Amino acid dipepetide frequency for Halobacterium sp. DL1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.381AlaAla: 14.381 ± 0.196	0.756AlaCys: 0.756 ± 0.031	10.374AlaAsp: 10.374 ± 0.146	8.546AlaGlu: 8.546 ± 0.126	4.305AlaPhe: 4.305 ± 0.075	9.754AlaGly: 9.754 ± 0.125	1.962AlaHis: 1.962 ± 0.053	4.093AlaIle: 4.093 ± 0.076	1.92AlaLys: 1.92 ± 0.041	10.71AlaLeu: 10.71 ± 0.142	2.119AlaMet: 2.119 ± 0.051	2.529AlaAsn: 2.529 ± 0.054	4.03AlaPro: 4.03 ± 0.066	2.318AlaGln: 2.318 ± 0.051	6.066AlaArg: 6.066 ± 0.094	5.674AlaSer: 5.674 ± 0.085	6.802AlaThr: 6.802 ± 0.119	11.398AlaVal: 11.398 ± 0.155	1.197AlaTrp: 1.197 ± 0.036	2.802AlaTyr: 2.802 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.595CysAla: 0.595 ± 0.03	0.073CysCys: 0.073 ± 0.01	0.531CysAsp: 0.531 ± 0.022	0.648CysGlu: 0.648 ± 0.025	0.209CysPhe: 0.209 ± 0.016	0.867CysGly: 0.867 ± 0.036	0.185CysHis: 0.185 ± 0.015	0.24CysIle: 0.24 ± 0.014	0.109CysLys: 0.109 ± 0.012	0.519CysLeu: 0.519 ± 0.024	0.096CysMet: 0.096 ± 0.011	0.174CysAsn: 0.174 ± 0.013	0.544CysPro: 0.544 ± 0.024	0.163CysGln: 0.163 ± 0.013	0.437CysArg: 0.437 ± 0.023	0.394CysSer: 0.394 ± 0.023	0.409CysThr: 0.409 ± 0.023	0.503CysVal: 0.503 ± 0.024	0.07CysTrp: 0.07 ± 0.009	0.179CysTyr: 0.179 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	11.02AspAla: 11.02 ± 0.141	0.75AspCys: 0.75 ± 0.031	7.814AspAsp: 7.814 ± 0.123	7.707AspGlu: 7.707 ± 0.101	2.069AspPhe: 2.069 ± 0.054	7.603AspGly: 7.603 ± 0.113	2.064AspHis: 2.064 ± 0.049	2.93AspIle: 2.93 ± 0.067	0.961AspLys: 0.961 ± 0.037	7.254AspLeu: 7.254 ± 0.101	1.21AspMet: 1.21 ± 0.038	1.318AspAsn: 1.318 ± 0.044	4.576AspPro: 4.576 ± 0.075	1.869AspGln: 1.869 ± 0.05	5.752AspArg: 5.752 ± 0.089	3.854AspSer: 3.854 ± 0.074	4.122AspThr: 4.122 ± 0.08	8.958AspVal: 8.958 ± 0.12	1.06AspTrp: 1.06 ± 0.036	2.304AspTyr: 2.304 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	8.797GluAla: 8.797 ± 0.124	0.514GluCys: 0.514 ± 0.027	6.466GluAsp: 6.466 ± 0.12	7.107GluGlu: 7.107 ± 0.13	3.311GluPhe: 3.311 ± 0.06	5.471GluGly: 5.471 ± 0.081	2.065GluHis: 2.065 ± 0.049	3.059GluIle: 3.059 ± 0.068	1.932GluLys: 1.932 ± 0.055	7.784GluLeu: 7.784 ± 0.114	1.977GluMet: 1.977 ± 0.048	2.519GluAsn: 2.519 ± 0.052	3.542GluPro: 3.542 ± 0.068	2.957GluGln: 2.957 ± 0.066	7.641GluArg: 7.641 ± 0.122	5.0GluSer: 5.0 ± 0.083	6.089GluThr: 6.089 ± 0.105	6.002GluVal: 6.002 ± 0.092	1.129GluTrp: 1.129 ± 0.036	2.595GluTyr: 2.595 ± 0.064	0.0GluXaa: 0.0 ± 0.0
Phe	3.954PheAla: 3.954 ± 0.078	0.284PheCys: 0.284 ± 0.018	3.541PheAsp: 3.541 ± 0.065	3.227PheGlu: 3.227 ± 0.07	1.096PhePhe: 1.096 ± 0.044	3.449PheGly: 3.449 ± 0.06	0.706PheHis: 0.706 ± 0.029	0.909PheIle: 0.909 ± 0.04	0.489PheLys: 0.489 ± 0.022	2.947PheLeu: 2.947 ± 0.07	0.509PheMet: 0.509 ± 0.023	0.698PheAsn: 0.698 ± 0.028	1.466PhePro: 1.466 ± 0.043	0.906PheGln: 0.906 ± 0.031	1.876PheArg: 1.876 ± 0.047	1.753PheSer: 1.753 ± 0.045	1.893PheThr: 1.893 ± 0.048	3.604PheVal: 3.604 ± 0.064	0.398PheTrp: 0.398 ± 0.023	0.906PheTyr: 0.906 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.148GlyAla: 8.148 ± 0.117	0.675GlyCys: 0.675 ± 0.028	7.091GlyAsp: 7.091 ± 0.097	7.351GlyGlu: 7.351 ± 0.103	3.34GlyPhe: 3.34 ± 0.071	7.423GlyGly: 7.423 ± 0.137	1.758GlyHis: 1.758 ± 0.045	3.558GlyIle: 3.558 ± 0.069	1.91GlyLys: 1.91 ± 0.051	7.202GlyLeu: 7.202 ± 0.121	1.712GlyMet: 1.712 ± 0.047	1.941GlyAsn: 1.941 ± 0.051	3.212GlyPro: 3.212 ± 0.064	2.07GlyGln: 2.07 ± 0.05	4.813GlyArg: 4.813 ± 0.095	4.794GlySer: 4.794 ± 0.092	5.232GlyThr: 5.232 ± 0.079	8.419GlyVal: 8.419 ± 0.126	1.05GlyTrp: 1.05 ± 0.036	2.652GlyTyr: 2.652 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.243HisAla: 2.243 ± 0.05	0.216HisCys: 0.216 ± 0.018	1.935HisAsp: 1.935 ± 0.052	1.839HisGlu: 1.839 ± 0.051	0.584HisPhe: 0.584 ± 0.023	2.014HisGly: 2.014 ± 0.042	0.589HisHis: 0.589 ± 0.026	0.654HisIle: 0.654 ± 0.03	0.304HisLys: 0.304 ± 0.019	1.774HisLeu: 1.774 ± 0.043	0.278HisMet: 0.278 ± 0.016	0.437HisAsn: 0.437 ± 0.022	1.284HisPro: 1.284 ± 0.039	0.529HisGln: 0.529 ± 0.024	1.309HisArg: 1.309 ± 0.039	0.947HisSer: 0.947 ± 0.03	1.014HisThr: 1.014 ± 0.032	2.148HisVal: 2.148 ± 0.048	0.211HisTrp: 0.211 ± 0.015	0.572HisTyr: 0.572 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	3.82IleAla: 3.82 ± 0.067	0.22IleCys: 0.22 ± 0.017	3.091IleAsp: 3.091 ± 0.063	3.519IleGlu: 3.519 ± 0.067	0.884IlePhe: 0.884 ± 0.037	2.99IleGly: 2.99 ± 0.066	0.742IleHis: 0.742 ± 0.033	1.092IleIle: 1.092 ± 0.04	0.629IleLys: 0.629 ± 0.028	2.599IleLeu: 2.599 ± 0.063	0.41IleMet: 0.41 ± 0.025	0.761IleAsn: 0.761 ± 0.03	1.836IlePro: 1.836 ± 0.05	1.03IleGln: 1.03 ± 0.035	2.175IleArg: 2.175 ± 0.05	1.813IleSer: 1.813 ± 0.055	1.92IleThr: 1.92 ± 0.055	3.161IleVal: 3.161 ± 0.056	0.249IleTrp: 0.249 ± 0.016	0.808IleTyr: 0.808 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	1.777LysAla: 1.777 ± 0.048	0.097LysCys: 0.097 ± 0.01	1.141LysAsp: 1.141 ± 0.041	1.393LysGlu: 1.393 ± 0.043	0.602LysPhe: 0.602 ± 0.03	1.282LysGly: 1.282 ± 0.044	0.513LysHis: 0.513 ± 0.024	0.674LysIle: 0.674 ± 0.029	0.486LysLys: 0.486 ± 0.027	1.719LysLeu: 1.719 ± 0.047	0.387LysMet: 0.387 ± 0.021	0.535LysAsn: 0.535 ± 0.025	0.917LysPro: 0.917 ± 0.034	0.843LysGln: 0.843 ± 0.032	1.687LysArg: 1.687 ± 0.049	1.125LysSer: 1.125 ± 0.037	1.312LysThr: 1.312 ± 0.04	1.297LysVal: 1.297 ± 0.039	0.232LysTrp: 0.232 ± 0.016	0.618LysTyr: 0.618 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	11.677LeuAla: 11.677 ± 0.14	0.539LeuCys: 0.539 ± 0.025	8.107LeuAsp: 8.107 ± 0.096	6.533LeuGlu: 6.533 ± 0.115	3.139LeuPhe: 3.139 ± 0.07	7.721LeuGly: 7.721 ± 0.107	1.637LeuHis: 1.637 ± 0.045	2.165LeuIle: 2.165 ± 0.059	1.573LeuLys: 1.573 ± 0.049	8.661LeuLeu: 8.661 ± 0.142	1.294LeuMet: 1.294 ± 0.041	1.871LeuAsn: 1.871 ± 0.051	4.24LeuPro: 4.24 ± 0.084	2.255LeuGln: 2.255 ± 0.055	5.614LeuArg: 5.614 ± 0.09	5.425LeuSer: 5.425 ± 0.088	5.187LeuThr: 5.187 ± 0.073	9.029LeuVal: 9.029 ± 0.137	0.831LeuTrp: 0.831 ± 0.034	2.202LeuTyr: 2.202 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.745MetAla: 1.745 ± 0.051	0.096MetCys: 0.096 ± 0.011	1.329MetAsp: 1.329 ± 0.045	1.198MetGlu: 1.198 ± 0.041	0.51MetPhe: 0.51 ± 0.021	1.349MetGly: 1.349 ± 0.04	0.375MetHis: 0.375 ± 0.021	0.478MetIle: 0.478 ± 0.022	0.425MetLys: 0.425 ± 0.022	1.584MetLeu: 1.584 ± 0.045	0.281MetMet: 0.281 ± 0.017	0.578MetAsn: 0.578 ± 0.023	0.875MetPro: 0.875 ± 0.029	0.524MetGln: 0.524 ± 0.025	1.129MetArg: 1.129 ± 0.034	1.489MetSer: 1.489 ± 0.04	1.428MetThr: 1.428 ± 0.037	1.388MetVal: 1.388 ± 0.04	0.158MetTrp: 0.158 ± 0.013	0.38MetTyr: 0.38 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.669AsnAla: 2.669 ± 0.053	0.23AsnCys: 0.23 ± 0.015	1.714AsnAsp: 1.714 ± 0.05	1.791AsnGlu: 1.791 ± 0.052	0.727AsnPhe: 0.727 ± 0.031	1.989AsnGly: 1.989 ± 0.062	0.498AsnHis: 0.498 ± 0.024	0.858AsnIle: 0.858 ± 0.037	0.426AsnLys: 0.426 ± 0.021	2.05AsnLeu: 2.05 ± 0.053	0.46AsnMet: 0.46 ± 0.02	0.568AsnAsn: 0.568 ± 0.029	1.597AsnPro: 1.597 ± 0.042	0.643AsnGln: 0.643 ± 0.025	1.643AsnArg: 1.643 ± 0.047	1.063AsnSer: 1.063 ± 0.034	1.248AsnThr: 1.248 ± 0.042	2.486AsnVal: 2.486 ± 0.049	0.327AsnTrp: 0.327 ± 0.019	0.691AsnTyr: 0.691 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	4.636ProAla: 4.636 ± 0.076	0.211ProCys: 0.211 ± 0.016	4.571ProAsp: 4.571 ± 0.073	4.806ProGlu: 4.806 ± 0.082	1.598ProPhe: 1.598 ± 0.049	3.827ProGly: 3.827 ± 0.06	0.925ProHis: 0.925 ± 0.032	1.558ProIle: 1.558 ± 0.047	0.888ProLys: 0.888 ± 0.028	3.809ProLeu: 3.809 ± 0.071	0.777ProMet: 0.777 ± 0.029	1.152ProAsn: 1.152 ± 0.037	2.084ProPro: 2.084 ± 0.051	1.092ProGln: 1.092 ± 0.043	2.264ProArg: 2.264 ± 0.059	2.486ProSer: 2.486 ± 0.057	2.965ProThr: 2.965 ± 0.057	4.272ProVal: 4.272 ± 0.08	0.489ProTrp: 0.489 ± 0.022	1.14ProTyr: 1.14 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	2.575GlnAla: 2.575 ± 0.051	0.161GlnCys: 0.161 ± 0.012	1.554GlnAsp: 1.554 ± 0.047	1.852GlnGlu: 1.852 ± 0.054	1.199GlnPhe: 1.199 ± 0.038	1.671GlnGly: 1.671 ± 0.045	0.582GlnHis: 0.582 ± 0.028	0.979GlnIle: 0.979 ± 0.038	0.647GlnLys: 0.647 ± 0.029	2.243GlnLeu: 2.243 ± 0.051	0.592GlnMet: 0.592 ± 0.026	0.905GlnAsn: 0.905 ± 0.032	1.16GlnPro: 1.16 ± 0.036	1.119GlnGln: 1.119 ± 0.05	2.099GlnArg: 2.099 ± 0.053	1.793GlnSer: 1.793 ± 0.052	1.852GlnThr: 1.852 ± 0.05	2.033GlnVal: 2.033 ± 0.049	0.365GlnTrp: 0.365 ± 0.02	0.923GlnTyr: 0.923 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	6.501ArgAla: 6.501 ± 0.102	0.437ArgCys: 0.437 ± 0.022	5.204ArgAsp: 5.204 ± 0.085	6.867ArgGlu: 6.867 ± 0.101	2.263ArgPhe: 2.263 ± 0.053	4.516ArgGly: 4.516 ± 0.069	1.254ArgHis: 1.254 ± 0.038	2.596ArgIle: 2.596 ± 0.056	1.378ArgLys: 1.378 ± 0.039	5.743ArgLeu: 5.743 ± 0.092	1.234ArgMet: 1.234 ± 0.032	1.699ArgAsn: 1.699 ± 0.043	2.387ArgPro: 2.387 ± 0.06	1.852ArgGln: 1.852 ± 0.05	4.643ArgArg: 4.643 ± 0.08	3.351ArgSer: 3.351 ± 0.072	3.755ArgThr: 3.755 ± 0.064	5.985ArgVal: 5.985 ± 0.105	0.759ArgTrp: 0.759 ± 0.033	1.838ArgTyr: 1.838 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.228SerAla: 5.228 ± 0.09	0.291SerCys: 0.291 ± 0.019	4.091SerAsp: 4.091 ± 0.072	4.408SerGlu: 4.408 ± 0.076	2.043SerPhe: 2.043 ± 0.043	5.376SerGly: 5.376 ± 0.077	1.083SerHis: 1.083 ± 0.037	1.989SerIle: 1.989 ± 0.049	1.221SerLys: 1.221 ± 0.035	4.898SerLeu: 4.898 ± 0.073	1.096SerMet: 1.096 ± 0.036	1.336SerAsn: 1.336 ± 0.037	2.53SerPro: 2.53 ± 0.049	1.41SerGln: 1.41 ± 0.043	3.216SerArg: 3.216 ± 0.061	2.87SerSer: 2.87 ± 0.067	3.284SerThr: 3.284 ± 0.07	5.411SerVal: 5.411 ± 0.084	0.615SerTrp: 0.615 ± 0.026	1.42SerTyr: 1.42 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.702ThrAla: 6.702 ± 0.1	0.342ThrCys: 0.342 ± 0.02	5.107ThrAsp: 5.107 ± 0.081	4.737ThrGlu: 4.737 ± 0.083	2.194ThrPhe: 2.194 ± 0.047	5.462ThrGly: 5.462 ± 0.078	1.158ThrHis: 1.158 ± 0.036	2.419ThrIle: 2.419 ± 0.058	1.106ThrLys: 1.106 ± 0.039	5.658ThrLeu: 5.658 ± 0.088	0.99ThrMet: 0.99 ± 0.031	1.482ThrAsn: 1.482 ± 0.046	3.128ThrPro: 3.128 ± 0.061	1.371ThrGln: 1.371 ± 0.044	3.275ThrArg: 3.275 ± 0.054	2.873ThrSer: 2.873 ± 0.058	4.432ThrThr: 4.432 ± 0.133	6.846ThrVal: 6.846 ± 0.128	0.604ThrTrp: 0.604 ± 0.029	1.681ThrTyr: 1.681 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	11.448ValAla: 11.448 ± 0.171	0.713ValCys: 0.713 ± 0.026	8.169ValAsp: 8.169 ± 0.103	8.977ValGlu: 8.977 ± 0.116	3.176ValPhe: 3.176 ± 0.062	8.35ValGly: 8.35 ± 0.129	1.963ValHis: 1.963 ± 0.044	2.465ValIle: 2.465 ± 0.055	1.547ValLys: 1.547 ± 0.046	8.793ValLeu: 8.793 ± 0.135	1.294ValMet: 1.294 ± 0.035	2.206ValAsn: 2.206 ± 0.048	4.45ValPro: 4.45 ± 0.072	2.21ValGln: 2.21 ± 0.045	5.867ValArg: 5.867 ± 0.087	5.249ValSer: 5.249 ± 0.084	6.388ValThr: 6.388 ± 0.092	10.799ValVal: 10.799 ± 0.143	0.917ValTrp: 0.917 ± 0.033	2.286ValTyr: 2.286 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.994TrpAla: 0.994 ± 0.036	0.1TrpCys: 0.1 ± 0.012	0.686TrpAsp: 0.686 ± 0.029	0.85TrpGlu: 0.85 ± 0.032	0.487TrpPhe: 0.487 ± 0.025	0.843TrpGly: 0.843 ± 0.029	0.226TrpHis: 0.226 ± 0.018	0.351TrpIle: 0.351 ± 0.02	0.269TrpLys: 0.269 ± 0.017	1.203TrpLeu: 1.203 ± 0.039	0.221TrpMet: 0.221 ± 0.014	0.335TrpAsn: 0.335 ± 0.018	0.438TrpPro: 0.438 ± 0.023	0.38TrpGln: 0.38 ± 0.018	0.866TrpArg: 0.866 ± 0.035	0.573TrpSer: 0.573 ± 0.026	0.802TrpThr: 0.802 ± 0.03	0.991TrpVal: 0.991 ± 0.032	0.212TrpTrp: 0.212 ± 0.017	0.368TrpTyr: 0.368 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.829TyrAla: 2.829 ± 0.052	0.239TyrCys: 0.239 ± 0.017	2.679TyrAsp: 2.679 ± 0.05	2.601TyrGlu: 2.601 ± 0.06	0.877TyrPhe: 0.877 ± 0.031	2.393TyrGly: 2.393 ± 0.045	0.597TyrHis: 0.597 ± 0.026	0.685TyrIle: 0.685 ± 0.031	0.417TyrLys: 0.417 ± 0.023	2.547TyrLeu: 2.547 ± 0.057	0.38TyrMet: 0.38 ± 0.02	0.631TyrAsn: 0.631 ± 0.029	1.254TyrPro: 1.254 ± 0.041	0.763TyrGln: 0.763 ± 0.029	1.888TyrArg: 1.888 ± 0.047	1.292TyrSer: 1.292 ± 0.036	1.434TyrThr: 1.434 ± 0.046	2.537TyrVal: 2.537 ± 0.058	0.323TyrTrp: 0.323 ± 0.02	0.918TyrTyr: 0.918 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3265 proteins (904200 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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