074
5.393AlaLeu: 5.393 ± 0.103
1.8AlaMet: 1.8 ± 0.048
2.951AlaAsn: 2.951 ± 0.072
2.069AlaPro: 2.069 ± 0.062
1.785AlaGln: 1.785 ± 0.046
2.154AlaArg: 2.154 ± 0.054
3.901AlaSer: 3.901 ± 0.08
3.129AlaThr: 3.129 ± 0.169
6.176AlaVal: 6.176 ± 0.097
0.502AlaTrp: 0.502 ± 0.029
2.53AlaTyr: 2.53 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.909CysAla: 0.909 ± 0.037
0.277CysCys: 0.277 ± 0.021
0.923CysAsp: 0.923 ± 0.031
0.905CysGlu: 0.905 ± 0.038
0.596CysPhe: 0.596 ± 0.026
1.522CysGly: 1.522 ± 0.051
0.211CysHis: 0.211 ± 0.016
1.026CysIle: 1.026 ± 0.046
0.775CysLys: 0.775 ± 0.037
1.031CysLeu: 1.031 ± 0.038
0.362CysMet: 0.362 ± 0.023
0.543CysAsn: 0.543 ± 0.028
0.555CysPro: 0.555 ± 0.028
0.312CysGln: 0.312 ± 0.021
0.622CysArg: 0.622 ± 0.039
1.038CysSer: 1.038 ± 0.04
0.626CysThr: 0.626 ± 0.029
0.99CysVal: 0.99 ± 0.037
0.073CysTrp: 0.073 ± 0.009
0.555CysTyr: 0.555 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.627AspAla: 3.627 ± 0.072
0.888AspCys: 0.888 ± 0.032
3.506AspAsp: 3.506 ± 0.075
4.957AspGlu: 4.957 ± 0.088
2.885AspPhe: 2.885 ± 0.061
5.254AspGly: 5.254 ± 0.115
0.521AspHis: 0.521 ± 0.023
5.782AspIle: 5.782 ± 0.101
4.691AspLys: 4.691 ± 0.083
4.389AspLeu: 4.389 ± 0.09
1.893AspMet: 1.893 ± 0.053
3.84AspAsn: 3.84 ± 0.079
1.709AspPro: 1.709 ± 0.048
0.851AspGln: 0.851 ± 0.034
2.191AspArg: 2.191 ± 0.061
4.146AspSer: 4.146 ± 0.075
3.415AspThr: 3.415 ± 0.073
4.09AspVal: 4.09 ± 0.084
0.615AspTrp: 0.615 ± 0.034
3.004AspTyr: 3.004 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
4.459GluAla: 4.459 ± 0.088
0.79GluCys: 0.79 ± 0.037
3.698GluAsp: 3.698 ± 0.064
4.899GluGlu: 4.899 ± 0.099
2.837GluPhe: 2.837 ± 0.07
3.505GluGly: 3.505 ± 0.071
0.984GluHis: 0.984 ± 0.04
6.08GluIle: 6.08 ± 0.108
6.022GluLys: 6.022 ± 0.113
6.134GluLeu: 6.134 ± 0.114
2.01GluMet: 2.01 ± 0.054
5.444GluAsn: 5.444 ± 0.094
2.261GluPro: 2.261 ± 0.083
2.309GluGln: 2.309 ± 0.065
2.86GluArg: 2.86 ± 0.077
3.829GluSer: 3.829 ± 0.075
4.055GluThr: 4.055 ± 0.079
4.103GluVal: 4.103 ± 0.084
0.568GluTrp: 0.568 ± 0.031
3.584GluTyr: 3.584 ± 0.084
0.0GluXaa: 0.0 ± 0.0
Phe
2.568PheAla: 2.568 ± 0.06
0.728PheCys: 0.728 ± 0.03
3.071PheAsp: 3.071 ± 0.07
2.944PheGlu: 2.944 ± 0.066
1.628PhePhe: 1.628 ± 0.057
3.222PheGly: 3.222 ± 0.066
0.53PheHis: 0.53 ± 0.024
3.198PheIle: 3.198 ± 0.081
2.709PheLys: 2.709 ± 0.061
3.135PheLeu: 3.135 ± 0.085
0.988PheMet: 0.988 ± 0.038
2.183PheAsn: 2.183 ± 0.056
1.154PhePro: 1.154 ± 0.042
0.799PheGln: 0.799 ± 0.031
1.397PheArg: 1.397 ± 0.041
3.32PheSer: 3.32 ± 0.082
2.293PheThr: 2.293 ± 0.057
2.62PheVal: 2.62 ± 0.069
0.349PheTrp: 0.349 ± 0.025
1.621PheTyr: 1.621 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
4.76GlyAla: 4.76 ± 0.103
1.091GlyCys: 1.091 ± 0.044
4.292GlyAsp: 4.292 ± 0.086
4.699GlyGlu: 4.699 ± 0.082
3.018GlyPhe: 3.018 ± 0.069
5.428GlyGly: 5.428 ± 0.14
1.07GlyHis: 1.07 ± 0.041
6.121GlyIle: 6.121 ± 0.106
5.204GlyLys: 5.204 ± 0.079
5.376GlyLeu: 5.376 ± 0.086
1.944GlyMet: 1.944 ± 0.055
3.868GlyAsn: 3.868 ± 0.102
1.114GlyPro: 1.114 ± 0.049
1.901GlyGln: 1.901 ± 0.059
2.742GlyArg: 2.742 ± 0.063
4.746GlySer: 4.746 ± 0.107
4.667GlyThr: 4.667 ± 0.111
4.974GlyVal: 4.974 ± 0.088
0.661GlyTrp: 0.661 ± 0.033
3.564GlyTyr: 3.564 ± 0.079
0.0GlyXaa: 0.0 ± 0.0
His
0.731HisAla: 0.731 ± 0.032
0.243HisCys: 0.243 ± 0.019
0.749HisAsp: 0.749 ± 0.03
0.771HisGlu: 0.771 ± 0.031
0.585HisPhe: 0.585 ± 0.03
1.017HisGly: 1.017 ± 0.036
0.298HisHis: 0.298 ± 0.02
1.178HisIle: 1.178 ± 0.041
0.91HisLys: 0.91 ± 0.035
1.034HisLeu: 1.034 ± 0.037
0.388HisMet: 0.388 ± 0.023
0.804HisAsn: 0.804 ± 0.03
0.598HisPro: 0.598 ± 0.03
0.363HisGln: 0.363 ± 0.022
0.609HisArg: 0.609 ± 0.029
0.904HisSer: 0.904 ± 0.039
0.784HisThr: 0.784 ± 0.038
0.719HisVal: 0.719 ± 0.037
0.143HisTrp: 0.143 ± 0.014
0.565HisTyr: 0.565 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.2IleAla: 5.2 ± 0.094
1.241IleCys: 1.241 ± 0.04
5.408IleAsp: 5.408 ± 0.1
5.62IleGlu: 5.62 ± 0.112
3.142IlePhe: 3.142 ± 0.082
5.167IleGly: 5.167 ± 0.107
1.004IleHis: 1.004 ± 0.037
6.833IleIle: 6.833 ± 0.124
6.311IleLys: 6.311 ± 0.1
6.614IleLeu: 6.614 ± 0.134
1.986IleMet: 1.986 ± 0.049
5.002IleAsn: 5.002 ± 0.092
3.046IlePro: 3.046 ± 0.074
1.884IleGln: 1.884 ± 0.051
2.942IleArg: 2.942 ± 0.078
6.319IleSer: 6.319 ± 0.102
4.919IleThr: 4.919 ± 0.089
5.184IleVal: 5.184 ± 0.083
0.617IleTrp: 0.617 ± 0.037
3.135IleTyr: 3.135 ± 0.068
0.0IleXaa: 0.0 ± 0.0
Lys
4.595LysAla: 4.595 ± 0.09
0.851LysCys: 0.851 ± 0.036
4.167LysAsp: 4.167 ± 0.078
5.175LysGlu: 5.175 ± 0.106
2.578LysPhe: 2.578 ± 0.065
3.812LysGly: 3.812 ± 0.071
1.093LysHis: 1.093 ± 0.042
6.146LysIle: 6.146 ± 0.114
5.868LysLys: 5.868 ± 0.12
5.812LysLeu: 5.812 ± 0.091
2.143LysMet: 2.143 ± 0.053
5.222LysAsn: 5.222 ± 0.095
2.377LysPro: 2.377 ± 0.064
2.151LysGln: 2.151 ± 0.059
3.009LysArg: 3.009 ± 0.069
4.76LysSer: 4.76 ± 0.085
4.438LysThr: 4.438 ± 0.078
4.338LysVal: 4.338 ± 0.075
0.588LysTrp: 0.588 ± 0.031
3.817LysTyr: 3.817 ± 0.075
0.0LysXaa: 0.0 ± 0.0
Leu
5.136LeuAla: 5.136 ± 0.082
1.262LeuCys: 1.262 ± 0.043
4.918LeuAsp: 4.918 ± 0.075
5.058LeuGlu: 5.058 ± 0.102
3.228LeuPhe: 3.228 ± 0.081
5.675LeuGly: 5.675 ± 0.098
1.001LeuHis: 1.001 ± 0.04
5.983LeuIle: 5.983 ± 0.106
6.387LeuLys: 6.387 ± 0.111
6.157LeuLeu: 6.157 ± 0.127
2.04LeuMet: 2.04 ± 0.056
4.755LeuAsn: 4.755 ± 0.089
3.063LeuPro: 3.063 ± 0.069
1.717LeuGln: 1.717 ± 0.056
3.042LeuArg: 3.042 ± 0.078
6.5LeuSer: 6.5 ± 0.11
4.64LeuThr: 4.64 ± 0.075
4.65LeuVal: 4.65 ± 0.081
0.582LeuTrp: 0.582 ± 0.031
3.071LeuTyr: 3.071 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
1.843MetAla: 1.843 ± 0.051
0.32MetCys: 0.32 ± 0.023
1.49MetAsp: 1.49 ± 0.046
1.624MetGlu: 1.624 ± 0.051
1.099MetPhe: 1.099 ± 0.038
1.888MetGly: 1.888 ± 0.055
0.328MetHis: 0.328 ± 0.021
1.843MetIle: 1.843 ± 0.055
2.15MetLys: 2.15 ± 0.046
2.268MetLeu: 2.268 ± 0.056
0.638MetMet: 0.638 ± 0.031
1.528MetAsn: 1.528 ± 0.046
1.106MetPro: 1.106 ± 0.044
0.8MetGln: 0.8 ± 0.031
1.112MetArg: 1.112 ± 0.041
2.004MetSer: 2.004 ± 0.054
1.6MetThr: 1.6 ± 0.051
1.589MetVal: 1.589 ± 0.053
0.168MetTrp: 0.168 ± 0.016
0.939MetTyr: 0.939 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.586AsnAla: 3.586 ± 0.086
0.913AsnCys: 0.913 ± 0.049
3.527AsnAsp: 3.527 ± 0.076
3.611AsnGlu: 3.611 ± 0.07
2.171AsnPhe: 2.171 ± 0.057
5.1AsnGly: 5.1 ± 0.12
0.718AsnHis: 0.718 ± 0.032
5.656AsnIle: 5.656 ± 0.109
3.963AsnLys: 3.963 ± 0.076
4.41AsnLeu: 4.41 ± 0.087
1.633AsnMet: 1.633 ± 0.046
4.066AsnAsn: 4.066 ± 0.107
2.332AsnPro: 2.332 ± 0.059
1.53AsnGln: 1.53 ± 0.051
2.087AsnArg: 2.087 ± 0.06
4.094AsnSer: 4.094 ± 0.084
3.258AsnThr: 3.258 ± 0.076
3.727AsnVal: 3.727 ± 0.077
0.514AsnTrp: 0.514 ± 0.024
2.553AsnTyr: 2.553 ± 0.063
0.0AsnXaa: 0.0 ± 0.0
Pro
2.216ProAla: 2.216 ± 0.064
0.446ProCys: 0.446 ± 0.039
2.366ProAsp: 2.366 ± 0.055
3.289ProGlu: 3.289 ± 0.103
1.293ProPhe: 1.293 ± 0.043
2.218ProGly: 2.218 ± 0.052
0.483ProHis: 0.483 ± 0.026
2.422ProIle: 2.422 ± 0.059
2.189ProLys: 2.189 ± 0.062
2.334ProLeu: 2.334 ± 0.058
0.79ProMet: 0.79 ± 0.032
1.693ProAsn: 1.693 ± 0.046
0.954ProPro: 0.954 ± 0.058
0.952ProGln: 0.952 ± 0.038
0.921ProArg: 0.921 ± 0.036
2.163ProSer: 2.163 ± 0.06
2.22ProThr: 2.22 ± 0.107
2.601ProVal: 2.601 ± 0.063
0.268ProTrp: 0.268 ± 0.016
1.443ProTyr: 1.443 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
1.671GlnAla: 1.671 ± 0.047
0.264GlnCys: 0.264 ± 0.02
1.356GlnAsp: 1.356 ± 0.044
1.674GlnGlu: 1.674 ± 0.05
0.947GlnPhe: 0.947 ± 0.036
1.544GlnGly: 1.544 ± 0.046
0.302GlnHis: 0.302 ± 0.021
2.292GlnIle: 2.292 ± 0.059
2.174GlnLys: 2.174 ± 0.064
2.176GlnLeu: 2.176 ± 0.054
0.782GlnMet: 0.782 ± 0.035
1.911GlnAsn: 1.911 ± 0.052
0.891GlnPro: 0.891 ± 0.04
0.788GlnGln: 0.788 ± 0.038
1.112GlnArg: 1.112 ± 0.045
1.667GlnSer: 1.667 ± 0.056
1.65GlnThr: 1.65 ± 0.055
1.474GlnVal: 1.474 ± 0.051
0.249GlnTrp: 0.249 ± 0.019
1.181GlnTyr: 1.181 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.327ArgAla: 2.327 ± 0.052
0.517ArgCys: 0.517 ± 0.028
2.075ArgAsp: 2.075 ± 0.051
2.824ArgGlu: 2.824 ± 0.069
1.708ArgPhe: 1.708 ± 0.048
2.201ArgGly: 2.201 ± 0.061
0.561ArgHis: 0.561 ± 0.029
3.172ArgIle: 3.172 ± 0.076
2.591ArgLys: 2.591 ± 0.064
3.237ArgLeu: 3.237 ± 0.072
1.103ArgMet: 1.103 ± 0.04
2.048ArgAsn: 2.048 ± 0.052
1.261ArgPro: 1.261 ± 0.055
1.268ArgGln: 1.268 ± 0.048
1.634ArgArg: 1.634 ± 0.061
2.004ArgSer: 2.004 ± 0.049
1.985ArgThr: 1.985 ± 0.045
2.377ArgVal: 2.377 ± 0.066
0.307ArgTrp: 0.307 ± 0.018
1.697ArgTyr: 1.697 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
5.095SerAla: 5.095 ± 0.099
0.787SerCys: 0.787 ± 0.034
4.83SerAsp: 4.83 ± 0.097
5.276SerGlu: 5.276 ± 0.09
2.79SerPhe: 2.79 ± 0.062
6.152SerGly: 6.152 ± 0.107
0.985SerHis: 0.985 ± 0.032
5.162SerIle: 5.162 ± 0.1
4.477SerLys: 4.477 ± 0.081
5.185SerLeu: 5.185 ± 0.087
1.575SerMet: 1.575 ± 0.047
3.641SerAsn: 3.641 ± 0.078
2.1SerPro: 2.1 ± 0.056
1.813SerGln: 1.813 ± 0.053
2.45SerArg: 2.45 ± 0.057
4.804SerSer: 4.804 ± 0.109
3.195SerThr: 3.195 ± 0.074
5.124SerVal: 5.124 ± 0.102
0.543SerTrp: 0.543 ± 0.027
2.927SerTyr: 2.927 ± 0.066
0.0SerXaa: 0.0 ± 0.0
Thr
5.02ThrAla: 5.02 ± 0.142
0.584ThrCys: 0.584 ± 0.028
3.741ThrAsp: 3.741 ± 0.083
4.036ThrGlu: 4.036 ± 0.093
2.317ThrPhe: 2.317 ± 0.062
4.443ThrGly: 4.443 ± 0.085
0.716ThrHis: 0.716 ± 0.03
4.434ThrIle: 4.434 ± 0.083
3.502ThrLys: 3.502 ± 0.075
4.408ThrLeu: 4.408 ± 0.078
1.228ThrMet: 1.228 ± 0.037
2.84ThrAsn: 2.84 ± 0.069
2.517ThrPro: 2.517 ± 0.1
1.606ThrGln: 1.606 ± 0.046
1.725ThrArg: 1.725 ± 0.051
3.504ThrSer: 3.504 ± 0.083
2.925ThrThr: 2.925 ± 0.075
4.993ThrVal: 4.993 ± 0.133
0.475ThrTrp: 0.475 ± 0.029
2.393ThrTyr: 2.393 ± 0.082
0.0ThrXaa: 0.0 ± 0.0
Val
4.052ValAla: 4.052 ± 0.096
1.073ValCys: 1.073 ± 0.042
3.964ValAsp: 3.964 ± 0.081
4.127ValGlu: 4.127 ± 0.083
2.908ValPhe: 2.908 ± 0.064
4.272ValGly: 4.272 ± 0.092
0.922ValHis: 0.922 ± 0.041
5.39ValIle: 5.39 ± 0.098
4.767ValLys: 4.767 ± 0.086
5.755ValLeu: 5.755 ± 0.095
1.831ValMet: 1.831 ± 0.047
3.588ValAsn: 3.588 ± 0.079
2.57ValPro: 2.57 ± 0.056
1.68ValGln: 1.68 ± 0.047
2.406ValArg: 2.406 ± 0.061
5.544ValSer: 5.544 ± 0.112
4.404ValThr: 4.404 ± 0.116
4.494ValVal: 4.494 ± 0.1
0.55ValTrp: 0.55 ± 0.03
2.921ValTyr: 2.921 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.518TrpAla: 0.518 ± 0.028
0.135TrpCys: 0.135 ± 0.013
0.59TrpAsp: 0.59 ± 0.027
0.514TrpGlu: 0.514 ± 0.028
0.338TrpPhe: 0.338 ± 0.022
0.689TrpGly: 0.689 ± 0.047
0.16TrpHis: 0.16 ± 0.014
0.582TrpIle: 0.582 ± 0.028
0.543TrpLys: 0.543 ± 0.029
0.665TrpLeu: 0.665 ± 0.035
0.185TrpMet: 0.185 ± 0.017
0.584TrpAsn: 0.584 ± 0.034
0.14TrpPro: 0.14 ± 0.013
0.293TrpGln: 0.293 ± 0.02
0.319TrpArg: 0.319 ± 0.021
0.523TrpSer: 0.523 ± 0.031
0.454TrpThr: 0.454 ± 0.026
0.475TrpVal: 0.475 ± 0.026
0.115TrpTrp: 0.115 ± 0.014
0.411TrpTyr: 0.411 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.694TyrAla: 2.694 ± 0.063
0.649TyrCys: 0.649 ± 0.031
3.11TyrAsp: 3.11 ± 0.095
2.798TyrGlu: 2.798 ± 0.066
1.844TyrPhe: 1.844 ± 0.047
3.165TyrGly: 3.165 ± 0.075
0.567TyrHis: 0.567 ± 0.026
3.7TyrIle: 3.7 ± 0.071
3.005TyrLys: 3.005 ± 0.068
3.352TyrLeu: 3.352 ± 0.068
1.018TyrMet: 1.018 ± 0.041
2.938TyrAsn: 2.938 ± 0.077
1.443TyrPro: 1.443 ± 0.043
1.303TyrGln: 1.303 ± 0.048
1.566TyrArg: 1.566 ± 0.043
3.142TyrSer: 3.142 ± 0.065
2.749TyrThr: 2.749 ± 0.075
2.52TyrVal: 2.52 ± 0.054
0.346TyrTrp: 0.346 ± 0.021
2.074TyrTyr: 2.074 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2258 proteins (762331 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski