Amino acid dipepetide frequency for Vulgatibacter incomptus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.19AlaAla: 17.19 ± 0.221
1.5AlaCys: 1.5 ± 0.051
6.164AlaAsp: 6.164 ± 0.07
8.231AlaGlu: 8.231 ± 0.102
4.324AlaPhe: 4.324 ± 0.063
11.264AlaGly: 11.264 ± 0.122
2.09AlaHis: 2.09 ± 0.042
5.862AlaIle: 5.862 ± 0.072
4.197AlaLys: 4.197 ± 0.085
13.172AlaLeu: 13.172 ± 0.185
2.564AlaMet: 2.564 ± 0.052
2.336AlaAsn: 2.336 ± 0.044
6.632AlaPro: 6.632 ± 0.104
3.162AlaGln: 3.162 ± 0.055
10.309AlaArg: 10.309 ± 0.131
7.747AlaSer: 7.747 ± 0.094
6.02AlaThr: 6.02 ± 0.104
8.492AlaVal: 8.492 ± 0.098
1.786AlaTrp: 1.786 ± 0.049
2.132AlaTyr: 2.132 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.241CysAla: 1.241 ± 0.042
0.108CysCys: 0.108 ± 0.014
0.686CysAsp: 0.686 ± 0.037
0.649CysGlu: 0.649 ± 0.026
0.307CysPhe: 0.307 ± 0.016
1.337CysGly: 1.337 ± 0.068
0.257CysHis: 0.257 ± 0.017
0.3CysIle: 0.3 ± 0.015
0.264CysLys: 0.264 ± 0.014
0.807CysLeu: 0.807 ± 0.024
0.139CysMet: 0.139 ± 0.012
0.26CysAsn: 0.26 ± 0.02
0.605CysPro: 0.605 ± 0.03
0.235CysGln: 0.235 ± 0.014
0.708CysArg: 0.708 ± 0.027
0.723CysSer: 0.723 ± 0.032
0.575CysThr: 0.575 ± 0.033
0.742CysVal: 0.742 ± 0.031
0.234CysTrp: 0.234 ± 0.026
0.186CysTyr: 0.186 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.7AspAla: 6.7 ± 0.085
0.571AspCys: 0.571 ± 0.031
3.312AspAsp: 3.312 ± 0.052
4.471AspGlu: 4.471 ± 0.07
1.977AspPhe: 1.977 ± 0.045
5.977AspGly: 5.977 ± 0.102
1.102AspHis: 1.102 ± 0.028
1.447AspIle: 1.447 ± 0.037
1.239AspLys: 1.239 ± 0.031
6.324AspLeu: 6.324 ± 0.083
0.703AspMet: 0.703 ± 0.024
0.786AspAsn: 0.786 ± 0.028
4.432AspPro: 4.432 ± 0.075
1.323AspGln: 1.323 ± 0.035
4.859AspArg: 4.859 ± 0.07
2.554AspSer: 2.554 ± 0.047
1.929AspThr: 1.929 ± 0.037
4.308AspVal: 4.308 ± 0.063
0.785AspTrp: 0.785 ± 0.028
1.038AspTyr: 1.038 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
9.077GluAla: 9.077 ± 0.125
0.507GluCys: 0.507 ± 0.028
2.865GluAsp: 2.865 ± 0.052
4.659GluGlu: 4.659 ± 0.078
1.378GluPhe: 1.378 ± 0.032
5.823GluGly: 5.823 ± 0.075
1.282GluHis: 1.282 ± 0.032
3.225GluIle: 3.225 ± 0.057
2.623GluLys: 2.623 ± 0.061
8.614GluLeu: 8.614 ± 0.128
1.09GluMet: 1.09 ± 0.033
1.286GluAsn: 1.286 ± 0.034
3.597GluPro: 3.597 ± 0.067
1.932GluGln: 1.932 ± 0.043
6.561GluArg: 6.561 ± 0.098
3.256GluSer: 3.256 ± 0.053
2.98GluThr: 2.98 ± 0.052
5.282GluVal: 5.282 ± 0.072
0.756GluTrp: 0.756 ± 0.029
0.975GluTyr: 0.975 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
4.092PheAla: 4.092 ± 0.07
0.366PheCys: 0.366 ± 0.021
2.643PheAsp: 2.643 ± 0.049
2.518PheGlu: 2.518 ± 0.052
1.393PhePhe: 1.393 ± 0.039
3.442PheGly: 3.442 ± 0.062
0.763PheHis: 0.763 ± 0.025
0.876PheIle: 0.876 ± 0.028
0.704PheLys: 0.704 ± 0.021
3.332PheLeu: 3.332 ± 0.061
0.493PheMet: 0.493 ± 0.021
0.769PheAsn: 0.769 ± 0.025
1.735PhePro: 1.735 ± 0.041
0.945PheGln: 0.945 ± 0.032
2.603PheArg: 2.603 ± 0.044
2.117PheSer: 2.117 ± 0.044
1.807PheThr: 1.807 ± 0.041
3.068PheVal: 3.068 ± 0.05
0.449PheTrp: 0.449 ± 0.019
0.746PheTyr: 0.746 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
10.651GlyAla: 10.651 ± 0.117
1.069GlyCys: 1.069 ± 0.039
5.197GlyAsp: 5.197 ± 0.085
5.955GlyGlu: 5.955 ± 0.084
3.365GlyPhe: 3.365 ± 0.06
9.391GlyGly: 9.391 ± 0.162
1.714GlyHis: 1.714 ± 0.039
4.1GlyIle: 4.1 ± 0.051
3.517GlyLys: 3.517 ± 0.064
8.712GlyLeu: 8.712 ± 0.118
1.925GlyMet: 1.925 ± 0.043
2.015GlyAsn: 2.015 ± 0.053
4.445GlyPro: 4.445 ± 0.071
2.529GlyGln: 2.529 ± 0.065
7.221GlyArg: 7.221 ± 0.091
6.137GlySer: 6.137 ± 0.097
5.396GlyThr: 5.396 ± 0.134
6.518GlyVal: 6.518 ± 0.081
1.352GlyTrp: 1.352 ± 0.047
2.006GlyTyr: 2.006 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.238HisAla: 2.238 ± 0.044
0.212HisCys: 0.212 ± 0.012
1.026HisAsp: 1.026 ± 0.03
1.195HisGlu: 1.195 ± 0.028
0.788HisPhe: 0.788 ± 0.024
1.913HisGly: 1.913 ± 0.041
0.505HisHis: 0.505 ± 0.025
0.478HisIle: 0.478 ± 0.018
0.372HisLys: 0.372 ± 0.016
2.178HisLeu: 2.178 ± 0.042
0.304HisMet: 0.304 ± 0.017
0.301HisAsn: 0.301 ± 0.016
1.418HisPro: 1.418 ± 0.033
0.481HisGln: 0.481 ± 0.02
1.548HisArg: 1.548 ± 0.038
0.918HisSer: 0.918 ± 0.03
0.786HisThr: 0.786 ± 0.027
1.503HisVal: 1.503 ± 0.037
0.254HisTrp: 0.254 ± 0.015
0.418HisTyr: 0.418 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
5.538IleAla: 5.538 ± 0.075
0.451IleCys: 0.451 ± 0.022
2.969IleAsp: 2.969 ± 0.061
3.171IleGlu: 3.171 ± 0.057
1.393IlePhe: 1.393 ± 0.034
3.76IleGly: 3.76 ± 0.066
0.925IleHis: 0.925 ± 0.029
0.886IleIle: 0.886 ± 0.03
0.788IleLys: 0.788 ± 0.03
3.908IleLeu: 3.908 ± 0.065
0.39IleMet: 0.39 ± 0.019
0.719IleAsn: 0.719 ± 0.028
2.391IlePro: 2.391 ± 0.046
1.086IleGln: 1.086 ± 0.031
3.197IleArg: 3.197 ± 0.049
2.185IleSer: 2.185 ± 0.045
1.809IleThr: 1.809 ± 0.04
3.432IleVal: 3.432 ± 0.052
0.436IleTrp: 0.436 ± 0.022
0.764IleTyr: 0.764 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
3.945LysAla: 3.945 ± 0.079
0.157LysCys: 0.157 ± 0.011
1.518LysAsp: 1.518 ± 0.039
1.991LysGlu: 1.991 ± 0.044
0.655LysPhe: 0.655 ± 0.025
2.756LysGly: 2.756 ± 0.054
0.446LysHis: 0.446 ± 0.02
1.322LysIle: 1.322 ± 0.038
1.333LysLys: 1.333 ± 0.05
3.25LysLeu: 3.25 ± 0.064
0.586LysMet: 0.586 ± 0.02
0.697LysAsn: 0.697 ± 0.027
1.712LysPro: 1.712 ± 0.043
0.779LysGln: 0.779 ± 0.03
2.392LysArg: 2.392 ± 0.052
1.507LysSer: 1.507 ± 0.037
1.542LysThr: 1.542 ± 0.037
2.624LysVal: 2.624 ± 0.048
0.314LysTrp: 0.314 ± 0.014
0.459LysTyr: 0.459 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
14.525LeuAla: 14.525 ± 0.168
0.915LeuCys: 0.915 ± 0.029
6.532LeuAsp: 6.532 ± 0.094
7.548LeuGlu: 7.548 ± 0.107
3.431LeuPhe: 3.431 ± 0.062
9.642LeuGly: 9.642 ± 0.109
2.11LeuHis: 2.11 ± 0.049
3.017LeuIle: 3.017 ± 0.055
2.396LeuLys: 2.396 ± 0.052
10.537LeuLeu: 10.537 ± 0.149
1.447LeuMet: 1.447 ± 0.036
1.617LeuAsn: 1.617 ± 0.042
6.184LeuPro: 6.184 ± 0.08
2.705LeuGln: 2.705 ± 0.049
8.93LeuArg: 8.93 ± 0.108
6.343LeuSer: 6.343 ± 0.073
4.496LeuThr: 4.496 ± 0.07
8.62LeuVal: 8.62 ± 0.085
1.11LeuTrp: 1.11 ± 0.032
1.874LeuTyr: 1.874 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
2.201MetAla: 2.201 ± 0.042
0.136MetCys: 0.136 ± 0.012
0.87MetAsp: 0.87 ± 0.026
1.086MetGlu: 1.086 ± 0.028
0.457MetPhe: 0.457 ± 0.023
1.624MetGly: 1.624 ± 0.036
0.293MetHis: 0.293 ± 0.015
0.806MetIle: 0.806 ± 0.028
0.798MetLys: 0.798 ± 0.025
1.637MetLeu: 1.637 ± 0.035
0.346MetMet: 0.346 ± 0.019
0.51MetAsn: 0.51 ± 0.021
1.026MetPro: 1.026 ± 0.03
0.483MetGln: 0.483 ± 0.02
1.592MetArg: 1.592 ± 0.038
1.171MetSer: 1.171 ± 0.034
0.866MetThr: 0.866 ± 0.027
1.321MetVal: 1.321 ± 0.032
0.153MetTrp: 0.153 ± 0.011
0.238MetTyr: 0.238 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.24AsnAla: 2.24 ± 0.044
0.261AsnCys: 0.261 ± 0.02
1.105AsnAsp: 1.105 ± 0.03
1.196AsnGlu: 1.196 ± 0.034
0.74AsnPhe: 0.74 ± 0.026
2.069AsnGly: 2.069 ± 0.053
0.449AsnHis: 0.449 ± 0.019
0.605AsnIle: 0.605 ± 0.026
0.451AsnLys: 0.451 ± 0.022
2.284AsnLeu: 2.284 ± 0.046
0.294AsnMet: 0.294 ± 0.015
0.407AsnAsn: 0.407 ± 0.02
1.561AsnPro: 1.561 ± 0.043
0.562AsnGln: 0.562 ± 0.024
1.612AsnArg: 1.612 ± 0.039
0.821AsnSer: 0.821 ± 0.027
0.878AsnThr: 0.878 ± 0.028
1.713AsnVal: 1.713 ± 0.042
0.238AsnTrp: 0.238 ± 0.014
0.415AsnTyr: 0.415 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
7.275ProAla: 7.275 ± 0.091
0.438ProCys: 0.438 ± 0.025
3.538ProAsp: 3.538 ± 0.058
4.22ProGlu: 4.22 ± 0.063
2.021ProPhe: 2.021 ± 0.04
5.642ProGly: 5.642 ± 0.078
0.892ProHis: 0.892 ± 0.029
2.403ProIle: 2.403 ± 0.045
1.746ProLys: 1.746 ± 0.041
5.038ProLeu: 5.038 ± 0.063
1.184ProMet: 1.184 ± 0.032
1.184ProAsn: 1.184 ± 0.033
3.443ProPro: 3.443 ± 0.086
1.24ProGln: 1.24 ± 0.032
3.789ProArg: 3.789 ± 0.071
3.985ProSer: 3.985 ± 0.064
2.955ProThr: 2.955 ± 0.047
4.237ProVal: 4.237 ± 0.063
0.801ProTrp: 0.801 ± 0.027
1.108ProTyr: 1.108 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.602GlnAla: 3.602 ± 0.061
0.219GlnCys: 0.219 ± 0.019
1.125GlnAsp: 1.125 ± 0.036
1.555GlnGlu: 1.555 ± 0.038
0.645GlnPhe: 0.645 ± 0.022
2.292GlnGly: 2.292 ± 0.047
0.441GlnHis: 0.441 ± 0.017
1.199GlnIle: 1.199 ± 0.032
0.849GlnLys: 0.849 ± 0.031
2.908GlnLeu: 2.908 ± 0.05
0.49GlnMet: 0.49 ± 0.019
0.575GlnAsn: 0.575 ± 0.023
1.491GlnPro: 1.491 ± 0.037
0.835GlnGln: 0.835 ± 0.039
2.249GlnArg: 2.249 ± 0.047
1.284GlnSer: 1.284 ± 0.035
1.224GlnThr: 1.224 ± 0.036
2.37GlnVal: 2.37 ± 0.047
0.286GlnTrp: 0.286 ± 0.016
0.432GlnTyr: 0.432 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
9.392ArgAla: 9.392 ± 0.123
0.826ArgCys: 0.826 ± 0.031
4.119ArgAsp: 4.119 ± 0.068
5.649ArgGlu: 5.649 ± 0.109
3.428ArgPhe: 3.428 ± 0.056
5.874ArgGly: 5.874 ± 0.085
1.574ArgHis: 1.574 ± 0.042
4.429ArgIle: 4.429 ± 0.065
2.671ArgLys: 2.671 ± 0.052
9.216ArgLeu: 9.216 ± 0.125
1.91ArgMet: 1.91 ± 0.039
1.628ArgAsn: 1.628 ± 0.037
4.253ArgPro: 4.253 ± 0.076
2.158ArgGln: 2.158 ± 0.045
7.011ArgArg: 7.011 ± 0.113
4.97ArgSer: 4.97 ± 0.072
3.749ArgThr: 3.749 ± 0.052
5.767ArgVal: 5.767 ± 0.071
1.233ArgTrp: 1.233 ± 0.031
1.878ArgTyr: 1.878 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
6.808SerAla: 6.808 ± 0.083
0.803SerCys: 0.803 ± 0.036
2.971SerAsp: 2.971 ± 0.052
3.213SerGlu: 3.213 ± 0.054
2.581SerPhe: 2.581 ± 0.054
5.952SerGly: 5.952 ± 0.088
1.038SerHis: 1.038 ± 0.027
2.632SerIle: 2.632 ± 0.047
1.666SerLys: 1.666 ± 0.039
6.104SerLeu: 6.104 ± 0.064
1.159SerMet: 1.159 ± 0.031
1.381SerAsn: 1.381 ± 0.049
3.442SerPro: 3.442 ± 0.055
1.482SerGln: 1.482 ± 0.034
4.673SerArg: 4.673 ± 0.068
3.942SerSer: 3.942 ± 0.073
3.031SerThr: 3.031 ± 0.065
4.2SerVal: 4.2 ± 0.069
1.005SerTrp: 1.005 ± 0.035
1.182SerTyr: 1.182 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
5.38ThrAla: 5.38 ± 0.1
0.686ThrCys: 0.686 ± 0.035
2.369ThrAsp: 2.369 ± 0.049
2.509ThrGlu: 2.509 ± 0.052
2.047ThrPhe: 2.047 ± 0.049
4.999ThrGly: 4.999 ± 0.12
0.842ThrHis: 0.842 ± 0.025
2.217ThrIle: 2.217 ± 0.055
1.307ThrLys: 1.307 ± 0.042
5.053ThrLeu: 5.053 ± 0.072
0.795ThrMet: 0.795 ± 0.028
1.124ThrAsn: 1.124 ± 0.037
3.053ThrPro: 3.053 ± 0.064
1.094ThrGln: 1.094 ± 0.033
3.383ThrArg: 3.383 ± 0.053
3.069ThrSer: 3.069 ± 0.064
2.638ThrThr: 2.638 ± 0.081
4.006ThrVal: 4.006 ± 0.093
0.72ThrTrp: 0.72 ± 0.028
1.019ThrTyr: 1.019 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
9.781ValAla: 9.781 ± 0.108
0.786ValCys: 0.786 ± 0.032
4.835ValAsp: 4.835 ± 0.07
5.869ValGlu: 5.869 ± 0.078
2.595ValPhe: 2.595 ± 0.046
6.61ValGly: 6.61 ± 0.083
1.543ValHis: 1.543 ± 0.036
3.199ValIle: 3.199 ± 0.056
2.14ValLys: 2.14 ± 0.053
7.37ValLeu: 7.37 ± 0.089
1.202ValMet: 1.202 ± 0.03
1.534ValAsn: 1.534 ± 0.036
4.218ValPro: 4.218 ± 0.059
2.052ValGln: 2.052 ± 0.041
6.263ValArg: 6.263 ± 0.064
4.503ValSer: 4.503 ± 0.069
3.843ValThr: 3.843 ± 0.1
6.914ValVal: 6.914 ± 0.107
0.826ValTrp: 0.826 ± 0.028
1.45ValTyr: 1.45 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.273TrpAla: 1.273 ± 0.035
0.146TrpCys: 0.146 ± 0.012
0.691TrpAsp: 0.691 ± 0.025
0.734TrpGlu: 0.734 ± 0.025
0.475TrpPhe: 0.475 ± 0.022
1.05TrpGly: 1.05 ± 0.036
0.239TrpHis: 0.239 ± 0.016
0.734TrpIle: 0.734 ± 0.024
0.475TrpLys: 0.475 ± 0.02
1.523TrpLeu: 1.523 ± 0.04
0.331TrpMet: 0.331 ± 0.019
0.361TrpAsn: 0.361 ± 0.019
0.605TrpPro: 0.605 ± 0.022
0.417TrpGln: 0.417 ± 0.021
1.026TrpArg: 1.026 ± 0.03
0.998TrpSer: 0.998 ± 0.034
0.845TrpThr: 0.845 ± 0.032
0.828TrpVal: 0.828 ± 0.031
0.215TrpTrp: 0.215 ± 0.016
0.232TrpTyr: 0.232 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.025TyrAla: 2.025 ± 0.045
0.206TyrCys: 0.206 ± 0.015
1.302TyrAsp: 1.302 ± 0.044
1.349TyrGlu: 1.349 ± 0.041
0.857TyrPhe: 0.857 ± 0.028
1.797TyrGly: 1.797 ± 0.041
0.332TyrHis: 0.332 ± 0.02
0.46TyrIle: 0.46 ± 0.021
0.448TyrLys: 0.448 ± 0.019
2.011TyrLeu: 2.011 ± 0.039
0.264TyrMet: 0.264 ± 0.016
0.412TyrAsn: 0.412 ± 0.021
0.896TyrPro: 0.896 ± 0.029
0.572TyrGln: 0.572 ± 0.021
1.807TyrArg: 1.807 ± 0.041
1.037TyrSer: 1.037 ± 0.032
0.939TyrThr: 0.939 ± 0.04
1.589TyrVal: 1.589 ± 0.037
0.246TyrTrp: 0.246 ± 0.014
0.469TyrTyr: 0.469 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3704 proteins (1270377 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski