Amino acid dipepetide frequency for Brachybacterium endophyticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.423AlaAla: 17.423 ± 0.187	0.75AlaCys: 0.75 ± 0.026	8.405AlaAsp: 8.405 ± 0.119	8.004AlaGlu: 8.004 ± 0.095	3.342AlaPhe: 3.342 ± 0.06	11.744AlaGly: 11.744 ± 0.117	2.655AlaHis: 2.655 ± 0.053	5.032AlaIle: 5.032 ± 0.078	2.312AlaLys: 2.312 ± 0.059	13.993AlaLeu: 13.993 ± 0.162	2.695AlaMet: 2.695 ± 0.057	1.768AlaAsn: 1.768 ± 0.045	6.961AlaPro: 6.961 ± 0.099	3.971AlaGln: 3.971 ± 0.069	9.928AlaArg: 9.928 ± 0.109	7.259AlaSer: 7.259 ± 0.088	6.578AlaThr: 6.578 ± 0.08	10.274AlaVal: 10.274 ± 0.117	1.644AlaTrp: 1.644 ± 0.041	2.028AlaTyr: 2.028 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.732CysAla: 0.732 ± 0.029	0.057CysCys: 0.057 ± 0.007	0.311CysAsp: 0.311 ± 0.017	0.357CysGlu: 0.357 ± 0.019	0.174CysPhe: 0.174 ± 0.014	0.659CysGly: 0.659 ± 0.025	0.13CysHis: 0.13 ± 0.011	0.204CysIle: 0.204 ± 0.014	0.066CysLys: 0.066 ± 0.008	0.511CysLeu: 0.511 ± 0.023	0.081CysMet: 0.081 ± 0.009	0.096CysAsn: 0.096 ± 0.01	0.34CysPro: 0.34 ± 0.02	0.109CysGln: 0.109 ± 0.01	0.411CysArg: 0.411 ± 0.018	0.355CysSer: 0.355 ± 0.019	0.376CysThr: 0.376 ± 0.02	0.436CysVal: 0.436 ± 0.021	0.095CysTrp: 0.095 ± 0.01	0.123CysTyr: 0.123 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.569AspAla: 8.569 ± 0.113	0.287AspCys: 0.287 ± 0.018	3.864AspAsp: 3.864 ± 0.073	4.542AspGlu: 4.542 ± 0.068	1.485AspPhe: 1.485 ± 0.04	6.441AspGly: 6.441 ± 0.095	1.594AspHis: 1.594 ± 0.044	2.037AspIle: 2.037 ± 0.051	0.922AspLys: 0.922 ± 0.039	7.347AspLeu: 7.347 ± 0.088	1.0AspMet: 1.0 ± 0.036	0.705AspAsn: 0.705 ± 0.024	5.172AspPro: 5.172 ± 0.086	1.906AspGln: 1.906 ± 0.041	4.599AspArg: 4.599 ± 0.071	3.027AspSer: 3.027 ± 0.058	2.913AspThr: 2.913 ± 0.054	5.793AspVal: 5.793 ± 0.079	0.927AspTrp: 0.927 ± 0.032	1.111AspTyr: 1.111 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.491GluAla: 7.491 ± 0.09	0.265GluCys: 0.265 ± 0.017	4.839GluAsp: 4.839 ± 0.084	4.057GluGlu: 4.057 ± 0.08	1.517GluPhe: 1.517 ± 0.042	5.272GluGly: 5.272 ± 0.071	1.88GluHis: 1.88 ± 0.046	2.755GluIle: 2.755 ± 0.049	1.767GluLys: 1.767 ± 0.053	6.058GluLeu: 6.058 ± 0.094	1.089GluMet: 1.089 ± 0.033	1.366GluAsn: 1.366 ± 0.037	2.89GluPro: 2.89 ± 0.053	2.802GluGln: 2.802 ± 0.061	5.434GluArg: 5.434 ± 0.088	3.241GluSer: 3.241 ± 0.054	3.106GluThr: 3.106 ± 0.059	4.957GluVal: 4.957 ± 0.074	0.685GluTrp: 0.685 ± 0.022	1.098GluTyr: 1.098 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.627PheAla: 3.627 ± 0.062	0.197PheCys: 0.197 ± 0.013	2.043PheAsp: 2.043 ± 0.045	1.627PheGlu: 1.627 ± 0.045	0.998PhePhe: 0.998 ± 0.042	2.916PheGly: 2.916 ± 0.061	0.601PheHis: 0.601 ± 0.027	0.92PheIle: 0.92 ± 0.033	0.358PheLys: 0.358 ± 0.022	2.797PheLeu: 2.797 ± 0.066	0.467PheMet: 0.467 ± 0.021	0.51PheAsn: 0.51 ± 0.022	1.392PhePro: 1.392 ± 0.041	0.663PheGln: 0.663 ± 0.027	1.693PheArg: 1.693 ± 0.045	1.798PheSer: 1.798 ± 0.047	1.955PheThr: 1.955 ± 0.04	2.501PheVal: 2.501 ± 0.054	0.456PheTrp: 0.456 ± 0.019	0.592PheTyr: 0.592 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	11.371GlyAla: 11.371 ± 0.128	0.569GlyCys: 0.569 ± 0.022	5.146GlyAsp: 5.146 ± 0.087	5.644GlyGlu: 5.644 ± 0.082	2.883GlyPhe: 2.883 ± 0.054	8.442GlyGly: 8.442 ± 0.122	2.058GlyHis: 2.058 ± 0.04	4.535GlyIle: 4.535 ± 0.07	2.209GlyLys: 2.209 ± 0.057	8.864GlyLeu: 8.864 ± 0.113	2.075GlyMet: 2.075 ± 0.042	1.517GlyAsn: 1.517 ± 0.036	4.667GlyPro: 4.667 ± 0.071	2.536GlyGln: 2.536 ± 0.061	7.285GlyArg: 7.285 ± 0.094	6.486GlySer: 6.486 ± 0.096	6.18GlyThr: 6.18 ± 0.087	7.167GlyVal: 7.167 ± 0.092	1.41GlyTrp: 1.41 ± 0.04	1.986GlyTyr: 1.986 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.595HisAla: 2.595 ± 0.056	0.142HisCys: 0.142 ± 0.01	1.506HisAsp: 1.506 ± 0.041	1.482HisGlu: 1.482 ± 0.036	0.497HisPhe: 0.497 ± 0.023	2.326HisGly: 2.326 ± 0.05	0.657HisHis: 0.657 ± 0.025	0.595HisIle: 0.595 ± 0.024	0.279HisLys: 0.279 ± 0.017	2.694HisLeu: 2.694 ± 0.051	0.327HisMet: 0.327 ± 0.019	0.3HisAsn: 0.3 ± 0.019	1.589HisPro: 1.589 ± 0.033	0.644HisGln: 0.644 ± 0.029	2.019HisArg: 2.019 ± 0.042	1.033HisSer: 1.033 ± 0.034	1.087HisThr: 1.087 ± 0.032	1.926HisVal: 1.926 ± 0.041	0.309HisTrp: 0.309 ± 0.018	0.406HisTyr: 0.406 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.204IleAla: 6.204 ± 0.101	0.252IleCys: 0.252 ± 0.016	3.14IleAsp: 3.14 ± 0.061	2.661IleGlu: 2.661 ± 0.057	0.984IlePhe: 0.984 ± 0.041	4.545IleGly: 4.545 ± 0.076	0.723IleHis: 0.723 ± 0.028	1.56IleIle: 1.56 ± 0.052	0.592IleLys: 0.592 ± 0.026	3.542IleLeu: 3.542 ± 0.071	0.647IleMet: 0.647 ± 0.027	0.647IleAsn: 0.647 ± 0.025	2.366IlePro: 2.366 ± 0.044	0.912IleGln: 0.912 ± 0.027	2.405IleArg: 2.405 ± 0.046	2.454IleSer: 2.454 ± 0.046	2.718IleThr: 2.718 ± 0.052	3.711IleVal: 3.711 ± 0.07	0.476IleTrp: 0.476 ± 0.023	0.645IleTyr: 0.645 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	2.156LysAla: 2.156 ± 0.057	0.068LysCys: 0.068 ± 0.007	1.526LysAsp: 1.526 ± 0.051	1.057LysGlu: 1.057 ± 0.042	0.371LysPhe: 0.371 ± 0.021	1.738LysGly: 1.738 ± 0.052	0.404LysHis: 0.404 ± 0.022	0.862LysIle: 0.862 ± 0.032	0.903LysLys: 0.903 ± 0.043	1.516LysLeu: 1.516 ± 0.044	0.365LysMet: 0.365 ± 0.021	0.511LysAsn: 0.511 ± 0.026	1.01LysPro: 1.01 ± 0.04	0.597LysGln: 0.597 ± 0.025	1.187LysArg: 1.187 ± 0.042	1.08LysSer: 1.08 ± 0.037	1.11LysThr: 1.11 ± 0.04	1.591LysVal: 1.591 ± 0.053	0.193LysTrp: 0.193 ± 0.015	0.399LysTyr: 0.399 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.092LeuAla: 14.092 ± 0.153	0.609LeuCys: 0.609 ± 0.028	6.725LeuAsp: 6.725 ± 0.088	6.543LeuGlu: 6.543 ± 0.076	2.707LeuPhe: 2.707 ± 0.063	9.514LeuGly: 9.514 ± 0.114	2.271LeuHis: 2.271 ± 0.053	3.856LeuIle: 3.856 ± 0.082	1.429LeuLys: 1.429 ± 0.044	11.022LeuLeu: 11.022 ± 0.155	1.832LeuMet: 1.832 ± 0.044	1.474LeuAsn: 1.474 ± 0.042	5.972LeuPro: 5.972 ± 0.087	2.683LeuGln: 2.683 ± 0.048	8.002LeuArg: 8.002 ± 0.097	5.639LeuSer: 5.639 ± 0.081	6.119LeuThr: 6.119 ± 0.084	9.407LeuVal: 9.407 ± 0.118	1.22LeuTrp: 1.22 ± 0.038	1.508LeuTyr: 1.508 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.033MetAla: 2.033 ± 0.046	0.118MetCys: 0.118 ± 0.01	1.07MetAsp: 1.07 ± 0.034	0.788MetGlu: 0.788 ± 0.027	0.592MetPhe: 0.592 ± 0.025	1.506MetGly: 1.506 ± 0.043	0.405MetHis: 0.405 ± 0.02	0.995MetIle: 0.995 ± 0.032	0.398MetLys: 0.398 ± 0.02	2.152MetLeu: 2.152 ± 0.044	0.424MetMet: 0.424 ± 0.02	0.476MetAsn: 0.476 ± 0.022	1.204MetPro: 1.204 ± 0.035	0.513MetGln: 0.513 ± 0.022	1.479MetArg: 1.479 ± 0.034	1.575MetSer: 1.575 ± 0.036	1.594MetThr: 1.594 ± 0.033	1.491MetVal: 1.491 ± 0.034	0.233MetTrp: 0.233 ± 0.015	0.322MetTyr: 0.322 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.037AsnAla: 2.037 ± 0.044	0.102AsnCys: 0.102 ± 0.011	0.966AsnAsp: 0.966 ± 0.038	0.805AsnGlu: 0.805 ± 0.029	0.489AsnPhe: 0.489 ± 0.027	1.524AsnGly: 1.524 ± 0.044	0.361AsnHis: 0.361 ± 0.02	0.733AsnIle: 0.733 ± 0.028	0.31AsnLys: 0.31 ± 0.017	1.689AsnLeu: 1.689 ± 0.043	0.319AsnMet: 0.319 ± 0.016	0.339AsnAsn: 0.339 ± 0.019	1.289AsnPro: 1.289 ± 0.036	0.498AsnGln: 0.498 ± 0.02	1.07AsnArg: 1.07 ± 0.03	0.898AsnSer: 0.898 ± 0.027	0.951AsnThr: 0.951 ± 0.029	1.311AsnVal: 1.311 ± 0.044	0.287AsnTrp: 0.287 ± 0.016	0.399AsnTyr: 0.399 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.3ProAla: 7.3 ± 0.101	0.239ProCys: 0.239 ± 0.016	4.034ProAsp: 4.034 ± 0.069	4.405ProGlu: 4.405 ± 0.071	1.695ProPhe: 1.695 ± 0.04	5.63ProGly: 5.63 ± 0.076	1.291ProHis: 1.291 ± 0.036	1.862ProIle: 1.862 ± 0.04	0.894ProLys: 0.894 ± 0.033	5.198ProLeu: 5.198 ± 0.073	1.014ProMet: 1.014 ± 0.03	0.808ProAsn: 0.808 ± 0.034	2.479ProPro: 2.479 ± 0.065	1.764ProGln: 1.764 ± 0.041	4.029ProArg: 4.029 ± 0.073	3.888ProSer: 3.888 ± 0.063	3.536ProThr: 3.536 ± 0.059	4.653ProVal: 4.653 ± 0.074	0.838ProTrp: 0.838 ± 0.029	1.042ProTyr: 1.042 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.462GlnAla: 3.462 ± 0.063	0.126GlnCys: 0.126 ± 0.013	1.854GlnAsp: 1.854 ± 0.045	1.874GlnGlu: 1.874 ± 0.046	0.748GlnPhe: 0.748 ± 0.029	2.616GlnGly: 2.616 ± 0.055	0.66GlnHis: 0.66 ± 0.027	1.447GlnIle: 1.447 ± 0.039	0.766GlnLys: 0.766 ± 0.029	2.974GlnLeu: 2.974 ± 0.055	0.586GlnMet: 0.586 ± 0.024	0.619GlnAsn: 0.619 ± 0.024	1.288GlnPro: 1.288 ± 0.037	1.399GlnGln: 1.399 ± 0.051	2.391GlnArg: 2.391 ± 0.054	1.412GlnSer: 1.412 ± 0.033	1.357GlnThr: 1.357 ± 0.036	2.605GlnVal: 2.605 ± 0.052	0.464GlnTrp: 0.464 ± 0.024	0.597GlnTyr: 0.597 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.235ArgAla: 9.235 ± 0.115	0.407ArgCys: 0.407 ± 0.02	4.239ArgAsp: 4.239 ± 0.075	5.582ArgGlu: 5.582 ± 0.084	2.358ArgPhe: 2.358 ± 0.043	6.146ArgGly: 6.146 ± 0.09	1.71ArgHis: 1.71 ± 0.039	3.761ArgIle: 3.761 ± 0.06	1.205ArgLys: 1.205 ± 0.038	7.222ArgLeu: 7.222 ± 0.104	1.853ArgMet: 1.853 ± 0.038	1.141ArgAsn: 1.141 ± 0.034	4.254ArgPro: 4.254 ± 0.072	1.88ArgGln: 1.88 ± 0.042	7.719ArgArg: 7.719 ± 0.108	5.161ArgSer: 5.161 ± 0.075	5.305ArgThr: 5.305 ± 0.075	5.551ArgVal: 5.551 ± 0.075	1.11ArgTrp: 1.11 ± 0.031	1.378ArgTyr: 1.378 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	7.808SerAla: 7.808 ± 0.103	0.313SerCys: 0.313 ± 0.02	3.414SerAsp: 3.414 ± 0.06	3.218SerGlu: 3.218 ± 0.06	1.909SerPhe: 1.909 ± 0.042	6.348SerGly: 6.348 ± 0.087	1.177SerHis: 1.177 ± 0.036	2.398SerIle: 2.398 ± 0.051	1.149SerLys: 1.149 ± 0.038	5.587SerLeu: 5.587 ± 0.074	1.257SerMet: 1.257 ± 0.034	0.927SerAsn: 0.927 ± 0.034	3.489SerPro: 3.489 ± 0.074	1.602SerGln: 1.602 ± 0.038	4.531SerArg: 4.531 ± 0.078	4.445SerSer: 4.445 ± 0.087	3.961SerThr: 3.961 ± 0.065	4.604SerVal: 4.604 ± 0.069	1.05SerTrp: 1.05 ± 0.036	1.069SerTyr: 1.069 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	7.443ThrAla: 7.443 ± 0.094	0.342ThrCys: 0.342 ± 0.018	3.696ThrAsp: 3.696 ± 0.064	3.236ThrGlu: 3.236 ± 0.058	1.749ThrPhe: 1.749 ± 0.04	5.913ThrGly: 5.913 ± 0.087	1.127ThrHis: 1.127 ± 0.033	2.45ThrIle: 2.45 ± 0.054	1.127ThrLys: 1.127 ± 0.036	5.846ThrLeu: 5.846 ± 0.082	1.07ThrMet: 1.07 ± 0.029	0.998ThrAsn: 0.998 ± 0.033	3.87ThrPro: 3.87 ± 0.055	1.463ThrGln: 1.463 ± 0.036	4.038ThrArg: 4.038 ± 0.066	3.909ThrSer: 3.909 ± 0.066	3.983ThrThr: 3.983 ± 0.07	5.3ThrVal: 5.3 ± 0.062	1.004ThrTrp: 1.004 ± 0.033	1.185ThrTyr: 1.185 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	9.532ValAla: 9.532 ± 0.099	0.576ValCys: 0.576 ± 0.022	5.404ValAsp: 5.404 ± 0.074	4.817ValGlu: 4.817 ± 0.075	2.487ValPhe: 2.487 ± 0.056	6.953ValGly: 6.953 ± 0.097	2.028ValHis: 2.028 ± 0.041	3.926ValIle: 3.926 ± 0.069	1.348ValLys: 1.348 ± 0.04	10.279ValLeu: 10.279 ± 0.134	1.625ValMet: 1.625 ± 0.041	1.464ValAsn: 1.464 ± 0.041	4.806ValPro: 4.806 ± 0.068	2.221ValGln: 2.221 ± 0.041	6.446ValArg: 6.446 ± 0.079	4.594ValSer: 4.594 ± 0.07	5.019ValThr: 5.019 ± 0.08	8.137ValVal: 8.137 ± 0.115	0.987ValTrp: 0.987 ± 0.032	1.32ValTyr: 1.32 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.48TrpAla: 1.48 ± 0.036	0.094TrpCys: 0.094 ± 0.01	0.883TrpAsp: 0.883 ± 0.027	0.77TrpGlu: 0.77 ± 0.025	0.508TrpPhe: 0.508 ± 0.019	1.059TrpGly: 1.059 ± 0.033	0.352TrpHis: 0.352 ± 0.019	0.674TrpIle: 0.674 ± 0.026	0.318TrpLys: 0.318 ± 0.018	1.381TrpLeu: 1.381 ± 0.038	0.339TrpMet: 0.339 ± 0.016	0.405TrpAsn: 0.405 ± 0.024	0.6TrpPro: 0.6 ± 0.024	0.551TrpGln: 0.551 ± 0.02	1.152TrpArg: 1.152 ± 0.038	0.958TrpSer: 0.958 ± 0.029	0.841TrpThr: 0.841 ± 0.027	1.049TrpVal: 1.049 ± 0.034	0.354TrpTrp: 0.354 ± 0.018	0.297TrpTyr: 0.297 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.176TyrAla: 2.176 ± 0.044	0.111TyrCys: 0.111 ± 0.01	1.175TyrAsp: 1.175 ± 0.035	1.101TyrGlu: 1.101 ± 0.033	0.621TyrPhe: 0.621 ± 0.026	1.735TyrGly: 1.735 ± 0.047	0.328TyrHis: 0.328 ± 0.02	0.58TyrIle: 0.58 ± 0.022	0.294TyrLys: 0.294 ± 0.018	1.953TyrLeu: 1.953 ± 0.04	0.301TyrMet: 0.301 ± 0.017	0.308TyrAsn: 0.308 ± 0.018	0.961TyrPro: 0.961 ± 0.029	0.529TyrGln: 0.529 ± 0.026	1.4TyrArg: 1.4 ± 0.04	1.042TyrSer: 1.042 ± 0.03	1.059TyrThr: 1.059 ± 0.037	1.506TyrVal: 1.506 ± 0.038	0.323TyrTrp: 0.323 ± 0.016	0.452TyrTyr: 0.452 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3043 proteins (1043044 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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