Amino acid dipepetide frequency for Apis mellifera associated microvirus 44

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.571AlaAla: 10.571 ± 4.172
0.0AlaCys: 0.0 ± 0.0
7.047AlaAsp: 7.047 ± 1.627
4.228AlaGlu: 4.228 ± 2.143
2.819AlaPhe: 2.819 ± 0.56
5.638AlaGly: 5.638 ± 1.398
0.705AlaHis: 0.705 ± 0.654
4.228AlaIle: 4.228 ± 0.801
2.114AlaLys: 2.114 ± 0.917
11.276AlaLeu: 11.276 ± 2.746
4.228AlaMet: 4.228 ± 1.932
2.819AlaAsn: 2.819 ± 1.445
13.39AlaPro: 13.39 ± 5.252
2.819AlaGln: 2.819 ± 1.28
11.276AlaArg: 11.276 ± 2.038
4.933AlaSer: 4.933 ± 1.337
3.524AlaThr: 3.524 ± 2.368
6.342AlaVal: 6.342 ± 1.821
0.705AlaTrp: 0.705 ± 0.493
1.409AlaTyr: 1.409 ± 1.115
0.0AlaXaa: 0.0 ± 0.0
Cys
0.705CysAla: 0.705 ± 0.493
0.705CysCys: 0.705 ± 0.705
0.705CysAsp: 0.705 ± 0.705
0.705CysGlu: 0.705 ± 0.705
0.0CysPhe: 0.0 ± 0.0
0.705CysGly: 0.705 ± 0.705
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.705CysLeu: 0.705 ± 0.705
0.0CysMet: 0.0 ± 0.0
0.705CysAsn: 0.705 ± 0.493
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
1.409CysArg: 1.409 ± 1.41
2.114CysSer: 2.114 ± 1.262
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
4.228AspAla: 4.228 ± 1.152
0.705AspCys: 0.705 ± 0.705
2.114AspAsp: 2.114 ± 1.669
2.819AspGlu: 2.819 ± 0.949
3.524AspPhe: 3.524 ± 1.919
5.638AspGly: 5.638 ± 1.254
1.409AspHis: 1.409 ± 1.093
2.819AspIle: 2.819 ± 1.015
2.114AspLys: 2.114 ± 1.159
2.819AspLeu: 2.819 ± 0.56
1.409AspMet: 1.409 ± 0.925
1.409AspAsn: 1.409 ± 0.644
5.638AspPro: 5.638 ± 2.33
2.819AspGln: 2.819 ± 1.015
0.705AspArg: 0.705 ± 0.493
0.705AspSer: 0.705 ± 0.705
5.638AspThr: 5.638 ± 3.247
2.114AspVal: 2.114 ± 0.917
0.0AspTrp: 0.0 ± 0.0
2.114AspTyr: 2.114 ± 0.942
0.0AspXaa: 0.0 ± 0.0
Glu
7.047GluAla: 7.047 ± 1.59
0.0GluCys: 0.0 ± 0.0
2.819GluAsp: 2.819 ± 1.015
2.819GluGlu: 2.819 ± 1.116
2.114GluPhe: 2.114 ± 0.4
0.705GluGly: 0.705 ± 0.813
1.409GluHis: 1.409 ± 0.648
2.819GluIle: 2.819 ± 1.688
4.228GluLys: 4.228 ± 1.72
2.114GluLeu: 2.114 ± 0.4
0.705GluMet: 0.705 ± 0.813
2.819GluAsn: 2.819 ± 1.313
0.705GluPro: 0.705 ± 0.654
2.819GluGln: 2.819 ± 0.563
2.114GluArg: 2.114 ± 1.961
1.409GluSer: 1.409 ± 0.991
2.819GluThr: 2.819 ± 0.563
2.819GluVal: 2.819 ± 1.359
0.0GluTrp: 0.0 ± 0.0
2.819GluTyr: 2.819 ± 1.313
0.0GluXaa: 0.0 ± 0.0
Phe
4.228PheAla: 4.228 ± 1.018
0.0PheCys: 0.0 ± 0.0
2.819PheAsp: 2.819 ± 2.37
2.114PheGlu: 2.114 ± 0.845
0.705PhePhe: 0.705 ± 0.493
2.114PheGly: 2.114 ± 0.4
1.409PheHis: 1.409 ± 1.308
1.409PheIle: 1.409 ± 0.986
0.705PheLys: 0.705 ± 0.654
0.705PheLeu: 0.705 ± 0.654
0.705PheMet: 0.705 ± 0.705
1.409PheAsn: 1.409 ± 0.644
2.114PhePro: 2.114 ± 1.022
2.819PheGln: 2.819 ± 0.563
1.409PheArg: 1.409 ± 0.986
4.228PheSer: 4.228 ± 1.885
2.819PheThr: 2.819 ± 1.288
2.819PheVal: 2.819 ± 1.297
0.705PheTrp: 0.705 ± 0.493
2.114PheTyr: 2.114 ± 1.182
0.0PheXaa: 0.0 ± 0.0
Gly
7.047GlyAla: 7.047 ± 2.176
0.705GlyCys: 0.705 ± 0.705
5.638GlyAsp: 5.638 ± 1.126
0.705GlyGlu: 0.705 ± 0.705
1.409GlyPhe: 1.409 ± 0.702
11.276GlyGly: 11.276 ± 2.73
1.409GlyHis: 1.409 ± 0.986
3.524GlyIle: 3.524 ± 0.976
4.933GlyLys: 4.933 ± 1.988
4.933GlyLeu: 4.933 ± 2.135
2.114GlyMet: 2.114 ± 0.845
2.819GlyAsn: 2.819 ± 0.56
2.819GlyPro: 2.819 ± 1.971
3.524GlyGln: 3.524 ± 2.462
4.228GlyArg: 4.228 ± 2.669
6.342GlySer: 6.342 ± 1.993
3.524GlyThr: 3.524 ± 1.537
5.638GlyVal: 5.638 ± 2.159
0.0GlyTrp: 0.0 ± 0.0
8.457GlyTyr: 8.457 ± 0.81
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.705HisCys: 0.705 ± 0.705
1.409HisAsp: 1.409 ± 1.093
0.705HisGlu: 0.705 ± 0.654
0.705HisPhe: 0.705 ± 0.654
4.228HisGly: 4.228 ± 1.005
0.705HisHis: 0.705 ± 0.493
1.409HisIle: 1.409 ± 0.644
0.0HisLys: 0.0 ± 0.0
2.114HisLeu: 2.114 ± 1.262
0.705HisMet: 0.705 ± 0.493
1.409HisAsn: 1.409 ± 0.702
1.409HisPro: 1.409 ± 0.644
0.0HisGln: 0.0 ± 0.0
1.409HisArg: 1.409 ± 0.648
2.114HisSer: 2.114 ± 0.845
0.0HisThr: 0.0 ± 0.0
1.409HisVal: 1.409 ± 0.648
1.409HisTrp: 1.409 ± 0.986
2.114HisTyr: 2.114 ± 1.262
0.0HisXaa: 0.0 ± 0.0
Ile
4.933IleAla: 4.933 ± 2.69
0.0IleCys: 0.0 ± 0.0
1.409IleAsp: 1.409 ± 0.986
2.114IleGlu: 2.114 ± 0.4
2.819IlePhe: 2.819 ± 1.971
5.638IleGly: 5.638 ± 2.054
2.114IleHis: 2.114 ± 1.262
0.0IleIle: 0.0 ± 0.0
0.705IleLys: 0.705 ± 0.654
1.409IleLeu: 1.409 ± 0.644
0.705IleMet: 0.705 ± 0.493
3.524IleAsn: 3.524 ± 0.976
2.114IlePro: 2.114 ± 1.118
1.409IleGln: 1.409 ± 0.644
2.819IleArg: 2.819 ± 1.308
3.524IleSer: 3.524 ± 1.767
3.524IleThr: 3.524 ± 1.814
0.0IleVal: 0.0 ± 0.0
0.705IleTrp: 0.705 ± 0.493
1.409IleTyr: 1.409 ± 0.986
0.0IleXaa: 0.0 ± 0.0
Lys
3.524LysAla: 3.524 ± 1.895
0.705LysCys: 0.705 ± 0.705
2.114LysAsp: 2.114 ± 0.4
3.524LysGlu: 3.524 ± 0.808
0.705LysPhe: 0.705 ± 0.493
5.638LysGly: 5.638 ± 1.12
1.409LysHis: 1.409 ± 1.093
0.705LysIle: 0.705 ± 0.705
3.524LysLys: 3.524 ± 0.881
3.524LysLeu: 3.524 ± 1.031
0.0LysMet: 0.0 ± 0.0
2.114LysAsn: 2.114 ± 1.159
4.933LysPro: 4.933 ± 2.952
1.409LysGln: 1.409 ± 1.115
2.819LysArg: 2.819 ± 1.743
2.114LysSer: 2.114 ± 1.159
0.0LysThr: 0.0 ± 0.0
2.114LysVal: 2.114 ± 2.115
0.0LysTrp: 0.0 ± 0.0
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
4.933LeuAla: 4.933 ± 2.039
0.0LeuCys: 0.0 ± 0.0
4.933LeuAsp: 4.933 ± 1.849
2.114LeuGlu: 2.114 ± 1.246
2.114LeuPhe: 2.114 ± 0.4
7.752LeuGly: 7.752 ± 0.613
0.705LeuHis: 0.705 ± 0.705
2.819LeuIle: 2.819 ± 0.563
3.524LeuLys: 3.524 ± 1.623
4.933LeuLeu: 4.933 ± 3.133
2.819LeuMet: 2.819 ± 0.906
6.342LeuAsn: 6.342 ± 1.867
4.933LeuPro: 4.933 ± 1.829
8.457LeuGln: 8.457 ± 2.036
7.047LeuArg: 7.047 ± 2.553
5.638LeuSer: 5.638 ± 2.675
3.524LeuThr: 3.524 ± 1.878
3.524LeuVal: 3.524 ± 1.45
0.705LeuTrp: 0.705 ± 0.705
0.705LeuTyr: 0.705 ± 0.654
0.0LeuXaa: 0.0 ± 0.0
Met
2.819MetAla: 2.819 ± 0.869
0.705MetCys: 0.705 ± 0.493
1.409MetAsp: 1.409 ± 1.308
2.114MetGlu: 2.114 ± 1.448
1.409MetPhe: 1.409 ± 1.115
1.409MetGly: 1.409 ± 0.644
1.409MetHis: 1.409 ± 0.644
0.705MetIle: 0.705 ± 0.493
2.114MetLys: 2.114 ± 0.911
0.705MetLeu: 0.705 ± 0.813
0.705MetMet: 0.705 ± 0.654
0.705MetAsn: 0.705 ± 0.654
2.819MetPro: 2.819 ± 1.255
0.705MetGln: 0.705 ± 0.654
1.409MetArg: 1.409 ± 0.844
4.228MetSer: 4.228 ± 0.695
0.0MetThr: 0.0 ± 0.0
1.409MetVal: 1.409 ± 0.844
0.0MetTrp: 0.0 ± 0.0
0.705MetTyr: 0.705 ± 0.493
0.0MetXaa: 0.0 ± 0.0
Asn
2.114AsnAla: 2.114 ± 0.942
0.705AsnCys: 0.705 ± 0.493
2.114AsnAsp: 2.114 ± 0.845
1.409AsnGlu: 1.409 ± 0.644
0.705AsnPhe: 0.705 ± 0.654
2.114AsnGly: 2.114 ± 1.262
0.705AsnHis: 0.705 ± 0.493
2.819AsnIle: 2.819 ± 1.359
1.409AsnLys: 1.409 ± 0.702
7.047AsnLeu: 7.047 ± 1.761
1.409AsnMet: 1.409 ± 1.308
2.819AsnAsn: 2.819 ± 1.288
1.409AsnPro: 1.409 ± 0.702
0.705AsnGln: 0.705 ± 0.654
7.752AsnArg: 7.752 ± 2.086
1.409AsnSer: 1.409 ± 0.648
2.114AsnThr: 2.114 ± 1.118
2.114AsnVal: 2.114 ± 0.942
2.114AsnTrp: 2.114 ± 0.4
0.705AsnTyr: 0.705 ± 0.493
0.0AsnXaa: 0.0 ± 0.0
Pro
11.276ProAla: 11.276 ± 6.199
0.705ProCys: 0.705 ± 0.705
2.819ProAsp: 2.819 ± 1.508
3.524ProGlu: 3.524 ± 1.463
2.819ProPhe: 2.819 ± 0.563
5.638ProGly: 5.638 ± 2.875
3.524ProHis: 3.524 ± 0.939
4.933ProIle: 4.933 ± 2.033
2.819ProLys: 2.819 ± 2.004
3.524ProLeu: 3.524 ± 1.379
2.819ProMet: 2.819 ± 1.847
2.114ProAsn: 2.114 ± 1.099
4.933ProPro: 4.933 ± 3.18
0.0ProGln: 0.0 ± 0.0
4.933ProArg: 4.933 ± 1.766
4.933ProSer: 4.933 ± 1.426
4.228ProThr: 4.228 ± 1.747
5.638ProVal: 5.638 ± 0.755
1.409ProTrp: 1.409 ± 0.844
0.705ProTyr: 0.705 ± 0.493
0.0ProXaa: 0.0 ± 0.0
Gln
3.524GlnAla: 3.524 ± 0.808
0.0GlnCys: 0.0 ± 0.0
3.524GlnAsp: 3.524 ± 1.813
1.409GlnGlu: 1.409 ± 0.986
1.409GlnPhe: 1.409 ± 0.644
2.819GlnGly: 2.819 ± 1.28
1.409GlnHis: 1.409 ± 0.644
0.705GlnIle: 0.705 ± 0.654
4.228GlnLys: 4.228 ± 0.695
1.409GlnLeu: 1.409 ± 1.093
2.114GlnMet: 2.114 ± 0.865
3.524GlnAsn: 3.524 ± 1.29
1.409GlnPro: 1.409 ± 0.975
2.114GlnGln: 2.114 ± 1.201
5.638GlnArg: 5.638 ± 1.391
0.705GlnSer: 0.705 ± 0.705
3.524GlnThr: 3.524 ± 0.808
2.819GlnVal: 2.819 ± 0.949
0.705GlnTrp: 0.705 ± 0.654
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
5.638ArgAla: 5.638 ± 2.172
2.819ArgCys: 2.819 ± 1.939
0.705ArgAsp: 0.705 ± 0.493
4.228ArgGlu: 4.228 ± 1.476
5.638ArgPhe: 5.638 ± 1.811
3.524ArgGly: 3.524 ± 0.857
0.705ArgHis: 0.705 ± 0.493
4.228ArgIle: 4.228 ± 1.026
2.819ArgLys: 2.819 ± 2.229
7.047ArgLeu: 7.047 ± 4.213
2.114ArgMet: 2.114 ± 0.892
2.819ArgAsn: 2.819 ± 0.563
5.638ArgPro: 5.638 ± 1.924
2.114ArgGln: 2.114 ± 0.845
4.933ArgArg: 4.933 ± 1.779
7.752ArgSer: 7.752 ± 2.616
4.228ArgThr: 4.228 ± 0.801
4.228ArgVal: 4.228 ± 2.197
1.409ArgTrp: 1.409 ± 0.702
4.933ArgTyr: 4.933 ± 0.84
0.0ArgXaa: 0.0 ± 0.0
Ser
11.98SerAla: 11.98 ± 2.371
0.0SerCys: 0.0 ± 0.0
2.819SerAsp: 2.819 ± 0.56
3.524SerGlu: 3.524 ± 1.34
2.819SerPhe: 2.819 ± 1.359
4.228SerGly: 4.228 ± 2.401
1.409SerHis: 1.409 ± 0.648
3.524SerIle: 3.524 ± 0.881
2.114SerLys: 2.114 ± 0.845
4.933SerLeu: 4.933 ± 2.363
2.114SerMet: 2.114 ± 1.448
2.114SerAsn: 2.114 ± 1.479
5.638SerPro: 5.638 ± 1.974
4.228SerGln: 4.228 ± 1.227
5.638SerArg: 5.638 ± 2.82
14.799SerSer: 14.799 ± 7.403
4.933SerThr: 4.933 ± 1.692
2.114SerVal: 2.114 ± 0.911
1.409SerTrp: 1.409 ± 1.41
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
4.228ThrAla: 4.228 ± 2.401
0.0ThrCys: 0.0 ± 0.0
2.114ThrAsp: 2.114 ± 0.4
2.114ThrGlu: 2.114 ± 0.865
1.409ThrPhe: 1.409 ± 0.844
6.342ThrGly: 6.342 ± 3.168
0.0ThrHis: 0.0 ± 0.0
2.114ThrIle: 2.114 ± 1.479
0.0ThrLys: 0.0 ± 0.0
7.752ThrLeu: 7.752 ± 2.472
1.409ThrMet: 1.409 ± 0.644
2.114ThrAsn: 2.114 ± 1.479
2.819ThrPro: 2.819 ± 2.024
0.705ThrGln: 0.705 ± 0.493
2.114ThrArg: 2.114 ± 0.4
7.752ThrSer: 7.752 ± 1.37
1.409ThrThr: 1.409 ± 0.648
2.114ThrVal: 2.114 ± 1.479
0.705ThrTrp: 0.705 ± 0.493
2.114ThrTyr: 2.114 ± 1.246
0.0ThrXaa: 0.0 ± 0.0
Val
7.047ValAla: 7.047 ± 1.03
0.0ValCys: 0.0 ± 0.0
2.819ValAsp: 2.819 ± 1.255
1.409ValGlu: 1.409 ± 0.644
0.705ValPhe: 0.705 ± 0.705
2.819ValGly: 2.819 ± 0.563
2.114ValHis: 2.114 ± 0.4
0.0ValIle: 0.0 ± 0.0
2.114ValLys: 2.114 ± 0.942
5.638ValLeu: 5.638 ± 1.652
0.0ValMet: 0.0 ± 0.0
0.705ValAsn: 0.705 ± 0.493
7.047ValPro: 7.047 ± 0.801
3.524ValGln: 3.524 ± 1.14
4.933ValArg: 4.933 ± 1.928
3.524ValSer: 3.524 ± 0.976
2.114ValThr: 2.114 ± 0.4
3.524ValVal: 3.524 ± 1.753
0.705ValTrp: 0.705 ± 0.493
1.409ValTyr: 1.409 ± 0.986
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.705TrpAsp: 0.705 ± 0.493
2.819TrpGlu: 2.819 ± 1.508
1.409TrpPhe: 1.409 ± 0.644
2.114TrpGly: 2.114 ± 0.4
0.705TrpHis: 0.705 ± 0.493
0.0TrpIle: 0.0 ± 0.0
0.705TrpLys: 0.705 ± 0.705
0.705TrpLeu: 0.705 ± 0.705
0.0TrpMet: 0.0 ± 0.0
1.409TrpAsn: 1.409 ± 0.986
0.705TrpPro: 0.705 ± 0.705
0.705TrpGln: 0.705 ± 0.493
1.409TrpArg: 1.409 ± 0.702
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.228TyrAla: 4.228 ± 1.026
0.0TyrCys: 0.0 ± 0.0
0.705TyrAsp: 0.705 ± 0.493
0.705TyrGlu: 0.705 ± 0.894
2.114TyrPhe: 2.114 ± 0.4
0.705TyrGly: 0.705 ± 0.705
0.705TyrHis: 0.705 ± 0.705
2.114TyrIle: 2.114 ± 1.262
0.705TyrLys: 0.705 ± 0.493
4.228TyrLeu: 4.228 ± 1.442
0.705TyrMet: 0.705 ± 0.588
0.0TyrAsn: 0.0 ± 0.0
2.819TyrPro: 2.819 ± 0.869
2.114TyrGln: 2.114 ± 0.865
3.524TyrArg: 3.524 ± 0.976
2.114TyrSer: 2.114 ± 0.865
1.409TyrThr: 1.409 ± 0.925
1.409TyrVal: 1.409 ± 0.986
0.705TyrTrp: 0.705 ± 0.493
2.819TyrTyr: 2.819 ± 0.869
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1420 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski