Amino acid dipepetide frequency for Ochrobactrum thiophenivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.643AlaAla: 12.643 ± 0.145	0.886AlaCys: 0.886 ± 0.029	5.952AlaAsp: 5.952 ± 0.084	6.576AlaGlu: 6.576 ± 0.083	4.443AlaPhe: 4.443 ± 0.06	8.756AlaGly: 8.756 ± 0.097	2.047AlaHis: 2.047 ± 0.041	7.267AlaIle: 7.267 ± 0.085	4.808AlaLys: 4.808 ± 0.072	11.698AlaLeu: 11.698 ± 0.111	3.205AlaMet: 3.205 ± 0.052	3.281AlaAsn: 3.281 ± 0.051	4.32AlaPro: 4.32 ± 0.065	3.712AlaGln: 3.712 ± 0.062	6.366AlaArg: 6.366 ± 0.081	6.343AlaSer: 6.343 ± 0.078	5.303AlaThr: 5.303 ± 0.067	7.522AlaVal: 7.522 ± 0.086	1.212AlaTrp: 1.212 ± 0.036	2.569AlaTyr: 2.569 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.83CysAla: 0.83 ± 0.028	0.1CysCys: 0.1 ± 0.01	0.487CysAsp: 0.487 ± 0.021	0.414CysGlu: 0.414 ± 0.016	0.369CysPhe: 0.369 ± 0.019	0.835CysGly: 0.835 ± 0.026	0.216CysHis: 0.216 ± 0.014	0.464CysIle: 0.464 ± 0.02	0.254CysLys: 0.254 ± 0.016	0.751CysLeu: 0.751 ± 0.025	0.176CysMet: 0.176 ± 0.013	0.228CysAsn: 0.228 ± 0.013	0.342CysPro: 0.342 ± 0.02	0.203CysGln: 0.203 ± 0.015	0.472CysArg: 0.472 ± 0.02	0.491CysSer: 0.491 ± 0.019	0.4CysThr: 0.4 ± 0.018	0.552CysVal: 0.552 ± 0.023	0.095CysTrp: 0.095 ± 0.009	0.196CysTyr: 0.196 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.116AspAla: 6.116 ± 0.097	0.472AspCys: 0.472 ± 0.02	3.075AspAsp: 3.075 ± 0.06	3.695AspGlu: 3.695 ± 0.057	2.357AspPhe: 2.357 ± 0.043	4.676AspGly: 4.676 ± 0.066	1.233AspHis: 1.233 ± 0.035	3.603AspIle: 3.603 ± 0.056	2.366AspLys: 2.366 ± 0.048	5.394AspLeu: 5.394 ± 0.064	1.509AspMet: 1.509 ± 0.039	1.849AspAsn: 1.849 ± 0.042	2.814AspPro: 2.814 ± 0.05	1.796AspGln: 1.796 ± 0.037	3.625AspArg: 3.625 ± 0.057	2.218AspSer: 2.218 ± 0.044	2.63AspThr: 2.63 ± 0.046	4.082AspVal: 4.082 ± 0.064	0.891AspTrp: 0.891 ± 0.026	1.629AspTyr: 1.629 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	6.725GluAla: 6.725 ± 0.08	0.357GluCys: 0.357 ± 0.018	2.89GluAsp: 2.89 ± 0.053	3.504GluGlu: 3.504 ± 0.071	1.907GluPhe: 1.907 ± 0.039	4.003GluGly: 4.003 ± 0.062	1.217GluHis: 1.217 ± 0.032	3.913GluIle: 3.913 ± 0.056	3.315GluLys: 3.315 ± 0.063	5.593GluLeu: 5.593 ± 0.081	1.593GluMet: 1.593 ± 0.039	2.318GluAsn: 2.318 ± 0.045	2.485GluPro: 2.485 ± 0.056	2.33GluGln: 2.33 ± 0.047	4.407GluArg: 4.407 ± 0.064	2.517GluSer: 2.517 ± 0.048	3.572GluThr: 3.572 ± 0.053	3.709GluVal: 3.709 ± 0.058	0.722GluTrp: 0.722 ± 0.024	1.188GluTyr: 1.188 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.503PheAla: 4.503 ± 0.07	0.4PheCys: 0.4 ± 0.016	2.738PheAsp: 2.738 ± 0.042	2.257PheGlu: 2.257 ± 0.038	1.699PhePhe: 1.699 ± 0.047	3.698PheGly: 3.698 ± 0.06	0.797PheHis: 0.797 ± 0.025	2.389PheIle: 2.389 ± 0.048	1.457PheLys: 1.457 ± 0.035	3.648PheLeu: 3.648 ± 0.06	0.99PheMet: 0.99 ± 0.031	1.465PheAsn: 1.465 ± 0.038	1.634PhePro: 1.634 ± 0.037	1.111PheGln: 1.111 ± 0.035	2.166PheArg: 2.166 ± 0.039	2.91PheSer: 2.91 ± 0.053	2.136PheThr: 2.136 ± 0.043	2.942PheVal: 2.942 ± 0.048	0.605PheTrp: 0.605 ± 0.023	1.094PheTyr: 1.094 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	7.659GlyAla: 7.659 ± 0.084	0.707GlyCys: 0.707 ± 0.026	4.077GlyAsp: 4.077 ± 0.065	4.458GlyGlu: 4.458 ± 0.062	3.761GlyPhe: 3.761 ± 0.062	6.475GlyGly: 6.475 ± 0.101	1.772GlyHis: 1.772 ± 0.043	5.356GlyIle: 5.356 ± 0.068	4.12GlyLys: 4.12 ± 0.062	8.241GlyLeu: 8.241 ± 0.086	2.194GlyMet: 2.194 ± 0.045	2.633GlyAsn: 2.633 ± 0.051	2.782GlyPro: 2.782 ± 0.049	2.666GlyGln: 2.666 ± 0.057	4.746GlyArg: 4.746 ± 0.06	4.903GlySer: 4.903 ± 0.079	4.387GlyThr: 4.387 ± 0.072	5.859GlyVal: 5.859 ± 0.073	1.21GlyTrp: 1.21 ± 0.035	2.395GlyTyr: 2.395 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.043HisAla: 2.043 ± 0.045	0.204HisCys: 0.204 ± 0.012	1.217HisAsp: 1.217 ± 0.033	1.177HisGlu: 1.177 ± 0.034	0.886HisPhe: 0.886 ± 0.031	1.715HisGly: 1.715 ± 0.04	0.555HisHis: 0.555 ± 0.027	1.26HisIle: 1.26 ± 0.031	0.732HisLys: 0.732 ± 0.025	1.973HisLeu: 1.973 ± 0.036	0.546HisMet: 0.546 ± 0.021	0.635HisAsn: 0.635 ± 0.023	1.129HisPro: 1.129 ± 0.029	0.612HisGln: 0.612 ± 0.021	1.217HisArg: 1.217 ± 0.033	1.089HisSer: 1.089 ± 0.029	0.835HisThr: 0.835 ± 0.024	1.468HisVal: 1.468 ± 0.033	0.284HisTrp: 0.284 ± 0.017	0.606HisTyr: 0.606 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	8.036IleAla: 8.036 ± 0.088	0.646IleCys: 0.646 ± 0.026	4.004IleAsp: 4.004 ± 0.055	4.213IleGlu: 4.213 ± 0.059	2.317IlePhe: 2.317 ± 0.048	5.693IleGly: 5.693 ± 0.069	1.119IleHis: 1.119 ± 0.028	3.755IleIle: 3.755 ± 0.061	2.302IleLys: 2.302 ± 0.044	5.47IleLeu: 5.47 ± 0.072	1.394IleMet: 1.394 ± 0.03	2.18IleAsn: 2.18 ± 0.043	2.614IlePro: 2.614 ± 0.043	1.527IleGln: 1.527 ± 0.037	3.42IleArg: 3.42 ± 0.053	3.95IleSer: 3.95 ± 0.064	3.283IleThr: 3.283 ± 0.046	4.905IleVal: 4.905 ± 0.067	0.714IleTrp: 0.714 ± 0.025	1.448IleTyr: 1.448 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	5.067LysAla: 5.067 ± 0.068	0.187LysCys: 0.187 ± 0.013	2.332LysAsp: 2.332 ± 0.052	2.199LysGlu: 2.199 ± 0.053	1.246LysPhe: 1.246 ± 0.037	3.198LysGly: 3.198 ± 0.051	0.829LysHis: 0.829 ± 0.027	2.633LysIle: 2.633 ± 0.05	2.093LysLys: 2.093 ± 0.046	4.576LysLeu: 4.576 ± 0.061	1.145LysMet: 1.145 ± 0.03	1.546LysAsn: 1.546 ± 0.039	2.529LysPro: 2.529 ± 0.051	1.479LysGln: 1.479 ± 0.029	3.013LysArg: 3.013 ± 0.049	2.756LysSer: 2.756 ± 0.047	2.62LysThr: 2.62 ± 0.048	2.778LysVal: 2.778 ± 0.045	0.447LysTrp: 0.447 ± 0.019	0.843LysTyr: 0.843 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.236LeuAla: 11.236 ± 0.093	0.845LeuCys: 0.845 ± 0.027	5.607LeuAsp: 5.607 ± 0.065	5.394LeuGlu: 5.394 ± 0.069	3.869LeuPhe: 3.869 ± 0.074	7.828LeuGly: 7.828 ± 0.097	1.801LeuHis: 1.801 ± 0.037	6.157LeuIle: 6.157 ± 0.082	4.613LeuLys: 4.613 ± 0.066	9.202LeuLeu: 9.202 ± 0.121	2.57LeuMet: 2.57 ± 0.048	3.357LeuAsn: 3.357 ± 0.052	5.051LeuPro: 5.051 ± 0.06	2.875LeuGln: 2.875 ± 0.051	5.737LeuArg: 5.737 ± 0.066	7.176LeuSer: 7.176 ± 0.083	5.606LeuThr: 5.606 ± 0.067	6.907LeuVal: 6.907 ± 0.087	0.999LeuTrp: 0.999 ± 0.032	2.291LeuTyr: 2.291 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.774MetAla: 2.774 ± 0.053	0.168MetCys: 0.168 ± 0.011	1.169MetAsp: 1.169 ± 0.03	1.228MetGlu: 1.228 ± 0.035	0.817MetPhe: 0.817 ± 0.027	1.857MetGly: 1.857 ± 0.037	0.453MetHis: 0.453 ± 0.018	1.673MetIle: 1.673 ± 0.036	1.256MetLys: 1.256 ± 0.036	2.678MetLeu: 2.678 ± 0.053	0.73MetMet: 0.73 ± 0.03	0.957MetAsn: 0.957 ± 0.028	1.455MetPro: 1.455 ± 0.034	1.008MetGln: 1.008 ± 0.028	1.935MetArg: 1.935 ± 0.039	1.93MetSer: 1.93 ± 0.037	1.823MetThr: 1.823 ± 0.039	1.723MetVal: 1.723 ± 0.037	0.225MetTrp: 0.225 ± 0.014	0.312MetTyr: 0.312 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.749AsnAla: 3.749 ± 0.053	0.267AsnCys: 0.267 ± 0.016	1.871AsnAsp: 1.871 ± 0.041	1.759AsnGlu: 1.759 ± 0.041	1.308AsnPhe: 1.308 ± 0.038	3.027AsnGly: 3.027 ± 0.054	0.647AsnHis: 0.647 ± 0.022	2.096AsnIle: 2.096 ± 0.036	1.218AsnLys: 1.218 ± 0.033	3.099AsnLeu: 3.099 ± 0.052	0.877AsnMet: 0.877 ± 0.029	1.158AsnAsn: 1.158 ± 0.034	2.09AsnPro: 2.09 ± 0.045	1.043AsnGln: 1.043 ± 0.03	2.098AsnArg: 2.098 ± 0.04	1.856AsnSer: 1.856 ± 0.045	1.567AsnThr: 1.567 ± 0.037	2.43AsnVal: 2.43 ± 0.046	0.542AsnTrp: 0.542 ± 0.021	0.907AsnTyr: 0.907 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.68ProAla: 4.68 ± 0.068	0.279ProCys: 0.279 ± 0.017	3.188ProAsp: 3.188 ± 0.052	3.459ProGlu: 3.459 ± 0.052	2.053ProPhe: 2.053 ± 0.043	3.416ProGly: 3.416 ± 0.049	1.03ProHis: 1.03 ± 0.029	2.536ProIle: 2.536 ± 0.045	1.965ProLys: 1.965 ± 0.042	4.378ProLeu: 4.378 ± 0.062	1.015ProMet: 1.015 ± 0.027	1.506ProAsn: 1.506 ± 0.038	1.684ProPro: 1.684 ± 0.043	1.769ProGln: 1.769 ± 0.038	2.203ProArg: 2.203 ± 0.045	2.719ProSer: 2.719 ± 0.05	2.284ProThr: 2.284 ± 0.043	3.977ProVal: 3.977 ± 0.061	0.582ProTrp: 0.582 ± 0.023	1.201ProTyr: 1.201 ± 0.03	0.001ProXaa: 0.001 ± 0.001
Gln	3.703GlnAla: 3.703 ± 0.065	0.184GlnCys: 0.184 ± 0.011	1.529GlnAsp: 1.529 ± 0.036	1.572GlnGlu: 1.572 ± 0.034	1.293GlnPhe: 1.293 ± 0.029	2.217GlnGly: 2.217 ± 0.045	0.686GlnHis: 0.686 ± 0.023	2.12GlnIle: 2.12 ± 0.036	1.609GlnLys: 1.609 ± 0.032	3.046GlnLeu: 3.046 ± 0.054	0.969GlnMet: 0.969 ± 0.031	1.194GlnAsn: 1.194 ± 0.03	1.64GlnPro: 1.64 ± 0.039	1.347GlnGln: 1.347 ± 0.04	2.29GlnArg: 2.29 ± 0.051	2.258GlnSer: 2.258 ± 0.04	1.839GlnThr: 1.839 ± 0.037	2.134GlnVal: 2.134 ± 0.039	0.409GlnTrp: 0.409 ± 0.018	0.729GlnTyr: 0.729 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	5.812ArgAla: 5.812 ± 0.077	0.397ArgCys: 0.397 ± 0.019	3.578ArgAsp: 3.578 ± 0.058	3.827ArgGlu: 3.827 ± 0.058	2.817ArgPhe: 2.817 ± 0.052	3.992ArgGly: 3.992 ± 0.06	1.419ArgHis: 1.419 ± 0.039	4.024ArgIle: 4.024 ± 0.06	2.763ArgLys: 2.763 ± 0.051	6.467ArgLeu: 6.467 ± 0.078	1.659ArgMet: 1.659 ± 0.035	2.148ArgAsn: 2.148 ± 0.043	2.674ArgPro: 2.674 ± 0.052	2.301ArgGln: 2.301 ± 0.047	4.049ArgArg: 4.049 ± 0.069	3.549ArgSer: 3.549 ± 0.063	2.914ArgThr: 2.914 ± 0.049	4.042ArgVal: 4.042 ± 0.059	0.811ArgTrp: 0.811 ± 0.026	1.717ArgTyr: 1.717 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.249SerAla: 6.249 ± 0.072	0.416SerCys: 0.416 ± 0.021	3.448SerAsp: 3.448 ± 0.056	3.387SerGlu: 3.387 ± 0.058	2.814SerPhe: 2.814 ± 0.048	5.997SerGly: 5.997 ± 0.083	1.222SerHis: 1.222 ± 0.034	3.727SerIle: 3.727 ± 0.055	2.415SerLys: 2.415 ± 0.05	5.912SerLeu: 5.912 ± 0.076	1.552SerMet: 1.552 ± 0.033	1.937SerAsn: 1.937 ± 0.036	2.604SerPro: 2.604 ± 0.047	1.932SerGln: 1.932 ± 0.038	3.54SerArg: 3.54 ± 0.057	3.609SerSer: 3.609 ± 0.061	3.001SerThr: 3.001 ± 0.053	4.498SerVal: 4.498 ± 0.068	0.778SerTrp: 0.778 ± 0.024	1.573SerTyr: 1.573 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.655ThrAla: 5.655 ± 0.067	0.403ThrCys: 