Amino acid dipepetide frequency for Sulfitobacter phage phiCB2047-B

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.864AlaAla: 5.864 ± 0.679
0.451AlaCys: 0.451 ± 0.158
5.143AlaAsp: 5.143 ± 0.509
4.872AlaGlu: 4.872 ± 0.535
2.346AlaPhe: 2.346 ± 0.295
4.195AlaGly: 4.195 ± 0.599
1.038AlaHis: 1.038 ± 0.255
3.338AlaIle: 3.338 ± 0.432
4.872AlaLys: 4.872 ± 0.455
5.639AlaLeu: 5.639 ± 0.673
2.12AlaMet: 2.12 ± 0.314
3.879AlaAsn: 3.879 ± 0.557
2.707AlaPro: 2.707 ± 0.406
3.022AlaGln: 3.022 ± 0.516
3.338AlaArg: 3.338 ± 0.421
4.782AlaSer: 4.782 ± 0.474
4.827AlaThr: 4.827 ± 0.467
4.962AlaVal: 4.962 ± 0.677
0.857AlaTrp: 0.857 ± 0.248
2.526AlaTyr: 2.526 ± 0.346
0.0AlaXaa: 0.0 ± 0.0
Cys
0.316CysAla: 0.316 ± 0.142
0.0CysCys: 0.0 ± 0.0
0.361CysAsp: 0.361 ± 0.157
0.767CysGlu: 0.767 ± 0.238
0.361CysPhe: 0.361 ± 0.124
0.496CysGly: 0.496 ± 0.201
0.361CysHis: 0.361 ± 0.152
0.226CysIle: 0.226 ± 0.12
0.361CysLys: 0.361 ± 0.142
0.361CysLeu: 0.361 ± 0.126
0.226CysMet: 0.226 ± 0.111
0.316CysAsn: 0.316 ± 0.145
0.361CysPro: 0.361 ± 0.163
0.406CysGln: 0.406 ± 0.146
0.18CysArg: 0.18 ± 0.096
0.226CysSer: 0.226 ± 0.127
0.361CysThr: 0.361 ± 0.123
0.406CysVal: 0.406 ± 0.157
0.09CysTrp: 0.09 ± 0.072
0.316CysTyr: 0.316 ± 0.142
0.0CysXaa: 0.0 ± 0.0
Asp
5.233AspAla: 5.233 ± 0.498
0.361AspCys: 0.361 ± 0.133
4.195AspAsp: 4.195 ± 0.565
4.782AspGlu: 4.782 ± 0.601
2.977AspPhe: 2.977 ± 0.336
5.052AspGly: 5.052 ± 0.51
1.353AspHis: 1.353 ± 0.247
4.15AspIle: 4.15 ± 0.421
4.195AspLys: 4.195 ± 0.58
6.27AspLeu: 6.27 ± 0.467
2.301AspMet: 2.301 ± 0.322
3.022AspAsn: 3.022 ± 0.301
2.932AspPro: 2.932 ± 0.416
1.985AspGln: 1.985 ± 0.292
3.203AspArg: 3.203 ± 0.371
4.015AspSer: 4.015 ± 0.359
4.06AspThr: 4.06 ± 0.616
4.601AspVal: 4.601 ± 0.563
0.767AspTrp: 0.767 ± 0.189
2.436AspTyr: 2.436 ± 0.432
0.0AspXaa: 0.0 ± 0.0
Glu
5.594GluAla: 5.594 ± 0.555
0.316GluCys: 0.316 ± 0.121
4.737GluAsp: 4.737 ± 0.523
5.909GluGlu: 5.909 ± 0.765
3.293GluPhe: 3.293 ± 0.347
4.556GluGly: 4.556 ± 0.416
1.083GluHis: 1.083 ± 0.226
4.376GluIle: 4.376 ± 0.508
4.331GluLys: 4.331 ± 0.442
5.594GluLeu: 5.594 ± 0.499
2.481GluMet: 2.481 ± 0.359
3.699GluAsn: 3.699 ± 0.365
2.075GluPro: 2.075 ± 0.321
3.158GluGln: 3.158 ± 0.445
3.248GluArg: 3.248 ± 0.393
4.556GluSer: 4.556 ± 0.46
4.646GluThr: 4.646 ± 0.476
5.007GluVal: 5.007 ± 0.435
0.541GluTrp: 0.541 ± 0.181
2.165GluTyr: 2.165 ± 0.272
0.0GluXaa: 0.0 ± 0.0
Phe
2.075PheAla: 2.075 ± 0.324
0.135PheCys: 0.135 ± 0.074
2.571PheAsp: 2.571 ± 0.359
2.301PheGlu: 2.301 ± 0.295
1.534PhePhe: 1.534 ± 0.298
2.752PheGly: 2.752 ± 0.363
0.767PheHis: 0.767 ± 0.25
2.752PheIle: 2.752 ± 0.31
2.887PheLys: 2.887 ± 0.4
2.661PheLeu: 2.661 ± 0.321
1.759PheMet: 1.759 ± 0.234
2.526PheAsn: 2.526 ± 0.327
1.218PhePro: 1.218 ± 0.211
1.308PheGln: 1.308 ± 0.231
1.759PheArg: 1.759 ± 0.268
2.752PheSer: 2.752 ± 0.312
1.985PheThr: 1.985 ± 0.298
2.887PheVal: 2.887 ± 0.491
0.496PheTrp: 0.496 ± 0.164
1.353PheTyr: 1.353 ± 0.216
0.0PheXaa: 0.0 ± 0.0
Gly
5.007GlyAla: 5.007 ± 0.688
0.361GlyCys: 0.361 ± 0.173
4.466GlyAsp: 4.466 ± 0.543
4.872GlyGlu: 4.872 ± 0.599
3.158GlyPhe: 3.158 ± 0.363
4.827GlyGly: 4.827 ± 0.53
0.812GlyHis: 0.812 ± 0.212
4.015GlyIle: 4.015 ± 0.354
3.925GlyLys: 3.925 ± 0.456
5.097GlyLeu: 5.097 ± 0.464
2.391GlyMet: 2.391 ± 0.363
3.383GlyAsn: 3.383 ± 0.391
1.534GlyPro: 1.534 ± 0.27
1.804GlyGln: 1.804 ± 0.285
2.571GlyArg: 2.571 ± 0.313
4.511GlySer: 4.511 ± 0.406
4.691GlyThr: 4.691 ± 0.54
4.466GlyVal: 4.466 ± 0.542
0.902GlyTrp: 0.902 ± 0.253
3.113GlyTyr: 3.113 ± 0.322
0.0GlyXaa: 0.0 ± 0.0
His
0.857HisAla: 0.857 ± 0.221
0.045HisCys: 0.045 ± 0.04
0.947HisAsp: 0.947 ± 0.267
0.947HisGlu: 0.947 ± 0.22
0.722HisPhe: 0.722 ± 0.172
0.677HisGly: 0.677 ± 0.209
0.541HisHis: 0.541 ± 0.203
1.263HisIle: 1.263 ± 0.275
1.353HisLys: 1.353 ± 0.34
1.804HisLeu: 1.804 ± 0.302
0.271HisMet: 0.271 ± 0.101
0.541HisAsn: 0.541 ± 0.135
0.722HisPro: 0.722 ± 0.219
0.767HisGln: 0.767 ± 0.202
0.677HisArg: 0.677 ± 0.206
0.812HisSer: 0.812 ± 0.25
0.812HisThr: 0.812 ± 0.218
1.308HisVal: 1.308 ± 0.297
0.361HisTrp: 0.361 ± 0.173
1.038HisTyr: 1.038 ± 0.281
0.0HisXaa: 0.0 ± 0.0
Ile
4.691IleAla: 4.691 ± 0.43
0.361IleCys: 0.361 ± 0.132
3.699IleAsp: 3.699 ± 0.293
4.421IleGlu: 4.421 ± 0.421
1.895IlePhe: 1.895 ± 0.271
3.744IleGly: 3.744 ± 0.343
0.857IleHis: 0.857 ± 0.215
3.383IleIle: 3.383 ± 0.361
3.925IleLys: 3.925 ± 0.434
4.15IleLeu: 4.15 ± 0.512
1.714IleMet: 1.714 ± 0.256
2.391IleAsn: 2.391 ± 0.305
3.248IlePro: 3.248 ± 0.33
3.338IleGln: 3.338 ± 0.366
2.752IleArg: 2.752 ± 0.381
4.015IleSer: 4.015 ± 0.423
4.06IleThr: 4.06 ± 0.499
3.383IleVal: 3.383 ± 0.473
0.451IleTrp: 0.451 ± 0.16
2.21IleTyr: 2.21 ± 0.33
0.0IleXaa: 0.0 ± 0.0
Lys
4.691LysAla: 4.691 ± 0.454
0.451LysCys: 0.451 ± 0.154
5.007LysAsp: 5.007 ± 0.584
4.872LysGlu: 4.872 ± 0.473
2.165LysPhe: 2.165 ± 0.272
4.556LysGly: 4.556 ± 0.345
1.263LysHis: 1.263 ± 0.299
3.789LysIle: 3.789 ± 0.473
5.188LysLys: 5.188 ± 0.579
5.233LysLeu: 5.233 ± 0.529
1.759LysMet: 1.759 ± 0.279
3.879LysAsn: 3.879 ± 0.36
2.03LysPro: 2.03 ± 0.347
2.977LysGln: 2.977 ± 0.382
2.707LysArg: 2.707 ± 0.329
4.511LysSer: 4.511 ± 0.453
4.015LysThr: 4.015 ± 0.478
4.511LysVal: 4.511 ± 0.568
0.586LysTrp: 0.586 ± 0.141
1.985LysTyr: 1.985 ± 0.355
0.0LysXaa: 0.0 ± 0.0
Leu
4.782LeuAla: 4.782 ± 0.524
0.677LeuCys: 0.677 ± 0.191
5.819LeuAsp: 5.819 ± 0.495
5.413LeuGlu: 5.413 ± 0.42
2.526LeuPhe: 2.526 ± 0.363
4.195LeuGly: 4.195 ± 0.411
1.218LeuHis: 1.218 ± 0.229
4.421LeuIle: 4.421 ± 0.358
5.503LeuLys: 5.503 ± 0.484
5.729LeuLeu: 5.729 ± 0.64
2.436LeuMet: 2.436 ± 0.346
5.143LeuAsn: 5.143 ± 0.397
4.15LeuPro: 4.15 ± 0.51
2.707LeuGln: 2.707 ± 0.354
3.519LeuArg: 3.519 ± 0.423
6.586LeuSer: 6.586 ± 0.529
5.549LeuThr: 5.549 ± 0.515
4.917LeuVal: 4.917 ± 0.462
1.038LeuTrp: 1.038 ± 0.244
2.256LeuTyr: 2.256 ± 0.402
0.0LeuXaa: 0.0 ± 0.0
Met
2.391MetAla: 2.391 ± 0.334
0.135MetCys: 0.135 ± 0.076
2.21MetAsp: 2.21 ± 0.354
1.714MetGlu: 1.714 ± 0.336
1.308MetPhe: 1.308 ± 0.216
2.075MetGly: 2.075 ± 0.34
0.226MetHis: 0.226 ± 0.092
1.804MetIle: 1.804 ± 0.301
1.759MetLys: 1.759 ± 0.309
2.526MetLeu: 2.526 ± 0.316
0.902MetMet: 0.902 ± 0.183
2.661MetAsn: 2.661 ± 0.372
1.308MetPro: 1.308 ± 0.251
1.398MetGln: 1.398 ± 0.305
1.579MetArg: 1.579 ± 0.285
1.85MetSer: 1.85 ± 0.326
1.804MetThr: 1.804 ± 0.233
2.391MetVal: 2.391 ± 0.254
0.226MetTrp: 0.226 ± 0.093
0.992MetTyr: 0.992 ± 0.21
0.0MetXaa: 0.0 ± 0.0
Asn
3.609AsnAla: 3.609 ± 0.433
0.586AsnCys: 0.586 ± 0.196
3.248AsnAsp: 3.248 ± 0.37
3.519AsnGlu: 3.519 ± 0.66
2.526AsnPhe: 2.526 ± 0.278
4.015AsnGly: 4.015 ± 0.436
1.038AsnHis: 1.038 ± 0.208
2.661AsnIle: 2.661 ± 0.308
3.654AsnLys: 3.654 ± 0.343
5.413AsnLeu: 5.413 ± 0.487
2.075AsnMet: 2.075 ± 0.284
3.338AsnAsn: 3.338 ± 0.43
2.797AsnPro: 2.797 ± 0.316
2.752AsnGln: 2.752 ± 0.325
2.391AsnArg: 2.391 ± 0.288
3.564AsnSer: 3.564 ± 0.463
3.564AsnThr: 3.564 ± 0.481
3.248AsnVal: 3.248 ± 0.399
0.722AsnTrp: 0.722 ± 0.25
2.165AsnTyr: 2.165 ± 0.271
0.0AsnXaa: 0.0 ± 0.0
Pro
2.707ProAla: 2.707 ± 0.355
0.271ProCys: 0.271 ± 0.101
3.564ProAsp: 3.564 ± 0.448
3.744ProGlu: 3.744 ± 0.37
1.759ProPhe: 1.759 ± 0.248
0.902ProGly: 0.902 ± 0.197
0.902ProHis: 0.902 ± 0.16
2.481ProIle: 2.481 ± 0.314
2.842ProLys: 2.842 ± 0.414
2.752ProLeu: 2.752 ± 0.341
1.083ProMet: 1.083 ± 0.207
2.661ProAsn: 2.661 ± 0.409
0.947ProPro: 0.947 ± 0.241
1.489ProGln: 1.489 ± 0.21
1.038ProArg: 1.038 ± 0.255
2.526ProSer: 2.526 ± 0.334
2.932ProThr: 2.932 ± 0.391
3.473ProVal: 3.473 ± 0.353
0.361ProTrp: 0.361 ± 0.114
0.902ProTyr: 0.902 ± 0.235
0.0ProXaa: 0.0 ± 0.0
Gln
3.428GlnAla: 3.428 ± 0.412
0.18GlnCys: 0.18 ± 0.078
2.03GlnAsp: 2.03 ± 0.306
2.752GlnGlu: 2.752 ± 0.297
1.173GlnPhe: 1.173 ± 0.248
2.616GlnGly: 2.616 ± 0.404
0.722GlnHis: 0.722 ± 0.216
2.21GlnIle: 2.21 ± 0.327
3.113GlnLys: 3.113 ± 0.376
3.203GlnLeu: 3.203 ± 0.448
1.308GlnMet: 1.308 ± 0.253
2.21GlnAsn: 2.21 ± 0.388
1.308GlnPro: 1.308 ± 0.217
1.985GlnGln: 1.985 ± 0.394
1.804GlnArg: 1.804 ± 0.196
3.158GlnSer: 3.158 ± 0.25
2.707GlnThr: 2.707 ± 0.289
2.707GlnVal: 2.707 ± 0.311
0.451GlnTrp: 0.451 ± 0.16
1.218GlnTyr: 1.218 ± 0.245
0.0GlnXaa: 0.0 ± 0.0
Arg
2.842ArgAla: 2.842 ± 0.435
0.406ArgCys: 0.406 ± 0.151
2.977ArgAsp: 2.977 ± 0.329
3.248ArgGlu: 3.248 ± 0.334
1.534ArgPhe: 1.534 ± 0.348
2.481ArgGly: 2.481 ± 0.321
0.586ArgHis: 0.586 ± 0.179
2.752ArgIle: 2.752 ± 0.343
2.707ArgLys: 2.707 ± 0.346
3.879ArgLeu: 3.879 ± 0.378
1.534ArgMet: 1.534 ± 0.255
3.113ArgAsn: 3.113 ± 0.329
1.173ArgPro: 1.173 ± 0.229
1.624ArgGln: 1.624 ± 0.276
2.075ArgArg: 2.075 ± 0.37
2.752ArgSer: 2.752 ± 0.396
2.526ArgThr: 2.526 ± 0.356
2.932ArgVal: 2.932 ± 0.306
0.496ArgTrp: 0.496 ± 0.165
1.85ArgTyr: 1.85 ± 0.298
0.0ArgXaa: 0.0 ± 0.0
Ser
4.24SerAla: 4.24 ± 0.382
0.406SerCys: 0.406 ± 0.144
4.466SerAsp: 4.466 ± 0.493
5.143SerGlu: 5.143 ± 0.351
2.977SerPhe: 2.977 ± 0.373
6.225SerGly: 6.225 ± 0.533
0.767SerHis: 0.767 ± 0.224
4.466SerIle: 4.466 ± 0.481
4.331SerLys: 4.331 ± 0.447
4.737SerLeu: 4.737 ± 0.605
2.526SerMet: 2.526 ± 0.301
4.195SerAsn: 4.195 ± 0.606
2.256SerPro: 2.256 ± 0.318
2.797SerGln: 2.797 ± 0.498
2.21SerArg: 2.21 ± 0.328
4.917SerSer: 4.917 ± 0.763
4.331SerThr: 4.331 ± 0.381
5.233SerVal: 5.233 ± 0.475
0.361SerTrp: 0.361 ± 0.132
2.436SerTyr: 2.436 ± 0.314
0.0SerXaa: 0.0 ± 0.0
Thr
4.285ThrAla: 4.285 ± 0.352
0.451ThrCys: 0.451 ± 0.216
3.654ThrAsp: 3.654 ± 0.415
4.15ThrGlu: 4.15 ± 0.388
2.707ThrPhe: 2.707 ± 0.395
5.052ThrGly: 5.052 ± 0.41
0.992ThrHis: 0.992 ± 0.248
3.564ThrIle: 3.564 ± 0.532
4.24ThrLys: 4.24 ± 0.451
5.233ThrLeu: 5.233 ± 0.543
1.624ThrMet: 1.624 ± 0.221
3.383ThrAsn: 3.383 ± 0.38
3.789ThrPro: 3.789 ± 0.468
2.21ThrGln: 2.21 ± 0.331
2.842ThrArg: 2.842 ± 0.453
5.097ThrSer: 5.097 ± 0.566
3.97ThrThr: 3.97 ± 0.499
4.421ThrVal: 4.421 ± 0.464
1.038ThrTrp: 1.038 ± 0.184
2.481ThrTyr: 2.481 ± 0.307
0.0ThrXaa: 0.0 ± 0.0
Val
4.421ValAla: 4.421 ± 0.36
0.586ValCys: 0.586 ± 0.194
4.601ValAsp: 4.601 ± 0.386
4.646ValGlu: 4.646 ± 0.49
1.804ValPhe: 1.804 ± 0.258
4.646ValGly: 4.646 ± 0.741
1.308ValHis: 1.308 ± 0.225
4.24ValIle: 4.24 ± 0.457
4.466ValLys: 4.466 ± 0.418
5.097ValLeu: 5.097 ± 0.46
1.579ValMet: 1.579 ± 0.276
3.789ValAsn: 3.789 ± 0.375
3.293ValPro: 3.293 ± 0.482
2.752ValGln: 2.752 ± 0.34
3.383ValArg: 3.383 ± 0.38
5.323ValSer: 5.323 ± 0.726
5.188ValThr: 5.188 ± 0.56
3.834ValVal: 3.834 ± 0.388
0.496ValTrp: 0.496 ± 0.137
2.346ValTyr: 2.346 ± 0.365
0.0ValXaa: 0.0 ± 0.0
Trp
1.128TrpAla: 1.128 ± 0.227
0.045TrpCys: 0.045 ± 0.048
0.902TrpAsp: 0.902 ± 0.179
0.767TrpGlu: 0.767 ± 0.291
0.541TrpPhe: 0.541 ± 0.19
0.767TrpGly: 0.767 ± 0.176
0.271TrpHis: 0.271 ± 0.116
0.767TrpIle: 0.767 ± 0.161
0.632TrpLys: 0.632 ± 0.182
0.586TrpLeu: 0.586 ± 0.163
0.361TrpMet: 0.361 ± 0.1
0.722TrpAsn: 0.722 ± 0.188
0.316TrpPro: 0.316 ± 0.121
0.226TrpGln: 0.226 ± 0.088
0.451TrpArg: 0.451 ± 0.154
0.451TrpSer: 0.451 ± 0.143
0.767TrpThr: 0.767 ± 0.194
0.451TrpVal: 0.451 ± 0.161
0.09TrpTrp: 0.09 ± 0.068
0.496TrpTyr: 0.496 ± 0.186
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.616TyrAla: 2.616 ± 0.266
0.271TyrCys: 0.271 ± 0.119
3.293TyrAsp: 3.293 ± 0.345
2.571TyrGlu: 2.571 ± 0.329
1.173TyrPhe: 1.173 ± 0.198
2.075TyrGly: 2.075 ± 0.367
0.361TyrHis: 0.361 ± 0.133
2.03TyrIle: 2.03 ± 0.287
1.895TyrLys: 1.895 ± 0.244
2.616TyrLeu: 2.616 ± 0.392
0.767TyrMet: 0.767 ± 0.202
2.03TyrAsn: 2.03 ± 0.33
1.173TyrPro: 1.173 ± 0.167
1.579TyrGln: 1.579 ± 0.257
1.759TyrArg: 1.759 ± 0.334
2.616TyrSer: 2.616 ± 0.376
2.391TyrThr: 2.391 ± 0.282
2.661TyrVal: 2.661 ± 0.289
0.406TyrTrp: 0.406 ± 0.142
0.902TyrTyr: 0.902 ± 0.199
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 75 proteins (22169 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski