Amino acid dipepetide frequency for Erwinia sp. 198

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.897AlaAla: 11.897 ± 0.142	1.143AlaCys: 1.143 ± 0.034	5.374AlaAsp: 5.374 ± 0.077	6.147AlaGlu: 6.147 ± 0.077	3.746AlaPhe: 3.746 ± 0.058	8.266AlaGly: 8.266 ± 0.104	1.82AlaHis: 1.82 ± 0.042	5.929AlaIle: 5.929 ± 0.075	3.833AlaLys: 3.833 ± 0.063	12.761AlaLeu: 12.761 ± 0.116	3.048AlaMet: 3.048 ± 0.052	2.93AlaAsn: 2.93 ± 0.051	3.827AlaPro: 3.827 ± 0.068	4.732AlaGln: 4.732 ± 0.074	6.102AlaArg: 6.102 ± 0.075	6.113AlaSer: 6.113 ± 0.068	5.134AlaThr: 5.134 ± 0.068	7.242AlaVal: 7.242 ± 0.085	1.757AlaTrp: 1.757 ± 0.038	2.023AlaTyr: 2.023 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.918CysAla: 0.918 ± 0.024	0.176CysCys: 0.176 ± 0.011	0.553CysAsp: 0.553 ± 0.024	0.557CysGlu: 0.557 ± 0.023	0.437CysPhe: 0.437 ± 0.02	1.015CysGly: 1.015 ± 0.033	0.292CysHis: 0.292 ± 0.016	0.49CysIle: 0.49 ± 0.023	0.298CysLys: 0.298 ± 0.015	1.047CysLeu: 1.047 ± 0.029	0.219CysMet: 0.219 ± 0.014	0.283CysAsn: 0.283 ± 0.015	0.436CysPro: 0.436 ± 0.02	0.428CysGln: 0.428 ± 0.017	0.672CysArg: 0.672 ± 0.025	0.663CysSer: 0.663 ± 0.025	0.437CysThr: 0.437 ± 0.017	0.705CysVal: 0.705 ± 0.027	0.182CysTrp: 0.182 ± 0.012	0.313CysTyr: 0.313 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.131AspAla: 5.131 ± 0.067	0.489AspCys: 0.489 ± 0.019	2.761AspAsp: 2.761 ± 0.047	3.402AspGlu: 3.402 ± 0.064	2.177AspPhe: 2.177 ± 0.046	3.767AspGly: 3.767 ± 0.066	0.959AspHis: 0.959 ± 0.027	3.236AspIle: 3.236 ± 0.053	2.39AspLys: 2.39 ± 0.051	4.758AspLeu: 4.758 ± 0.063	1.269AspMet: 1.269 ± 0.031	2.045AspAsn: 2.045 ± 0.046	2.25AspPro: 2.25 ± 0.046	1.401AspGln: 1.401 ± 0.035	3.368AspArg: 3.368 ± 0.053	2.898AspSer: 2.898 ± 0.053	2.367AspThr: 2.367 ± 0.043	3.528AspVal: 3.528 ± 0.053	0.811AspTrp: 0.811 ± 0.024	1.966AspTyr: 1.966 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	6.13GluAla: 6.13 ± 0.084	0.434GluCys: 0.434 ± 0.02	2.324GluAsp: 2.324 ± 0.048	3.543GluGlu: 3.543 ± 0.067	1.679GluPhe: 1.679 ± 0.036	3.613GluGly: 3.613 ± 0.064	1.243GluHis: 1.243 ± 0.033	3.187GluIle: 3.187 ± 0.058	3.414GluLys: 3.414 ± 0.051	5.834GluLeu: 5.834 ± 0.076	1.692GluMet: 1.692 ± 0.036	2.286GluAsn: 2.286 ± 0.045	2.102GluPro: 2.102 ± 0.048	3.443GluGln: 3.443 ± 0.066	3.692GluArg: 3.692 ± 0.06	2.796GluSer: 2.796 ± 0.045	3.095GluThr: 3.095 ± 0.054	3.811GluVal: 3.811 ± 0.073	0.769GluTrp: 0.769 ± 0.028	1.279GluTyr: 1.279 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.821PheAla: 3.821 ± 0.061	0.561PheCys: 0.561 ± 0.023	2.293PheAsp: 2.293 ± 0.048	1.592PheGlu: 1.592 ± 0.035	1.71PhePhe: 1.71 ± 0.046	3.112PheGly: 3.112 ± 0.05	0.833PheHis: 0.833 ± 0.023	2.476PheIle: 2.476 ± 0.049	1.269PheLys: 1.269 ± 0.031	3.332PheLeu: 3.332 ± 0.059	0.984PheMet: 0.984 ± 0.03	1.689PheAsn: 1.689 ± 0.039	1.581PhePro: 1.581 ± 0.038	1.189PheGln: 1.189 ± 0.033	1.99PheArg: 1.99 ± 0.039	3.211PheSer: 3.211 ± 0.053	2.385PheThr: 2.385 ± 0.044	2.341PheVal: 2.341 ± 0.044	0.671PheTrp: 0.671 ± 0.023	1.23PheTyr: 1.23 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	6.514GlyAla: 6.514 ± 0.081	0.957GlyCys: 0.957 ± 0.031	3.74GlyAsp: 3.74 ± 0.057	4.767GlyGlu: 4.767 ± 0.059	3.268GlyPhe: 3.268 ± 0.048	5.58GlyGly: 5.58 ± 0.109	1.619GlyHis: 1.619 ± 0.039	4.66GlyIle: 4.66 ± 0.063	3.981GlyLys: 3.981 ± 0.063	7.598GlyLeu: 7.598 ± 0.077	2.335GlyMet: 2.335 ± 0.048	2.696GlyAsn: 2.696 ± 0.055	2.046GlyPro: 2.046 ± 0.039	3.04GlyGln: 3.04 ± 0.058	4.132GlyArg: 4.132 ± 0.063	4.55GlySer: 4.55 ± 0.076	3.727GlyThr: 3.727 ± 0.054	5.699GlyVal: 5.699 ± 0.071	1.392GlyTrp: 1.392 ± 0.037	2.633GlyTyr: 2.633 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.927HisAla: 1.927 ± 0.04	0.315HisCys: 0.315 ± 0.016	1.135HisAsp: 1.135 ± 0.032	1.116HisGlu: 1.116 ± 0.029	1.053HisPhe: 1.053 ± 0.029	1.731HisGly: 1.731 ± 0.039	0.747HisHis: 0.747 ± 0.026	1.198HisIle: 1.198 ± 0.034	0.741HisLys: 0.741 ± 0.024	2.211HisLeu: 2.211 ± 0.038	0.487HisMet: 0.487 ± 0.019	0.774HisAsn: 0.774 ± 0.022	1.248HisPro: 1.248 ± 0.031	1.203HisGln: 1.203 ± 0.032	1.309HisArg: 1.309 ± 0.034	1.255HisSer: 1.255 ± 0.03	1.056HisThr: 1.056 ± 0.026	1.203HisVal: 1.203 ± 0.034	0.413HisTrp: 0.413 ± 0.018	0.882HisTyr: 0.882 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.497IleAla: 6.497 ± 0.083	0.61IleCys: 0.61 ± 0.024	3.396IleAsp: 3.396 ± 0.046	3.119IleGlu: 3.119 ± 0.053	2.081IlePhe: 2.081 ± 0.043	4.506IleGly: 4.506 ± 0.053	1.116IleHis: 1.116 ± 0.031	2.927IleIle: 2.927 ± 0.054	2.254IleLys: 2.254 ± 0.039	4.514IleLeu: 4.514 ± 0.077	1.204IleMet: 1.204 ± 0.03	2.415IleAsn: 2.415 ± 0.045	2.366IlePro: 2.366 ± 0.043	1.701IleGln: 1.701 ± 0.037	2.947IleArg: 2.947 ± 0.048	3.537IleSer: 3.537 ± 0.057	3.275IleThr: 3.275 ± 0.059	3.926IleVal: 3.926 ± 0.052	0.659IleTrp: 0.659 ± 0.022	1.421IleTyr: 1.421 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.5LysAla: 4.5 ± 0.078	0.221LysCys: 0.221 ± 0.012	1.944LysAsp: 1.944 ± 0.042	2.496LysGlu: 2.496 ± 0.054	1.11LysPhe: 1.11 ± 0.03	2.961LysGly: 2.961 ± 0.049	0.782LysHis: 0.782 ± 0.023	2.34LysIle: 2.34 ± 0.048	2.344LysLys: 2.344 ± 0.052	4.212LysLeu: 4.212 ± 0.059	1.249LysMet: 1.249 ± 0.031	1.76LysAsn: 1.76 ± 0.035	2.12LysPro: 2.12 ± 0.045	1.874LysGln: 1.874 ± 0.04	2.438LysArg: 2.438 ± 0.049	2.293LysSer: 2.293 ± 0.042	2.527LysThr: 2.527 ± 0.045	2.863LysVal: 2.863 ± 0.052	0.444LysTrp: 0.444 ± 0.02	1.004LysTyr: 1.004 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	12.49LeuAla: 12.49 ± 0.13	1.245LeuCys: 1.245 ± 0.037	5.346LeuAsp: 5.346 ± 0.079	5.342LeuGlu: 5.342 ± 0.08	4.364LeuPhe: 4.364 ± 0.067	7.272LeuGly: 7.272 ± 0.094	2.325LeuHis: 2.325 ± 0.045	5.925LeuIle: 5.925 ± 0.077	4.612LeuLys: 4.612 ± 0.063	12.718LeuLeu: 12.718 ± 0.176	2.932LeuMet: 2.932 ± 0.055	4.197LeuAsn: 4.197 ± 0.058	5.859LeuPro: 5.859 ± 0.082	4.524LeuGln: 4.524 ± 0.063	6.455LeuArg: 6.455 ± 0.078	7.67LeuSer: 7.67 ± 0.091	6.717LeuThr: 6.717 ± 0.087	6.949LeuVal: 6.949 ± 0.083	1.404LeuTrp: 1.404 ± 0.036	2.607LeuTyr: 2.607 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.934MetAla: 2.934 ± 0.053	0.16MetCys: 0.16 ± 0.012	1.141MetAsp: 1.141 ± 0.032	1.209MetGlu: 1.209 ± 0.034	0.805MetPhe: 0.805 ± 0.032	1.775MetGly: 1.775 ± 0.039	0.517MetHis: 0.517 ± 0.02	1.369MetIle: 1.369 ± 0.034	1.401MetLys: 1.401 ± 0.033	3.26MetLeu: 3.26 ± 0.056	0.825MetMet: 0.825 ± 0.029	0.981MetAsn: 0.981 ± 0.025	1.39MetPro: 1.39 ± 0.033	1.257MetGln: 1.257 ± 0.03	1.506MetArg: 1.506 ± 0.039	1.767MetSer: 1.767 ± 0.038	1.748MetThr: 1.748 ± 0.039	1.818MetVal: 1.818 ± 0.046	0.224MetTrp: 0.224 ± 0.013	0.458MetTyr: 0.458 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.474AsnAla: 3.474 ± 0.055	0.308AsnCys: 0.308 ± 0.015	1.912AsnAsp: 1.912 ± 0.04	1.821AsnGlu: 1.821 ± 0.039	1.357AsnPhe: 1.357 ± 0.035	3.077AsnGly: 3.077 ± 0.054	0.762AsnHis: 0.762 ± 0.023	2.1AsnIle: 2.1 ± 0.037	1.48AsnLys: 1.48 ± 0.037	3.517AsnLeu: 3.517 ± 0.053	0.849AsnMet: 0.849 ± 0.026	1.497AsnAsn: 1.497 ± 0.04	1.914AsnPro: 1.914 ± 0.044	1.52AsnGln: 1.52 ± 0.045	2.067AsnArg: 2.067 ± 0.046	2.034AsnSer: 2.034 ± 0.044	1.754AsnThr: 1.754 ± 0.039	2.383AsnVal: 2.383 ± 0.04	0.553AsnTrp: 0.553 ± 0.023	1.17AsnTyr: 1.17 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.001ProAla: 5.001 ± 0.081	0.375ProCys: 0.375 ± 0.019	2.775ProAsp: 2.775 ± 0.049	3.431ProGlu: 3.431 ± 0.06	1.793ProPhe: 1.793 ± 0.037	3.67ProGly: 3.67 ± 0.059	1.059ProHis: 1.059 ± 0.033	1.606ProIle: 1.606 ± 0.037	1.39ProLys: 1.39 ± 0.04	5.27ProLeu: 5.27 ± 0.07	1.081ProMet: 1.081 ± 0.031	1.163ProAsn: 1.163 ± 0.031	1.745ProPro: 1.745 ± 0.04	2.468ProGln: 2.468 ± 0.045	1.944ProArg: 1.944 ± 0.042	2.039ProSer: 2.039 ± 0.042	2.123ProThr: 2.123 ± 0.037	4.055ProVal: 4.055 ± 0.071	0.732ProTrp: 0.732 ± 0.025	1.137ProTyr: 1.137 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.22GlnAla: 5.22 ± 0.089	0.304GlnCys: 0.304 ± 0.015	1.896GlnAsp: 1.896 ± 0.033	2.271GlnGlu: 2.271 ± 0.045	1.379GlnPhe: 1.379 ± 0.035	3.157GlnGly: 3.157 ± 0.059	1.272GlnHis: 1.272 ± 0.033	2.261GlnIle: 2.261 ± 0.037	1.786GlnLys: 1.786 ± 0.046	5.22GlnLeu: 5.22 ± 0.073	1.174GlnMet: 1.174 ± 0.029	1.419GlnAsn: 1.419 ± 0.034	2.498GlnPro: 2.498 ± 0.058	3.771GlnGln: 3.771 ± 0.092	3.322GlnArg: 3.322 ± 0.061	2.423GlnSer: 2.423 ± 0.054	2.268GlnThr: 2.268 ± 0.048	2.786GlnVal: 2.786 ± 0.053	0.621GlnTrp: 0.621 ± 0.025	1.081GlnTyr: 1.081 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	4.965ArgAla: 4.965 ± 0.056	0.584ArgCys: 0.584 ± 0.025	3.036ArgAsp: 3.036 ± 0.05	3.876ArgGlu: 3.876 ± 0.056	2.772ArgPhe: 2.772 ± 0.048	3.422ArgGly: 3.422 ± 0.048	1.624ArgHis: 1.624 ± 0.039	3.282ArgIle: 3.282 ± 0.053	2.335ArgLys: 2.335 ± 0.048	7.224ArgLeu: 7.224 ± 0.081	1.565ArgMet: 1.565 ± 0.034	2.016ArgAsn: 2.016 ± 0.045	2.508ArgPro: 2.508 ± 0.038	3.517ArgGln: 3.517 ± 0.064	3.771ArgArg: 3.771 ± 0.063	2.961ArgSer: 2.961 ± 0.052	2.444ArgThr: 2.444 ± 0.045	3.904ArgVal: 3.904 ± 0.058	1.042ArgTrp: 1.042 ± 0.031	2.347ArgTyr: 2.347 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.127SerAla: 6.127 ± 0.075	0.563SerCys: 0.563 ± 0.021	3.06SerAsp: 3.06 ± 0.05	3.337SerGlu: 3.337 ± 0.055	2.306SerPhe: 2.306 ± 0.051	5.534SerGly: 5.534 ± 0.08	1.427SerHis: 1.427 ± 0.035	2.601SerIle: 2.601 ± 0.053	2.072SerLys: 2.072 ± 0.047	7.183SerLeu: 7.183 ± 0.098	1.412SerMet: 1.412 ± 0.034	1.834SerAsn: 1.834 ± 0.042	2.667SerPro: 2.667 ± 0.05	2.609SerGln: 2.609 ± 0.051	3.623SerArg: 3.623 ± 0.045	3.61SerSer: 3.61 ± 0.071	2.903SerThr: 2.903 ± 0.057	4.389SerVal: 4.389 ± 0.059	1.092SerTrp: 1.092 ± 0.031	1.642SerTyr: 1.642 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.377ThrAla: 5.377 ± 0.077	0.448ThrCys: 0.448 ± 0.02	2.612ThrAsp: 2.612 ± 0.046	2.65ThrGlu: 2.65 ± 0.045	1.984ThrPhe: 1.984 ± 0.039	4.698ThrGly: 4.698 ± 0.072	1.165ThrHis: 1.165 ± 0.031	2.684ThrIle: 2.684 ± 0.054	1.426ThrLys: 1.426 ± 0.032	7.707ThrLeu: 7.707 ± 0.105	1.095ThrMet: 1.095 ± 0.034	1.468ThrAsn: 1.468 ± 0.035	3.176ThrPro: 3.176 ± 0.053	2.107ThrGln: 2.107 ± 0.046	3.065ThrArg: 3.065 ± 0.05	2.901ThrSer: 2.901 ± 0.054	2.832ThrThr: 2.832 ± 0.053	3.782ThrVal: 3.782 ± 0.055	0.763ThrTrp: 0.763 ± 0.025	1.081ThrTyr: 1.081 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	7.379ValAla: 7.379 ± 0.093	0.698ValCys: 0.698 ± 0.024	3.493ValAsp: 3.493 ± 0.055	3.911ValGlu: 3.911 ± 0.074	2.45ValPhe: 2.45 ± 0.049	4.688ValGly: 4.688 ± 0.074	1.228ValHis: 1.228 ± 0.034	4.257ValIle: 4.257 ± 0.057	3.07ValLys: 3.07 ± 0.05	7.077ValLeu: 7.077 ± 0.098	2.15ValMet: 2.15 ± 0.044	2.663ValAsn: 2.663 ± 0.041	3.099ValPro: 3.099 ± 0.051	2.424ValGln: 2.424 ± 0.045	3.717ValArg: 3.717 ± 0.061	4.724ValSer: 4.724 ± 0.067	4.296ValThr: 4.296 ± 0.064	5.217ValVal: 5.217 ± 0.076	0.929ValTrp: 0.929 ± 0.028	1.564ValTyr: 1.564 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.028TrpAla: 1.028 ± 0.031	0.17TrpCys: 0.17 ± 0.01	0.653TrpAsp: 0.653 ± 0.025	0.583TrpGlu: 0.583 ± 0.022	0.679TrpPhe: 0.679 ± 0.024	0.896TrpGly: 0.896 ± 0.028	0.493TrpHis: 0.493 ± 0.023	0.714TrpIle: 0.714 ± 0.026	0.488TrpLys: 0.488 ± 0.022	2.466TrpLeu: 2.466 ± 0.05	0.399TrpMet: 0.399 ± 0.02	0.462TrpAsn: 0.462 ± 0.019	0.696TrpPro: 0.696 ± 0.027	1.298TrpGln: 1.298 ± 0.037	1.145TrpArg: 1.145 ± 0.032	0.832TrpSer: 0.832 ± 0.025	0.599TrpThr: 0.599 ± 0.023	0.836TrpVal: 0.836 ± 0.026	0.247TrpTrp: 0.247 ± 0.015	0.435TrpTyr: 0.435 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.494TyrAla: 2.494 ± 0.048	0.359TyrCys: 0.359 ± 0.018	1.529TyrAsp: 1.529 ± 0.038	1.198TyrGlu: 1.198 ± 0.031	1.12TyrPhe: 1.12 ± 0.032	2.195TyrGly: 2.195 ± 0.045	0.721TyrHis: 0.721 ± 0.025	1.229TyrIle: 1.229 ± 0.033	0.9TyrLys: 0.9 ± 0.029	3.045TyrLeu: 3.045 ± 0.049	0.574TyrMet: 0.574 ± 0.02	0.968TyrAsn: 0.968 ± 0.035	1.329TyrPro: 1.329 ± 0.033	1.622TyrGln: 1.622 ± 0.034	1.933TyrArg: 1.933 ± 0.038	1.713TyrSer: 1.713 ± 0.039	1.333TyrThr: 1.333 ± 0.029	1.599TyrVal: 1.599 ± 0.033	0.414TyrTrp: 0.414 ± 0.021	0.881TyrTyr: 0.881 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4064 proteins (1278030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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