Amino acid dipepetide frequency for Olavius sp. associated proteobacterium Delta 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.555AlaAla: 8.555 ± 0.074	1.082AlaCys: 1.082 ± 0.021	4.806AlaAsp: 4.806 ± 0.051	5.253AlaGlu: 5.253 ± 0.049	3.475AlaPhe: 3.475 ± 0.034	7.194AlaGly: 7.194 ± 0.062	1.476AlaHis: 1.476 ± 0.026	5.533AlaIle: 5.533 ± 0.05	4.217AlaLys: 4.217 ± 0.044	8.216AlaLeu: 8.216 ± 0.07	2.332AlaMet: 2.332 ± 0.038	2.642AlaAsn: 2.642 ± 0.034	2.754AlaPro: 2.754 ± 0.038	2.65AlaGln: 2.65 ± 0.037	4.461AlaArg: 4.461 ± 0.045	4.311AlaSer: 4.311 ± 0.044	3.803AlaThr: 3.803 ± 0.04	6.438AlaVal: 6.438 ± 0.055	0.906AlaTrp: 0.906 ± 0.019	2.491AlaTyr: 2.491 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	0.891CysAla: 0.891 ± 0.019	0.233CysCys: 0.233 ± 0.009	0.648CysAsp: 0.648 ± 0.016	0.618CysGlu: 0.618 ± 0.015	0.519CysPhe: 0.519 ± 0.014	1.21CysGly: 1.21 ± 0.025	0.406CysHis: 0.406 ± 0.019	0.738CysIle: 0.738 ± 0.017	0.519CysLys: 0.519 ± 0.013	1.159CysLeu: 1.159 ± 0.022	0.286CysMet: 0.286 ± 0.011	0.456CysAsn: 0.456 ± 0.013	0.717CysPro: 0.717 ± 0.018	0.431CysGln: 0.431 ± 0.014	0.857CysArg: 0.857 ± 0.018	0.74CysSer: 0.74 ± 0.018	0.548CysThr: 0.548 ± 0.014	0.696CysVal: 0.696 ± 0.017	0.171CysTrp: 0.171 ± 0.01	0.409CysTyr: 0.409 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	4.117AspAla: 4.117 ± 0.038	0.613AspCys: 0.613 ± 0.017	2.99AspAsp: 2.99 ± 0.046	3.555AspGlu: 3.555 ± 0.041	2.732AspPhe: 2.732 ± 0.034	3.962AspGly: 3.962 ± 0.059	1.197AspHis: 1.197 ± 0.02	4.228AspIle: 4.228 ± 0.036	2.854AspLys: 2.854 ± 0.032	5.894AspLeu: 5.894 ± 0.051	1.388AspMet: 1.388 ± 0.028	1.992AspAsn: 1.992 ± 0.032	3.017AspPro: 3.017 ± 0.038	2.179AspGln: 2.179 ± 0.03	3.26AspArg: 3.26 ± 0.029	2.959AspSer: 2.959 ± 0.042	2.553AspThr: 2.553 ± 0.037	3.403AspVal: 3.403 ± 0.042	0.762AspTrp: 0.762 ± 0.018	2.02AspTyr: 2.02 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	4.968GluAla: 4.968 ± 0.051	0.526GluCys: 0.526 ± 0.014	3.161GluAsp: 3.161 ± 0.04	3.708GluGlu: 3.708 ± 0.046	2.494GluPhe: 2.494 ± 0.035	3.508GluGly: 3.508 ± 0.038	1.116GluHis: 1.116 ± 0.018	5.044GluIle: 5.044 ± 0.048	4.553GluLys: 4.553 ± 0.043	5.822GluLeu: 5.822 ± 0.053	1.786GluMet: 1.786 ± 0.025	2.853GluAsn: 2.853 ± 0.032	2.221GluPro: 2.221 ± 0.03	2.232GluGln: 2.232 ± 0.032	3.035GluArg: 3.035 ± 0.039	3.267GluSer: 3.267 ± 0.034	3.272GluThr: 3.272 ± 0.037	3.848GluVal: 3.848 ± 0.038	0.617GluTrp: 0.617 ± 0.015	1.912GluTyr: 1.912 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.278PheAla: 3.278 ± 0.039	0.627PheCys: 0.627 ± 0.016	2.763PheAsp: 2.763 ± 0.036	2.638PheGlu: 2.638 ± 0.032	2.35PhePhe: 2.35 ± 0.04	3.389PheGly: 3.389 ± 0.033	0.918PheHis: 0.918 ± 0.019	3.087PheIle: 3.087 ± 0.038	2.469PheLys: 2.469 ± 0.037	4.365PheLeu: 4.365 ± 0.053	1.13PheMet: 1.13 ± 0.022	1.908PheAsn: 1.908 ± 0.027	1.821PhePro: 1.821 ± 0.025	1.488PheGln: 1.488 ± 0.025	2.085PheArg: 2.085 ± 0.029	3.176PheSer: 3.176 ± 0.038	2.227PheThr: 2.227 ± 0.032	2.815PheVal: 2.815 ± 0.037	0.655PheTrp: 0.655 ± 0.016	1.581PheTyr: 1.581 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	5.548GlyAla: 5.548 ± 0.064	1.122GlyCys: 1.122 ± 0.023	3.585GlyAsp: 3.585 ± 0.049	3.874GlyGlu: 3.874 ± 0.04	3.466GlyPhe: 3.466 ± 0.038	5.494GlyGly: 5.494 ± 0.063	1.562GlyHis: 1.562 ± 0.025	5.801GlyIle: 5.801 ± 0.05	4.513GlyLys: 4.513 ± 0.057	7.399GlyLeu: 7.399 ± 0.064	2.154GlyMet: 2.154 ± 0.028	2.798GlyAsn: 2.798 ± 0.046	2.46GlyPro: 2.46 ± 0.03	2.716GlyGln: 2.716 ± 0.033	3.997GlyArg: 3.997 ± 0.037	4.398GlySer: 4.398 ± 0.045	3.823GlyThr: 3.823 ± 0.05	4.897GlyVal: 4.897 ± 0.046	1.073GlyTrp: 1.073 ± 0.022	2.713GlyTyr: 2.713 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	1.433HisAla: 1.433 ± 0.024	0.317HisCys: 0.317 ± 0.01	1.053HisAsp: 1.053 ± 0.02	1.096HisGlu: 1.096 ± 0.023	1.038HisPhe: 1.038 ± 0.02	1.477HisGly: 1.477 ± 0.027	0.599HisHis: 0.599 ± 0.016	1.345HisIle: 1.345 ± 0.027	0.963HisLys: 0.963 ± 0.021	2.232HisLeu: 2.232 ± 0.033	0.481HisMet: 0.481 ± 0.012	0.771HisAsn: 0.771 ± 0.017	1.243HisPro: 1.243 ± 0.022	0.848HisGln: 0.848 ± 0.017	1.241HisArg: 1.241 ± 0.021	1.165HisSer: 1.165 ± 0.021	0.995HisThr: 0.995 ± 0.021	1.182HisVal: 1.182 ± 0.02	0.273HisTrp: 0.273 ± 0.01	0.752HisTyr: 0.752 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	5.946IleAla: 5.946 ± 0.049	0.983IleCys: 0.983 ± 0.019	4.276IleAsp: 4.276 ± 0.044	4.68IleGlu: 4.68 ± 0.041	3.339IlePhe: 3.339 ± 0.039	5.328IleGly: 5.328 ± 0.046	1.429IleHis: 1.429 ± 0.024	5.065IleIle: 5.065 ± 0.046	4.236IleLys: 4.236 ± 0.043	7.087IleLeu: 7.087 ± 0.067	1.649IleMet: 1.649 ± 0.025	3.013IleAsn: 3.013 ± 0.037	3.457IlePro: 3.457 ± 0.032	2.521IleGln: 2.521 ± 0.027	3.78IleArg: 3.78 ± 0.039	4.801IleSer: 4.801 ± 0.044	3.69IleThr: 3.69 ± 0.038	4.622IleVal: 4.622 ± 0.048	0.769IleTrp: 0.769 ± 0.02	2.235IleTyr: 2.235 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.602LysAla: 4.602 ± 0.048	0.531LysCys: 0.531 ± 0.016	3.149LysAsp: 3.149 ± 0.037	3.71LysGlu: 3.71 ± 0.041	2.108LysPhe: 2.108 ± 0.028	3.722LysGly: 3.722 ± 0.041	1.066LysHis: 1.066 ± 0.021	4.784LysIle: 4.784 ± 0.051	4.669LysLys: 4.669 ± 0.051	5.234LysLeu: 5.234 ± 0.049	1.646LysMet: 1.646 ± 0.027	2.733LysAsn: 2.733 ± 0.039	2.449LysPro: 2.449 ± 0.032	2.05LysGln: 2.05 ± 0.031	3.086LysArg: 3.086 ± 0.036	3.485LysSer: 3.485 ± 0.042	3.263LysThr: 3.263 ± 0.042	3.509LysVal: 3.509 ± 0.035	0.655LysTrp: 0.655 ± 0.014	1.864LysTyr: 1.864 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	8.925LeuAla: 8.925 ± 0.066	1.216LeuCys: 1.216 ± 0.02	5.465LeuAsp: 5.465 ± 0.048	5.88LeuGlu: 5.88 ± 0.056	4.339LeuPhe: 4.339 ± 0.052	6.92LeuGly: 6.92 ± 0.062	1.726LeuHis: 1.726 ± 0.024	6.972LeuIle: 6.972 ± 0.064	6.569LeuLys: 6.569 ± 0.052	9.233LeuLeu: 9.233 ± 0.09	2.494LeuMet: 2.494 ± 0.031	4.206LeuAsn: 4.206 ± 0.04	4.567LeuPro: 4.567 ± 0.04	3.206LeuGln: 3.206 ± 0.037	4.799LeuArg: 4.799 ± 0.048	6.717LeuSer: 6.717 ± 0.047	5.265LeuThr: 5.265 ± 0.051	6.367LeuVal: 6.367 ± 0.057	1.069LeuTrp: 1.069 ± 0.024	2.802LeuTyr: 2.802 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.514MetAla: 2.514 ± 0.033	0.246MetCys: 0.246 ± 0.01	1.441MetAsp: 1.441 ± 0.024	1.501MetGlu: 1.501 ± 0.024	0.837MetPhe: 0.837 ± 0.021	2.015MetGly: 2.015 ± 0.029	0.44MetHis: 0.44 ± 0.012	1.892MetIle: 1.892 ± 0.028	1.691MetLys: 1.691 ± 0.03	2.5MetLeu: 2.5 ± 0.031	0.685MetMet: 0.685 ± 0.016	1.135MetAsn: 1.135 ± 0.024	1.252MetPro: 1.252 ± 0.023	0.966MetGln: 0.966 ± 0.018	1.329MetArg: 1.329 ± 0.023	1.542MetSer: 1.542 ± 0.023	1.545MetThr: 1.545 ± 0.027	1.939MetVal: 1.939 ± 0.026	0.22MetTrp: 0.22 ± 0.009	0.543MetTyr: 0.543 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.805AsnAla: 2.805 ± 0.032	0.548AsnCys: 0.548 ± 0.014	1.97AsnAsp: 1.97 ± 0.032	2.067AsnGlu: 2.067 ± 0.03	1.769AsnPhe: 1.769 ± 0.028	2.733AsnGly: 2.733 ± 0.04	0.892AsnHis: 0.892 ± 0.018	2.997AsnIle: 2.997 ± 0.036	2.032AsnLys: 2.032 ± 0.026	4.339AsnLeu: 4.339 ± 0.049	1.002AsnMet: 1.002 ± 0.019	1.548AsnAsn: 1.548 ± 0.023	2.444AsnPro: 2.444 ± 0.03	1.606AsnGln: 1.606 ± 0.025	2.535AsnArg: 2.535 ± 0.034	2.274AsnSer: 2.274 ± 0.032	1.803AsnThr: 1.803 ± 0.026	2.332AsnVal: 2.332 ± 0.03	0.559AsnTrp: 0.559 ± 0.014	1.433AsnTyr: 1.433 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	3.985ProAla: 3.985 ± 0.041	0.432ProCys: 0.432 ± 0.012	3.043ProAsp: 3.043 ± 0.038	3.332ProGlu: 3.332 ± 0.037	2.003ProPhe: 2.003 ± 0.026	3.471ProGly: 3.471 ± 0.04	0.943ProHis: 0.943 ± 0.018	2.705ProIle: 2.705 ± 0.03	2.056ProLys: 2.056 ± 0.031	4.066ProLeu: 4.066 ± 0.039	1.01ProMet: 1.01 ± 0.017	1.561ProAsn: 1.561 ± 0.028	1.951ProPro: 1.951 ± 0.031	1.722ProGln: 1.722 ± 0.028	1.87ProArg: 1.87 ± 0.028	2.283ProSer: 2.283 ± 0.027	2.022ProThr: 2.022 ± 0.03	3.485ProVal: 3.485 ± 0.036	0.562ProTrp: 0.562 ± 0.016	1.394ProTyr: 1.394 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.166GlnAla: 3.166 ± 0.04	0.345GlnCys: 0.345 ± 0.011	1.838GlnAsp: 1.838 ± 0.029	2.126GlnGlu: 2.126 ± 0.026	1.38GlnPhe: 1.38 ± 0.022	2.28GlnGly: 2.28 ± 0.025	0.77GlnHis: 0.77 ± 0.018	2.715GlnIle: 2.715 ± 0.03	2.574GlnLys: 2.574 ± 0.033	3.303GlnLeu: 3.303 ± 0.036	0.987GlnMet: 0.987 ± 0.019	1.66GlnAsn: 1.66 ± 0.024	1.494GlnPro: 1.494 ± 0.026	1.523GlnGln: 1.523 ± 0.027	2.089GlnArg: 2.089 ± 0.031	2.089GlnSer: 2.089 ± 0.026	1.971GlnThr: 1.971 ± 0.026	2.374GlnVal: 2.374 ± 0.025	0.482GlnTrp: 0.482 ± 0.015	1.093GlnTyr: 1.093 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	3.751ArgAla: 3.751 ± 0.039	0.635ArgCys: 0.635 ± 0.017	2.743ArgAsp: 2.743 ± 0.029	3.262ArgGlu: 3.262 ± 0.038	2.589ArgPhe: 2.589 ± 0.035	3.094ArgGly: 3.094 ± 0.036	1.311ArgHis: 1.311 ± 0.022	4.215ArgIle: 4.215 ± 0.045	3.39ArgLys: 3.39 ± 0.042	5.629ArgLeu: 5.629 ± 0.06	1.476ArgMet: 1.476 ± 0.025	2.155ArgAsn: 2.155 ± 0.026	2.174ArgPro: 2.174 ± 0.029	2.469ArgGln: 2.469 ± 0.033	3.29ArgArg: 3.29 ± 0.046	3.079ArgSer: 3.079 ± 0.034	2.476ArgThr: 2.476 ± 0.034	3.503ArgVal: 3.503 ± 0.036	0.723ArgTrp: 0.723 ± 0.015	1.944ArgTyr: 1.944 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	4.684SerAla: 4.684 ± 0.042	0.717SerCys: 0.717 ± 0.019	3.359SerAsp: 3.359 ± 0.042	3.469SerGlu: 3.469 ± 0.041	2.791SerPhe: 2.791 ± 0.038	5.272SerGly: 5.272 ± 0.058	1.221SerHis: 1.221 ± 0.022	4.367SerIle: 4.367 ± 0.044	3.084SerLys: 3.084 ± 0.038	5.967SerLeu: 5.967 ± 0.052	1.636SerMet: 1.636 ± 0.026	2.136SerAsn: 2.136 ± 0.032	2.57SerPro: 2.57 ± 0.033	2.11SerGln: 2.11 ± 0.026	3.352SerArg: 3.352 ± 0.035	3.595SerSer: 3.595 ± 0.042	2.743SerThr: 2.743 ± 0.037	3.857SerVal: 3.857 ± 0.045	0.739SerTrp: 0.739 ± 0.016	1.865SerTyr: 1.865 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	4.494ThrAla: 4.494 ± 0.051	0.59ThrCys: 0.59 ± 0.014	2.844ThrAsp: 2.844 ± 0.042	2.82ThrGlu: 2.82 ± 0.033	2.136ThrPhe: 2.136 ± 0.031	4.544ThrGly: 4.544 ± 0.045	1.068ThrHis: 1.068 ± 0.021	3.768ThrIle: 3.768 ± 0.037	2.175ThrLys: 2.175 ± 0.032	5.008ThrLeu: 5.008 ± 0.041	1.218ThrMet: 1.218 ± 0.021	1.705ThrAsn: 1.705 ± 0.029	2.438ThrPro: 2.438 ± 0.035	1.432ThrGln: 1.432 ± 0.021	2.693ThrArg: 2.693 ± 0.028	2.743ThrSer: 2.743 ± 0.034	2.636ThrThr: 2.636 ± 0.041	3.772ThrVal: 3.772 ± 0.045	0.624ThrTrp: 0.624 ± 0.017	1.637ThrTyr: 1.637 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	5.787ValAla: 5.787 ± 0.054	0.864ValCys: 0.864 ± 0.018	3.906ValAsp: 3.906 ± 0.048	3.96ValGlu: 3.96 ± 0.046	3.109ValPhe: 3.109 ± 0.034	4.499ValGly: 4.499 ± 0.046	1.24ValHis: 1.24 ± 0.022	4.829ValIle: 4.829 ± 0.048	3.707ValLys: 3.707 ± 0.036	6.438ValLeu: 6.438 ± 0.06	1.806ValMet: 1.806 ± 0.023	2.683ValAsn: 2.683 ± 0.032	2.798ValPro: 2.798 ± 0.033	2.053ValGln: 2.053 ± 0.03	3.341ValArg: 3.341 ± 0.034	4.212ValSer: 4.212 ± 0.049	3.575ValThr: 3.575 ± 0.047	4.801ValVal: 4.801 ± 0.052	0.742ValTrp: 0.742 ± 0.015	2.047ValTyr: 2.047 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	0.846TrpAla: 0.846 ± 0.02	0.137TrpCys: 0.137 ± 0.007	0.689TrpAsp: 0.689 ± 0.016	0.665TrpGlu: 0.665 ± 0.016	0.543TrpPhe: 0.543 ± 0.015	0.916TrpGly: 0.916 ± 0.02	0.314TrpHis: 0.314 ± 0.01	0.877TrpIle: 0.877 ± 0.02	0.611TrpLys: 0.611 ± 0.015	1.298TrpLeu: 1.298 ± 0.024	0.377TrpMet: 0.377 ± 0.016	0.505TrpAsn: 0.505 ± 0.013	0.497TrpPro: 0.497 ± 0.014	0.727TrpGln: 0.727 ± 0.017	0.658TrpArg: 0.658 ± 0.015	0.742TrpSer: 0.742 ± 0.019	0.567TrpThr: 0.567 ± 0.016	0.752TrpVal: 0.752 ± 0.018	0.202TrpTrp: 0.202 ± 0.01	0.374TrpTyr: 0.374 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.298TyrAla: 2.298 ± 0.031	0.488TyrCys: 0.488 ± 0.015	1.946TyrAsp: 1.946 ± 0.044	1.73TyrGlu: 1.73 ± 0.025	1.756TyrPhe: 1.756 ± 0.028	2.365TyrGly: 2.365 ± 0.035	0.81TyrHis: 0.81 ± 0.016	1.945TyrIle: 1.945 ± 0.032	1.434TyrLys: 1.434 ± 0.025	3.547TyrLeu: 3.547 ± 0.041	0.693TyrMet: 0.693 ± 0.014	1.227TyrAsn: 1.227 ± 0.023	1.572TyrPro: 1.572 ± 0.027	1.33TyrGln: 1.33 ± 0.024	2.149TyrArg: 2.149 ± 0.031	1.957TyrSer: 1.957 ± 0.028	1.569TyrThr: 1.569 ± 0.03	1.804TyrVal: 1.804 ± 0.028	0.493TyrTrp: 0.493 ± 0.015	1.238TyrTyr: 1.238 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10776 proteins (2777551 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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