Amino acid dipepetide frequency for Aliifodinibius sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.208AlaAla: 6.208 ± 0.077	0.568AlaCys: 0.568 ± 0.022	4.296AlaAsp: 4.296 ± 0.062	5.205AlaGlu: 5.205 ± 0.069	3.241AlaPhe: 3.241 ± 0.05	6.022AlaGly: 6.022 ± 0.078	1.425AlaHis: 1.425 ± 0.032	4.708AlaIle: 4.708 ± 0.066	3.006AlaLys: 3.006 ± 0.051	7.359AlaLeu: 7.359 ± 0.075	1.855AlaMet: 1.855 ± 0.036	2.598AlaAsn: 2.598 ± 0.048	2.626AlaPro: 2.626 ± 0.047	2.736AlaGln: 2.736 ± 0.048	4.092AlaArg: 4.092 ± 0.066	4.751AlaSer: 4.751 ± 0.067	3.648AlaThr: 3.648 ± 0.05	5.232AlaVal: 5.232 ± 0.073	0.886AlaTrp: 0.886 ± 0.026	2.446AlaTyr: 2.446 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.451CysAla: 0.451 ± 0.022	0.11CysCys: 0.11 ± 0.01	0.367CysAsp: 0.367 ± 0.019	0.368CysGlu: 0.368 ± 0.019	0.319CysPhe: 0.319 ± 0.018	0.582CysGly: 0.582 ± 0.022	0.233CysHis: 0.233 ± 0.017	0.445CysIle: 0.445 ± 0.021	0.302CysLys: 0.302 ± 0.017	0.564CysLeu: 0.564 ± 0.022	0.147CysMet: 0.147 ± 0.011	0.255CysAsn: 0.255 ± 0.015	0.343CysPro: 0.343 ± 0.02	0.2CysGln: 0.2 ± 0.013	0.38CysArg: 0.38 ± 0.02	0.557CysSer: 0.557 ± 0.022	0.391CysThr: 0.391 ± 0.017	0.369CysVal: 0.369 ± 0.019	0.083CysTrp: 0.083 ± 0.009	0.272CysTyr: 0.272 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.805AspAla: 3.805 ± 0.052	0.333AspCys: 0.333 ± 0.018	3.203AspAsp: 3.203 ± 0.057	4.525AspGlu: 4.525 ± 0.073	2.968AspPhe: 2.968 ± 0.049	4.216AspGly: 4.216 ± 0.081	1.519AspHis: 1.519 ± 0.035	4.328AspIle: 4.328 ± 0.061	2.844AspLys: 2.844 ± 0.051	5.604AspLeu: 5.604 ± 0.079	1.367AspMet: 1.367 ± 0.034	2.438AspAsn: 2.438 ± 0.044	2.879AspPro: 2.879 ± 0.048	2.5AspGln: 2.5 ± 0.038	3.567AspArg: 3.567 ± 0.052	3.375AspSer: 3.375 ± 0.063	2.904AspThr: 2.904 ± 0.047	3.476AspVal: 3.476 ± 0.055	0.93AspTrp: 0.93 ± 0.026	2.406AspTyr: 2.406 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	5.802GluAla: 5.802 ± 0.083	0.359GluCys: 0.359 ± 0.018	4.169GluAsp: 4.169 ± 0.061	6.899GluGlu: 6.899 ± 0.109	2.37GluPhe: 2.37 ± 0.048	5.191GluGly: 5.191 ± 0.07	1.663GluHis: 1.663 ± 0.041	4.624GluIle: 4.624 ± 0.061	4.554GluLys: 4.554 ± 0.077	7.018GluLeu: 7.018 ± 0.082	1.876GluMet: 1.876 ± 0.038	3.313GluAsn: 3.313 ± 0.059	2.382GluPro: 2.382 ± 0.04	3.825GluGln: 3.825 ± 0.062	3.854GluArg: 3.854 ± 0.057	3.768GluSer: 3.768 ± 0.059	3.564GluThr: 3.564 ± 0.055	4.89GluVal: 4.89 ± 0.061	0.958GluTrp: 0.958 ± 0.029	2.38GluTyr: 2.38 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	2.906PheAla: 2.906 ± 0.052	0.347PheCys: 0.347 ± 0.017	2.886PheAsp: 2.886 ± 0.048	3.093PheGlu: 3.093 ± 0.052	2.098PhePhe: 2.098 ± 0.045	3.284PheGly: 3.284 ± 0.054	0.886PheHis: 0.886 ± 0.029	2.884PheIle: 2.884 ± 0.056	1.926PheLys: 1.926 ± 0.046	4.111PheLeu: 4.111 ± 0.065	1.021PheMet: 1.021 ± 0.027	2.099PheAsn: 2.099 ± 0.045	1.72PhePro: 1.72 ± 0.037	1.403PheGln: 1.403 ± 0.029	2.241PheArg: 2.241 ± 0.041	3.441PheSer: 3.441 ± 0.059	2.468PheThr: 2.468 ± 0.048	2.608PheVal: 2.608 ± 0.055	0.663PheTrp: 0.663 ± 0.024	1.683PheTyr: 1.683 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	5.075GlyAla: 5.075 ± 0.069	0.634GlyCys: 0.634 ± 0.024	3.959GlyAsp: 3.959 ± 0.071	4.872GlyGlu: 4.872 ± 0.064	3.385GlyPhe: 3.385 ± 0.05	5.642GlyGly: 5.642 ± 0.081	1.584GlyHis: 1.584 ± 0.042	5.423GlyIle: 5.423 ± 0.07	3.768GlyLys: 3.768 ± 0.064	6.796GlyLeu: 6.796 ± 0.095	2.122GlyMet: 2.122 ± 0.046	3.142GlyAsn: 3.142 ± 0.065	2.254GlyPro: 2.254 ± 0.055	2.791GlyGln: 2.791 ± 0.05	3.861GlyArg: 3.861 ± 0.052	4.879GlySer: 4.879 ± 0.069	4.361GlyThr: 4.361 ± 0.069	4.594GlyVal: 4.594 ± 0.06	1.22GlyTrp: 1.22 ± 0.035	3.189GlyTyr: 3.189 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.412HisAla: 1.412 ± 0.028	0.194HisCys: 0.194 ± 0.013	1.121HisAsp: 1.121 ± 0.031	1.335HisGlu: 1.335 ± 0.031	1.164HisPhe: 1.164 ± 0.03	1.497HisGly: 1.497 ± 0.039	0.697HisHis: 0.697 ± 0.027	1.472HisIle: 1.472 ± 0.035	0.985HisLys: 0.985 ± 0.029	2.099HisLeu: 2.099 ± 0.042	0.478HisMet: 0.478 ± 0.023	0.895HisAsn: 0.895 ± 0.027	1.379HisPro: 1.379 ± 0.036	0.901HisGln: 0.901 ± 0.026	1.27HisArg: 1.27 ± 0.035	1.358HisSer: 1.358 ± 0.035	1.113HisThr: 1.113 ± 0.032	1.14HisVal: 1.14 ± 0.031	0.37HisTrp: 0.37 ± 0.019	0.96HisTyr: 0.96 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.13IleAla: 5.13 ± 0.08	0.488IleCys: 0.488 ± 0.018	4.335IleAsp: 4.335 ± 0.066	4.709IleGlu: 4.709 ± 0.072	2.723IlePhe: 2.723 ± 0.054	4.7IleGly: 4.7 ± 0.066	1.401IleHis: 1.401 ± 0.034	4.236IleIle: 4.236 ± 0.068	3.159IleLys: 3.159 ± 0.055	5.7IleLeu: 5.7 ± 0.078	1.359IleMet: 1.359 ± 0.034	3.105IleAsn: 3.105 ± 0.053	3.175IlePro: 3.175 ± 0.05	2.436IleGln: 2.436 ± 0.044	3.641IleArg: 3.641 ± 0.049	4.752IleSer: 4.752 ± 0.061	3.871IleThr: 3.871 ± 0.058	3.788IleVal: 3.788 ± 0.063	0.73IleTrp: 0.73 ± 0.025	2.211IleTyr: 2.211 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	3.959LysAla: 3.959 ± 0.058	0.228LysCys: 0.228 ± 0.014	2.635LysAsp: 2.635 ± 0.053	4.49LysGlu: 4.49 ± 0.077	1.568LysPhe: 1.568 ± 0.037	3.289LysGly: 3.289 ± 0.048	1.063LysHis: 1.063 ± 0.026	3.294LysIle: 3.294 ± 0.059	3.96LysLys: 3.96 ± 0.082	4.526LysLeu: 4.526 ± 0.064	1.417LysMet: 1.417 ± 0.032	2.395LysAsn: 2.395 ± 0.045	2.027LysPro: 2.027 ± 0.041	2.255LysGln: 2.255 ± 0.042	2.825LysArg: 2.825 ± 0.054	2.92LysSer: 2.92 ± 0.052	2.774LysThr: 2.774 ± 0.048	3.278LysVal: 3.278 ± 0.054	0.636LysTrp: 0.636 ± 0.023	1.816LysTyr: 1.816 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	7.126LeuAla: 7.126 ± 0.075	0.657LeuCys: 0.657 ± 0.024	5.576LeuAsp: 5.576 ± 0.07	6.478LeuGlu: 6.478 ± 0.083	4.585LeuPhe: 4.585 ± 0.072	6.449LeuGly: 6.449 ± 0.083	1.906LeuHis: 1.906 ± 0.05	5.736LeuIle: 5.736 ± 0.071	5.185LeuLys: 5.185 ± 0.074	9.665LeuLeu: 9.665 ± 0.132	2.275LeuMet: 2.275 ± 0.042	4.262LeuAsn: 4.262 ± 0.062	4.225LeuPro: 4.225 ± 0.061	3.885LeuGln: 3.885 ± 0.063	4.775LeuArg: 4.775 ± 0.051	6.941LeuSer: 6.941 ± 0.085	5.097LeuThr: 5.097 ± 0.06	5.763LeuVal: 5.763 ± 0.065	1.145LeuTrp: 1.145 ± 0.036	3.185LeuTyr: 3.185 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.038MetAla: 2.038 ± 0.038	0.113MetCys: 0.113 ± 0.01	1.63MetAsp: 1.63 ± 0.037	1.762MetGlu: 1.762 ± 0.037	0.776MetPhe: 0.776 ± 0.033	1.89MetGly: 1.89 ± 0.038	0.498MetHis: 0.498 ± 0.019	1.582MetIle: 1.582 ± 0.039	1.594MetLys: 1.594 ± 0.035	2.235MetLeu: 2.235 ± 0.045	0.725MetMet: 0.725 ± 0.031	1.288MetAsn: 1.288 ± 0.034	1.134MetPro: 1.134 ± 0.031	0.999MetGln: 0.999 ± 0.027	1.168MetArg: 1.168 ± 0.029	1.49MetSer: 1.49 ± 0.032	1.257MetThr: 1.257 ± 0.03	1.683MetVal: 1.683 ± 0.038	0.191MetTrp: 0.191 ± 0.013	0.656MetTyr: 0.656 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.885AsnAla: 2.885 ± 0.049	0.263AsnCys: 0.263 ± 0.018	2.308AsnAsp: 2.308 ± 0.048	2.757AsnGlu: 2.757 ± 0.047	1.859AsnPhe: 1.859 ± 0.045	3.147AsnGly: 3.147 ± 0.059	0.967AsnHis: 0.967 ± 0.031	3.287AsnIle: 3.287 ± 0.053	2.214AsnLys: 2.214 ± 0.045	3.827AsnLeu: 3.827 ± 0.06	1.107AsnMet: 1.107 ± 0.031	2.146AsnAsn: 2.146 ± 0.053	2.508AsnPro: 2.508 ± 0.049	1.742AsnGln: 1.742 ± 0.044	2.709AsnArg: 2.709 ± 0.056	2.558AsnSer: 2.558 ± 0.048	2.345AsnThr: 2.345 ± 0.05	2.572AsnVal: 2.572 ± 0.049	0.649AsnTrp: 0.649 ± 0.026	1.811AsnTyr: 1.811 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	3.058ProAla: 3.058 ± 0.058	0.227ProCys: 0.227 ± 0.013	3.306ProAsp: 3.306 ± 0.049	3.829ProGlu: 3.829 ± 0.058	1.93ProPhe: 1.93 ± 0.036	3.459ProGly: 3.459 ± 0.056	0.93ProHis: 0.93 ± 0.026	2.272ProIle: 2.272 ± 0.045	1.655ProLys: 1.655 ± 0.041	3.738ProLeu: 3.738 ± 0.048	0.929ProMet: 0.929 ± 0.027	1.678ProAsn: 1.678 ± 0.037	1.549ProPro: 1.549 ± 0.04	1.423ProGln: 1.423 ± 0.032	1.919ProArg: 1.919 ± 0.045	2.683ProSer: 2.683 ± 0.055	1.979ProThr: 1.979 ± 0.043	3.384ProVal: 3.384 ± 0.054	0.524ProTrp: 0.524 ± 0.022	1.511ProTyr: 1.511 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.068GlnAla: 3.068 ± 0.046	0.204GlnCys: 0.204 ± 0.013	1.997GlnAsp: 1.997 ± 0.043	2.99GlnGlu: 2.99 ± 0.052	1.611GlnPhe: 1.611 ± 0.031	2.325GlnGly: 2.325 ± 0.045	0.937GlnHis: 0.937 ± 0.032	2.293GlnIle: 2.293 ± 0.048	2.524GlnLys: 2.524 ± 0.047	4.175GlnLeu: 4.175 ± 0.06	1.061GlnMet: 1.061 ± 0.031	1.813GlnAsn: 1.813 ± 0.042	1.714GlnPro: 1.714 ± 0.033	2.712GlnGln: 2.712 ± 0.056	2.153GlnArg: 2.153 ± 0.046	2.518GlnSer: 2.518 ± 0.048	2.139GlnThr: 2.139 ± 0.046	2.379GlnVal: 2.379 ± 0.05	0.614GlnTrp: 0.614 ± 0.021	1.45GlnTyr: 1.45 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	3.48ArgAla: 3.48 ± 0.057	0.323ArgCys: 0.323 ± 0.017	2.979ArgAsp: 2.979 ± 0.05	4.382ArgGlu: 4.382 ± 0.063	2.424ArgPhe: 2.424 ± 0.052	3.442ArgGly: 3.442 ± 0.051	1.167ArgHis: 1.167 ± 0.03	3.652ArgIle: 3.652 ± 0.058	3.263ArgLys: 3.263 ± 0.048	5.141ArgLeu: 5.141 ± 0.062	1.43ArgMet: 1.43 ± 0.034	2.423ArgAsn: 2.423 ± 0.049	2.011ArgPro: 2.011 ± 0.04	2.379ArgGln: 2.379 ± 0.046	2.999ArgArg: 2.999 ± 0.05	3.324ArgSer: 3.324 ± 0.058	2.64ArgThr: 2.64 ± 0.047	3.072ArgVal: 3.072 ± 0.051	0.843ArgTrp: 0.843 ± 0.026	2.364ArgTyr: 2.364 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.408SerAla: 4.408 ± 0.063	0.505SerCys: 0.505 ± 0.021	3.845SerAsp: 3.845 ± 0.049	4.33SerGlu: 4.33 ± 0.072	3.179SerPhe: 3.179 ± 0.054	5.394SerGly: 5.394 ± 0.073	1.288SerHis: 1.288 ± 0.029	4.27SerIle: 4.27 ± 0.071	2.919SerLys: 2.919 ± 0.048	6.225SerLeu: 6.225 ± 0.087	1.617SerMet: 1.617 ± 0.038	2.703SerAsn: 2.703 ± 0.052	2.607SerPro: 2.607 ± 0.047	2.207SerGln: 2.207 ± 0.043	3.648SerArg: 3.648 ± 0.059	4.705SerSer: 4.705 ± 0.073	3.503SerThr: 3.503 ± 0.055	4.124SerVal: 4.124 ± 0.059	0.981SerTrp: 0.981 ± 0.029	2.51SerTyr: 2.51 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	4.091ThrAla: 4.091 ± 0.06	0.314ThrCys: 0.314 ± 0.015	3.394ThrAsp: 3.394 ± 0.057	3.404ThrGlu: 3.404 ± 0.051	2.549ThrPhe: 2.549 ± 0.046	4.831ThrGly: 4.831 ± 0.07	1.106ThrHis: 1.106 ± 0.037	3.817ThrIle: 3.817 ± 0.051	2.088ThrLys: 2.088 ± 0.042	5.288ThrLeu: 5.288 ± 0.071	1.148ThrMet: 1.148 ± 0.03	2.058ThrAsn: 2.058 ± 0.041	2.517ThrPro: 2.517 ± 0.043	1.708ThrGln: 1.708 ± 0.035	2.311ThrArg: 2.311 ± 0.042	3.378ThrSer: 3.378 ± 0.054	2.978ThrThr: 2.978 ± 0.058	3.772ThrVal: 3.772 ± 0.056	0.526ThrTrp: 0.526 ± 0.02	2.021ThrTyr: 2.021 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	4.729ValAla: 4.729 ± 0.069	0.471ValCys: 0.471 ± 0.021	4.074ValAsp: 4.074 ± 0.066	4.519ValGlu: 4.519 ± 0.058	2.698ValPhe: 2.698 ± 0.05	4.422ValGly: 4.422 ± 0.068	1.332ValHis: 1.332 ± 0.031	4.334ValIle: 4.334 ± 0.059	2.95ValLys: 2.95 ± 0.056	5.963ValLeu: 5.963 ± 0.08	1.585ValMet: 1.585 ± 0.04	2.77ValAsn: 2.77 ± 0.049	2.754ValPro: 2.754 ± 0.046	2.374ValGln: 2.374 ± 0.048	3.253ValArg: 3.253 ± 0.043	4.34ValSer: 4.34 ± 0.07	3.642ValThr: 3.642 ± 0.059	4.276ValVal: 4.276 ± 0.064	0.702ValTrp: 0.702 ± 0.026	2.02ValTyr: 2.02 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.893TrpAla: 0.893 ± 0.03	0.099TrpCys: 0.099 ± 0.009	0.783TrpAsp: 0.783 ± 0.031	0.903TrpGlu: 0.903 ± 0.031	0.542TrpPhe: 0.542 ± 0.023	0.986TrpGly: 0.986 ± 0.03	0.339TrpHis: 0.339 ± 0.018	0.904TrpIle: 0.904 ± 0.023	0.782TrpLys: 0.782 ± 0.028	1.295TrpLeu: 1.295 ± 0.035	0.438TrpMet: 0.438 ± 0.018	0.625TrpAsn: 0.625 ± 0.023	0.505TrpPro: 0.505 ± 0.021	0.575TrpGln: 0.575 ± 0.023	0.66TrpArg: 0.66 ± 0.024	0.883TrpSer: 0.883 ± 0.031	0.751TrpThr: 0.751 ± 0.027	0.772TrpVal: 0.772 ± 0.027	0.241TrpTrp: 0.241 ± 0.015	0.48TrpTyr: 0.48 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.383TyrAla: 2.383 ± 0.047	0.298TyrCys: 0.298 ± 0.015	2.325TyrAsp: 2.325 ± 0.049	2.609TyrGlu: 2.609 ± 0.052	1.778TyrPhe: 1.778 ± 0.041	2.782TyrGly: 2.782 ± 0.045	0.898TyrHis: 0.898 ± 0.026	2.088TyrIle: 2.088 ± 0.04	1.68TyrLys: 1.68 ± 0.037	3.588TyrLeu: 3.588 ± 0.051	0.752TyrMet: 0.752 ± 0.025	1.655TyrAsn: 1.655 ± 0.043	1.675TyrPro: 1.675 ± 0.035	1.626TyrGln: 1.626 ± 0.04	2.413TyrArg: 2.413 ± 0.049	2.344TyrSer: 2.344 ± 0.045	1.876TyrThr: 1.876 ± 0.038	2.037TyrVal: 2.037 ± 0.041	0.565TyrTrp: 0.565 ± 0.022	1.566TyrTyr: 1.566 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3822 proteins (1296162 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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