Amino acid dipepetide frequency for Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.061AlaAla: 6.061 ± 0.112
0.981AlaCys: 0.981 ± 0.031
3.693AlaAsp: 3.693 ± 0.061
5.64AlaGlu: 5.64 ± 0.082
3.09AlaPhe: 3.09 ± 0.063
6.478AlaGly: 6.478 ± 0.095
1.08AlaHis: 1.08 ± 0.031
4.959AlaIle: 4.959 ± 0.087
4.061AlaLys: 4.061 ± 0.069
7.383AlaLeu: 7.383 ± 0.126
1.71AlaMet: 1.71 ± 0.052
2.318AlaAsn: 2.318 ± 0.049
2.162AlaPro: 2.162 ± 0.049
1.542AlaGln: 1.542 ± 0.037
3.374AlaArg: 3.374 ± 0.055
4.567AlaSer: 4.567 ± 0.08
3.054AlaThr: 3.054 ± 0.065
5.899AlaVal: 5.899 ± 0.083
0.661AlaTrp: 0.661 ± 0.037
2.314AlaTyr: 2.314 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.777CysAla: 0.777 ± 0.032
0.231CysCys: 0.231 ± 0.017
0.597CysAsp: 0.597 ± 0.027
0.798CysGlu: 0.798 ± 0.03
0.53CysPhe: 0.53 ± 0.025
1.267CysGly: 1.267 ± 0.045
0.241CysHis: 0.241 ± 0.016
0.901CysIle: 0.901 ± 0.031
0.743CysLys: 0.743 ± 0.027
0.977CysLeu: 0.977 ± 0.037
0.319CysMet: 0.319 ± 0.017
0.434CysAsn: 0.434 ± 0.022
0.794CysPro: 0.794 ± 0.034
0.278CysGln: 0.278 ± 0.017
0.7CysArg: 0.7 ± 0.03
0.88CysSer: 0.88 ± 0.034
0.66CysThr: 0.66 ± 0.024
0.731CysVal: 0.731 ± 0.026
0.104CysTrp: 0.104 ± 0.01
0.397CysTyr: 0.397 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
3.492AspAla: 3.492 ± 0.064
0.62AspCys: 0.62 ± 0.026
2.095AspAsp: 2.095 ± 0.053
3.936AspGlu: 3.936 ± 0.07
2.765AspPhe: 2.765 ± 0.055
3.556AspGly: 3.556 ± 0.078
0.836AspHis: 0.836 ± 0.034
4.666AspIle: 4.666 ± 0.07
2.952AspLys: 2.952 ± 0.057
5.13AspLeu: 5.13 ± 0.07
1.407AspMet: 1.407 ± 0.039
1.962AspAsn: 1.962 ± 0.057
2.595AspPro: 2.595 ± 0.048
1.075AspGln: 1.075 ± 0.036
2.834AspArg: 2.834 ± 0.057
3.775AspSer: 3.775 ± 0.071
2.671AspThr: 2.671 ± 0.069
3.607AspVal: 3.607 ± 0.062
0.534AspTrp: 0.534 ± 0.026
2.09AspTyr: 2.09 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
5.874GluAla: 5.874 ± 0.118
0.816GluCys: 0.816 ± 0.035
4.137GluAsp: 4.137 ± 0.069
7.617GluGlu: 7.617 ± 0.146
2.971GluPhe: 2.971 ± 0.054
4.966GluGly: 4.966 ± 0.082
1.195GluHis: 1.195 ± 0.034
6.909GluIle: 6.909 ± 0.094
7.703GluLys: 7.703 ± 0.129
7.362GluLeu: 7.362 ± 0.113
2.194GluMet: 2.194 ± 0.048
4.737GluAsn: 4.737 ± 0.084
2.453GluPro: 2.453 ± 0.05
1.916GluGln: 1.916 ± 0.048
3.473GluArg: 3.473 ± 0.078
4.526GluSer: 4.526 ± 0.07
4.201GluThr: 4.201 ± 0.073
5.083GluVal: 5.083 ± 0.082
0.723GluTrp: 0.723 ± 0.03
2.746GluTyr: 2.746 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
2.847PheAla: 2.847 ± 0.061
0.582PheCys: 0.582 ± 0.023
2.354PheAsp: 2.354 ± 0.053
3.382PheGlu: 3.382 ± 0.067
2.049PhePhe: 2.049 ± 0.061
3.17PheGly: 3.17 ± 0.066
0.654PheHis: 0.654 ± 0.027
3.11PheIle: 3.11 ± 0.06
2.355PheLys: 2.355 ± 0.049
4.376PheLeu: 4.376 ± 0.088
1.021PheMet: 1.021 ± 0.035
1.637PheAsn: 1.637 ± 0.047
1.634PhePro: 1.634 ± 0.043
0.999PheGln: 0.999 ± 0.029
2.093PheArg: 2.093 ± 0.044
3.524PheSer: 3.524 ± 0.075
2.339PheThr: 2.339 ± 0.049
2.832PheVal: 2.832 ± 0.06
0.454PheTrp: 0.454 ± 0.022
1.551PheTyr: 1.551 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
4.942GlyAla: 4.942 ± 0.089
1.059GlyCys: 1.059 ± 0.034
3.587GlyAsp: 3.587 ± 0.074
5.086GlyGlu: 5.086 ± 0.076
3.43GlyPhe: 3.43 ± 0.066
4.707GlyGly: 4.707 ± 0.094
1.237GlyHis: 1.237 ± 0.034
6.613GlyIle: 6.613 ± 0.09
5.81GlyLys: 5.81 ± 0.084
6.247GlyLeu: 6.247 ± 0.097
2.081GlyMet: 2.081 ± 0.058
3.335GlyAsn: 3.335 ± 0.088
2.056GlyPro: 2.056 ± 0.047
1.59GlyGln: 1.59 ± 0.038
3.047GlyArg: 3.047 ± 0.058
4.966GlySer: 4.966 ± 0.091
4.264GlyThr: 4.264 ± 0.079
5.009GlyVal: 5.009 ± 0.089
0.742GlyTrp: 0.742 ± 0.03
2.848GlyTyr: 2.848 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
1.176HisAla: 1.176 ± 0.037
0.271HisCys: 0.271 ± 0.016
0.887HisAsp: 0.887 ± 0.028
1.171HisGlu: 1.171 ± 0.038
0.763HisPhe: 0.763 ± 0.031
1.203HisGly: 1.203 ± 0.039
0.374HisHis: 0.374 ± 0.02
1.262HisIle: 1.262 ± 0.031
0.84HisLys: 0.84 ± 0.03
1.537HisLeu: 1.537 ± 0.041
0.458HisMet: 0.458 ± 0.023
0.671HisAsn: 0.671 ± 0.026
0.935HisPro: 0.935 ± 0.028
0.374HisGln: 0.374 ± 0.018
0.903HisArg: 0.903 ± 0.029
1.08HisSer: 1.08 ± 0.043
0.814HisThr: 0.814 ± 0.032
1.134HisVal: 1.134 ± 0.033
0.202HisTrp: 0.202 ± 0.013
0.597HisTyr: 0.597 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
5.485IleAla: 5.485 ± 0.082
0.996IleCys: 0.996 ± 0.029
4.139IleAsp: 4.139 ± 0.073
6.097IleGlu: 6.097 ± 0.088
3.509IlePhe: 3.509 ± 0.069
5.332IleGly: 5.332 ± 0.083
1.399IleHis: 1.399 ± 0.039
5.46IleIle: 5.46 ± 0.093
4.961IleLys: 4.961 ± 0.086
7.157IleLeu: 7.157 ± 0.103
1.686IleMet: 1.686 ± 0.044
3.146IleAsn: 3.146 ± 0.069
3.521IlePro: 3.521 ± 0.068
1.963IleGln: 1.963 ± 0.044
3.653IleArg: 3.653 ± 0.06
5.877IleSer: 5.877 ± 0.069
4.031IleThr: 4.031 ± 0.076
4.934IleVal: 4.934 ± 0.075
0.623IleTrp: 0.623 ± 0.025
2.586IleTyr: 2.586 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
5.053LysAla: 5.053 ± 0.083
0.701LysCys: 0.701 ± 0.031
3.598LysAsp: 3.598 ± 0.069
6.345LysGlu: 6.345 ± 0.105
2.141LysPhe: 2.141 ± 0.052
4.411LysGly: 4.411 ± 0.075
1.079LysHis: 1.079 ± 0.036
5.403LysIle: 5.403 ± 0.088
5.809LysLys: 5.809 ± 0.095
5.704LysLeu: 5.704 ± 0.071
1.827LysMet: 1.827 ± 0.046
3.77LysAsn: 3.77 ± 0.055
2.482LysPro: 2.482 ± 0.046
1.756LysGln: 1.756 ± 0.047
2.909LysArg: 2.909 ± 0.065
3.854LysSer: 3.854 ± 0.074
3.6LysThr: 3.6 ± 0.064
4.322LysVal: 4.322 ± 0.069
0.555LysTrp: 0.555 ± 0.024
2.39LysTyr: 2.39 ± 0.057
0.0LysXaa: 0.0 ± 0.0
Leu
6.904LeuAla: 6.904 ± 0.109
1.02LeuCys: 1.02 ± 0.037
5.12LeuAsp: 5.12 ± 0.078
7.892LeuGlu: 7.892 ± 0.111
4.121LeuPhe: 4.121 ± 0.084
6.56LeuGly: 6.56 ± 0.108
1.55LeuHis: 1.55 ± 0.04
6.781LeuIle: 6.781 ± 0.095
7.081LeuLys: 7.081 ± 0.099
9.058LeuLeu: 9.058 ± 0.131
2.357LeuMet: 2.357 ± 0.051
3.986LeuAsn: 3.986 ± 0.07
3.827LeuPro: 3.827 ± 0.07
2.414LeuGln: 2.414 ± 0.057
4.154LeuArg: 4.154 ± 0.074
6.743LeuSer: 6.743 ± 0.098
4.659LeuThr: 4.659 ± 0.071
5.922LeuVal: 5.922 ± 0.083
0.807LeuTrp: 0.807 ± 0.032
2.918LeuTyr: 2.918 ± 0.055
0.0LeuXaa: 0.0 ± 0.0
Met
1.798MetAla: 1.798 ± 0.047
0.272MetCys: 0.272 ± 0.018
1.371MetAsp: 1.371 ± 0.039
2.01MetGlu: 2.01 ± 0.057
0.833MetPhe: 0.833 ± 0.028
1.984MetGly: 1.984 ± 0.057
0.459MetHis: 0.459 ± 0.022
1.741MetIle: 1.741 ± 0.053
1.968MetLys: 1.968 ± 0.04
2.399MetLeu: 2.399 ± 0.056
0.598MetMet: 0.598 ± 0.027
1.07MetAsn: 1.07 ± 0.029
1.02MetPro: 1.02 ± 0.032
0.796MetGln: 0.796 ± 0.028
1.122MetArg: 1.122 ± 0.036
1.546MetSer: 1.546 ± 0.035
1.308MetThr: 1.308 ± 0.039
1.653MetVal: 1.653 ± 0.041
0.181MetTrp: 0.181 ± 0.013
0.749MetTyr: 0.749 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
2.799AsnAla: 2.799 ± 0.062
0.61AsnCys: 0.61 ± 0.03
1.67AsnAsp: 1.67 ± 0.047
2.975AsnGlu: 2.975 ± 0.062
1.886AsnPhe: 1.886 ± 0.042
2.952AsnGly: 2.952 ± 0.068
0.636AsnHis: 0.636 ± 0.028
3.711AsnIle: 3.711 ± 0.066
2.327AsnLys: 2.327 ± 0.059
4.175AsnLeu: 4.175 ± 0.07
1.075AsnMet: 1.075 ± 0.035
2.217AsnAsn: 2.217 ± 0.095
2.503AsnPro: 2.503 ± 0.058
1.039AsnGln: 1.039 ± 0.034
2.146AsnArg: 2.146 ± 0.045
3.186AsnSer: 3.186 ± 0.081
2.399AsnThr: 2.399 ± 0.064
2.993AsnVal: 2.993 ± 0.069
0.455AsnTrp: 0.455 ± 0.024
1.63AsnTyr: 1.63 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
3.119ProAla: 3.119 ± 0.06
0.504ProCys: 0.504 ± 0.023
2.913ProAsp: 2.913 ± 0.061
5.113ProGlu: 5.113 ± 0.078
1.699ProPhe: 1.699 ± 0.046
3.132ProGly: 3.132 ± 0.06
0.667ProHis: 0.667 ± 0.025
2.23ProIle: 2.23 ± 0.053
1.867ProLys: 1.867 ± 0.047
3.565ProLeu: 3.565 ± 0.065
0.759ProMet: 0.759 ± 0.029
1.108ProAsn: 1.108 ± 0.034
1.32ProPro: 1.32 ± 0.038
0.989ProGln: 0.989 ± 0.032
1.466ProArg: 1.466 ± 0.04
2.453ProSer: 2.453 ± 0.059
1.606ProThr: 1.606 ± 0.048
3.77ProVal: 3.77 ± 0.08
0.343ProTrp: 0.343 ± 0.019
1.468ProTyr: 1.468 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
1.926GlnAla: 1.926 ± 0.053
0.276GlnCys: 0.276 ± 0.017
1.224GlnAsp: 1.224 ± 0.037
2.089GlnGlu: 2.089 ± 0.041
0.919GlnPhe: 0.919 ± 0.034
1.607GlnGly: 1.607 ± 0.044
0.426GlnHis: 0.426 ± 0.019
1.999GlnIle: 1.999 ± 0.05
2.226GlnLys: 2.226 ± 0.048
2.168GlnLeu: 2.168 ± 0.052
0.676GlnMet: 0.676 ± 0.026
1.242GlnAsn: 1.242 ± 0.039
0.82GlnPro: 0.82 ± 0.035
0.742GlnGln: 0.742 ± 0.032
1.122GlnArg: 1.122 ± 0.035
1.225GlnSer: 1.225 ± 0.037
1.24GlnThr: 1.24 ± 0.041
1.702GlnVal: 1.702 ± 0.043
0.197GlnTrp: 0.197 ± 0.013
0.857GlnTyr: 0.857 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
3.19ArgAla: 3.19 ± 0.059
0.523ArgCys: 0.523 ± 0.025
2.686ArgAsp: 2.686 ± 0.052
4.069ArgGlu: 4.069 ± 0.077
1.986ArgPhe: 1.986 ± 0.05
2.779ArgGly: 2.779 ± 0.056
0.761ArgHis: 0.761 ± 0.026
3.788ArgIle: 3.788 ± 0.071
3.966ArgLys: 3.966 ± 0.079
4.145ArgLeu: 4.145 ± 0.06
1.253ArgMet: 1.253 ± 0.038
2.204ArgAsn: 2.204 ± 0.041
1.526ArgPro: 1.526 ± 0.039
1.325ArgGln: 1.325 ± 0.039
2.138ArgArg: 2.138 ± 0.051
2.58ArgSer: 2.58 ± 0.047
2.264ArgThr: 2.264 ± 0.048
3.156ArgVal: 3.156 ± 0.052
0.431ArgTrp: 0.431 ± 0.021
1.747ArgTyr: 1.747 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
4.248SerAla: 4.248 ± 0.068
0.756SerCys: 0.756 ± 0.029
3.576SerAsp: 3.576 ± 0.065
5.256SerGlu: 5.256 ± 0.076
2.945SerPhe: 2.945 ± 0.057
6.125SerGly: 6.125 ± 0.084
1.063SerHis: 1.063 ± 0.031
4.9SerIle: 4.9 ± 0.071
3.8SerLys: 3.8 ± 0.067
6.316SerLeu: 6.316 ± 0.097
1.676SerMet: 1.676 ± 0.042
2.636SerAsn: 2.636 ± 0.074
2.97SerPro: 2.97 ± 0.066
1.769SerGln: 1.769 ± 0.048
3.575SerArg: 3.575 ± 0.062
5.198SerSer: 5.198 ± 0.107
3.387SerThr: 3.387 ± 0.065
4.514SerVal: 4.514 ± 0.092
0.691SerTrp: 0.691 ± 0.027
2.28SerTyr: 2.28 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
4.004ThrAla: 4.004 ± 0.083
0.645ThrCys: 0.645 ± 0.025
2.83ThrAsp: 2.83 ± 0.059
3.915ThrGlu: 3.915 ± 0.078
2.113ThrPhe: 2.113 ± 0.051
4.969ThrGly: 4.969 ± 0.085
0.888ThrHis: 0.888 ± 0.033
3.719ThrIle: 3.719 ± 0.081
2.479ThrLys: 2.479 ± 0.055
4.926ThrLeu: 4.926 ± 0.069
1.012ThrMet: 1.012 ± 0.035
1.851ThrAsn: 1.851 ± 0.073
2.414ThrPro: 2.414 ± 0.054
1.162ThrGln: 1.162 ± 0.039
2.164ThrArg: 2.164 ± 0.046
3.226ThrSer: 3.226 ± 0.06
2.43ThrThr: 2.43 ± 0.062
4.158ThrVal: 4.158 ± 0.09
0.457ThrTrp: 0.457 ± 0.021
1.794ThrTyr: 1.794 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
4.469ValAla: 4.469 ± 0.077
0.932ValCys: 0.932 ± 0.036
3.624ValAsp: 3.624 ± 0.064
4.988ValGlu: 4.988 ± 0.076
3.144ValPhe: 3.144 ± 0.065
4.133ValGly: 4.133 ± 0.095
1.275ValHis: 1.275 ± 0.035
5.292ValIle: 5.292 ± 0.079
4.323ValLys: 4.323 ± 0.074
6.987ValLeu: 6.987 ± 0.098
1.667ValMet: 1.667 ± 0.041
2.904ValAsn: 2.904 ± 0.051
3.2ValPro: 3.2 ± 0.059
1.749ValGln: 1.749 ± 0.039
3.264ValArg: 3.264 ± 0.066
5.294ValSer: 5.294 ± 0.083
3.826ValThr: 3.826 ± 0.088
4.71ValVal: 4.71 ± 0.087
0.628ValTrp: 0.628 ± 0.027
2.53ValTyr: 2.53 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.605TrpAla: 0.605 ± 0.024
0.101TrpCys: 0.101 ± 0.012
0.589TrpAsp: 0.589 ± 0.03
0.715TrpGlu: 0.715 ± 0.027
0.373TrpPhe: 0.373 ± 0.022
0.626TrpGly: 0.626 ± 0.027
0.177TrpHis: 0.177 ± 0.013
0.716TrpIle: 0.716 ± 0.027
0.765TrpLys: 0.765 ± 0.032
0.815TrpLeu: 0.815 ± 0.029
0.246TrpMet: 0.246 ± 0.015
0.591TrpAsn: 0.591 ± 0.028
0.237TrpPro: 0.237 ± 0.014
0.313TrpGln: 0.313 ± 0.022
0.395TrpArg: 0.395 ± 0.021
0.519TrpSer: 0.519 ± 0.024
0.478TrpThr: 0.478 ± 0.022
0.596TrpVal: 0.596 ± 0.025
0.133TrpTrp: 0.133 ± 0.01
0.369TrpTyr: 0.369 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.258TyrAla: 2.258 ± 0.049
0.464TyrCys: 0.464 ± 0.02
1.91TyrAsp: 1.91 ± 0.047
2.506TyrGlu: 2.506 ± 0.059
1.695TyrPhe: 1.695 ± 0.042
2.698TyrGly: 2.698 ± 0.05
0.654TyrHis: 0.654 ± 0.026
2.398TyrIle: 2.398 ± 0.05
1.672TyrLys: 1.672 ± 0.043
3.446TyrLeu: 3.446 ± 0.066
0.857TyrMet: 0.857 ± 0.032
1.568TyrAsn: 1.568 ± 0.048
1.62TyrPro: 1.62 ± 0.045
0.891TyrGln: 0.891 ± 0.031
1.983TyrArg: 1.983 ± 0.046
2.661TyrSer: 2.661 ± 0.057
1.93TyrThr: 1.93 ± 0.056
2.213TyrVal: 2.213 ± 0.05
0.439TyrTrp: 0.439 ± 0.021
1.442TyrTyr: 1.442 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3303 proteins (1004248 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski