Amino acid dipepetide frequency for Paenimaribius caenipelagi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.158AlaAla: 15.158 ± 0.187	1.088AlaCys: 1.088 ± 0.036	6.819AlaAsp: 6.819 ± 0.094	8.688AlaGlu: 8.688 ± 0.112	3.942AlaPhe: 3.942 ± 0.069	10.107AlaGly: 10.107 ± 0.123	2.165AlaHis: 2.165 ± 0.043	5.613AlaIle: 5.613 ± 0.078	3.52AlaLys: 3.52 ± 0.058	13.452AlaLeu: 13.452 ± 0.147	3.484AlaMet: 3.484 ± 0.057	2.569AlaAsn: 2.569 ± 0.055	5.522AlaPro: 5.522 ± 0.097	4.079AlaGln: 4.079 ± 0.07	8.827AlaArg: 8.827 ± 0.098	5.509AlaSer: 5.509 ± 0.083	5.899AlaThr: 5.899 ± 0.087	7.887AlaVal: 7.887 ± 0.113	1.288AlaTrp: 1.288 ± 0.037	2.408AlaTyr: 2.408 ± 0.048	0.001AlaXaa: 0.001 ± 0.001
Cys	1.103CysAla: 1.103 ± 0.034	0.115CysCys: 0.115 ± 0.01	0.678CysAsp: 0.678 ± 0.03	0.519CysGlu: 0.519 ± 0.023	0.335CysPhe: 0.335 ± 0.016	1.01CysGly: 1.01 ± 0.036	0.275CysHis: 0.275 ± 0.018	0.411CysIle: 0.411 ± 0.021	0.208CysLys: 0.208 ± 0.013	0.907CysLeu: 0.907 ± 0.025	0.164CysMet: 0.164 ± 0.013	0.218CysAsn: 0.218 ± 0.013	0.576CysPro: 0.576 ± 0.023	0.282CysGln: 0.282 ± 0.016	0.646CysArg: 0.646 ± 0.027	0.478CysSer: 0.478 ± 0.021	0.464CysThr: 0.464 ± 0.026	0.637CysVal: 0.637 ± 0.032	0.118CysTrp: 0.118 ± 0.009	0.228CysTyr: 0.228 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.296AspAla: 7.296 ± 0.103	0.523AspCys: 0.523 ± 0.026	3.679AspAsp: 3.679 ± 0.109	3.692AspGlu: 3.692 ± 0.064	2.213AspPhe: 2.213 ± 0.047	5.957AspGly: 5.957 ± 0.082	1.422AspHis: 1.422 ± 0.038	2.896AspIle: 2.896 ± 0.054	1.541AspLys: 1.541 ± 0.04	7.152AspLeu: 7.152 ± 0.088	1.597AspMet: 1.597 ± 0.036	1.32AspAsn: 1.32 ± 0.039	3.845AspPro: 3.845 ± 0.062	2.04AspGln: 2.04 ± 0.039	4.786AspArg: 4.786 ± 0.069	2.43AspSer: 2.43 ± 0.078	3.186AspThr: 3.186 ± 0.1	4.397AspVal: 4.397 ± 0.065	1.253AspTrp: 1.253 ± 0.038	1.452AspTyr: 1.452 ± 0.034	0.002AspXaa: 0.002 ± 0.001
Glu	8.457GluAla: 8.457 ± 0.113	0.41GluCys: 0.41 ± 0.018	3.575GluAsp: 3.575 ± 0.067	3.644GluGlu: 3.644 ± 0.058	1.811GluPhe: 1.811 ± 0.043	4.883GluGly: 4.883 ± 0.072	1.185GluHis: 1.185 ± 0.031	4.127GluIle: 4.127 ± 0.058	2.008GluLys: 2.008 ± 0.046	5.399GluLeu: 5.399 ± 0.06	1.841GluMet: 1.841 ± 0.045	1.785GluAsn: 1.785 ± 0.046	2.605GluPro: 2.605 ± 0.053	2.017GluGln: 2.017 ± 0.044	4.826GluArg: 4.826 ± 0.073	2.427GluSer: 2.427 ± 0.043	4.092GluThr: 4.092 ± 0.063	4.39GluVal: 4.39 ± 0.067	0.681GluTrp: 0.681 ± 0.023	1.029GluTyr: 1.029 ± 0.031	0.002GluXaa: 0.002 ± 0.001
Phe	4.103PheAla: 4.103 ± 0.062	0.435PheCys: 0.435 ± 0.023	2.831PheAsp: 2.831 ± 0.061	2.187PheGlu: 2.187 ± 0.049	1.439PhePhe: 1.439 ± 0.045	3.732PheGly: 3.732 ± 0.069	0.732PheHis: 0.732 ± 0.027	1.569PheIle: 1.569 ± 0.046	0.886PheLys: 0.886 ± 0.032	3.309PheLeu: 3.309 ± 0.061	0.747PheMet: 0.747 ± 0.026	0.988PheAsn: 0.988 ± 0.03	1.459PhePro: 1.459 ± 0.036	0.943PheGln: 0.943 ± 0.028	2.241PheArg: 2.241 ± 0.048	2.086PheSer: 2.086 ± 0.041	1.968PheThr: 1.968 ± 0.045	2.635PheVal: 2.635 ± 0.052	0.561PheTrp: 0.561 ± 0.023	0.934PheTyr: 0.934 ± 0.032	0.001PheXaa: 0.001 ± 0.001
Gly	9.587GlyAla: 9.587 ± 0.103	0.873GlyCys: 0.873 ± 0.031	5.293GlyAsp: 5.293 ± 0.132	4.796GlyGlu: 4.796 ± 0.066	3.417GlyPhe: 3.417 ± 0.057	7.807GlyGly: 7.807 ± 0.181	1.922GlyHis: 1.922 ± 0.05	4.513GlyIle: 4.513 ± 0.08	2.989GlyLys: 2.989 ± 0.059	8.966GlyLeu: 8.966 ± 0.114	2.352GlyMet: 2.352 ± 0.05	2.292GlyAsn: 2.292 ± 0.093	3.776GlyPro: 3.776 ± 0.064	3.413GlyGln: 3.413 ± 0.058	6.049GlyArg: 6.049 ± 0.075	4.637GlySer: 4.637 ± 0.08	4.901GlyThr: 4.901 ± 0.081	6.285GlyVal: 6.285 ± 0.086	1.471GlyTrp: 1.471 ± 0.04	2.294GlyTyr: 2.294 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.263HisAla: 2.263 ± 0.049	0.272HisCys: 0.272 ± 0.014	1.278HisAsp: 1.278 ± 0.032	1.098HisGlu: 1.098 ± 0.031	0.76HisPhe: 0.76 ± 0.026	1.842HisGly: 1.842 ± 0.044	0.534HisHis: 0.534 ± 0.023	0.956HisIle: 0.956 ± 0.033	0.552HisLys: 0.552 ± 0.023	2.209HisLeu: 2.209 ± 0.05	0.517HisMet: 0.517 ± 0.022	0.459HisAsn: 0.459 ± 0.02	1.366HisPro: 1.366 ± 0.037	0.589HisGln: 0.589 ± 0.027	1.616HisArg: 1.616 ± 0.04	0.938HisSer: 0.938 ± 0.029	0.832HisThr: 0.832 ± 0.026	1.545HisVal: 1.545 ± 0.039	0.358HisTrp: 0.358 ± 0.019	0.554HisTyr: 0.554 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.662IleAla: 6.662 ± 0.101	0.661IleCys: 0.661 ± 0.025	3.573IleAsp: 3.573 ± 0.065	3.55IleGlu: 3.55 ± 0.059	1.785IlePhe: 1.785 ± 0.044	4.854IleGly: 4.854 ± 0.08	1.01IleHis: 1.01 ± 0.029	2.265IleIle: 2.265 ± 0.056	1.21IleLys: 1.21 ± 0.039	4.828IleLeu: 4.828 ± 0.072	1.063IleMet: 1.063 ± 0.032	1.282IleAsn: 1.282 ± 0.035	2.432IlePro: 2.432 ± 0.05	1.141IleGln: 1.141 ± 0.032	3.668IleArg: 3.668 ± 0.054	3.162IleSer: 3.162 ± 0.059	3.015IleThr: 3.015 ± 0.055	3.622IleVal: 3.622 ± 0.063	0.781IleTrp: 0.781 ± 0.028	1.198IleTyr: 1.198 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.562LysAla: 3.562 ± 0.057	0.2LysCys: 0.2 ± 0.013	1.661LysAsp: 1.661 ± 0.044	1.549LysGlu: 1.549 ± 0.048	0.866LysPhe: 0.866 ± 0.029	2.519LysGly: 2.519 ± 0.052	0.565LysHis: 0.565 ± 0.024	1.797LysIle: 1.797 ± 0.044	1.142LysLys: 1.142 ± 0.047	2.808LysLeu: 2.808 ± 0.056	0.811LysMet: 0.811 ± 0.03	0.755LysAsn: 0.755 ± 0.023	1.675LysPro: 1.675 ± 0.039	0.788LysGln: 0.788 ± 0.025	2.281LysArg: 2.281 ± 0.058	1.784LysSer: 1.784 ± 0.038	1.861LysThr: 1.861 ± 0.04	2.244LysVal: 2.244 ± 0.049	0.379LysTrp: 0.379 ± 0.018	0.656LysTyr: 0.656 ± 0.028	0.002LysXaa: 0.002 ± 0.001
Leu	12.03LeuAla: 12.03 ± 0.118	1.054LeuCys: 1.054 ± 0.033	6.326LeuAsp: 6.326 ± 0.082	5.358LeuGlu: 5.358 ± 0.072	3.492LeuPhe: 3.492 ± 0.058	8.374LeuGly: 8.374 ± 0.092	1.871LeuHis: 1.871 ± 0.043	5.445LeuIle: 5.445 ± 0.081	3.206LeuLys: 3.206 ± 0.052	8.725LeuLeu: 8.725 ± 0.114	2.523LeuMet: 2.523 ± 0.052	2.688LeuAsn: 2.688 ± 0.052	5.559LeuPro: 5.559 ± 0.089	2.625LeuGln: 2.625 ± 0.045	7.467LeuArg: 7.467 ± 0.091	7.082LeuSer: 7.082 ± 0.096	6.471LeuThr: 6.471 ± 0.072	6.675LeuVal: 6.675 ± 0.088	1.335LeuTrp: 1.335 ± 0.038	2.089LeuTyr: 2.089 ± 0.04	0.002LeuXaa: 0.002 ± 0.001
Met	3.368MetAla: 3.368 ± 0.06	0.191MetCys: 0.191 ± 0.012	1.384MetAsp: 1.384 ± 0.039	1.428MetGlu: 1.428 ± 0.038	0.722MetPhe: 0.722 ± 0.026	2.16MetGly: 2.16 ± 0.051	0.392MetHis: 0.392 ± 0.02	1.459MetIle: 1.459 ± 0.043	0.923MetLys: 0.923 ± 0.034	2.388MetLeu: 2.388 ± 0.051	0.671MetMet: 0.671 ± 0.028	0.736MetAsn: 0.736 ± 0.024	1.359MetPro: 1.359 ± 0.033	0.887MetGln: 0.887 ± 0.029	1.855MetArg: 1.855 ± 0.039	1.757MetSer: 1.757 ± 0.036	2.049MetThr: 2.049 ± 0.043	1.786MetVal: 1.786 ± 0.043	0.223MetTrp: 0.223 ± 0.014	0.293MetTyr: 0.293 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.078AsnAla: 3.078 ± 0.058	0.272AsnCys: 0.272 ± 0.018	1.651AsnAsp: 1.651 ± 0.086	1.236AsnGlu: 1.236 ± 0.035	0.999AsnPhe: 0.999 ± 0.033	2.388AsnGly: 2.388 ± 0.052	0.535AsnHis: 0.535 ± 0.023	1.331AsnIle: 1.331 ± 0.041	0.654AsnLys: 0.654 ± 0.026	2.501AsnLeu: 2.501 ± 0.048	0.624AsnMet: 0.624 ± 0.023	0.643AsnAsn: 0.643 ± 0.025	1.789AsnPro: 1.789 ± 0.037	0.672AsnGln: 0.672 ± 0.026	1.82AsnArg: 1.82 ± 0.039	1.204AsnSer: 1.204 ± 0.035	1.311AsnThr: 1.311 ± 0.039	1.791AsnVal: 1.791 ± 0.039	0.404AsnTrp: 0.404 ± 0.019	0.625AsnTyr: 0.625 ± 0.024	0.001AsnXaa: 0.001 ± 0.001
Pro	5.361ProAla: 5.361 ± 0.078	0.397ProCys: 0.397 ± 0.021	4.144ProAsp: 4.144 ± 0.067	4.415ProGlu: 4.415 ± 0.068	1.895ProPhe: 1.895 ± 0.037	4.673ProGly: 4.673 ± 0.072	1.037ProHis: 1.037 ± 0.031	2.207ProIle: 2.207 ± 0.039	1.538ProLys: 1.538 ± 0.039	4.587ProLeu: 4.587 ± 0.077	1.262ProMet: 1.262 ± 0.034	1.357ProAsn: 1.357 ± 0.034	2.317ProPro: 2.317 ± 0.056	1.656ProGln: 1.656 ± 0.042	2.989ProArg: 2.989 ± 0.059	2.681ProSer: 2.681 ± 0.048	2.396ProThr: 2.396 ± 0.053	4.27ProVal: 4.27 ± 0.07	0.689ProTrp: 0.689 ± 0.024	1.089ProTyr: 1.089 ± 0.03	0.001ProXaa: 0.001 ± 0.001
Gln	3.619GlnAla: 3.619 ± 0.061	0.244GlnCys: 0.244 ± 0.015	1.657GlnAsp: 1.657 ± 0.04	1.625GlnGlu: 1.625 ± 0.038	1.052GlnPhe: 1.052 ± 0.031	2.45GlnGly: 2.45 ± 0.044	0.568GlnHis: 0.568 ± 0.022	2.255GlnIle: 2.255 ± 0.048	1.153GlnLys: 1.153 ± 0.034	2.883GlnLeu: 2.883 ± 0.053	0.979GlnMet: 0.979 ± 0.027	0.889GlnAsn: 0.889 ± 0.027	1.581GlnPro: 1.581 ± 0.042	1.098GlnGln: 1.098 ± 0.038	2.347GlnArg: 2.347 ± 0.046	1.948GlnSer: 1.948 ± 0.042	1.939GlnThr: 1.939 ± 0.048	2.29GlnVal: 2.29 ± 0.043	0.401GlnTrp: 0.401 ± 0.02	0.568GlnTyr: 0.568 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.063ArgAla: 8.063 ± 0.096	0.542ArgCys: 0.542 ± 0.021	4.766ArgAsp: 4.766 ± 0.074	4.174ArgGlu: 4.174 ± 0.062	2.764ArgPhe: 2.764 ± 0.048	4.839ArgGly: 4.839 ± 0.069	1.784ArgHis: 1.784 ± 0.045	4.026ArgIle: 4.026 ± 0.058	2.499ArgLys: 2.499 ± 0.055	7.802ArgLeu: 7.802 ± 0.096	2.024ArgMet: 2.024 ± 0.048	1.851ArgAsn: 1.851 ± 0.043	3.58ArgPro: 3.58 ± 0.072	2.703ArgGln: 2.703 ± 0.059	5.586ArgArg: 5.586 ± 0.095	3.704ArgSer: 3.704 ± 0.054	3.196ArgThr: 3.196 ± 0.046	4.849ArgVal: 4.849 ± 0.073	1.026ArgTrp: 1.026 ± 0.032	1.738ArgTyr: 1.738 ± 0.041	0.002ArgXaa: 0.002 ± 0.001
Ser	5.971SerAla: 5.971 ± 0.082	0.493SerCys: 0.493 ± 0.022	3.636SerAsp: 3.636 ± 0.06	3.326SerGlu: 3.326 ± 0.058	2.236SerPhe: 2.236 ± 0.052	5.792SerGly: 5.792 ± 0.109	1.163SerHis: 1.163 ± 0.034	2.386SerIle: 2.386 ± 0.054	1.559SerLys: 1.559 ± 0.034	5.224SerLeu: 5.224 ± 0.071	1.374SerMet: 1.374 ± 0.038	1.439SerAsn: 1.439 ± 0.034	2.668SerPro: 2.668 ± 0.05	1.622SerGln: 1.622 ± 0.04	3.552SerArg: 3.552 ± 0.068	2.737SerSer: 2.737 ± 0.061	2.632SerThr: 2.632 ± 0.051	3.954SerVal: 3.954 ± 0.066	0.751SerTrp: 0.751 ± 0.025	1.4SerTyr: 1.4 ± 0.034	0.002SerXaa: 0.002 ± 0.001
Thr	6.279ThrAla: 6.279 ± 0.088	0.545ThrCys: 0.545 ± 0.024	3.257ThrAsp: 3.257 ± 0.057	3.248ThrGlu: 3.248 ± 0.068	1.92ThrPhe: 1.92 ± 0.043	5.722ThrGly: 5.722 ± 0.078	1.153ThrHis: 1.153 ± 0.034	2.717ThrIle: 2.717 ± 0.064	1.401ThrLys: 1.401 ± 0.038	6.199ThrLeu: 6.199 ± 0.087	1.237ThrMet: 1.237 ± 0.034	1.319ThrAsn: 1.319 ± 0.035	3.474ThrPro: 3.474 ± 0.058	1.545ThrGln: 1.545 ± 0.036	3.753ThrArg: 3.753 ± 0.062	2.849ThrSer: 2.849 ± 0.05	2.922ThrThr: 2.922 ± 0.058	4.287ThrVal: 4.287 ± 0.073	0.646ThrTrp: 0.646 ± 0.023	1.269ThrTyr: 1.269 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.357ValAla: 8.357 ± 0.098	0.629ValCys: 0.629 ± 0.024	4.089ValAsp: 4.089 ± 0.062	4.644ValGlu: 4.644 ± 0.072	2.759ValPhe: 2.759 ± 0.046	5.288ValGly: 5.288 ± 0.072	1.338ValHis: 1.338 ± 0.037	4.151ValIle: 4.151 ± 0.072	1.954ValLys: 1.954 ± 0.05	7.286ValLeu: 7.286 ± 0.094	1.919ValMet: 1.919 ± 0.048	1.893ValAsn: 1.893 ± 0.044	3.616ValPro: 3.616 ± 0.057	2.13ValGln: 2.13 ± 0.043	4.36ValArg: 4.36 ± 0.07	4.361ValSer: 4.361 ± 0.06	4.802ValThr: 4.802 ± 0.074	5.345ValVal: 5.345 ± 0.081	1.018ValTrp: 1.018 ± 0.034	1.43ValTyr: 1.43 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.325TrpAla: 1.325 ± 0.037	0.162TrpCys: 0.162 ± 0.011	0.781TrpAsp: 0.781 ± 0.027	0.645TrpGlu: 0.645 ± 0.025	0.558TrpPhe: 0.558 ± 0.025	0.995TrpGly: 0.995 ± 0.033	0.348TrpHis: 0.348 ± 0.019	0.746TrpIle: 0.746 ± 0.025	0.425TrpLys: 0.425 ± 0.02	1.562TrpLeu: 1.562 ± 0.041	0.374TrpMet: 0.374 ± 0.018	0.429TrpAsn: 0.429 ± 0.02	0.716TrpPro: 0.716 ± 0.023	0.618TrpGln: 0.618 ± 0.026	1.218TrpArg: 1.218 ± 0.035	0.929TrpSer: 0.929 ± 0.025	0.736TrpThr: 0.736 ± 0.029	0.901TrpVal: 0.901 ± 0.03	0.229TrpTrp: 0.229 ± 0.013	0.284TrpTyr: 0.284 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.38TyrAla: 2.38 ± 0.045	0.266TyrCys: 0.266 ± 0.015	1.597TyrAsp: 1.597 ± 0.035	1.371TyrGlu: 1.371 ± 0.034	0.817TyrPhe: 0.817 ± 0.027	2.237TyrGly: 2.237 ± 0.052	0.538TyrHis: 0.538 ± 0.023	0.893TyrIle: 0.893 ± 0.03	0.536TyrLys: 0.536 ± 0.022	2.209TyrLeu: 2.209 ± 0.04	0.47TyrMet: 0.47 ± 0.019	0.616TyrAsn: 0.616 ± 0.022	1.047TyrPro: 1.047 ± 0.032	0.7TyrGln: 0.7 ± 0.026	1.63TyrArg: 1.63 ± 0.041	1.214TyrSer: 1.214 ± 0.039	1.069TyrThr: 1.069 ± 0.034	1.58TyrVal: 1.58 ± 0.037	0.367TyrTrp: 0.367 ± 0.019	0.575TyrTyr: 0.575 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.002XaaAsp: 0.002 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.002XaaPhe: 0.002 ± 0.001	0.001XaaGly: 0.001 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.002XaaGln: 0.002 ± 0.001	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3702 proteins (1141485 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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