Amino acid dipepetide frequency for Saccharomonospora sp. LRS4.154

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.081AlaAla: 20.081 ± 0.18	1.057AlaCys: 1.057 ± 0.032	8.995AlaAsp: 8.995 ± 0.094	9.93AlaGlu: 9.93 ± 0.107	3.364AlaPhe: 3.364 ± 0.052	12.879AlaGly: 12.879 ± 0.121	2.803AlaHis: 2.803 ± 0.052	3.309AlaIle: 3.309 ± 0.058	2.167AlaLys: 2.167 ± 0.057	14.763AlaLeu: 14.763 ± 0.123	2.353AlaMet: 2.353 ± 0.037	1.882AlaAsn: 1.882 ± 0.037	6.205AlaPro: 6.205 ± 0.088	3.511AlaGln: 3.511 ± 0.051	10.518AlaArg: 10.518 ± 0.099	5.886AlaSer: 5.886 ± 0.069	7.746AlaThr: 7.746 ± 0.074	13.2AlaVal: 13.2 ± 0.12	1.761AlaTrp: 1.761 ± 0.038	2.233AlaTyr: 2.233 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.028CysAla: 1.028 ± 0.027	0.098CysCys: 0.098 ± 0.009	0.467CysAsp: 0.467 ± 0.018	0.443CysGlu: 0.443 ± 0.017	0.187CysPhe: 0.187 ± 0.012	0.948CysGly: 0.948 ± 0.026	0.189CysHis: 0.189 ± 0.011	0.116CysIle: 0.116 ± 0.008	0.088CysLys: 0.088 ± 0.009	0.714CysLeu: 0.714 ± 0.02	0.087CysMet: 0.087 ± 0.008	0.108CysAsn: 0.108 ± 0.009	0.465CysPro: 0.465 ± 0.02	0.15CysGln: 0.15 ± 0.01	0.569CysArg: 0.569 ± 0.019	0.451CysSer: 0.451 ± 0.017	0.424CysThr: 0.424 ± 0.016	0.696CysVal: 0.696 ± 0.024	0.128CysTrp: 0.128 ± 0.009	0.171CysTyr: 0.171 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.144AspAla: 8.144 ± 0.097	0.391AspCys: 0.391 ± 0.017	4.523AspAsp: 4.523 ± 0.068	4.578AspGlu: 4.578 ± 0.065	1.546AspPhe: 1.546 ± 0.035	6.768AspGly: 6.768 ± 0.093	1.404AspHis: 1.404 ± 0.03	1.845AspIle: 1.845 ± 0.039	0.829AspLys: 0.829 ± 0.029	6.345AspLeu: 6.345 ± 0.074	0.768AspMet: 0.768 ± 0.025	0.975AspAsn: 0.975 ± 0.028	4.59AspPro: 4.59 ± 0.066	1.429AspGln: 1.429 ± 0.038	5.063AspArg: 5.063 ± 0.066	2.923AspSer: 2.923 ± 0.047	3.762AspThr: 3.762 ± 0.053	5.97AspVal: 5.97 ± 0.075	0.926AspTrp: 0.926 ± 0.028	1.317AspTyr: 1.317 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.091GluAla: 7.091 ± 0.081	0.403GluCys: 0.403 ± 0.019	2.902GluAsp: 2.902 ± 0.049	2.725GluGlu: 2.725 ± 0.053	1.774GluPhe: 1.774 ± 0.034	4.231GluGly: 4.231 ± 0.058	1.962GluHis: 1.962 ± 0.044	2.265GluIle: 2.265 ± 0.047	1.006GluLys: 1.006 ± 0.032	7.692GluLeu: 7.692 ± 0.081	0.823GluMet: 0.823 ± 0.025	1.018GluAsn: 1.018 ± 0.027	4.022GluPro: 4.022 ± 0.062	2.586GluGln: 2.586 ± 0.048	6.014GluArg: 6.014 ± 0.088	2.926GluSer: 2.926 ± 0.048	2.85GluThr: 2.85 ± 0.047	5.203GluVal: 5.203 ± 0.065	0.873GluTrp: 0.873 ± 0.025	1.102GluTyr: 1.102 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.95PheAla: 3.95 ± 0.051	0.254PheCys: 0.254 ± 0.014	2.197PheAsp: 2.197 ± 0.041	1.39PheGlu: 1.39 ± 0.034	0.803PhePhe: 0.803 ± 0.027	3.155PheGly: 3.155 ± 0.052	0.596PheHis: 0.596 ± 0.022	0.524PheIle: 0.524 ± 0.023	0.29PheLys: 0.29 ± 0.016	2.461PheLeu: 2.461 ± 0.044	0.306PheMet: 0.306 ± 0.016	0.482PheAsn: 0.482 ± 0.019	1.267PhePro: 1.267 ± 0.025	0.563PheGln: 0.563 ± 0.018	1.795PheArg: 1.795 ± 0.03	1.385PheSer: 1.385 ± 0.034	1.903PheThr: 1.903 ± 0.039	2.634PheVal: 2.634 ± 0.049	0.376PheTrp: 0.376 ± 0.019	0.529PheTyr: 0.529 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	11.102GlyAla: 11.102 ± 0.108	0.763GlyCys: 0.763 ± 0.026	5.649GlyAsp: 5.649 ± 0.075	5.94GlyGlu: 5.94 ± 0.073	2.821GlyPhe: 2.821 ± 0.047	8.871GlyGly: 8.871 ± 0.116	2.259GlyHis: 2.259 ± 0.048	3.216GlyIle: 3.216 ± 0.046	1.796GlyLys: 1.796 ± 0.04	9.373GlyLeu: 9.373 ± 0.091	2.104GlyMet: 2.104 ± 0.04	1.601GlyAsn: 1.601 ± 0.045	4.599GlyPro: 4.599 ± 0.061	2.705GlyGln: 2.705 ± 0.047	7.406GlyArg: 7.406 ± 0.076	5.239GlySer: 5.239 ± 0.069	6.24GlyThr: 6.24 ± 0.077	8.505GlyVal: 8.505 ± 0.081	1.656GlyTrp: 1.656 ± 0.032	2.214GlyTyr: 2.214 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.827HisAla: 2.827 ± 0.051	0.221HisCys: 0.221 ± 0.013	1.553HisAsp: 1.553 ± 0.037	1.258HisGlu: 1.258 ± 0.033	0.613HisPhe: 0.613 ± 0.023	2.522HisGly: 2.522 ± 0.045	0.644HisHis: 0.644 ± 0.027	0.515HisIle: 0.515 ± 0.021	0.241HisLys: 0.241 ± 0.012	2.275HisLeu: 2.275 ± 0.044	0.252HisMet: 0.252 ± 0.015	0.353HisAsn: 0.353 ± 0.015	1.679HisPro: 1.679 ± 0.033	0.561HisGln: 0.561 ± 0.018	2.172HisArg: 2.172 ± 0.039	1.07HisSer: 1.07 ± 0.032	1.272HisThr: 1.272 ± 0.03	2.008HisVal: 2.008 ± 0.039	0.339HisTrp: 0.339 ± 0.014	0.516HisTyr: 0.516 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	4.498IleAla: 4.498 ± 0.064	0.212IleCys: 0.212 ± 0.011	2.199IleAsp: 2.199 ± 0.04	1.923IleGlu: 1.923 ± 0.038	0.616IlePhe: 0.616 ± 0.024	3.209IleGly: 3.209 ± 0.053	0.52IleHis: 0.52 ± 0.019	0.779IleIle: 0.779 ± 0.026	0.502IleLys: 0.502 ± 0.02	2.008IleLeu: 2.008 ± 0.046	0.399IleMet: 0.399 ± 0.018	0.6IleAsn: 0.6 ± 0.022	1.551IlePro: 1.551 ± 0.039	0.596IleGln: 0.596 ± 0.02	1.858IleArg: 1.858 ± 0.036	1.511IleSer: 1.511 ± 0.035	2.086IleThr: 2.086 ± 0.042	2.803IleVal: 2.803 ± 0.045	0.316IleTrp: 0.316 ± 0.016	0.467IleTyr: 0.467 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.044LysAla: 2.044 ± 0.055	0.071LysCys: 0.071 ± 0.007	0.838LysAsp: 0.838 ± 0.029	0.787LysGlu: 0.787 ± 0.033	0.351LysPhe: 0.351 ± 0.019	1.204LysGly: 1.204 ± 0.034	0.363LysHis: 0.363 ± 0.017	0.653LysIle: 0.653 ± 0.024	0.454LysLys: 0.454 ± 0.024	1.632LysLeu: 1.632 ± 0.04	0.261LysMet: 0.261 ± 0.013	0.331LysAsn: 0.331 ± 0.016	1.045LysPro: 1.045 ± 0.031	0.564LysGln: 0.564 ± 0.024	1.256LysArg: 1.256 ± 0.036	0.86LysSer: 0.86 ± 0.028	0.925LysThr: 0.925 ± 0.027	1.386LysVal: 1.386 ± 0.038	0.174LysTrp: 0.174 ± 0.011	0.3LysTyr: 0.3 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.42LeuAla: 16.42 ± 0.139	0.809LeuCys: 0.809 ± 0.024	7.521LeuAsp: 7.521 ± 0.089	4.323LeuGlu: 4.323 ± 0.064	2.589LeuPhe: 2.589 ± 0.047	9.76LeuGly: 9.76 ± 0.08	2.247LeuHis: 2.247 ± 0.042	2.544LeuIle: 2.544 ± 0.048	1.262LeuLys: 1.262 ± 0.038	11.418LeuLeu: 11.418 ± 0.116	1.211LeuMet: 1.211 ± 0.032	1.517LeuAsn: 1.517 ± 0.036	6.364LeuPro: 6.364 ± 0.074	1.712LeuGln: 1.712 ± 0.033	9.669LeuArg: 9.669 ± 0.085	5.776LeuSer: 5.776 ± 0.068	6.687LeuThr: 6.687 ± 0.065	10.185LeuVal: 10.185 ± 0.105	1.309LeuTrp: 1.309 ± 0.038	1.666LeuTyr: 1.666 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.041MetAla: 2.041 ± 0.035	0.093MetCys: 0.093 ± 0.006	0.742MetAsp: 0.742 ± 0.025	0.627MetGlu: 0.627 ± 0.022	0.451MetPhe: 0.451 ± 0.019	1.155MetGly: 1.155 ± 0.028	0.278MetHis: 0.278 ± 0.014	0.599MetIle: 0.599 ± 0.02	0.301MetLys: 0.301 ± 0.014	1.692MetLeu: 1.692 ± 0.038	0.242MetMet: 0.242 ± 0.014	0.391MetAsn: 0.391 ± 0.017	1.039MetPro: 1.039 ± 0.028	0.37MetGln: 0.37 ± 0.015	1.424MetArg: 1.424 ± 0.029	1.348MetSer: 1.348 ± 0.031	1.457MetThr: 1.457 ± 0.036	1.291MetVal: 1.291 ± 0.028	0.182MetTrp: 0.182 ± 0.012	0.228MetTyr: 0.228 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.08AsnAla: 2.08 ± 0.043	0.143AsnCys: 0.143 ± 0.009	0.938AsnAsp: 0.938 ± 0.026	0.786AsnGlu: 0.786 ± 0.026	0.437AsnPhe: 0.437 ± 0.018	1.607AsnGly: 1.607 ± 0.037	0.354AsnHis: 0.354 ± 0.017	0.562AsnIle: 0.562 ± 0.018	0.284AsnLys: 0.284 ± 0.016	1.663AsnLeu: 1.663 ± 0.034	0.278AsnMet: 0.278 ± 0.013	0.348AsnAsn: 0.348 ± 0.018	1.296AsnPro: 1.296 ± 0.032	0.48AsnGln: 0.48 ± 0.018	1.206AsnArg: 1.206 ± 0.029	0.883AsnSer: 0.883 ± 0.024	1.054AsnThr: 1.054 ± 0.029	1.307AsnVal: 1.307 ± 0.029	0.256AsnTrp: 0.256 ± 0.014	0.404AsnTyr: 0.404 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.585ProAla: 7.585 ± 0.088	0.328ProCys: 0.328 ± 0.016	4.522ProAsp: 4.522 ± 0.065	4.62ProGlu: 4.62 ± 0.067	1.443ProPhe: 1.443 ± 0.03	6.53ProGly: 6.53 ± 0.076	1.363ProHis: 1.363 ± 0.029	1.319ProIle: 1.319 ± 0.028	0.954ProLys: 0.954 ± 0.033	5.053ProLeu: 5.053 ± 0.059	0.963ProMet: 0.963 ± 0.029	0.872ProAsn: 0.872 ± 0.023	3.621ProPro: 3.621 ± 0.079	1.473ProGln: 1.473 ± 0.037	3.983ProArg: 3.983 ± 0.059	3.238ProSer: 3.238 ± 0.053	3.2ProThr: 3.2 ± 0.05	5.447ProVal: 5.447 ± 0.063	0.962ProTrp: 0.962 ± 0.033	1.058ProTyr: 1.058 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.473GlnAla: 3.473 ± 0.064	0.154GlnCys: 0.154 ± 0.01	1.227GlnAsp: 1.227 ± 0.029	1.209GlnGlu: 1.209 ± 0.031	0.667GlnPhe: 0.667 ± 0.022	2.073GlnGly: 2.073 ± 0.04	0.672GlnHis: 0.672 ± 0.021	0.886GlnIle: 0.886 ± 0.03	0.366GlnLys: 0.366 ± 0.015	2.979GlnLeu: 2.979 ± 0.046	0.365GlnMet: 0.365 ± 0.018	0.435GlnAsn: 0.435 ± 0.019	1.665GlnPro: 1.665 ± 0.045	1.238GlnGln: 1.238 ± 0.042	2.9GlnArg: 2.9 ± 0.045	1.157GlnSer: 1.157 ± 0.028	1.082GlnThr: 1.082 ± 0.025	2.232GlnVal: 2.232 ± 0.037	0.448GlnTrp: 0.448 ± 0.015	0.531GlnTyr: 0.531 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	10.302ArgAla: 10.302 ± 0.105	0.653ArgCys: 0.653 ± 0.022	5.01ArgAsp: 5.01 ± 0.062	5.068ArgGlu: 5.068 ± 0.064	2.394ArgPhe: 2.394 ± 0.041	6.281ArgGly: 6.281 ± 0.068	2.294ArgHis: 2.294 ± 0.044	2.821ArgIle: 2.821 ± 0.047	1.457ArgLys: 1.457 ± 0.041	8.906ArgLeu: 8.906 ± 0.091	1.771ArgMet: 1.771 ± 0.035	1.344ArgAsn: 1.344 ± 0.032	4.785ArgPro: 4.785 ± 0.063	2.427ArgGln: 2.427 ± 0.04	8.544ArgArg: 8.544 ± 0.112	4.281ArgSer: 4.281 ± 0.053	5.116ArgThr: 5.116 ± 0.071	6.93ArgVal: 6.93 ± 0.076	1.537ArgTrp: 1.537 ± 0.034	1.941ArgTyr: 1.941 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.973SerAla: 6.973 ± 0.072	0.396SerCys: 0.396 ± 0.016	2.946SerAsp: 2.946 ± 0.046	2.852SerGlu: 2.852 ± 0.048	1.482SerPhe: 1.482 ± 0.03	6.075SerGly: 6.075 ± 0.065	0.982SerHis: 0.982 ± 0.028	1.411SerIle: 1.411 ± 0.031	0.79SerLys: 0.79 ± 0.025	4.909SerLeu: 4.909 ± 0.07	1.102SerMet: 1.102 ± 0.029	0.835SerAsn: 0.835 ± 0.027	3.099SerPro: 3.099 ± 0.043	1.25SerGln: 1.25 ± 0.029	4.015SerArg: 4.015 ± 0.056	2.862SerSer: 2.862 ± 0.05	3.142SerThr: 3.142 ± 0.054	4.691SerVal: 4.691 ± 0.067	0.901SerTrp: 0.901 ± 0.028	1.1SerTyr: 1.1 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	8.356ThrAla: 8.356 ± 0.083	0.402ThrCys: 0.402 ± 0.017	3.784ThrAsp: 3.784 ± 0.058	3.677ThrGlu: 3.677 ± 0.051	1.602ThrPhe: 1.602 ± 0.037	6.44ThrGly: 6.44 ± 0.075	1.156ThrHis: 1.156 ± 0.031	1.736ThrIle: 1.736 ± 0.037	0.923ThrLys: 0.923 ± 0.032	5.945ThrLeu: 5.945 ± 0.065	1.009ThrMet: 1.009 ± 0.031	0.917ThrAsn: 0.917 ± 0.028	3.808ThrPro: 3.808 ± 0.057	1.251ThrGln: 1.251 ± 0.032	4.133ThrArg: 4.133 ± 0.06	3.16ThrSer: 3.16 ± 0.049	4.063ThrThr: 4.063 ± 0.058	6.623ThrVal: 6.623 ± 0.074	0.84ThrTrp: 0.84 ± 0.024	1.21ThrTyr: 1.21 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	12.767ValAla: 12.767 ± 0.118	0.773ValCys: 0.773 ± 0.027	5.863ValAsp: 5.863 ± 0.066	5.491ValGlu: 5.491 ± 0.066	2.638ValPhe: 2.638 ± 0.045	7.395ValGly: 7.395 ± 0.077	1.928ValHis: 1.928 ± 0.04	2.725ValIle: 2.725 ± 0.046	1.306ValLys: 1.306 ± 0.034	11.096ValLeu: 11.096 ± 0.106	1.224ValMet: 1.224 ± 0.029	1.653ValAsn: 1.653 ± 0.037	5.464ValPro: 5.464 ± 0.07	1.816ValGln: 1.816 ± 0.039	7.99ValArg: 7.99 ± 0.087	5.031ValSer: 5.031 ± 0.056	6.052ValThr: 6.052 ± 0.072	10.024ValVal: 10.024 ± 0.107	1.184ValTrp: 1.184 ± 0.027	1.485ValTyr: 1.485 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.571TrpAla: 1.571 ± 0.037	0.151TrpCys: 0.151 ± 0.011	0.807TrpAsp: 0.807 ± 0.025	0.733TrpGlu: 0.733 ± 0.024	0.487TrpPhe: 0.487 ± 0.02	1.007TrpGly: 1.007 ± 0.033	0.394TrpHis: 0.394 ± 0.017	0.47TrpIle: 0.47 ± 0.018	0.229TrpLys: 0.229 ± 0.012	1.941TrpLeu: 1.941 ± 0.042	0.267TrpMet: 0.267 ± 0.013	0.346TrpAsn: 0.346 ± 0.016	0.862TrpPro: 0.862 ± 0.024	0.579TrpGln: 0.579 ± 0.019	1.498TrpArg: 1.498 ± 0.036	0.855TrpSer: 0.855 ± 0.029	0.885TrpThr: 0.885 ± 0.025	1.123TrpVal: 1.123 ± 0.03	0.4TrpTrp: 0.4 ± 0.019	0.282TrpTyr: 0.282 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.311TyrAla: 2.311 ± 0.047	0.158TyrCys: 0.158 ± 0.012	1.414TyrAsp: 1.414 ± 0.039	1.105TyrGlu: 1.105 ± 0.033	0.596TyrPhe: 0.596 ± 0.023	1.947TyrGly: 1.947 ± 0.045	0.484TyrHis: 0.484 ± 0.017	0.357TyrIle: 0.357 ± 0.015	0.256TyrLys: 0.256 ± 0.016	2.121TyrLeu: 2.121 ± 0.042	0.166TyrMet: 0.166 ± 0.011	0.357TyrAsn: 0.357 ± 0.017	1.108TyrPro: 1.108 ± 0.028	0.498TyrGln: 0.498 ± 0.02	1.847TyrArg: 1.847 ± 0.034	0.971TyrSer: 0.971 ± 0.024	1.088TyrThr: 1.088 ± 0.028	1.647TyrVal: 1.647 ± 0.037	0.323TyrTrp: 0.323 ± 0.016	0.46TyrTyr: 0.46 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4456 proteins (1458872 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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