Amino acid dipepetide frequency for Rhodospirillum centenum (strain ATCC 51521 / SW)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.936AlaAla: 21.936 ± 0.25	1.144AlaCys: 1.144 ± 0.034	8.142AlaAsp: 8.142 ± 0.094	8.551AlaGlu: 8.551 ± 0.114	3.949AlaPhe: 3.949 ± 0.07	13.541AlaGly: 13.541 ± 0.147	2.082AlaHis: 2.082 ± 0.044	4.686AlaIle: 4.686 ± 0.067	2.829AlaLys: 2.829 ± 0.062	15.13AlaLeu: 15.13 ± 0.166	3.077AlaMet: 3.077 ± 0.059	2.165AlaAsn: 2.165 ± 0.049	7.045AlaPro: 7.045 ± 0.103	3.872AlaGln: 3.872 ± 0.067	10.679AlaArg: 10.679 ± 0.131	5.099AlaSer: 5.099 ± 0.087	6.324AlaThr: 6.324 ± 0.108	10.771AlaVal: 10.771 ± 0.108	1.64AlaTrp: 1.64 ± 0.04	2.333AlaTyr: 2.333 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.919CysAla: 0.919 ± 0.031	0.105CysCys: 0.105 ± 0.009	0.476CysAsp: 0.476 ± 0.022	0.351CysGlu: 0.351 ± 0.018	0.29CysPhe: 0.29 ± 0.015	0.879CysGly: 0.879 ± 0.03	0.207CysHis: 0.207 ± 0.015	0.335CysIle: 0.335 ± 0.017	0.131CysLys: 0.131 ± 0.01	0.843CysLeu: 0.843 ± 0.028	0.135CysMet: 0.135 ± 0.011	0.174CysAsn: 0.174 ± 0.013	0.516CysPro: 0.516 ± 0.024	0.214CysGln: 0.214 ± 0.015	0.769CysArg: 0.769 ± 0.028	0.336CysSer: 0.336 ± 0.017	0.424CysThr: 0.424 ± 0.018	0.514CysVal: 0.514 ± 0.022	0.11CysTrp: 0.11 ± 0.009	0.174CysTyr: 0.174 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.406AspAla: 7.406 ± 0.098	0.413AspCys: 0.413 ± 0.018	3.088AspAsp: 3.088 ± 0.064	2.856AspGlu: 2.856 ± 0.056	1.92AspPhe: 1.92 ± 0.038	6.403AspGly: 6.403 ± 0.078	1.115AspHis: 1.115 ± 0.03	2.428AspIle: 2.428 ± 0.038	1.038AspLys: 1.038 ± 0.029	7.05AspLeu: 7.05 ± 0.092	1.2AspMet: 1.2 ± 0.033	0.95AspAsn: 0.95 ± 0.029	4.299AspPro: 4.299 ± 0.073	1.569AspGln: 1.569 ± 0.039	5.712AspArg: 5.712 ± 0.077	2.189AspSer: 2.189 ± 0.046	2.744AspThr: 2.744 ± 0.059	3.906AspVal: 3.906 ± 0.071	1.114AspTrp: 1.114 ± 0.032	1.296AspTyr: 1.296 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	8.157GluAla: 8.157 ± 0.13	0.262GluCys: 0.262 ± 0.016	2.73GluAsp: 2.73 ± 0.052	3.551GluGlu: 3.551 ± 0.071	1.469GluPhe: 1.469 ± 0.038	4.487GluGly: 4.487 ± 0.068	1.105GluHis: 1.105 ± 0.032	2.925GluIle: 2.925 ± 0.049	1.692GluLys: 1.692 ± 0.043	5.375GluLeu: 5.375 ± 0.077	1.466GluMet: 1.466 ± 0.038	1.146GluAsn: 1.146 ± 0.033	3.029GluPro: 3.029 ± 0.053	2.034GluGln: 2.034 ± 0.051	5.59GluArg: 5.59 ± 0.078	2.119GluSer: 2.119 ± 0.041	3.622GluThr: 3.622 ± 0.057	4.339GluVal: 4.339 ± 0.067	0.567GluTrp: 0.567 ± 0.023	0.863GluTyr: 0.863 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.947PheAla: 3.947 ± 0.061	0.36PheCys: 0.36 ± 0.018	2.394PheAsp: 2.394 ± 0.049	1.75PheGlu: 1.75 ± 0.042	1.164PhePhe: 1.164 ± 0.034	3.212PheGly: 3.212 ± 0.051	0.701PheHis: 0.701 ± 0.024	1.206PheIle: 1.206 ± 0.038	0.702PheLys: 0.702 ± 0.026	3.354PheLeu: 3.354 ± 0.061	0.657PheMet: 0.657 ± 0.025	0.802PheAsn: 0.802 ± 0.026	1.54PhePro: 1.54 ± 0.036	0.966PheGln: 0.966 ± 0.031	2.572PheArg: 2.572 ± 0.047	1.682PheSer: 1.682 ± 0.046	1.851PheThr: 1.851 ± 0.041	2.451PheVal: 2.451 ± 0.049	0.48PheTrp: 0.48 ± 0.022	0.782PheTyr: 0.782 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	10.113GlyAla: 10.113 ± 0.109	0.864GlyCys: 0.864 ± 0.028	4.833GlyAsp: 4.833 ± 0.067	4.687GlyGlu: 4.687 ± 0.06	3.493GlyPhe: 3.493 ± 0.052	8.774GlyGly: 8.774 ± 0.142	1.955GlyHis: 1.955 ± 0.044	4.135GlyIle: 4.135 ± 0.059	2.251GlyLys: 2.251 ± 0.057	9.987GlyLeu: 9.987 ± 0.103	2.363GlyMet: 2.363 ± 0.044	1.856GlyAsn: 1.856 ± 0.05	4.891GlyPro: 4.891 ± 0.072	2.938GlyGln: 2.938 ± 0.052	8.507GlyArg: 8.507 ± 0.093	4.732GlySer: 4.732 ± 0.102	5.745GlyThr: 5.745 ± 0.128	6.277GlyVal: 6.277 ± 0.078	1.6GlyTrp: 1.6 ± 0.04	2.128GlyTyr: 2.128 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.333HisAla: 2.333 ± 0.048	0.191HisCys: 0.191 ± 0.012	1.169HisAsp: 1.169 ± 0.032	0.923HisGlu: 0.923 ± 0.03	0.65HisPhe: 0.65 ± 0.023	1.977HisGly: 1.977 ± 0.045	0.532HisHis: 0.532 ± 0.023	0.679HisIle: 0.679 ± 0.024	0.351HisLys: 0.351 ± 0.019	2.114HisLeu: 2.114 ± 0.045	0.402HisMet: 0.402 ± 0.018	0.34HisAsn: 0.34 ± 0.017	1.485HisPro: 1.485 ± 0.042	0.537HisGln: 0.537 ± 0.023	1.753HisArg: 1.753 ± 0.042	0.744HisSer: 0.744 ± 0.026	0.828HisThr: 0.828 ± 0.024	1.429HisVal: 1.429 ± 0.036	0.333HisTrp: 0.333 ± 0.014	0.463HisTyr: 0.463 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	5.654IleAla: 5.654 ± 0.073	0.366IleCys: 0.366 ± 0.018	2.942IleAsp: 2.942 ± 0.051	2.566IleGlu: 2.566 ± 0.051	1.04IlePhe: 1.04 ± 0.033	4.08IleGly: 4.08 ± 0.06	0.758IleHis: 0.758 ± 0.024	1.348IleIle: 1.348 ± 0.039	0.84IleLys: 0.84 ± 0.03	3.754IleLeu: 3.754 ± 0.051	0.668IleMet: 0.668 ± 0.025	0.937IleAsn: 0.937 ± 0.032	2.07IlePro: 2.07 ± 0.044	1.124IleGln: 1.124 ± 0.03	3.114IleArg: 3.114 ± 0.055	1.824IleSer: 1.824 ± 0.043	2.122IleThr: 2.122 ± 0.07	3.387IleVal: 3.387 ± 0.056	0.415IleTrp: 0.415 ± 0.017	0.802IleTyr: 0.802 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.176LysAla: 3.176 ± 0.068	0.099LysCys: 0.099 ± 0.009	1.31LysAsp: 1.31 ± 0.04	1.309LysGlu: 1.309 ± 0.039	0.561LysPhe: 0.561 ± 0.025	2.039LysGly: 2.039 ± 0.046	0.36LysHis: 0.36 ± 0.02	0.895LysIle: 0.895 ± 0.031	0.768LysLys: 0.768 ± 0.033	2.24LysLeu: 2.24 ± 0.045	0.449LysMet: 0.449 ± 0.022	0.47LysAsn: 0.47 ± 0.021	1.435LysPro: 1.435 ± 0.04	0.71LysGln: 0.71 ± 0.026	1.739LysArg: 1.739 ± 0.042	1.075LysSer: 1.075 ± 0.031	1.286LysThr: 1.286 ± 0.034	1.885LysVal: 1.885 ± 0.049	0.201LysTrp: 0.201 ± 0.012	0.45LysTyr: 0.45 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.631LeuAla: 15.631 ± 0.164	0.912LeuCys: 0.912 ± 0.029	6.788LeuAsp: 6.788 ± 0.093	6.062LeuGlu: 6.062 ± 0.085	3.562LeuPhe: 3.562 ± 0.056	8.685LeuGly: 8.685 ± 0.1	2.174LeuHis: 2.174 ± 0.051	3.919LeuIle: 3.919 ± 0.063	2.729LeuLys: 2.729 ± 0.053	11.781LeuLeu: 11.781 ± 0.172	2.074LeuMet: 2.074 ± 0.042	2.211LeuAsn: 2.211 ± 0.046	7.04LeuPro: 7.04 ± 0.083	2.445LeuGln: 2.445 ± 0.047	8.93LeuArg: 8.93 ± 0.106	6.047LeuSer: 6.047 ± 0.083	6.308LeuThr: 6.308 ± 0.108	8.319LeuVal: 8.319 ± 0.109	1.314LeuTrp: 1.314 ± 0.035	2.016LeuTyr: 2.016 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.947MetAla: 2.947 ± 0.059	0.098MetCys: 0.098 ± 0.01	1.152MetAsp: 1.152 ± 0.033	1.075MetGlu: 1.075 ± 0.03	0.492MetPhe: 0.492 ± 0.02	1.581MetGly: 1.581 ± 0.044	0.358MetHis: 0.358 ± 0.017	0.885MetIle: 0.885 ± 0.026	0.662MetLys: 0.662 ± 0.028	2.403MetLeu: 2.403 ± 0.049	0.51MetMet: 0.51 ± 0.021	0.496MetAsn: 0.496 ± 0.022	1.534MetPro: 1.534 ± 0.039	0.766MetGln: 0.766 ± 0.023	1.659MetArg: 1.659 ± 0.035	1.18MetSer: 1.18 ± 0.03	1.578MetThr: 1.578 ± 0.037	1.664MetVal: 1.664 ± 0.042	0.17MetTrp: 0.17 ± 0.011	0.229MetTyr: 0.229 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.402AsnAla: 2.402 ± 0.051	0.168AsnCys: 0.168 ± 0.013	1.072AsnAsp: 1.072 ± 0.041	0.917AsnGlu: 0.917 ± 0.027	0.641AsnPhe: 0.641 ± 0.026	1.861AsnGly: 1.861 ± 0.054	0.382AsnHis: 0.382 ± 0.019	0.926AsnIle: 0.926 ± 0.035	0.408AsnLys: 0.408 ± 0.02	2.238AsnLeu: 2.238 ± 0.044	0.405AsnMet: 0.405 ± 0.02	0.484AsnAsn: 0.484 ± 0.026	1.523AsnPro: 1.523 ± 0.038	0.561AsnGln: 0.561 ± 0.024	1.767AsnArg: 1.767 ± 0.041	0.817AsnSer: 0.817 ± 0.031	0.981AsnThr: 0.981 ± 0.034	1.46AsnVal: 1.46 ± 0.045	0.308AsnTrp: 0.308 ± 0.016	0.47AsnTyr: 0.47 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	9.439ProAla: 9.439 ± 0.12	0.414ProCys: 0.414 ± 0.02	4.638ProAsp: 4.638 ± 0.072	4.229ProGlu: 4.229 ± 0.061	2.008ProPhe: 2.008 ± 0.041	6.291ProGly: 6.291 ± 0.08	1.071ProHis: 1.071 ± 0.035	1.612ProIle: 1.612 ± 0.031	1.209ProLys: 1.209 ± 0.037	5.689ProLeu: 5.689 ± 0.076	1.147ProMet: 1.147 ± 0.033	0.915ProAsn: 0.915 ± 0.028	4.427ProPro: 4.427 ± 0.091	1.641ProGln: 1.641 ± 0.041	3.768ProArg: 3.768 ± 0.055	2.491ProSer: 2.491 ± 0.043	2.689ProThr: 2.689 ± 0.055	5.425ProVal: 5.425 ± 0.081	0.893ProTrp: 0.893 ± 0.029	1.06ProTyr: 1.06 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.416GlnAla: 4.416 ± 0.067	0.178GlnCys: 0.178 ± 0.012	1.512GlnAsp: 1.512 ± 0.04	1.773GlnGlu: 1.773 ± 0.045	0.907GlnPhe: 0.907 ± 0.027	2.596GlnGly: 2.596 ± 0.05	0.535GlnHis: 0.535 ± 0.021	1.477GlnIle: 1.477 ± 0.035	0.758GlnLys: 0.758 ± 0.03	2.431GlnLeu: 2.431 ± 0.05	0.659GlnMet: 0.659 ± 0.021	0.601GlnAsn: 0.601 ± 0.024	1.864GlnPro: 1.864 ± 0.047	1.243GlnGln: 1.243 ± 0.047	2.484GlnArg: 2.484 ± 0.05	1.42GlnSer: 1.42 ± 0.039	1.65GlnThr: 1.65 ± 0.04	2.563GlnVal: 2.563 ± 0.045	0.294GlnTrp: 0.294 ± 0.017	0.513GlnTyr: 0.513 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	9.566ArgAla: 9.566 ± 0.119	0.626ArgCys: 0.626 ± 0.025	4.609ArgAsp: 4.609 ± 0.063	4.44ArgGlu: 4.44 ± 0.066	3.276ArgPhe: 3.276 ± 0.057	5.835ArgGly: 5.835 ± 0.076	2.047ArgHis: 2.047 ± 0.045	4.093ArgIle: 4.093 ± 0.059	1.646ArgLys: 1.646 ± 0.048	10.579ArgLeu: 10.579 ± 0.118	1.947ArgMet: 1.947 ± 0.043	1.69ArgAsn: 1.69 ± 0.035	5.466ArgPro: 5.466 ± 0.073	3.067ArgGln: 3.067 ± 0.055	8.326ArgArg: 8.326 ± 0.109	3.798ArgSer: 3.798 ± 0.057	4.63ArgThr: 4.63 ± 0.063	5.601ArgVal: 5.601 ± 0.079	1.197ArgTrp: 1.197 ± 0.033	1.762ArgTyr: 1.762 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.509SerAla: 5.509 ± 0.082	0.352SerCys: 0.352 ± 0.016	2.436SerAsp: 2.436 ± 0.054	2.043SerGlu: 2.043 ± 0.044	1.877SerPhe: 1.877 ± 0.044	5.127SerGly: 5.127 ± 0.102	0.885SerHis: 0.885 ± 0.025	1.938SerIle: 1.938 ± 0.053	0.883SerLys: 0.883 ± 0.031	4.977SerLeu: 4.977 ± 0.066	0.95SerMet: 0.95 ± 0.03	0.999SerAsn: 0.999 ± 0.044	2.788SerPro: 2.788 ± 0.048	1.271SerGln: 1.271 ± 0.037	3.586SerArg: 3.586 ± 0.062	2.129SerSer: 2.129 ± 0.067	2.175SerThr: 2.175 ± 0.054	3.606SerVal: 3.606 ± 0.068	0.649SerTrp: 0.649 ± 0.022	1.097SerTyr: 1.097 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	7.558ThrAla: 7.558 ± 0.118	0.39ThrCys: 0.39 ± 0.019	3.167ThrAsp: 3.167 ± 0.073	2.743ThrGlu: 2.743 ± 0.048	1.603ThrPhe: 1.603 ± 0.041	5.909ThrGly: 5.909 ± 0.119	0.849ThrHis: 0.849 ± 0.026	2.086ThrIle: 2.086 ± 0.053	0.942ThrLys: 0.942 ± 0.033	6.565ThrLeu: 6.565 ± 0.105	0.96ThrMet: 0.96 ± 0.023	0.968ThrAsn: 0.968 ± 0.036	3.644ThrPro: 3.644 ± 0.069	1.32ThrGln: 1.32 ± 0.036	3.685ThrArg: 3.685 ± 0.05	2.194ThrSer: 2.194 ± 0.055	2.682ThrThr: 2.682 ± 0.066	5.373ThrVal: 5.373 ± 0.108	0.644ThrTrp: 0.644 ± 0.026	1.07ThrTyr: 1.07 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	10.269ValAla: 10.269 ± 0.115	0.644ValCys: 0.644 ± 0.023	4.28ValAsp: 4.28 ± 0.067	4.985ValGlu: 4.985 ± 0.064	2.448ValPhe: 2.448 ± 0.048	5.973ValGly: 5.973 ± 0.093	1.373ValHis: 1.373 ± 0.034	3.018ValIle: 3.018 ± 0.05	1.872ValLys: 1.872 ± 0.047	8.603ValLeu: 8.603 ± 0.097	1.664ValMet: 1.664 ± 0.045	1.804ValAsn: 1.804 ± 0.054	4.794ValPro: 4.794 ± 0.067	2.394ValGln: 2.394 ± 0.051	6.262ValArg: 6.262 ± 0.076	3.759ValSer: 3.759 ± 0.057	4.833ValThr: 4.833 ± 0.113	6.332ValVal: 6.332 ± 0.096	0.99ValTrp: 0.99 ± 0.027	1.353ValTyr: 1.353 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.236TrpAla: 1.236 ± 0.033	0.123TrpCys: 0.123 ± 0.01	0.671TrpAsp: 0.671 ± 0.023	0.641TrpGlu: 0.641 ± 0.022	0.503TrpPhe: 0.503 ± 0.018	0.875TrpGly: 0.875 ± 0.031	0.327TrpHis: 0.327 ± 0.018	0.563TrpIle: 0.563 ± 0.02	0.324TrpLys: 0.324 ± 0.015	1.784TrpLeu: 1.784 ± 0.04	0.322TrpMet: 0.322 ± 0.017	0.354TrpAsn: 0.354 ± 0.017	0.728TrpPro: 0.728 ± 0.026	0.609TrpGln: 0.609 ± 0.022	1.338TrpArg: 1.338 ± 0.036	0.747TrpSer: 0.747 ± 0.025	0.856TrpThr: 0.856 ± 0.025	0.926TrpVal: 0.926 ± 0.03	0.221TrpTrp: 0.221 ± 0.013	0.293TrpTyr: 0.293 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.38TyrAla: 2.38 ± 0.052	0.19TyrCys: 0.19 ± 0.013	1.287TyrAsp: 1.287 ± 0.037	1.077TyrGlu: 1.077 ± 0.033	0.72TyrPhe: 0.72 ± 0.023	2.004TyrGly: 2.004 ± 0.044	0.418TyrHis: 0.418 ± 0.02	0.657TyrIle: 0.657 ± 0.021	0.422TyrLys: 0.422 ± 0.019	2.05TyrLeu: 2.05 ± 0.046	0.382TyrMet: 0.382 ± 0.018	0.429TyrAsn: 0.429 ± 0.019	0.938TyrPro: 0.938 ± 0.032	0.594TyrGln: 0.594 ± 0.022	1.959TyrArg: 1.959 ± 0.045	0.896TyrSer: 0.896 ± 0.035	1.022TyrThr: 1.022 ± 0.035	1.424TyrVal: 1.424 ± 0.034	0.302TyrTrp: 0.302 ± 0.017	0.492TyrTyr: 0.492 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3984 proteins (1255268 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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