Amino acid dipepetide frequency for Sulfitobacter sp. JBTF-M27

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.093AlaAla: 15.093 ± 0.166
1.064AlaCys: 1.064 ± 0.032
6.973AlaAsp: 6.973 ± 0.082
7.841AlaGlu: 7.841 ± 0.09
4.309AlaPhe: 4.309 ± 0.056
9.46AlaGly: 9.46 ± 0.105
2.325AlaHis: 2.325 ± 0.045
5.891AlaIle: 5.891 ± 0.069
4.317AlaLys: 4.317 ± 0.064
12.907AlaLeu: 12.907 ± 0.135
3.713AlaMet: 3.713 ± 0.053
2.792AlaAsn: 2.792 ± 0.05
5.317AlaPro: 5.317 ± 0.075
4.533AlaGln: 4.533 ± 0.063
7.494AlaArg: 7.494 ± 0.092
5.654AlaSer: 5.654 ± 0.066
5.738AlaThr: 5.738 ± 0.068
7.982AlaVal: 7.982 ± 0.087
1.346AlaTrp: 1.346 ± 0.038
2.535AlaTyr: 2.535 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
1.09CysAla: 1.09 ± 0.032
0.114CysCys: 0.114 ± 0.01
0.637CysAsp: 0.637 ± 0.024
0.462CysGlu: 0.462 ± 0.019
0.354CysPhe: 0.354 ± 0.014
0.945CysGly: 0.945 ± 0.027
0.261CysHis: 0.261 ± 0.015
0.451CysIle: 0.451 ± 0.017
0.272CysLys: 0.272 ± 0.013
0.806CysLeu: 0.806 ± 0.024
0.19CysMet: 0.19 ± 0.011
0.246CysAsn: 0.246 ± 0.013
0.485CysPro: 0.485 ± 0.022
0.282CysGln: 0.282 ± 0.015
0.483CysArg: 0.483 ± 0.018
0.442CysSer: 0.442 ± 0.02
0.478CysThr: 0.478 ± 0.021
0.646CysVal: 0.646 ± 0.018
0.127CysTrp: 0.127 ± 0.01
0.242CysTyr: 0.242 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.574AspAla: 7.574 ± 0.087
0.53AspCys: 0.53 ± 0.019
3.696AspAsp: 3.696 ± 0.076
3.715AspGlu: 3.715 ± 0.054
2.384AspPhe: 2.384 ± 0.044
5.496AspGly: 5.496 ± 0.086
1.408AspHis: 1.408 ± 0.033
3.36AspIle: 3.36 ± 0.053
1.967AspLys: 1.967 ± 0.043
6.459AspLeu: 6.459 ± 0.07
1.782AspMet: 1.782 ± 0.037
1.513AspAsn: 1.513 ± 0.037
3.713AspPro: 3.713 ± 0.058
2.128AspGln: 2.128 ± 0.037
3.957AspArg: 3.957 ± 0.064
2.182AspSer: 2.182 ± 0.047
3.268AspThr: 3.268 ± 0.062
4.751AspVal: 4.751 ± 0.06
1.101AspTrp: 1.101 ± 0.026
1.592AspTyr: 1.592 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
7.767GluAla: 7.767 ± 0.084
0.371GluCys: 0.371 ± 0.017
3.669GluAsp: 3.669 ± 0.061
3.684GluGlu: 3.684 ± 0.066
1.861GluPhe: 1.861 ± 0.04
4.79GluGly: 4.79 ± 0.062
1.203GluHis: 1.203 ± 0.028
3.803GluIle: 3.803 ± 0.056
2.49GluLys: 2.49 ± 0.046
5.287GluLeu: 5.287 ± 0.071
2.019GluMet: 2.019 ± 0.039
2.045GluAsn: 2.045 ± 0.035
2.397GluPro: 2.397 ± 0.043
2.098GluGln: 2.098 ± 0.042
4.081GluArg: 4.081 ± 0.063
2.128GluSer: 2.128 ± 0.042
3.897GluThr: 3.897 ± 0.055
4.575GluVal: 4.575 ± 0.065
0.74GluTrp: 0.74 ± 0.026
1.188GluTyr: 1.188 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
4.451PheAla: 4.451 ± 0.061
0.47PheCys: 0.47 ± 0.018
3.036PheAsp: 3.036 ± 0.043
2.513PheGlu: 2.513 ± 0.04
1.531PhePhe: 1.531 ± 0.037
3.737PheGly: 3.737 ± 0.052
0.759PheHis: 0.759 ± 0.024
1.769PheIle: 1.769 ± 0.041
1.16PheLys: 1.16 ± 0.031
3.347PheLeu: 3.347 ± 0.063
0.908PheMet: 0.908 ± 0.024
1.149PheAsn: 1.149 ± 0.032
1.523PhePro: 1.523 ± 0.034
1.126PheGln: 1.126 ± 0.028
2.075PheArg: 2.075 ± 0.039
2.288PheSer: 2.288 ± 0.042
2.084PheThr: 2.084 ± 0.044
2.779PheVal: 2.779 ± 0.051
0.613PheTrp: 0.613 ± 0.021
0.917PheTyr: 0.917 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
9.047GlyAla: 9.047 ± 0.099
0.811GlyCys: 0.811 ± 0.023
4.882GlyAsp: 4.882 ± 0.083
4.456GlyGlu: 4.456 ± 0.066
3.647GlyPhe: 3.647 ± 0.057
7.105GlyGly: 7.105 ± 0.107
1.883GlyHis: 1.883 ± 0.038
4.604GlyIle: 4.604 ± 0.06
3.42GlyLys: 3.42 ± 0.053
8.54GlyLeu: 8.54 ± 0.083
2.668GlyMet: 2.668 ± 0.048
2.321GlyAsn: 2.321 ± 0.053
3.529GlyPro: 3.529 ± 0.053
3.22GlyGln: 3.22 ± 0.054
5.108GlyArg: 5.108 ± 0.06
4.271GlySer: 4.271 ± 0.06
4.706GlyThr: 4.706 ± 0.072
6.149GlyVal: 6.149 ± 0.074
1.439GlyTrp: 1.439 ± 0.033
2.297GlyTyr: 2.297 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
2.293HisAla: 2.293 ± 0.038
0.251HisCys: 0.251 ± 0.014
1.283HisAsp: 1.283 ± 0.033
1.095HisGlu: 1.095 ± 0.025
0.846HisPhe: 0.846 ± 0.024
1.809HisGly: 1.809 ± 0.037
0.577HisHis: 0.577 ± 0.024
1.091HisIle: 1.091 ± 0.028
0.605HisLys: 0.605 ± 0.022
2.231HisLeu: 2.231 ± 0.044
0.572HisMet: 0.572 ± 0.021
0.505HisAsn: 0.505 ± 0.019
1.304HisPro: 1.304 ± 0.03
0.65HisGln: 0.65 ± 0.021
1.283HisArg: 1.283 ± 0.034
0.972HisSer: 0.972 ± 0.028
0.89HisThr: 0.89 ± 0.029
1.495HisVal: 1.495 ± 0.035
0.335HisTrp: 0.335 ± 0.015
0.548HisTyr: 0.548 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
7.01IleAla: 7.01 ± 0.083
0.668IleCys: 0.668 ± 0.02
3.672IleAsp: 3.672 ± 0.052
3.807IleGlu: 3.807 ± 0.056
1.888IlePhe: 1.888 ± 0.046
4.928IleGly: 4.928 ± 0.062
0.915IleHis: 0.915 ± 0.028
2.686IleIle: 2.686 ± 0.052
1.884IleLys: 1.884 ± 0.043
4.804IleLeu: 4.804 ± 0.065
1.214IleMet: 1.214 ± 0.031
1.648IleAsn: 1.648 ± 0.035
2.443IlePro: 2.443 ± 0.05
1.37IleGln: 1.37 ± 0.032
3.071IleArg: 3.071 ± 0.047
3.365IleSer: 3.365 ± 0.056
3.23IleThr: 3.23 ± 0.048
3.899IleVal: 3.899 ± 0.06
0.784IleTrp: 0.784 ± 0.027
1.201IleTyr: 1.201 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
4.362LysAla: 4.362 ± 0.056
0.201LysCys: 0.201 ± 0.012
2.127LysAsp: 2.127 ± 0.042
1.978LysGlu: 1.978 ± 0.042
1.068LysPhe: 1.068 ± 0.028
3.109LysGly: 3.109 ± 0.053
0.741LysHis: 0.741 ± 0.022
1.801LysIle: 1.801 ± 0.036
1.513LysLys: 1.513 ± 0.045
3.355LysLeu: 3.355 ± 0.061
1.041LysMet: 1.041 ± 0.027
1.029LysAsn: 1.029 ± 0.027
1.982LysPro: 1.982 ± 0.039
1.085LysGln: 1.085 ± 0.032
2.475LysArg: 2.475 ± 0.047
2.123LysSer: 2.123 ± 0.039
2.186LysThr: 2.186 ± 0.04
2.576LysVal: 2.576 ± 0.043
0.458LysTrp: 0.458 ± 0.018
0.75LysTyr: 0.75 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
11.73LeuAla: 11.73 ± 0.128
0.95LeuCys: 0.95 ± 0.028
5.911LeuAsp: 5.911 ± 0.076
5.646LeuGlu: 5.646 ± 0.073
3.562LeuPhe: 3.562 ± 0.055
8.039LeuGly: 8.039 ± 0.09
1.878LeuHis: 1.878 ± 0.039
5.723LeuIle: 5.723 ± 0.079
3.558LeuLys: 3.558 ± 0.055
8.492LeuLeu: 8.492 ± 0.113
2.811LeuMet: 2.811 ± 0.046
2.98LeuAsn: 2.98 ± 0.044
5.161LeuPro: 5.161 ± 0.061
2.901LeuGln: 2.901 ± 0.047
6.574LeuArg: 6.574 ± 0.074
6.748LeuSer: 6.748 ± 0.066
5.876LeuThr: 5.876 ± 0.065
6.419LeuVal: 6.419 ± 0.075
1.238LeuTrp: 1.238 ± 0.034
1.964LeuTyr: 1.964 ± 0.039
0.0LeuXaa: 0.0 ± 0.0
Met
3.441MetAla: 3.441 ± 0.049
0.224MetCys: 0.224 ± 0.013
1.542MetAsp: 1.542 ± 0.035
1.429MetGlu: 1.429 ± 0.032
0.901MetPhe: 0.901 ± 0.027
2.369MetGly: 2.369 ± 0.046
0.501MetHis: 0.501 ± 0.02
1.703MetIle: 1.703 ± 0.036
1.189MetLys: 1.189 ± 0.03
2.778MetLeu: 2.778 ± 0.053
0.87MetMet: 0.87 ± 0.028
0.918MetAsn: 0.918 ± 0.024
1.558MetPro: 1.558 ± 0.031
1.07MetGln: 1.07 ± 0.029
1.952MetArg: 1.952 ± 0.04
1.903MetSer: 1.903 ± 0.036
2.067MetThr: 2.067 ± 0.038
1.851MetVal: 1.851 ± 0.037
0.263MetTrp: 0.263 ± 0.014
0.411MetTyr: 0.411 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.464AsnAla: 3.464 ± 0.051
0.279AsnCys: 0.279 ± 0.014
1.671AsnAsp: 1.671 ± 0.048
1.392AsnGlu: 1.392 ± 0.032
1.089AsnPhe: 1.089 ± 0.026
2.537AsnGly: 2.537 ± 0.047
0.573AsnHis: 0.573 ± 0.022
1.598AsnIle: 1.598 ± 0.033
0.839AsnLys: 0.839 ± 0.023
2.733AsnLeu: 2.733 ± 0.045
0.787AsnMet: 0.787 ± 0.025
0.816AsnAsn: 0.816 ± 0.028
1.909AsnPro: 1.909 ± 0.039
0.845AsnGln: 0.845 ± 0.025
1.758AsnArg: 1.758 ± 0.037
1.282AsnSer: 1.282 ± 0.028
1.532AsnThr: 1.532 ± 0.031
2.081AsnVal: 2.081 ± 0.044
0.456AsnTrp: 0.456 ± 0.018
0.705AsnTyr: 0.705 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
5.055ProAla: 5.055 ± 0.07
0.344ProCys: 0.344 ± 0.018
4.039ProAsp: 4.039 ± 0.06
3.866ProGlu: 3.866 ± 0.055
2.022ProPhe: 2.022 ± 0.036
4.041ProGly: 4.041 ± 0.055
1.064ProHis: 1.064 ± 0.031
2.376ProIle: 2.376 ± 0.043
1.916ProLys: 1.916 ± 0.042
4.488ProLeu: 4.488 ± 0.059
1.33ProMet: 1.33 ± 0.035
1.44ProAsn: 1.44 ± 0.029
2.203ProPro: 2.203 ± 0.045
1.723ProGln: 1.723 ± 0.036
2.475ProArg: 2.475 ± 0.046
2.535ProSer: 2.535 ± 0.043
2.497ProThr: 2.497 ± 0.047
3.894ProVal: 3.894 ± 0.06
0.638ProTrp: 0.638 ± 0.022
1.151ProTyr: 1.151 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.967GlnAla: 3.967 ± 0.058
0.205GlnCys: 0.205 ± 0.011
1.877GlnAsp: 1.877 ± 0.04
1.86GlnGlu: 1.86 ± 0.038
1.212GlnPhe: 1.212 ± 0.03
2.575GlnGly: 2.575 ± 0.048
0.644GlnHis: 0.644 ± 0.024
2.177GlnIle: 2.177 ± 0.042
1.231GlnLys: 1.231 ± 0.032
2.992GlnLeu: 2.992 ± 0.052
1.149GlnMet: 1.149 ± 0.029
1.043GlnAsn: 1.043 ± 0.026
1.619GlnPro: 1.619 ± 0.038
1.237GlnGln: 1.237 ± 0.035
2.154GlnArg: 2.154 ± 0.043
2.039GlnSer: 2.039 ± 0.041
2.118GlnThr: 2.118 ± 0.038
2.389GlnVal: 2.389 ± 0.043
0.396GlnTrp: 0.396 ± 0.016
0.642GlnTyr: 0.642 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
7.134ArgAla: 7.134 ± 0.08
0.48ArgCys: 0.48 ± 0.017
4.013ArgAsp: 4.013 ± 0.057
3.643ArgGlu: 3.643 ± 0.066
2.509ArgPhe: 2.509 ± 0.044
4.127ArgGly: 4.127 ± 0.058
1.448ArgHis: 1.448 ± 0.032
3.598ArgIle: 3.598 ± 0.055
2.489ArgLys: 2.489 ± 0.039
6.632ArgLeu: 6.632 ± 0.088
1.937ArgMet: 1.937 ± 0.031
1.821ArgAsn: 1.821 ± 0.038
2.917ArgPro: 2.917 ± 0.051
2.244ArgGln: 2.244 ± 0.048
4.362ArgArg: 4.362 ± 0.062
3.147ArgSer: 3.147 ± 0.055
2.988ArgThr: 2.988 ± 0.054
4.373ArgVal: 4.373 ± 0.057
0.917ArgTrp: 0.917 ± 0.03
1.564ArgTyr: 1.564 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
5.745SerAla: 5.745 ± 0.067
0.434SerCys: 0.434 ± 0.017
3.666SerAsp: 3.666 ± 0.055
3.127SerGlu: 3.127 ± 0.046
2.397SerPhe: 2.397 ± 0.045
5.237SerGly: 5.237 ± 0.06
1.076SerHis: 1.076 ± 0.028
2.772SerIle: 2.772 ± 0.04
1.887SerLys: 1.887 ± 0.037
5.044SerLeu: 5.044 ± 0.051
1.497SerMet: 1.497 ± 0.032
1.564SerAsn: 1.564 ± 0.034
2.479SerPro: 2.479 ± 0.044
1.734SerGln: 1.734 ± 0.037
3.12SerArg: 3.12 ± 0.055
2.804SerSer: 2.804 ± 0.042
2.684SerThr: 2.684 ± 0.045
3.93SerVal: 3.93 ± 0.061
0.707SerTrp: 0.707 ± 0.021
1.338SerTyr: 1.338 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
6.103ThrAla: 6.103 ± 0.065
0.521ThrCys: 0.521 ± 0.022
3.364ThrAsp: 3.364 ± 0.052
3.097ThrGlu: 3.097 ± 0.048
2.146ThrPhe: 2.146 ± 0.038
5.236ThrGly: 5.236 ± 0.068
1.134ThrHis: 1.134 ± 0.029
2.907ThrIle: 2.907 ± 0.05
1.745ThrLys: 1.745 ± 0.038
6.152ThrLeu: 6.152 ± 0.076
1.325ThrMet: 1.325 ± 0.033
1.406ThrAsn: 1.406 ± 0.035
3.313ThrPro: 3.313 ± 0.05
1.746ThrGln: 1.746 ± 0.035
3.207ThrArg: 3.207 ± 0.051
2.985ThrSer: 2.985 ± 0.049
2.871ThrThr: 2.871 ± 0.056
4.211ThrVal: 4.211 ± 0.064
0.696ThrTrp: 0.696 ± 0.021
1.366ThrTyr: 1.366 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
8.079ValAla: 8.079 ± 0.09
0.677ValCys: 0.677 ± 0.022
4.134ValAsp: 4.134 ± 0.061
4.438ValGlu: 4.438 ± 0.055
2.912ValPhe: 2.912 ± 0.049
5.362ValGly: 5.362 ± 0.071
1.363ValHis: 1.363 ± 0.03
4.404ValIle: 4.404 ± 0.062
2.357ValLys: 2.357 ± 0.044
7.217ValLeu: 7.217 ± 0.085
2.179ValMet: 2.179 ± 0.046
2.036ValAsn: 2.036 ± 0.043
3.535ValPro: 3.535 ± 0.048
2.257ValGln: 2.257 ± 0.045
4.16ValArg: 4.16 ± 0.063
4.362ValSer: 4.362 ± 0.056
4.528ValThr: 4.528 ± 0.06
5.355ValVal: 5.355 ± 0.083
0.947ValTrp: 0.947 ± 0.028
1.499ValTyr: 1.499 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.348TrpAla: 1.348 ± 0.035
0.154TrpCys: 0.154 ± 0.01
0.775TrpAsp: 0.775 ± 0.024
0.698TrpGlu: 0.698 ± 0.022
0.593TrpPhe: 0.593 ± 0.022
1.036TrpGly: 1.036 ± 0.03
0.36TrpHis: 0.36 ± 0.018
0.732TrpIle: 0.732 ± 0.02
0.457TrpLys: 0.457 ± 0.019
1.569TrpLeu: 1.569 ± 0.037
0.433TrpMet: 0.433 ± 0.017
0.447TrpAsn: 0.447 ± 0.018
0.648TrpPro: 0.648 ± 0.023
0.573TrpGln: 0.573 ± 0.018
1.045TrpArg: 1.045 ± 0.031
0.813TrpSer: 0.813 ± 0.024
0.74TrpThr: 0.74 ± 0.023
0.885TrpVal: 0.885 ± 0.027
0.246TrpTrp: 0.246 ± 0.015
0.273TrpTyr: 0.273 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.527TyrAla: 2.527 ± 0.042
0.264TyrCys: 0.264 ± 0.016
1.613TyrAsp: 1.613 ± 0.035
1.348TyrGlu: 1.348 ± 0.036
1.004TyrPhe: 1.004 ± 0.028
2.164TyrGly: 2.164 ± 0.04
0.52TyrHis: 0.52 ± 0.022
1.043TyrIle: 1.043 ± 0.027
0.666TyrLys: 0.666 ± 0.021
2.33TyrLeu: 2.33 ± 0.042
0.513TyrMet: 0.513 ± 0.018
0.628TyrAsn: 0.628 ± 0.022
1.063TyrPro: 1.063 ± 0.025
0.704TyrGln: 0.704 ± 0.024
1.512TyrArg: 1.512 ± 0.039
1.198TyrSer: 1.198 ± 0.031
1.152TyrThr: 1.152 ± 0.031
1.559TyrVal: 1.559 ± 0.039
0.376TyrTrp: 0.376 ± 0.017
0.623TyrTyr: 0.623 ± 0.02
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4488 proteins (1404947 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski