Amino acid dipepetide frequency for Lutibacter oricola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.685AlaAla: 3.685 ± 0.066	0.526AlaCys: 0.526 ± 0.022	2.983AlaAsp: 2.983 ± 0.062	3.799AlaGlu: 3.799 ± 0.073	2.913AlaPhe: 2.913 ± 0.048	3.931AlaGly: 3.931 ± 0.081	0.97AlaHis: 0.97 ± 0.03	5.256AlaIle: 5.256 ± 0.085	4.667AlaLys: 4.667 ± 0.074	5.282AlaLeu: 5.282 ± 0.082	1.336AlaMet: 1.336 ± 0.037	3.463AlaAsn: 3.463 ± 0.059	1.826AlaPro: 1.826 ± 0.038	2.074AlaGln: 2.074 ± 0.035	1.683AlaArg: 1.683 ± 0.041	4.01AlaSer: 4.01 ± 0.064	3.584AlaThr: 3.584 ± 0.085	4.037AlaVal: 4.037 ± 0.066	0.582AlaTrp: 0.582 ± 0.023	2.303AlaTyr: 2.303 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.423CysAla: 0.423 ± 0.019	0.098CysCys: 0.098 ± 0.01	0.51CysAsp: 0.51 ± 0.029	0.509CysGlu: 0.509 ± 0.025	0.416CysPhe: 0.416 ± 0.018	0.609CysGly: 0.609 ± 0.025	0.18CysHis: 0.18 ± 0.02	0.572CysIle: 0.572 ± 0.025	0.563CysLys: 0.563 ± 0.02	0.576CysLeu: 0.576 ± 0.019	0.149CysMet: 0.149 ± 0.01	0.532CysAsn: 0.532 ± 0.023	0.321CysPro: 0.321 ± 0.021	0.193CysGln: 0.193 ± 0.013	0.188CysArg: 0.188 ± 0.01	0.599CysSer: 0.599 ± 0.036	0.466CysThr: 0.466 ± 0.025	0.409CysVal: 0.409 ± 0.019	0.086CysTrp: 0.086 ± 0.009	0.32CysTyr: 0.32 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.363AspAla: 3.363 ± 0.054	0.436AspCys: 0.436 ± 0.02	2.727AspAsp: 2.727 ± 0.064	3.522AspGlu: 3.522 ± 0.057	3.351AspPhe: 3.351 ± 0.058	3.612AspGly: 3.612 ± 0.07	0.72AspHis: 0.72 ± 0.024	4.303AspIle: 4.303 ± 0.062	4.38AspLys: 4.38 ± 0.067	4.895AspLeu: 4.895 ± 0.057	1.004AspMet: 1.004 ± 0.026	3.405AspAsn: 3.405 ± 0.071	1.538AspPro: 1.538 ± 0.043	1.178AspGln: 1.178 ± 0.033	1.603AspArg: 1.603 ± 0.033	3.127AspSer: 3.127 ± 0.053	2.551AspThr: 2.551 ± 0.058	3.593AspVal: 3.593 ± 0.063	0.757AspTrp: 0.757 ± 0.025	2.725AspTyr: 2.725 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.007GluAla: 4.007 ± 0.072	0.383GluCys: 0.383 ± 0.018	3.461GluAsp: 3.461 ± 0.054	4.86GluGlu: 4.86 ± 0.086	3.351GluPhe: 3.351 ± 0.052	3.857GluGly: 3.857 ± 0.057	1.114GluHis: 1.114 ± 0.032	6.053GluIle: 6.053 ± 0.081	6.308GluLys: 6.308 ± 0.085	6.571GluLeu: 6.571 ± 0.085	1.585GluMet: 1.585 ± 0.034	5.225GluAsn: 5.225 ± 0.073	1.544GluPro: 1.544 ± 0.037	2.115GluGln: 2.115 ± 0.047	2.145GluArg: 2.145 ± 0.05	3.282GluSer: 3.282 ± 0.058	3.739GluThr: 3.739 ± 0.057	4.493GluVal: 4.493 ± 0.068	0.69GluTrp: 0.69 ± 0.024	2.517GluTyr: 2.517 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	2.708PheAla: 2.708 ± 0.052	0.419PheCys: 0.419 ± 0.019	3.167PheAsp: 3.167 ± 0.055	3.646PheGlu: 3.646 ± 0.055	2.618PhePhe: 2.618 ± 0.056	3.555PheGly: 3.555 ± 0.054	0.735PheHis: 0.735 ± 0.027	4.134PheIle: 4.134 ± 0.074	4.384PheLys: 4.384 ± 0.065	4.449PheLeu: 4.449 ± 0.069	1.096PheMet: 1.096 ± 0.031	3.896PheAsn: 3.896 ± 0.063	1.592PhePro: 1.592 ± 0.036	1.368PheGln: 1.368 ± 0.029	1.379PheArg: 1.379 ± 0.032	4.01PheSer: 4.01 ± 0.056	3.096PheThr: 3.096 ± 0.061	3.01PheVal: 3.01 ± 0.055	0.614PheTrp: 0.614 ± 0.023	2.203PheTyr: 2.203 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	4.021GlyAla: 4.021 ± 0.073	0.613GlyCys: 0.613 ± 0.027	3.278GlyAsp: 3.278 ± 0.067	3.92GlyGlu: 3.92 ± 0.055	3.585GlyPhe: 3.585 ± 0.059	4.423GlyGly: 4.423 ± 0.072	1.07GlyHis: 1.07 ± 0.028	5.343GlyIle: 5.343 ± 0.076	5.416GlyLys: 5.416 ± 0.08	5.43GlyLeu: 5.43 ± 0.071	1.549GlyMet: 1.549 ± 0.035	3.814GlyAsn: 3.814 ± 0.068	1.327GlyPro: 1.327 ± 0.033	1.592GlyGln: 1.592 ± 0.039	1.934GlyArg: 1.934 ± 0.043	3.903GlySer: 3.903 ± 0.064	3.943GlyThr: 3.943 ± 0.094	4.693GlyVal: 4.693 ± 0.067	0.775GlyTrp: 0.775 ± 0.028	2.871GlyTyr: 2.871 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.778HisAla: 0.778 ± 0.025	0.163HisCys: 0.163 ± 0.011	0.763HisAsp: 0.763 ± 0.026	0.786HisGlu: 0.786 ± 0.022	1.085HisPhe: 1.085 ± 0.031	0.989HisGly: 0.989 ± 0.034	0.432HisHis: 0.432 ± 0.021	1.381HisIle: 1.381 ± 0.036	1.391HisLys: 1.391 ± 0.035	1.665HisLeu: 1.665 ± 0.038	0.319HisMet: 0.319 ± 0.016	1.041HisAsn: 1.041 ± 0.027	0.823HisPro: 0.823 ± 0.027	0.583HisGln: 0.583 ± 0.021	0.551HisArg: 0.551 ± 0.022	1.061HisSer: 1.061 ± 0.031	0.941HisThr: 0.941 ± 0.023	0.792HisVal: 0.792 ± 0.024	0.254HisTrp: 0.254 ± 0.016	0.778HisTyr: 0.778 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.34IleAla: 5.34 ± 0.07	0.652IleCys: 0.652 ± 0.03	4.957IleAsp: 4.957 ± 0.068	6.174IleGlu: 6.174 ± 0.071	3.649IlePhe: 3.649 ± 0.07	5.333IleGly: 5.333 ± 0.077	1.249IleHis: 1.249 ± 0.034	6.497IleIle: 6.497 ± 0.087	6.756IleLys: 6.756 ± 0.092	6.954IleLeu: 6.954 ± 0.091	1.395IleMet: 1.395 ± 0.039	5.307IleAsn: 5.307 ± 0.074	3.089IlePro: 3.089 ± 0.048	2.435IleGln: 2.435 ± 0.047	2.26IleArg: 2.26 ± 0.046	6.334IleSer: 6.334 ± 0.082	4.953IleThr: 4.953 ± 0.091	5.053IleVal: 5.053 ± 0.072	0.71IleTrp: 0.71 ± 0.025	2.966IleTyr: 2.966 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.91LysAla: 4.91 ± 0.076	0.408LysCys: 0.408 ± 0.02	4.479LysAsp: 4.479 ± 0.074	6.903LysGlu: 6.903 ± 0.091	3.581LysPhe: 3.581 ± 0.061	5.186LysGly: 5.186 ± 0.065	1.56LysHis: 1.56 ± 0.041	7.024LysIle: 7.024 ± 0.083	8.347LysLys: 8.347 ± 0.132	7.474LysLeu: 7.474 ± 0.094	2.053LysMet: 2.053 ± 0.037	6.773LysAsn: 6.773 ± 0.091	2.766LysPro: 2.766 ± 0.057	2.948LysGln: 2.948 ± 0.065	2.823LysArg: 2.823 ± 0.059	4.961LysSer: 4.961 ± 0.077	5.229LysThr: 5.229 ± 0.068	5.24LysVal: 5.24 ± 0.074	0.986LysTrp: 0.986 ± 0.034	3.536LysTyr: 3.536 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	5.354LeuAla: 5.354 ± 0.074	0.611LeuCys: 0.611 ± 0.025	4.713LeuAsp: 4.713 ± 0.068	5.812LeuGlu: 5.812 ± 0.078	4.815LeuPhe: 4.815 ± 0.071	5.531LeuGly: 5.531 ± 0.079	1.342LeuHis: 1.342 ± 0.031	7.296LeuIle: 7.296 ± 0.121	8.557LeuLys: 8.557 ± 0.116	8.177LeuLeu: 8.177 ± 0.114	1.874LeuMet: 1.874 ± 0.041	6.462LeuAsn: 6.462 ± 0.09	3.225LeuPro: 3.225 ± 0.06	2.686LeuGln: 2.686 ± 0.057	2.594LeuArg: 2.594 ± 0.052	5.951LeuSer: 5.951 ± 0.088	5.138LeuThr: 5.138 ± 0.086	5.379LeuVal: 5.379 ± 0.076	0.778LeuTrp: 0.778 ± 0.027	3.066LeuTyr: 3.066 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	1.403MetAla: 1.403 ± 0.037	0.162MetCys: 0.162 ± 0.012	1.061MetAsp: 1.061 ± 0.027	1.199MetGlu: 1.199 ± 0.031	0.943MetPhe: 0.943 ± 0.03	1.338MetGly: 1.338 ± 0.033	0.39MetHis: 0.39 ± 0.016	1.415MetIle: 1.415 ± 0.041	2.237MetLys: 2.237 ± 0.043	1.909MetLeu: 1.909 ± 0.039	0.498MetMet: 0.498 ± 0.024	1.323MetAsn: 1.323 ± 0.033	0.802MetPro: 0.802 ± 0.025	0.663MetGln: 0.663 ± 0.024	0.73MetArg: 0.73 ± 0.027	1.333MetSer: 1.333 ± 0.035	1.007MetThr: 1.007 ± 0.029	1.292MetVal: 1.292 ± 0.031	0.185MetTrp: 0.185 ± 0.013	0.789MetTyr: 0.789 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.749AsnAla: 3.749 ± 0.065	0.584AsnCys: 0.584 ± 0.044	3.418AsnAsp: 3.418 ± 0.067	4.553AsnGlu: 4.553 ± 0.064	3.57AsnPhe: 3.57 ± 0.064	4.468AsnGly: 4.468 ± 0.073	1.081AsnHis: 1.081 ± 0.029	5.534AsnIle: 5.534 ± 0.075	5.882AsnLys: 5.882 ± 0.081	5.983AsnLeu: 5.983 ± 0.086	1.306AsnMet: 1.306 ± 0.031	5.188AsnAsn: 5.188 ± 0.092	2.775AsnPro: 2.775 ± 0.048	1.985AsnGln: 1.985 ± 0.038	1.945AsnArg: 1.945 ± 0.044	4.945AsnSer: 4.945 ± 0.08	4.026AsnThr: 4.026 ± 0.075	3.969AsnVal: 3.969 ± 0.067	0.975AsnTrp: 0.975 ± 0.029	3.358AsnTyr: 3.358 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	1.772ProAla: 1.772 ± 0.048	0.201ProCys: 0.201 ± 0.014	1.652ProAsp: 1.652 ± 0.04	2.467ProGlu: 2.467 ± 0.046	1.88ProPhe: 1.88 ± 0.039	1.727ProGly: 1.727 ± 0.042	0.645ProHis: 0.645 ± 0.023	2.699ProIle: 2.699 ± 0.043	2.759ProLys: 2.759 ± 0.051	2.676ProLeu: 2.676 ± 0.047	0.704ProMet: 0.704 ± 0.028	2.45ProAsn: 2.45 ± 0.054	0.747ProPro: 0.747 ± 0.03	0.974ProGln: 0.974 ± 0.029	0.854ProArg: 0.854 ± 0.029	2.252ProSer: 2.252 ± 0.039	2.104ProThr: 2.104 ± 0.045	2.18ProVal: 2.18 ± 0.051	0.374ProTrp: 0.374 ± 0.017	1.379ProTyr: 1.379 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	1.654GlnAla: 1.654 ± 0.038	0.198GlnCys: 0.198 ± 0.013	1.342GlnAsp: 1.342 ± 0.036	1.896GlnGlu: 1.896 ± 0.036	1.58GlnPhe: 1.58 ± 0.032	1.657GlnGly: 1.657 ± 0.043	0.555GlnHis: 0.555 ± 0.024	2.406GlnIle: 2.406 ± 0.044	2.825GlnLys: 2.825 ± 0.052	3.148GlnLeu: 3.148 ± 0.05	0.678GlnMet: 0.678 ± 0.024	2.076GlnAsn: 2.076 ± 0.048	0.943GlnPro: 0.943 ± 0.027	1.288GlnGln: 1.288 ± 0.034	0.98GlnArg: 0.98 ± 0.026	1.628GlnSer: 1.628 ± 0.036	1.703GlnThr: 1.703 ± 0.039	1.738GlnVal: 1.738 ± 0.036	0.314GlnTrp: 0.314 ± 0.016	1.132GlnTyr: 1.132 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	1.808ArgAla: 1.808 ± 0.041	0.179ArgCys: 0.179 ± 0.013	1.59ArgAsp: 1.59 ± 0.037	1.848ArgGlu: 1.848 ± 0.041	1.64ArgPhe: 1.64 ± 0.035	1.766ArgGly: 1.766 ± 0.036	0.505ArgHis: 0.505 ± 0.02	2.567ArgIle: 2.567 ± 0.045	2.712ArgLys: 2.712 ± 0.054	2.686ArgLeu: 2.686 ± 0.049	0.742ArgMet: 0.742 ± 0.026	1.932ArgAsn: 1.932 ± 0.043	0.993ArgPro: 0.993 ± 0.031	0.784ArgGln: 0.784 ± 0.027	1.064ArgArg: 1.064 ± 0.039	1.648ArgSer: 1.648 ± 0.038	1.696ArgThr: 1.696 ± 0.034	1.953ArgVal: 1.953 ± 0.035	0.394ArgTrp: 0.394 ± 0.019	1.286ArgTyr: 1.286 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	3.529SerAla: 3.529 ± 0.064	0.697SerCys: 0.697 ± 0.026	3.15SerAsp: 3.15 ± 0.052	4.42SerGlu: 4.42 ± 0.06	3.788SerPhe: 3.788 ± 0.059	4.302SerGly: 4.302 ± 0.075	1.065SerHis: 1.065 ± 0.032	5.799SerIle: 5.799 ± 0.074	6.001SerLys: 6.001 ± 0.076	5.697SerLeu: 5.697 ± 0.079	1.22SerMet: 1.22 ± 0.032	4.653SerAsn: 4.653 ± 0.08	1.932SerPro: 1.932 ± 0.043	1.871SerGln: 1.871 ± 0.04	1.873SerArg: 1.873 ± 0.039	4.518SerSer: 4.518 ± 0.077	3.919SerThr: 3.919 ± 0.066	4.011SerVal: 4.011 ± 0.059	0.793SerTrp: 0.793 ± 0.026	2.863SerTyr: 2.863 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	3.545ThrAla: 3.545 ± 0.079	0.393ThrCys: 0.393 ± 0.027	3.201ThrAsp: 3.201 ± 0.071	3.59ThrGlu: 3.59 ± 0.06	2.874ThrPhe: 2.874 ± 0.052	3.844ThrGly: 3.844 ± 0.074	1.001ThrHis: 1.001 ± 0.028	5.31ThrIle: 5.31 ± 0.102	4.384ThrLys: 4.384 ± 0.06	5.029ThrLeu: 5.029 ± 0.079	0.911ThrMet: 0.911 ± 0.026	3.804ThrAsn: 3.804 ± 0.071	2.408ThrPro: 2.408 ± 0.061	1.639ThrGln: 1.639 ± 0.044	1.496ThrArg: 1.496 ± 0.035	4.281ThrSer: 4.281 ± 0.07	3.699ThrThr: 3.699 ± 0.091	4.018ThrVal: 4.018 ± 0.133	0.627ThrTrp: 0.627 ± 0.026	2.47ThrTyr: 2.47 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	3.847ValAla: 3.847 ± 0.064	0.572ValCys: 0.572 ± 0.024	3.685ValAsp: 3.685 ± 0.06	4.443ValGlu: 4.443 ± 0.055	3.274ValPhe: 3.274 ± 0.056	3.968ValGly: 3.968 ± 0.067	0.964ValHis: 0.964 ± 0.031	4.939ValIle: 4.939 ± 0.074	4.963ValLys: 4.963 ± 0.074	5.921ValLeu: 5.921 ± 0.07	1.186ValMet: 1.186 ± 0.031	4.066ValAsn: 4.066 ± 0.065	2.058ValPro: 2.058 ± 0.051	1.623ValGln: 1.623 ± 0.035	1.893ValArg: 1.893 ± 0.043	4.691ValSer: 4.691 ± 0.07	3.618ValThr: 3.618 ± 0.112	4.461ValVal: 4.461 ± 0.08	0.7ValTrp: 0.7 ± 0.025	2.367ValTyr: 2.367 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.657TrpAla: 0.657 ± 0.022	0.087TrpCys: 0.087 ± 0.008	0.666TrpAsp: 0.666 ± 0.024	0.743TrpGlu: 0.743 ± 0.026	0.601TrpPhe: 0.601 ± 0.024	0.745TrpGly: 0.745 ± 0.026	0.262TrpHis: 0.262 ± 0.016	0.748TrpIle: 0.748 ± 0.029	0.986TrpLys: 0.986 ± 0.034	0.94TrpLeu: 0.94 ± 0.028	0.314TrpMet: 0.314 ± 0.015	0.834TrpAsn: 0.834 ± 0.027	0.298TrpPro: 0.298 ± 0.016	0.39TrpGln: 0.39 ± 0.021	0.404TrpArg: 0.404 ± 0.018	0.694TrpSer: 0.694 ± 0.024	0.592TrpThr: 0.592 ± 0.028	0.686TrpVal: 0.686 ± 0.024	0.184TrpTrp: 0.184 ± 0.015	0.486TrpTyr: 0.486 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.356TyrAla: 2.356 ± 0.048	0.337TyrCys: 0.337 ± 0.015	1.989TyrAsp: 1.989 ± 0.039	2.209TyrGlu: 2.209 ± 0.044	2.565TyrPhe: 2.565 ± 0.043	2.659TyrGly: 2.659 ± 0.048	0.736TyrHis: 0.736 ± 0.025	2.787TyrIle: 2.787 ± 0.05	3.67TyrLys: 3.67 ± 0.054	3.898TyrLeu: 3.898 ± 0.059	0.759TyrMet: 0.759 ± 0.023	3.053TyrAsn: 3.053 ± 0.057	1.49TyrPro: 1.49 ± 0.035	1.35TyrGln: 1.35 ± 0.036	1.393TyrArg: 1.393 ± 0.037	2.875TyrSer: 2.875 ± 0.055	2.519TyrThr: 2.519 ± 0.057	2.233TyrVal: 2.233 ± 0.042	0.537TyrTrp: 0.537 ± 0.021	1.922TyrTyr: 1.922 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3464 proteins (1260383 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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