0.403 ± 0.019	2.842ThrAsp: 2.842 ± 0.049	2.774ThrGlu: 2.774 ± 0.053	2.09ThrPhe: 2.09 ± 0.043	4.815ThrGly: 4.815 ± 0.069	1.047ThrHis: 1.047 ± 0.031	3.57ThrIle: 3.57 ± 0.057	1.9ThrLys: 1.9 ± 0.038	5.696ThrLeu: 5.696 ± 0.072	1.241ThrMet: 1.241 ± 0.031	1.574ThrAsn: 1.574 ± 0.039	3.01ThrPro: 3.01 ± 0.048	1.51ThrGln: 1.51 ± 0.035	2.931ThrArg: 2.931 ± 0.044	3.138ThrSer: 3.138 ± 0.054	2.897ThrThr: 2.897 ± 0.052	4.268ThrVal: 4.268 ± 0.06	0.583ThrTrp: 0.583 ± 0.021	1.344ThrTyr: 1.344 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	7.864ValAla: 7.864 ± 0.08	0.571ValCys: 0.571 ± 0.02	3.865ValAsp: 3.865 ± 0.054	4.478ValGlu: 4.478 ± 0.062	2.957ValPhe: 2.957 ± 0.047	5.169ValGly: 5.169 ± 0.072	1.295ValHis: 1.295 ± 0.034	4.574ValIle: 4.574 ± 0.069	2.872ValLys: 2.872 ± 0.047	7.305ValLeu: 7.305 ± 0.081	1.908ValMet: 1.908 ± 0.038	2.27ValAsn: 2.27 ± 0.045	3.335ValPro: 3.335 ± 0.054	2.117ValGln: 2.117 ± 0.041	4.161ValArg: 4.161 ± 0.057	4.881ValSer: 4.881 ± 0.065	4.282ValThr: 4.282 ± 0.055	5.403ValVal: 5.403 ± 0.075	0.807ValTrp: 0.807 ± 0.026	1.549ValTyr: 1.549 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.045TrpAla: 1.045 ± 0.028	0.131TrpCys: 0.131 ± 0.011	0.602TrpAsp: 0.602 ± 0.023	0.513TrpGlu: 0.513 ± 0.019	0.548TrpPhe: 0.548 ± 0.024	0.835TrpGly: 0.835 ± 0.03	0.3TrpHis: 0.3 ± 0.017	0.686TrpIle: 0.686 ± 0.025	0.563TrpLys: 0.563 ± 0.021	1.54TrpLeu: 1.54 ± 0.04	0.345TrpMet: 0.345 ± 0.017	0.526TrpAsn: 0.526 ± 0.02	0.612TrpPro: 0.612 ± 0.023	0.582TrpGln: 0.582 ± 0.02	0.918TrpArg: 0.918 ± 0.03	0.825TrpSer: 0.825 ± 0.027	0.663TrpThr: 0.663 ± 0.025	0.736TrpVal: 0.736 ± 0.027	0.205TrpTrp: 0.205 ± 0.012	0.31TrpTyr: 0.31 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.516TyrAla: 2.516 ± 0.045	0.257TyrCys: 0.257 ± 0.014	1.557TyrAsp: 1.557 ± 0.033	1.381TyrGlu: 1.381 ± 0.033	1.088TyrPhe: 1.088 ± 0.029	2.201TyrGly: 2.201 ± 0.042	0.497TyrHis: 0.497 ± 0.021	1.185TyrIle: 1.185 ± 0.031	0.895TyrLys: 0.895 ± 0.027	2.455TyrLeu: 2.455 ± 0.049	0.554TyrMet: 0.554 ± 0.021	0.847TyrAsn: 0.847 ± 0.027	1.124TyrPro: 1.124 ± 0.034	0.846TyrGln: 0.846 ± 0.028	1.669TyrArg: 1.669 ± 0.04	1.493TyrSer: 1.493 ± 0.037	1.245TyrThr: 1.245 ± 0.029	1.726TyrVal: 1.726 ± 0.042	0.364TyrTrp: 0.364 ± 0.017	0.689TyrTyr: 0.689 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4365 proteins (1258635 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---