Amino acid dipepetide frequency for Acrocarpospora pleiomorpha

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.914AlaAla: 18.914 ± 0.11	1.084AlaCys: 1.084 ± 0.016	7.903AlaAsp: 7.903 ± 0.055	8.297AlaGlu: 8.297 ± 0.067	3.644AlaPhe: 3.644 ± 0.037	12.222AlaGly: 12.222 ± 0.072	2.548AlaHis: 2.548 ± 0.029	5.092AlaIle: 5.092 ± 0.041	2.743AlaLys: 2.743 ± 0.037	13.831AlaLeu: 13.831 ± 0.078	2.648AlaMet: 2.648 ± 0.033	2.307AlaAsn: 2.307 ± 0.034	5.682AlaPro: 5.682 ± 0.047	3.612AlaGln: 3.612 ± 0.033	9.594AlaArg: 9.594 ± 0.067	5.902AlaSer: 5.902 ± 0.048	7.222AlaThr: 7.222 ± 0.056	11.173AlaVal: 11.173 ± 0.084	1.9AlaTrp: 1.9 ± 0.024	2.717AlaTyr: 2.717 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	0.99CysAla: 0.99 ± 0.015	0.102CysCys: 0.102 ± 0.006	0.515CysAsp: 0.515 ± 0.012	0.392CysGlu: 0.392 ± 0.012	0.23CysPhe: 0.23 ± 0.008	0.953CysGly: 0.953 ± 0.018	0.21CysHis: 0.21 ± 0.008	0.167CysIle: 0.167 ± 0.007	0.104CysLys: 0.104 ± 0.006	0.729CysLeu: 0.729 ± 0.015	0.119CysMet: 0.119 ± 0.006	0.143CysAsn: 0.143 ± 0.006	0.492CysPro: 0.492 ± 0.011	0.216CysGln: 0.216 ± 0.008	0.568CysArg: 0.568 ± 0.015	0.411CysSer: 0.411 ± 0.011	0.435CysThr: 0.435 ± 0.012	0.682CysVal: 0.682 ± 0.014	0.127CysTrp: 0.127 ± 0.006	0.172CysTyr: 0.172 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	6.766AspAla: 6.766 ± 0.059	0.377AspCys: 0.377 ± 0.01	3.388AspAsp: 3.388 ± 0.039	3.571AspGlu: 3.571 ± 0.038	1.675AspPhe: 1.675 ± 0.022	5.871AspGly: 5.871 ± 0.057	1.435AspHis: 1.435 ± 0.026	2.11AspIle: 2.11 ± 0.023	1.042AspLys: 1.042 ± 0.018	6.871AspLeu: 6.871 ± 0.054	0.883AspMet: 0.883 ± 0.018	1.033AspAsn: 1.033 ± 0.022	4.491AspPro: 4.491 ± 0.039	1.831AspGln: 1.831 ± 0.025	4.727AspArg: 4.727 ± 0.047	2.482AspSer: 2.482 ± 0.027	2.729AspThr: 2.729 ± 0.03	4.772AspVal: 4.772 ± 0.04	1.035AspTrp: 1.035 ± 0.021	1.253AspTyr: 1.253 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	6.508GluAla: 6.508 ± 0.053	0.355GluCys: 0.355 ± 0.01	2.547GluAsp: 2.547 ± 0.03	3.104GluGlu: 3.104 ± 0.039	1.684GluPhe: 1.684 ± 0.02	3.769GluGly: 3.769 ± 0.032	1.491GluHis: 1.491 ± 0.02	2.772GluIle: 2.772 ± 0.031	1.175GluLys: 1.175 ± 0.021	6.836GluLeu: 6.836 ± 0.059	0.977GluMet: 0.977 ± 0.019	1.129GluAsn: 1.129 ± 0.019	3.288GluPro: 3.288 ± 0.034	2.106GluGln: 2.106 ± 0.027	5.123GluArg: 5.123 ± 0.052	2.691GluSer: 2.691 ± 0.031	2.864GluThr: 2.864 ± 0.027	4.434GluVal: 4.434 ± 0.044	0.833GluTrp: 0.833 ± 0.015	1.077GluTyr: 1.077 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.904PheAla: 3.904 ± 0.037	0.292PheCys: 0.292 ± 0.01	2.148PheAsp: 2.148 ± 0.025	1.518PheGlu: 1.518 ± 0.023	0.919PhePhe: 0.919 ± 0.02	3.169PheGly: 3.169 ± 0.034	0.664PheHis: 0.664 ± 0.012	0.932PheIle: 0.932 ± 0.015	0.518PheLys: 0.518 ± 0.012	2.755PheLeu: 2.755 ± 0.037	0.476PheMet: 0.476 ± 0.013	0.697PheAsn: 0.697 ± 0.016	1.571PhePro: 1.571 ± 0.023	0.825PheGln: 0.825 ± 0.016	1.969PheArg: 1.969 ± 0.026	1.575PheSer: 1.575 ± 0.02	2.124PheThr: 2.124 ± 0.026	2.395PheVal: 2.395 ± 0.034	0.463PheTrp: 0.463 ± 0.011	0.645PheTyr: 0.645 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	9.686GlyAla: 9.686 ± 0.051	0.802GlyCys: 0.802 ± 0.015	5.103GlyAsp: 5.103 ± 0.044	5.049GlyGlu: 5.049 ± 0.042	3.03GlyPhe: 3.03 ± 0.031	8.178GlyGly: 8.178 ± 0.063	2.208GlyHis: 2.208 ± 0.029	3.759GlyIle: 3.759 ± 0.038	2.326GlyLys: 2.326 ± 0.03	9.584GlyLeu: 9.584 ± 0.067	2.034GlyMet: 2.034 ± 0.024	1.968GlyAsn: 1.968 ± 0.034	4.755GlyPro: 4.755 ± 0.042	2.873GlyGln: 2.873 ± 0.031	7.192GlyArg: 7.192 ± 0.053	5.187GlySer: 5.187 ± 0.046	5.776GlyThr: 5.776 ± 0.061	7.855GlyVal: 7.855 ± 0.059	1.74GlyTrp: 1.74 ± 0.024	2.387GlyTyr: 2.387 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	2.632HisAla: 2.632 ± 0.028	0.19HisCys: 0.19 ± 0.007	1.336HisAsp: 1.336 ± 0.024	1.205HisGlu: 1.205 ± 0.018	0.599HisPhe: 0.599 ± 0.013	2.141HisGly: 2.141 ± 0.026	0.677HisHis: 0.677 ± 0.017	0.782HisIle: 0.782 ± 0.014	0.304HisLys: 0.304 ± 0.01	2.454HisLeu: 2.454 ± 0.029	0.337HisMet: 0.337 ± 0.01	0.418HisAsn: 0.418 ± 0.011	1.708HisPro: 1.708 ± 0.025	0.667HisGln: 0.667 ± 0.016	1.894HisArg: 1.894 ± 0.026	0.953HisSer: 0.953 ± 0.018	1.166HisThr: 1.166 ± 0.018	1.745HisVal: 1.745 ± 0.024	0.348HisTrp: 0.348 ± 0.011	0.498HisTyr: 0.498 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	5.787IleAla: 5.787 ± 0.046	0.328IleCys: 0.328 ± 0.012	2.738IleAsp: 2.738 ± 0.032	2.449IleGlu: 2.449 ± 0.03	1.053IlePhe: 1.053 ± 0.017	4.089IleGly: 4.089 ± 0.038	0.779IleHis: 0.779 ± 0.014	1.415IleIle: 1.415 ± 0.023	0.932IleLys: 0.932 ± 0.017	3.289IleLeu: 3.289 ± 0.038	0.681IleMet: 0.681 ± 0.015	0.938IleAsn: 0.938 ± 0.018	2.342IlePro: 2.342 ± 0.024	1.032IleGln: 1.032 ± 0.019	2.938IleArg: 2.938 ± 0.031	2.305IleSer: 2.305 ± 0.028	2.784IleThr: 2.784 ± 0.031	3.512IleVal: 3.512 ± 0.041	0.546IleTrp: 0.546 ± 0.015	0.747IleTyr: 0.747 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.568LysAla: 2.568 ± 0.029	0.115LysCys: 0.115 ± 0.006	1.105LysAsp: 1.105 ± 0.021	1.033LysGlu: 1.033 ± 0.02	0.515LysPhe: 0.515 ± 0.013	1.601LysGly: 1.601 ± 0.027	0.429LysHis: 0.429 ± 0.011	1.106LysIle: 1.106 ± 0.02	0.627LysLys: 0.627 ± 0.017	2.005LysLeu: 2.005 ± 0.027	0.383LysMet: 0.383 ± 0.012	0.507LysAsn: 0.507 ± 0.012	1.343LysPro: 1.343 ± 0.025	0.625LysGln: 0.625 ± 0.012	1.473LysArg: 1.473 ± 0.023	1.178LysSer: 1.178 ± 0.018	1.25LysThr: 1.25 ± 0.023	1.849LysVal: 1.849 ± 0.025	0.28LysTrp: 0.28 ± 0.009	0.437LysTyr: 0.437 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	15.859LeuAla: 15.859 ± 0.102	0.789LeuCys: 0.789 ± 0.015	6.654LeuAsp: 6.654 ± 0.05	4.713LeuGlu: 4.713 ± 0.042	2.706LeuPhe: 2.706 ± 0.032	9.333LeuGly: 9.333 ± 0.062	2.092LeuHis: 2.092 ± 0.029	4.338LeuIle: 4.338 ± 0.048	1.957LeuLys: 1.957 ± 0.025	11.049LeuLeu: 11.049 ± 0.077	1.705LeuMet: 1.705 ± 0.022	2.086LeuAsn: 2.086 ± 0.028	6.308LeuPro: 6.308 ± 0.044	2.205LeuGln: 2.205 ± 0.026	8.611LeuArg: 8.611 ± 0.056	5.788LeuSer: 5.788 ± 0.045	7.068LeuThr: 7.068 ± 0.055	8.824LeuVal: 8.824 ± 0.056	1.342LeuTrp: 1.342 ± 0.02	1.871LeuTyr: 1.871 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.426MetAla: 2.426 ± 0.027	0.13MetCys: 0.13 ± 0.006	0.904MetAsp: 0.904 ± 0.016	0.752MetGlu: 0.752 ± 0.016	0.568MetPhe: 0.568 ± 0.014	1.382MetGly: 1.382 ± 0.021	0.35MetHis: 0.35 ± 0.01	0.967MetIle: 0.967 ± 0.019	0.45MetLys: 0.45 ± 0.011	1.909MetLeu: 1.909 ± 0.026	0.334MetMet: 0.334 ± 0.01	0.492MetAsn: 0.492 ± 0.012	1.158MetPro: 1.158 ± 0.02	0.404MetGln: 0.404 ± 0.012	1.573MetArg: 1.573 ± 0.022	1.358MetSer: 1.358 ± 0.022	1.627MetThr: 1.627 ± 0.02	1.455MetVal: 1.455 ± 0.022	0.237MetTrp: 0.237 ± 0.009	0.334MetTyr: 0.334 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.429AsnAla: 2.429 ± 0.031	0.182AsnCys: 0.182 ± 0.009	1.068AsnAsp: 1.068 ± 0.019	0.922AsnGlu: 0.922 ± 0.015	0.575AsnPhe: 0.575 ± 0.015	2.155AsnGly: 2.155 ± 0.036	0.428AsnHis: 0.428 ± 0.011	0.791AsnIle: 0.791 ± 0.017	0.409AsnLys: 0.409 ± 0.011	2.063AsnLeu: 2.063 ± 0.029	0.342AsnMet: 0.342 ± 0.011	0.549AsnAsn: 0.549 ± 0.017	1.722AsnPro: 1.722 ± 0.027	0.669AsnGln: 0.669 ± 0.015	1.469AsnArg: 1.469 ± 0.019	1.034AsnSer: 1.034 ± 0.021	1.234AsnThr: 1.234 ± 0.025	1.654AsnVal: 1.654 ± 0.025	0.351AsnTrp: 0.351 ± 0.011	0.496AsnTyr: 0.496 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	7.805ProAla: 7.805 ± 0.065	0.333ProCys: 0.333 ± 0.011	4.338ProAsp: 4.338 ± 0.045	3.979ProGlu: 3.979 ± 0.036	1.663ProPhe: 1.663 ± 0.024	6.433ProGly: 6.433 ± 0.054	1.21ProHis: 1.21 ± 0.019	2.147ProIle: 2.147 ± 0.023	1.219ProLys: 1.219 ± 0.024	5.151ProLeu: 5.151 ± 0.042	1.119ProMet: 1.119 ± 0.019	1.152ProAsn: 1.152 ± 0.022	3.63ProPro: 3.63 ± 0.045	1.557ProGln: 1.557 ± 0.024	3.681ProArg: 3.681 ± 0.036	3.392ProSer: 3.392 ± 0.053	3.24ProThr: 3.24 ± 0.039	5.06ProVal: 5.06 ± 0.045	0.918ProTrp: 0.918 ± 0.017	1.453ProTyr: 1.453 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	4.001GlnAla: 4.001 ± 0.041	0.171GlnCys: 0.171 ± 0.007	1.345GlnAsp: 1.345 ± 0.02	1.406GlnGlu: 1.406 ± 0.022	0.773GlnPhe: 0.773 ± 0.016	2.201GlnGly: 2.201 ± 0.027	0.614GlnHis: 0.614 ± 0.014	1.379GlnIle: 1.379 ± 0.022	0.539GlnLys: 0.539 ± 0.012	3.035GlnLeu: 3.035 ± 0.03	0.54GlnMet: 0.54 ± 0.013	0.583GlnAsn: 0.583 ± 0.017	1.73GlnPro: 1.73 ± 0.026	1.091GlnGln: 1.091 ± 0.023	2.42GlnArg: 2.42 ± 0.029	1.336GlnSer: 1.336 ± 0.02	1.466GlnThr: 1.466 ± 0.02	2.704GlnVal: 2.704 ± 0.029	0.498GlnTrp: 0.498 ± 0.014	0.589GlnTyr: 0.589 ± 0.013	0.0GlnXaa: 0.0 ± 0.0
Arg	9.132ArgAla: 9.132 ± 0.062	0.593ArgCys: 0.593 ± 0.014	4.395ArgAsp: 4.395 ± 0.038	4.611ArgGlu: 4.611 ± 0.041	2.562ArgPhe: 2.562 ± 0.032	5.506ArgGly: 5.506 ± 0.047	2.055ArgHis: 2.055 ± 0.026	3.387ArgIle: 3.387 ± 0.034	1.566ArgLys: 1.566 ± 0.024	9.08ArgLeu: 9.08 ± 0.065	1.818ArgMet: 1.818 ± 0.023	1.509ArgAsn: 1.509 ± 0.02	4.504ArgPro: 4.504 ± 0.041	2.436ArgGln: 2.436 ± 0.03	7.255ArgArg: 7.255 ± 0.052	3.974ArgSer: 3.974 ± 0.037	4.482ArgThr: 4.482 ± 0.037	6.128ArgVal: 6.128 ± 0.051	1.415ArgTrp: 1.415 ± 0.019	1.883ArgTyr: 1.883 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	6.576SerAla: 6.576 ± 0.042	0.402SerCys: 0.402 ± 0.012	2.719SerAsp: 2.719 ± 0.029	2.367SerGlu: 2.367 ± 0.028	1.697SerPhe: 1.697 ± 0.024	6.105SerGly: 6.105 ± 0.058	1.077SerHis: 1.077 ± 0.015	2.007SerIle: 2.007 ± 0.023	0.976SerLys: 0.976 ± 0.018	5.036SerLeu: 5.036 ± 0.041	1.227SerMet: 1.227 ± 0.02	0.989SerAsn: 0.989 ± 0.021	3.503SerPro: 3.503 ± 0.044	1.351SerGln: 1.351 ± 0.02	3.857SerArg: 3.857 ± 0.038	2.903SerSer: 2.903 ± 0.037	3.114SerThr: 3.114 ± 0.034	4.255SerVal: 4.255 ± 0.036	1.017SerTrp: 1.017 ± 0.014	1.23SerTyr: 1.23 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	7.814ThrAla: 7.814 ± 0.055	0.489ThrCys: 0.489 ± 0.012	3.067ThrAsp: 3.067 ± 0.034	2.906ThrGlu: 2.906 ± 0.031	1.859ThrPhe: 1.859 ± 0.026	6.412ThrGly: 6.412 ± 0.053	1.171ThrHis: 1.171 ± 0.022	2.532ThrIle: 2.532 ± 0.031	1.163ThrLys: 1.163 ± 0.021	6.091ThrLeu: 6.091 ± 0.044	1.14ThrMet: 1.14 ± 0.018	1.157ThrAsn: 1.157 ± 0.023	4.169ThrPro: 4.169 ± 0.045	1.471ThrGln: 1.471 ± 0.023	4.044ThrArg: 4.044 ± 0.036	3.282ThrSer: 3.282 ± 0.037	3.889ThrThr: 3.889 ± 0.056	5.495ThrVal: 5.495 ± 0.055	1.028ThrTrp: 1.028 ± 0.018	1.358ThrTyr: 1.358 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	10.969ValAla: 10.969 ± 0.07	0.671ValCys: 0.671 ± 0.015	4.854ValAsp: 4.854 ± 0.046	4.591ValGlu: 4.591 ± 0.044	2.581ValPhe: 2.581 ± 0.031	6.596ValGly: 6.596 ± 0.047	1.754ValHis: 1.754 ± 0.019	3.711ValIle: 3.711 ± 0.038	1.664ValLys: 1.664 ± 0.021	9.262ValLeu: 9.262 ± 0.069	1.456ValMet: 1.456 ± 0.023	1.893ValAsn: 1.893 ± 0.028	5.002ValPro: 5.002 ± 0.041	2.063ValGln: 2.063 ± 0.028	6.627ValArg: 6.627 ± 0.05	4.604ValSer: 4.604 ± 0.041	5.742ValThr: 5.742 ± 0.043	7.775ValVal: 7.775 ± 0.064	1.129ValTrp: 1.129 ± 0.02	1.605ValTyr: 1.605 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.652TrpAla: 1.652 ± 0.022	0.151TrpCys: 0.151 ± 0.007	0.862TrpAsp: 0.862 ± 0.018	0.751TrpGlu: 0.751 ± 0.016	0.541TrpPhe: 0.541 ± 0.014	1.117TrpGly: 1.117 ± 0.017	0.403TrpHis: 0.403 ± 0.011	0.662TrpIle: 0.662 ± 0.013	0.341TrpLys: 0.341 ± 0.011	1.903TrpLeu: 1.903 ± 0.025	0.312TrpMet: 0.312 ± 0.01	0.493TrpAsn: 0.493 ± 0.015	0.895TrpPro: 0.895 ± 0.016	0.619TrpGln: 0.619 ± 0.015	1.396TrpArg: 1.396 ± 0.021	1.002TrpSer: 1.002 ± 0.019	1.091TrpThr: 1.091 ± 0.019	1.037TrpVal: 1.037 ± 0.016	0.362TrpTrp: 0.362 ± 0.01	0.355TrpTyr: 0.355 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.62TyrAla: 2.62 ± 0.029	0.199TyrCys: 0.199 ± 0.007	1.356TyrAsp: 1.356 ± 0.027	1.148TyrGlu: 1.148 ± 0.018	0.688TyrPhe: 0.688 ± 0.015	2.261TyrGly: 2.261 ± 0.024	0.459TyrHis: 0.459 ± 0.015	0.625TyrIle: 0.625 ± 0.013	0.372TyrLys: 0.372 ± 0.012	2.362TyrLeu: 2.362 ± 0.03	0.279TyrMet: 0.279 ± 0.008	0.501TyrAsn: 0.501 ± 0.015	1.187TyrPro: 1.187 ± 0.019	0.766TyrGln: 0.766 ± 0.017	1.882TyrArg: 1.882 ± 0.026	1.049TyrSer: 1.049 ± 0.022	1.233TyrThr: 1.233 ± 0.021	1.745TyrVal: 1.745 ± 0.025	0.375TyrTrp: 0.375 ± 0.011	0.493TyrTyr: 0.493 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10405 proteins (3444316 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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