Amino acid dipepetide frequency for Gordonia phage Sour

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.293AlaAla: 16.293 ± 1.053
1.025AlaCys: 1.025 ± 0.23
8.813AlaAsp: 8.813 ± 0.793
9.018AlaGlu: 9.018 ± 0.868
3.228AlaPhe: 3.228 ± 0.485
8.813AlaGly: 8.813 ± 1.15
2.613AlaHis: 2.613 ± 0.387
5.124AlaIle: 5.124 ± 0.55
2.716AlaLys: 2.716 ± 0.463
10.145AlaLeu: 10.145 ± 0.78
3.792AlaMet: 3.792 ± 0.539
2.921AlaAsn: 2.921 ± 0.413
5.841AlaPro: 5.841 ± 0.496
4.56AlaGln: 4.56 ± 0.45
8.505AlaArg: 8.505 ± 0.942
7.481AlaSer: 7.481 ± 0.529
7.634AlaThr: 7.634 ± 0.662
10.196AlaVal: 10.196 ± 0.773
2.459AlaTrp: 2.459 ± 0.345
2.408AlaTyr: 2.408 ± 0.328
0.0AlaXaa: 0.0 ± 0.0
Cys
0.871CysAla: 0.871 ± 0.218
0.0CysCys: 0.0 ± 0.0
0.974CysAsp: 0.974 ± 0.278
0.666CysGlu: 0.666 ± 0.252
0.205CysPhe: 0.205 ± 0.103
1.383CysGly: 1.383 ± 0.438
0.41CysHis: 0.41 ± 0.134
0.051CysIle: 0.051 ± 0.045
0.205CysLys: 0.205 ± 0.092
0.154CysLeu: 0.154 ± 0.09
0.256CysMet: 0.256 ± 0.122
0.307CysAsn: 0.307 ± 0.128
0.82CysPro: 0.82 ± 0.227
0.256CysGln: 0.256 ± 0.108
0.82CysArg: 0.82 ± 0.272
0.666CysSer: 0.666 ± 0.179
0.102CysThr: 0.102 ± 0.074
0.974CysVal: 0.974 ± 0.206
0.154CysTrp: 0.154 ± 0.126
0.256CysTyr: 0.256 ± 0.098
0.0CysXaa: 0.0 ± 0.0
Asp
8.198AspAla: 8.198 ± 0.675
0.615AspCys: 0.615 ± 0.144
5.841AspAsp: 5.841 ± 0.759
5.073AspGlu: 5.073 ± 0.621
1.486AspPhe: 1.486 ± 0.222
6.661AspGly: 6.661 ± 0.677
1.742AspHis: 1.742 ± 0.327
2.562AspIle: 2.562 ± 0.308
1.076AspLys: 1.076 ± 0.251
6.815AspLeu: 6.815 ± 0.747
1.435AspMet: 1.435 ± 0.287
1.537AspAsn: 1.537 ± 0.295
4.56AspPro: 4.56 ± 0.522
1.998AspGln: 1.998 ± 0.308
4.201AspArg: 4.201 ± 0.46
3.484AspSer: 3.484 ± 0.464
3.945AspThr: 3.945 ± 0.407
3.535AspVal: 3.535 ± 0.482
1.383AspTrp: 1.383 ± 0.245
1.23AspTyr: 1.23 ± 0.307
0.0AspXaa: 0.0 ± 0.0
Glu
7.481GluAla: 7.481 ± 0.575
0.512GluCys: 0.512 ± 0.188
3.587GluAsp: 3.587 ± 0.484
3.638GluGlu: 3.638 ± 0.551
1.793GluPhe: 1.793 ± 0.284
4.56GluGly: 4.56 ± 0.448
1.588GluHis: 1.588 ± 0.293
4.099GluIle: 4.099 ± 0.56
1.383GluLys: 1.383 ± 0.273
5.329GluLeu: 5.329 ± 0.547
1.537GluMet: 1.537 ± 0.273
1.486GluAsn: 1.486 ± 0.283
3.484GluPro: 3.484 ± 0.545
2.562GluGln: 2.562 ± 0.338
4.765GluArg: 4.765 ± 0.581
2.767GluSer: 2.767 ± 0.343
4.355GluThr: 4.355 ± 0.553
4.56GluVal: 4.56 ± 0.441
1.281GluTrp: 1.281 ± 0.216
1.332GluTyr: 1.332 ± 0.281
0.0GluXaa: 0.0 ± 0.0
Phe
3.023PheAla: 3.023 ± 0.299
0.154PheCys: 0.154 ± 0.089
2.254PheAsp: 2.254 ± 0.361
1.486PheGlu: 1.486 ± 0.307
0.666PhePhe: 0.666 ± 0.255
2.152PheGly: 2.152 ± 0.322
0.41PheHis: 0.41 ± 0.157
1.127PheIle: 1.127 ± 0.251
0.564PheLys: 0.564 ± 0.15
1.383PheLeu: 1.383 ± 0.344
0.717PheMet: 0.717 ± 0.157
0.461PheAsn: 0.461 ± 0.183
0.871PhePro: 0.871 ± 0.209
0.512PheGln: 0.512 ± 0.194
1.23PheArg: 1.23 ± 0.257
1.845PheSer: 1.845 ± 0.294
2.101PheThr: 2.101 ± 0.305
2.203PheVal: 2.203 ± 0.346
0.154PheTrp: 0.154 ± 0.093
0.564PheTyr: 0.564 ± 0.15
0.0PheXaa: 0.0 ± 0.0
Gly
8.454GlyAla: 8.454 ± 1.191
0.871GlyCys: 0.871 ± 0.262
5.175GlyAsp: 5.175 ± 0.496
5.124GlyGlu: 5.124 ± 0.496
1.896GlyPhe: 1.896 ± 0.43
7.327GlyGly: 7.327 ± 1.119
2.306GlyHis: 2.306 ± 0.338
4.714GlyIle: 4.714 ± 0.695
3.382GlyLys: 3.382 ± 0.395
8.044GlyLeu: 8.044 ± 0.958
1.64GlyMet: 1.64 ± 0.331
2.049GlyAsn: 2.049 ± 0.425
3.638GlyPro: 3.638 ± 0.429
3.33GlyGln: 3.33 ± 0.364
5.431GlyArg: 5.431 ± 0.55
5.38GlySer: 5.38 ± 0.525
5.534GlyThr: 5.534 ± 0.563
5.534GlyVal: 5.534 ± 0.55
2.203GlyTrp: 2.203 ± 0.335
2.613GlyTyr: 2.613 ± 0.477
0.0GlyXaa: 0.0 ± 0.0
His
2.408HisAla: 2.408 ± 0.419
0.307HisCys: 0.307 ± 0.124
1.537HisAsp: 1.537 ± 0.27
0.717HisGlu: 0.717 ± 0.162
0.564HisPhe: 0.564 ± 0.202
1.742HisGly: 1.742 ± 0.382
0.82HisHis: 0.82 ± 0.216
1.025HisIle: 1.025 ± 0.255
0.256HisLys: 0.256 ± 0.111
2.459HisLeu: 2.459 ± 0.342
0.307HisMet: 0.307 ± 0.122
0.564HisAsn: 0.564 ± 0.141
1.127HisPro: 1.127 ± 0.314
1.076HisGln: 1.076 ± 0.276
1.947HisArg: 1.947 ± 0.428
0.769HisSer: 0.769 ± 0.17
1.332HisThr: 1.332 ± 0.255
1.025HisVal: 1.025 ± 0.23
0.461HisTrp: 0.461 ± 0.179
0.564HisTyr: 0.564 ± 0.19
0.0HisXaa: 0.0 ± 0.0
Ile
6.968IleAla: 6.968 ± 0.73
0.359IleCys: 0.359 ± 0.149
4.714IleAsp: 4.714 ± 0.512
4.663IleGlu: 4.663 ± 0.493
0.871IlePhe: 0.871 ± 0.213
5.073IleGly: 5.073 ± 0.855
1.178IleHis: 1.178 ± 0.222
1.998IleIle: 1.998 ± 0.36
1.383IleLys: 1.383 ± 0.327
2.869IleLeu: 2.869 ± 0.41
1.178IleMet: 1.178 ± 0.311
1.23IleAsn: 1.23 ± 0.29
2.101IlePro: 2.101 ± 0.292
1.178IleGln: 1.178 ± 0.236
2.664IleArg: 2.664 ± 0.396
2.767IleSer: 2.767 ± 0.322
3.997IleThr: 3.997 ± 0.415
3.74IleVal: 3.74 ± 0.368
0.717IleTrp: 0.717 ± 0.188
0.666IleTyr: 0.666 ± 0.202
0.0IleXaa: 0.0 ± 0.0
Lys
3.177LysAla: 3.177 ± 0.436
0.41LysCys: 0.41 ± 0.125
0.974LysAsp: 0.974 ± 0.187
1.127LysGlu: 1.127 ± 0.283
0.359LysPhe: 0.359 ± 0.121
1.998LysGly: 1.998 ± 0.366
0.307LysHis: 0.307 ± 0.11
1.23LysIle: 1.23 ± 0.299
0.41LysLys: 0.41 ± 0.141
2.408LysLeu: 2.408 ± 0.404
0.615LysMet: 0.615 ± 0.18
0.717LysAsn: 0.717 ± 0.193
1.588LysPro: 1.588 ± 0.319
0.564LysGln: 0.564 ± 0.172
2.511LysArg: 2.511 ± 0.42
1.281LysSer: 1.281 ± 0.276
1.537LysThr: 1.537 ± 0.27
2.254LysVal: 2.254 ± 0.35
0.256LysTrp: 0.256 ± 0.101
0.41LysTyr: 0.41 ± 0.159
0.0LysXaa: 0.0 ± 0.0
Leu
10.657LeuAla: 10.657 ± 0.884
0.769LeuCys: 0.769 ± 0.225
6.661LeuAsp: 6.661 ± 0.645
3.945LeuGlu: 3.945 ± 0.434
1.64LeuPhe: 1.64 ± 0.377
7.02LeuGly: 7.02 ± 0.687
1.588LeuHis: 1.588 ± 0.326
4.509LeuIle: 4.509 ± 0.469
2.357LeuLys: 2.357 ± 0.329
5.277LeuLeu: 5.277 ± 0.519
1.998LeuMet: 1.998 ± 0.332
2.562LeuAsn: 2.562 ± 0.441
4.355LeuPro: 4.355 ± 0.511
2.511LeuGln: 2.511 ± 0.36
4.765LeuArg: 4.765 ± 0.585
4.97LeuSer: 4.97 ± 0.446
5.995LeuThr: 5.995 ± 0.49
5.482LeuVal: 5.482 ± 0.688
1.845LeuTrp: 1.845 ± 0.302
1.896LeuTyr: 1.896 ± 0.389
0.0LeuXaa: 0.0 ± 0.0
Met
2.972MetAla: 2.972 ± 0.436
0.205MetCys: 0.205 ± 0.116
1.281MetAsp: 1.281 ± 0.279
0.974MetGlu: 0.974 ± 0.256
0.769MetPhe: 0.769 ± 0.259
2.203MetGly: 2.203 ± 0.368
0.307MetHis: 0.307 ± 0.136
1.588MetIle: 1.588 ± 0.262
0.564MetLys: 0.564 ± 0.195
1.845MetLeu: 1.845 ± 0.31
0.41MetMet: 0.41 ± 0.15
0.512MetAsn: 0.512 ± 0.179
1.691MetPro: 1.691 ± 0.276
0.564MetGln: 0.564 ± 0.251
2.049MetArg: 2.049 ± 0.326
2.254MetSer: 2.254 ± 0.304
2.152MetThr: 2.152 ± 0.281
1.486MetVal: 1.486 ± 0.23
0.461MetTrp: 0.461 ± 0.152
0.564MetTyr: 0.564 ± 0.195
0.0MetXaa: 0.0 ± 0.0
Asn
3.587AsnAla: 3.587 ± 0.443
0.307AsnCys: 0.307 ± 0.128
1.896AsnAsp: 1.896 ± 0.302
1.178AsnGlu: 1.178 ± 0.278
0.615AsnPhe: 0.615 ± 0.262
2.716AsnGly: 2.716 ± 0.408
0.717AsnHis: 0.717 ± 0.189
0.769AsnIle: 0.769 ± 0.255
0.564AsnLys: 0.564 ± 0.134
1.998AsnLeu: 1.998 ± 0.321
0.256AsnMet: 0.256 ± 0.126
1.025AsnAsn: 1.025 ± 0.265
1.537AsnPro: 1.537 ± 0.257
0.512AsnGln: 0.512 ± 0.183
1.025AsnArg: 1.025 ± 0.186
1.947AsnSer: 1.947 ± 0.328
1.793AsnThr: 1.793 ± 0.338
2.357AsnVal: 2.357 ± 0.464
0.717AsnTrp: 0.717 ± 0.171
0.564AsnTyr: 0.564 ± 0.168
0.0AsnXaa: 0.0 ± 0.0
Pro
5.38ProAla: 5.38 ± 0.616
0.41ProCys: 0.41 ± 0.147
3.74ProAsp: 3.74 ± 0.568
5.124ProGlu: 5.124 ± 0.637
1.896ProPhe: 1.896 ± 0.297
4.304ProGly: 4.304 ± 0.518
0.922ProHis: 0.922 ± 0.269
2.767ProIle: 2.767 ± 0.287
1.076ProLys: 1.076 ± 0.212
3.74ProLeu: 3.74 ± 0.345
1.486ProMet: 1.486 ± 0.241
1.178ProAsn: 1.178 ± 0.217
3.177ProPro: 3.177 ± 0.399
1.383ProGln: 1.383 ± 0.266
3.279ProArg: 3.279 ± 0.453
4.099ProSer: 4.099 ± 0.428
4.611ProThr: 4.611 ± 0.556
4.304ProVal: 4.304 ± 0.381
1.076ProTrp: 1.076 ± 0.228
0.974ProTyr: 0.974 ± 0.283
0.0ProXaa: 0.0 ± 0.0
Gln
3.997GlnAla: 3.997 ± 0.456
0.307GlnCys: 0.307 ± 0.106
0.871GlnAsp: 0.871 ± 0.227
1.691GlnGlu: 1.691 ± 0.3
1.127GlnPhe: 1.127 ± 0.195
2.664GlnGly: 2.664 ± 0.351
0.717GlnHis: 0.717 ± 0.227
2.306GlnIle: 2.306 ± 0.472
0.41GlnLys: 0.41 ± 0.117
3.74GlnLeu: 3.74 ± 0.407
1.076GlnMet: 1.076 ± 0.304
0.82GlnAsn: 0.82 ± 0.281
1.64GlnPro: 1.64 ± 0.237
1.64GlnGln: 1.64 ± 0.457
2.767GlnArg: 2.767 ± 0.425
1.435GlnSer: 1.435 ± 0.331
2.101GlnThr: 2.101 ± 0.347
3.228GlnVal: 3.228 ± 0.456
0.615GlnTrp: 0.615 ± 0.168
0.564GlnTyr: 0.564 ± 0.146
0.0GlnXaa: 0.0 ± 0.0
Arg
8.352ArgAla: 8.352 ± 0.69
1.025ArgCys: 1.025 ± 0.282
4.458ArgAsp: 4.458 ± 0.5
3.894ArgGlu: 3.894 ± 0.453
1.947ArgPhe: 1.947 ± 0.374
4.765ArgGly: 4.765 ± 0.563
1.588ArgHis: 1.588 ± 0.31
3.279ArgIle: 3.279 ± 0.443
1.537ArgLys: 1.537 ± 0.274
6.251ArgLeu: 6.251 ± 0.588
1.588ArgMet: 1.588 ± 0.346
1.896ArgAsn: 1.896 ± 0.299
3.638ArgPro: 3.638 ± 0.464
2.767ArgGln: 2.767 ± 0.374
5.944ArgArg: 5.944 ± 0.808
3.638ArgSer: 3.638 ± 0.444
4.201ArgThr: 4.201 ± 0.518
3.894ArgVal: 3.894 ± 0.4
1.845ArgTrp: 1.845 ± 0.334
2.101ArgTyr: 2.101 ± 0.396
0.0ArgXaa: 0.0 ± 0.0
Ser
7.634SerAla: 7.634 ± 0.601
0.666SerCys: 0.666 ± 0.289
3.433SerAsp: 3.433 ± 0.456
2.921SerGlu: 2.921 ± 0.352
0.666SerPhe: 0.666 ± 0.21
6.353SerGly: 6.353 ± 0.633
0.615SerHis: 0.615 ± 0.144
3.689SerIle: 3.689 ± 0.379
1.588SerLys: 1.588 ± 0.351
4.56SerLeu: 4.56 ± 0.499
1.486SerMet: 1.486 ± 0.284
1.076SerAsn: 1.076 ± 0.227
4.099SerPro: 4.099 ± 0.49
2.152SerGln: 2.152 ± 0.259
3.792SerArg: 3.792 ± 0.515
3.535SerSer: 3.535 ± 0.377
4.201SerThr: 4.201 ± 0.542
4.304SerVal: 4.304 ± 0.379
1.23SerTrp: 1.23 ± 0.262
1.845SerTyr: 1.845 ± 0.352
0.0SerXaa: 0.0 ± 0.0
Thr
9.633ThrAla: 9.633 ± 0.77
0.461ThrCys: 0.461 ± 0.161
4.458ThrAsp: 4.458 ± 0.521
3.945ThrGlu: 3.945 ± 0.435
1.793ThrPhe: 1.793 ± 0.314
6.148ThrGly: 6.148 ± 0.446
0.769ThrHis: 0.769 ± 0.193
3.792ThrIle: 3.792 ± 0.403
2.049ThrLys: 2.049 ± 0.268
4.663ThrLeu: 4.663 ± 0.419
2.101ThrMet: 2.101 ± 0.309
1.845ThrAsn: 1.845 ± 0.373
4.714ThrPro: 4.714 ± 0.66
1.845ThrGln: 1.845 ± 0.308
4.253ThrArg: 4.253 ± 0.525
4.406ThrSer: 4.406 ± 0.567
5.073ThrThr: 5.073 ± 0.639
4.406ThrVal: 4.406 ± 0.363
1.486ThrTrp: 1.486 ± 0.253
1.64ThrTyr: 1.64 ± 0.272
0.0ThrXaa: 0.0 ± 0.0
Val
9.018ValAla: 9.018 ± 0.728
0.666ValCys: 0.666 ± 0.212
3.894ValAsp: 3.894 ± 0.495
4.816ValGlu: 4.816 ± 0.573
1.332ValPhe: 1.332 ± 0.25
5.79ValGly: 5.79 ± 0.419
1.332ValHis: 1.332 ± 0.254
4.304ValIle: 4.304 ± 0.655
1.691ValLys: 1.691 ± 0.266
5.636ValLeu: 5.636 ± 0.641
1.947ValMet: 1.947 ± 0.284
2.203ValAsn: 2.203 ± 0.358
3.894ValPro: 3.894 ± 0.463
2.152ValGln: 2.152 ± 0.327
5.38ValArg: 5.38 ± 0.644
4.406ValSer: 4.406 ± 0.597
6.148ValThr: 6.148 ± 0.731
5.277ValVal: 5.277 ± 0.646
1.383ValTrp: 1.383 ± 0.374
1.23ValTyr: 1.23 ± 0.273
0.0ValXaa: 0.0 ± 0.0
Trp
2.511TrpAla: 2.511 ± 0.431
0.307TrpCys: 0.307 ± 0.124
1.332TrpAsp: 1.332 ± 0.233
1.281TrpGlu: 1.281 ± 0.235
0.512TrpPhe: 0.512 ± 0.191
0.871TrpGly: 0.871 ± 0.203
0.512TrpHis: 0.512 ± 0.138
0.769TrpIle: 0.769 ± 0.203
0.41TrpLys: 0.41 ± 0.164
1.332TrpLeu: 1.332 ± 0.233
0.615TrpMet: 0.615 ± 0.179
1.23TrpAsn: 1.23 ± 0.442
1.025TrpPro: 1.025 ± 0.258
1.23TrpGln: 1.23 ± 0.237
1.178TrpArg: 1.178 ± 0.28
1.486TrpSer: 1.486 ± 0.337
1.076TrpThr: 1.076 ± 0.234
1.947TrpVal: 1.947 ± 0.302
0.359TrpTrp: 0.359 ± 0.132
0.359TrpTyr: 0.359 ± 0.117
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.972TyrAla: 2.972 ± 0.475
0.154TyrCys: 0.154 ± 0.117
1.537TyrAsp: 1.537 ± 0.259
0.82TyrGlu: 0.82 ± 0.209
0.512TyrPhe: 0.512 ± 0.174
2.101TyrGly: 2.101 ± 0.333
0.564TyrHis: 0.564 ± 0.175
0.615TyrIle: 0.615 ± 0.18
0.512TyrLys: 0.512 ± 0.148
2.152TyrLeu: 2.152 ± 0.321
0.359TyrMet: 0.359 ± 0.118
0.461TyrAsn: 0.461 ± 0.131
1.127TyrPro: 1.127 ± 0.272
0.922TyrGln: 0.922 ± 0.203
2.101TyrArg: 2.101 ± 0.339
1.23TyrSer: 1.23 ± 0.25
1.588TyrThr: 1.588 ± 0.282
1.793TyrVal: 1.793 ± 0.434
0.256TyrTrp: 0.256 ± 0.152
0.512TyrTyr: 0.512 ± 0.178
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 79 proteins (19518 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski