Amino acid dipepetide frequency for SAR202 cluster bacterium AC-647-P02_OGT_505m

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.92AlaAla: 6.92 ± 0.171
0.754AlaCys: 0.754 ± 0.042
4.036AlaAsp: 4.036 ± 0.112
4.505AlaGlu: 4.505 ± 0.111
3.012AlaPhe: 3.012 ± 0.096
6.343AlaGly: 6.343 ± 0.138
1.451AlaHis: 1.451 ± 0.062
5.928AlaIle: 5.928 ± 0.127
3.204AlaLys: 3.204 ± 0.089
7.705AlaLeu: 7.705 ± 0.15
2.174AlaMet: 2.174 ± 0.069
2.667AlaAsn: 2.667 ± 0.083
2.84AlaPro: 2.84 ± 0.076
2.03AlaGln: 2.03 ± 0.074
3.725AlaArg: 3.725 ± 0.094
5.558AlaSer: 5.558 ± 0.133
4.247AlaThr: 4.247 ± 0.096
5.94AlaVal: 5.94 ± 0.115
0.81AlaTrp: 0.81 ± 0.043
2.052AlaTyr: 2.052 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.664CysAla: 0.664 ± 0.04
0.105CysCys: 0.105 ± 0.017
0.554CysAsp: 0.554 ± 0.038
0.625CysGlu: 0.625 ± 0.04
0.382CysPhe: 0.382 ± 0.027
0.99CysGly: 0.99 ± 0.052
0.248CysHis: 0.248 ± 0.028
0.532CysIle: 0.532 ± 0.04
0.345CysLys: 0.345 ± 0.028
0.795CysLeu: 0.795 ± 0.047
0.204CysMet: 0.204 ± 0.024
0.328CysAsn: 0.328 ± 0.028
0.462CysPro: 0.462 ± 0.035
0.27CysGln: 0.27 ± 0.024
0.416CysArg: 0.416 ± 0.032
0.742CysSer: 0.742 ± 0.037
0.452CysThr: 0.452 ± 0.033
0.649CysVal: 0.649 ± 0.039
0.092CysTrp: 0.092 ± 0.015
0.226CysTyr: 0.226 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.858AspAla: 3.858 ± 0.106
0.506AspCys: 0.506 ± 0.038
2.981AspAsp: 2.981 ± 0.095
4.058AspGlu: 4.058 ± 0.125
2.524AspPhe: 2.524 ± 0.08
4.602AspGly: 4.602 ± 0.122
1.284AspHis: 1.284 ± 0.052
4.639AspIle: 4.639 ± 0.11
2.349AspLys: 2.349 ± 0.082
5.782AspLeu: 5.782 ± 0.133
1.663AspMet: 1.663 ± 0.074
2.023AspAsn: 2.023 ± 0.057
3.124AspPro: 3.124 ± 0.096
1.892AspGln: 1.892 ± 0.064
3.19AspArg: 3.19 ± 0.069
4.308AspSer: 4.308 ± 0.104
2.733AspThr: 2.733 ± 0.084
4.495AspVal: 4.495 ± 0.126
1.009AspTrp: 1.009 ± 0.05
2.001AspTyr: 2.001 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
4.989GluAla: 4.989 ± 0.125
0.525GluCys: 0.525 ± 0.034
3.822GluAsp: 3.822 ± 0.127
5.074GluGlu: 5.074 ± 0.142
2.492GluPhe: 2.492 ± 0.081
5.05GluGly: 5.05 ± 0.132
1.357GluHis: 1.357 ± 0.062
5.174GluIle: 5.174 ± 0.109
3.248GluLys: 3.248 ± 0.078
5.767GluLeu: 5.767 ± 0.128
1.848GluMet: 1.848 ± 0.071
3.304GluAsn: 3.304 ± 0.084
2.256GluPro: 2.256 ± 0.077
1.901GluGln: 1.901 ± 0.069
3.292GluArg: 3.292 ± 0.086
4.753GluSer: 4.753 ± 0.11
3.608GluThr: 3.608 ± 0.102
4.5GluVal: 4.5 ± 0.128
0.907GluTrp: 0.907 ± 0.05
2.118GluTyr: 2.118 ± 0.076
0.0GluXaa: 0.0 ± 0.0
Phe
2.969PheAla: 2.969 ± 0.093
0.457PheCys: 0.457 ± 0.04
2.779PheAsp: 2.779 ± 0.072
2.436PheGlu: 2.436 ± 0.088
1.61PhePhe: 1.61 ± 0.081
3.63PheGly: 3.63 ± 0.104
0.841PheHis: 0.841 ± 0.048
2.67PheIle: 2.67 ± 0.107
1.422PheLys: 1.422 ± 0.059
3.754PheLeu: 3.754 ± 0.139
1.048PheMet: 1.048 ± 0.049
1.505PheAsn: 1.505 ± 0.06
1.811PhePro: 1.811 ± 0.066
1.218PheGln: 1.218 ± 0.048
1.982PheArg: 1.982 ± 0.068
3.039PheSer: 3.039 ± 0.087
2.242PheThr: 2.242 ± 0.077
2.815PheVal: 2.815 ± 0.092
0.608PheTrp: 0.608 ± 0.043
1.177PheTyr: 1.177 ± 0.056
0.0PheXaa: 0.0 ± 0.0
Gly
6.292GlyAla: 6.292 ± 0.13
0.793GlyCys: 0.793 ± 0.046
4.313GlyAsp: 4.313 ± 0.128
4.938GlyGlu: 4.938 ± 0.136
3.941GlyPhe: 3.941 ± 0.108
6.684GlyGly: 6.684 ± 0.156
1.799GlyHis: 1.799 ± 0.074
6.868GlyIle: 6.868 ± 0.126
4.053GlyLys: 4.053 ± 0.111
7.539GlyLeu: 7.539 ± 0.152
2.502GlyMet: 2.502 ± 0.077
3.185GlyAsn: 3.185 ± 0.095
3.314GlyPro: 3.314 ± 0.093
2.492GlyGln: 2.492 ± 0.084
4.289GlyArg: 4.289 ± 0.127
6.132GlySer: 6.132 ± 0.135
4.838GlyThr: 4.838 ± 0.098
6.312GlyVal: 6.312 ± 0.14
1.437GlyTrp: 1.437 ± 0.062
2.638GlyTyr: 2.638 ± 0.083
0.0GlyXaa: 0.0 ± 0.0
His
1.225HisAla: 1.225 ± 0.055
0.238HisCys: 0.238 ± 0.024
1.043HisAsp: 1.043 ± 0.054
1.084HisGlu: 1.084 ± 0.054
0.87HisPhe: 0.87 ± 0.053
1.802HisGly: 1.802 ± 0.067
0.53HisHis: 0.53 ± 0.036
1.454HisIle: 1.454 ± 0.055
0.761HisLys: 0.761 ± 0.037
1.967HisLeu: 1.967 ± 0.073
0.552HisMet: 0.552 ± 0.04
0.788HisAsn: 0.788 ± 0.045
1.488HisPro: 1.488 ± 0.065
0.618HisGln: 0.618 ± 0.038
1.055HisArg: 1.055 ± 0.05
1.537HisSer: 1.537 ± 0.056
1.104HisThr: 1.104 ± 0.056
1.223HisVal: 1.223 ± 0.058
0.299HisTrp: 0.299 ± 0.028
0.581HisTyr: 0.581 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
6.088IleAla: 6.088 ± 0.135
0.79IleCys: 0.79 ± 0.044
4.656IleAsp: 4.656 ± 0.11
4.804IleGlu: 4.804 ± 0.116
2.905IlePhe: 2.905 ± 0.102
6.161IleGly: 6.161 ± 0.131
1.437IleHis: 1.437 ± 0.066
4.158IleIle: 4.158 ± 0.113
2.935IleLys: 2.935 ± 0.085
6.341IleLeu: 6.341 ± 0.142
1.59IleMet: 1.59 ± 0.07
2.837IleAsn: 2.837 ± 0.081
3.861IlePro: 3.861 ± 0.094
2.149IleGln: 2.149 ± 0.07
3.445IleArg: 3.445 ± 0.087
5.979IleSer: 5.979 ± 0.124
4.126IleThr: 4.126 ± 0.098
5.327IleVal: 5.327 ± 0.122
0.892IleTrp: 0.892 ± 0.053
1.843IleTyr: 1.843 ± 0.067
0.0IleXaa: 0.0 ± 0.0
Lys
3.073LysAla: 3.073 ± 0.094
0.35LysCys: 0.35 ± 0.027
2.507LysAsp: 2.507 ± 0.086
3.029LysGlu: 3.029 ± 0.083
1.646LysPhe: 1.646 ± 0.069
3.153LysGly: 3.153 ± 0.093
0.729LysHis: 0.729 ± 0.043
3.307LysIle: 3.307 ± 0.101
2.106LysLys: 2.106 ± 0.07
3.776LysLeu: 3.776 ± 0.099
1.349LysMet: 1.349 ± 0.06
2.023LysAsn: 2.023 ± 0.073
1.68LysPro: 1.68 ± 0.068
1.109LysGln: 1.109 ± 0.055
2.217LysArg: 2.217 ± 0.072
3.236LysSer: 3.236 ± 0.091
2.587LysThr: 2.587 ± 0.082
3.401LysVal: 3.401 ± 0.103
0.622LysTrp: 0.622 ± 0.044
1.371LysTyr: 1.371 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
7.649LeuAla: 7.649 ± 0.149
0.87LeuCys: 0.87 ± 0.051
5.711LeuAsp: 5.711 ± 0.128
6.112LeuGlu: 6.112 ± 0.162
3.392LeuPhe: 3.392 ± 0.105
8.247LeuGly: 8.247 ± 0.172
1.541LeuHis: 1.541 ± 0.066
6.385LeuIle: 6.385 ± 0.171
4.158LeuLys: 4.158 ± 0.104
7.904LeuLeu: 7.904 ± 0.18
2.388LeuMet: 2.388 ± 0.083
3.637LeuAsn: 3.637 ± 0.094
4.07LeuPro: 4.07 ± 0.103
2.526LeuGln: 2.526 ± 0.089
4.408LeuArg: 4.408 ± 0.105
7.522LeuSer: 7.522 ± 0.154
4.833LeuThr: 4.833 ± 0.125
6.613LeuVal: 6.613 ± 0.133
1.087LeuTrp: 1.087 ± 0.054
2.074LeuTyr: 2.074 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.621MetAla: 2.621 ± 0.086
0.243MetCys: 0.243 ± 0.021
1.524MetAsp: 1.524 ± 0.064
1.714MetGlu: 1.714 ± 0.061
0.924MetPhe: 0.924 ± 0.049
2.521MetGly: 2.521 ± 0.088
0.377MetHis: 0.377 ± 0.03
1.673MetIle: 1.673 ± 0.066
1.425MetLys: 1.425 ± 0.051
2.317MetLeu: 2.317 ± 0.068
0.785MetMet: 0.785 ± 0.048
1.092MetAsn: 1.092 ± 0.057
1.447MetPro: 1.447 ± 0.059
0.698MetGln: 0.698 ± 0.043
1.427MetArg: 1.427 ± 0.061
2.137MetSer: 2.137 ± 0.068
1.816MetThr: 1.816 ± 0.068
1.947MetVal: 1.947 ± 0.066
0.297MetTrp: 0.297 ± 0.027
0.591MetTyr: 0.591 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
2.862AsnAla: 2.862 ± 0.072
0.372AsnCys: 0.372 ± 0.035
1.904AsnAsp: 1.904 ± 0.065
2.264AsnGlu: 2.264 ± 0.066
1.573AsnPhe: 1.573 ± 0.065
2.969AsnGly: 2.969 ± 0.084
0.814AsnHis: 0.814 ± 0.042
3.11AsnIle: 3.11 ± 0.088
1.522AsnLys: 1.522 ± 0.058
4.068AsnLeu: 4.068 ± 0.099
1.162AsnMet: 1.162 ± 0.057
1.627AsnAsn: 1.627 ± 0.061
2.626AsnPro: 2.626 ± 0.081
1.242AsnGln: 1.242 ± 0.055
2.169AsnArg: 2.169 ± 0.083
2.789AsnSer: 2.789 ± 0.087
2.054AsnThr: 2.054 ± 0.071
2.835AsnVal: 2.835 ± 0.085
0.603AsnTrp: 0.603 ± 0.039
1.223AsnTyr: 1.223 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
2.893ProAla: 2.893 ± 0.098
0.28ProCys: 0.28 ± 0.03
3.455ProAsp: 3.455 ± 0.094
3.528ProGlu: 3.528 ± 0.104
1.77ProPhe: 1.77 ± 0.065
4.021ProGly: 4.021 ± 0.107
1.169ProHis: 1.169 ± 0.052
3.195ProIle: 3.195 ± 0.083
1.743ProLys: 1.743 ± 0.07
3.798ProLeu: 3.798 ± 0.106
1.228ProMet: 1.228 ± 0.057
1.901ProAsn: 1.901 ± 0.066
1.751ProPro: 1.751 ± 0.074
1.257ProGln: 1.257 ± 0.05
2.006ProArg: 2.006 ± 0.072
3.28ProSer: 3.28 ± 0.087
2.623ProThr: 2.623 ± 0.072
3.759ProVal: 3.759 ± 0.114
0.644ProTrp: 0.644 ± 0.041
1.503ProTyr: 1.503 ± 0.062
0.0ProXaa: 0.0 ± 0.0
Gln
2.232GlnAla: 2.232 ± 0.069
0.248GlnCys: 0.248 ± 0.025
1.364GlnAsp: 1.364 ± 0.054
2.006GlnGlu: 2.006 ± 0.072
1.213GlnPhe: 1.213 ± 0.059
2.176GlnGly: 2.176 ± 0.079
0.562GlnHis: 0.562 ± 0.033
2.468GlnIle: 2.468 ± 0.075
1.498GlnLys: 1.498 ± 0.062
2.609GlnLeu: 2.609 ± 0.078
0.919GlnMet: 0.919 ± 0.047
1.269GlnAsn: 1.269 ± 0.05
1.213GlnPro: 1.213 ± 0.057
0.87GlnGln: 0.87 ± 0.045
1.583GlnArg: 1.583 ± 0.062
2.203GlnSer: 2.203 ± 0.08
1.561GlnThr: 1.561 ± 0.062
1.94GlnVal: 1.94 ± 0.066
0.394GlnTrp: 0.394 ± 0.031
0.887GlnTyr: 0.887 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
3.411ArgAla: 3.411 ± 0.094
0.433ArgCys: 0.433 ± 0.036
3.068ArgAsp: 3.068 ± 0.086
3.586ArgGlu: 3.586 ± 0.104
1.984ArgPhe: 1.984 ± 0.073
3.759ArgGly: 3.759 ± 0.119
0.956ArgHis: 0.956 ± 0.052
3.79ArgIle: 3.79 ± 0.098
2.414ArgLys: 2.414 ± 0.078
4.551ArgLeu: 4.551 ± 0.095
1.451ArgMet: 1.451 ± 0.048
2.242ArgAsn: 2.242 ± 0.069
2.164ArgPro: 2.164 ± 0.071
1.653ArgGln: 1.653 ± 0.062
2.876ArgArg: 2.876 ± 0.087
3.589ArgSer: 3.589 ± 0.109
2.495ArgThr: 2.495 ± 0.085
3.734ArgVal: 3.734 ± 0.09
0.642ArgTrp: 0.642 ± 0.039
1.658ArgTyr: 1.658 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
5.235SerAla: 5.235 ± 0.121
0.618SerCys: 0.618 ± 0.043
4.821SerAsp: 4.821 ± 0.122
5.198SerGlu: 5.198 ± 0.11
2.981SerPhe: 2.981 ± 0.095
6.764SerGly: 6.764 ± 0.121
1.534SerHis: 1.534 ± 0.059
5.242SerIle: 5.242 ± 0.13
3.149SerLys: 3.149 ± 0.1
6.997SerLeu: 6.997 ± 0.141
2.164SerMet: 2.164 ± 0.077
3.025SerAsn: 3.025 ± 0.098
3.499SerPro: 3.499 ± 0.086
2.392SerGln: 2.392 ± 0.077
3.9SerArg: 3.9 ± 0.097
5.582SerSer: 5.582 ± 0.134
3.705SerThr: 3.705 ± 0.089
5.801SerVal: 5.801 ± 0.136
0.936SerTrp: 0.936 ± 0.054
1.928SerTyr: 1.928 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
3.963ThrAla: 3.963 ± 0.094
0.43ThrCys: 0.43 ± 0.03
3.326ThrAsp: 3.326 ± 0.088
3.406ThrGlu: 3.406 ± 0.092
2.183ThrPhe: 2.183 ± 0.065
5.235ThrGly: 5.235 ± 0.118
1.247ThrHis: 1.247 ± 0.048
3.72ThrIle: 3.72 ± 0.099
2.127ThrLys: 2.127 ± 0.08
4.853ThrLeu: 4.853 ± 0.104
1.371ThrMet: 1.371 ± 0.056
2.025ThrAsn: 2.025 ± 0.074
2.881ThrPro: 2.881 ± 0.088
1.539ThrGln: 1.539 ± 0.057
2.582ThrArg: 2.582 ± 0.078
4.16ThrSer: 4.16 ± 0.106
2.981ThrThr: 2.981 ± 0.099
4.247ThrVal: 4.247 ± 0.096
0.676ThrTrp: 0.676 ± 0.042
1.566ThrTyr: 1.566 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
6.122ValAla: 6.122 ± 0.123
0.69ValCys: 0.69 ± 0.045
4.566ValAsp: 4.566 ± 0.119
4.797ValGlu: 4.797 ± 0.12
2.772ValPhe: 2.772 ± 0.094
6.222ValGly: 6.222 ± 0.136
1.34ValHis: 1.34 ± 0.063
5.288ValIle: 5.288 ± 0.103
3.037ValLys: 3.037 ± 0.091
6.71ValLeu: 6.71 ± 0.145
1.991ValMet: 1.991 ± 0.074
2.874ValAsn: 2.874 ± 0.08
3.418ValPro: 3.418 ± 0.097
1.999ValGln: 1.999 ± 0.073
3.523ValArg: 3.523 ± 0.095
5.835ValSer: 5.835 ± 0.129
4.41ValThr: 4.41 ± 0.104
5.738ValVal: 5.738 ± 0.157
0.761ValTrp: 0.761 ± 0.041
1.916ValTyr: 1.916 ± 0.07
0.0ValXaa: 0.0 ± 0.0
Trp
0.856TrpAla: 0.856 ± 0.045
0.102TrpCys: 0.102 ± 0.015
0.977TrpAsp: 0.977 ± 0.053
0.771TrpGlu: 0.771 ± 0.043
0.574TrpPhe: 0.574 ± 0.042
1.247TrpGly: 1.247 ± 0.06
0.391TrpHis: 0.391 ± 0.033
1.033TrpIle: 1.033 ± 0.056
0.637TrpLys: 0.637 ± 0.039
1.167TrpLeu: 1.167 ± 0.062
0.44TrpMet: 0.44 ± 0.033
0.535TrpAsn: 0.535 ± 0.041
0.525TrpPro: 0.525 ± 0.034
0.467TrpGln: 0.467 ± 0.032
0.671TrpArg: 0.671 ± 0.04
0.861TrpSer: 0.861 ± 0.048
0.695TrpThr: 0.695 ± 0.038
0.797TrpVal: 0.797 ± 0.037
0.238TrpTrp: 0.238 ± 0.025
0.353TrpTyr: 0.353 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.979TyrAla: 1.979 ± 0.068
0.28TyrCys: 0.28 ± 0.023
1.612TyrAsp: 1.612 ± 0.054
2.05TyrGlu: 2.05 ± 0.081
1.264TyrPhe: 1.264 ± 0.058
2.784TyrGly: 2.784 ± 0.065
0.61TyrHis: 0.61 ± 0.039
1.692TyrIle: 1.692 ± 0.067
1.14TyrLys: 1.14 ± 0.052
2.728TyrLeu: 2.728 ± 0.078
0.744TyrMet: 0.744 ± 0.042
0.9TyrAsn: 0.9 ± 0.054
1.374TyrPro: 1.374 ± 0.059
0.892TyrGln: 0.892 ± 0.048
1.702TyrArg: 1.702 ± 0.064
2.23TyrSer: 2.23 ± 0.073
1.408TyrThr: 1.408 ± 0.065
1.933TyrVal: 1.933 ± 0.069
0.384TyrTrp: 0.384 ± 0.03
0.819TyrTyr: 0.819 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1332 proteins (411302 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski