Amino acid dipepetide frequency for Yaba monkey tumor virus (strain VR587) (YMTV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.133AlaAla: 1.133 ± 0.22
0.543AlaCys: 0.543 ± 0.117
1.369AlaAsp: 1.369 ± 0.241
1.369AlaGlu: 1.369 ± 0.178
1.393AlaPhe: 1.393 ± 0.18
0.897AlaGly: 0.897 ± 0.158
0.449AlaHis: 0.449 ± 0.102
3.376AlaIle: 3.376 ± 0.254
2.29AlaLys: 2.29 ± 0.233
2.526AlaLeu: 2.526 ± 0.219
0.661AlaMet: 0.661 ± 0.118
1.7AlaAsn: 1.7 ± 0.18
0.59AlaPro: 0.59 ± 0.104
0.401AlaGln: 0.401 ± 0.116
1.039AlaArg: 1.039 ± 0.165
2.502AlaSer: 2.502 ± 0.23
1.629AlaThr: 1.629 ± 0.186
2.125AlaVal: 2.125 ± 0.235
0.212AlaTrp: 0.212 ± 0.088
1.228AlaTyr: 1.228 ± 0.144
0.0AlaXaa: 0.0 ± 0.0
Cys
0.803CysAla: 0.803 ± 0.141
0.567CysCys: 0.567 ± 0.115
1.818CysAsp: 1.818 ± 0.221
1.086CysGlu: 1.086 ± 0.172
1.298CysPhe: 1.298 ± 0.159
1.062CysGly: 1.062 ± 0.183
0.26CysHis: 0.26 ± 0.073
1.841CysIle: 1.841 ± 0.216
1.747CysLys: 1.747 ± 0.239
1.794CysLeu: 1.794 ± 0.243
0.614CysMet: 0.614 ± 0.138
1.818CysAsn: 1.818 ± 0.237
0.543CysPro: 0.543 ± 0.125
0.33CysGln: 0.33 ± 0.087
0.637CysArg: 0.637 ± 0.127
1.959CysSer: 1.959 ± 0.223
1.015CysThr: 1.015 ± 0.171
1.487CysVal: 1.487 ± 0.206
0.236CysTrp: 0.236 ± 0.074
1.393CysTyr: 1.393 ± 0.186
0.0CysXaa: 0.0 ± 0.0
Asp
1.652AspAla: 1.652 ± 0.194
1.133AspCys: 1.133 ± 0.156
4.438AspAsp: 4.438 ± 0.454
3.824AspGlu: 3.824 ± 0.308
3.399AspPhe: 3.399 ± 0.266
2.29AspGly: 2.29 ± 0.256
0.779AspHis: 0.779 ± 0.153
6.964AspIle: 6.964 ± 0.29
4.462AspLys: 4.462 ± 0.343
3.871AspLeu: 3.871 ± 0.27
1.676AspMet: 1.676 ± 0.164
4.367AspAsn: 4.367 ± 0.323
1.275AspPro: 1.275 ± 0.163
0.921AspGln: 0.921 ± 0.172
1.487AspArg: 1.487 ± 0.203
3.99AspSer: 3.99 ± 0.329
2.738AspThr: 2.738 ± 0.209
5.382AspVal: 5.382 ± 0.389
0.33AspTrp: 0.33 ± 0.09
3.022AspTyr: 3.022 ± 0.265
0.0AspXaa: 0.0 ± 0.0
Glu
1.322GluAla: 1.322 ± 0.205
1.062GluCys: 1.062 ± 0.15
3.234GluAsp: 3.234 ± 0.289
3.494GluGlu: 3.494 ± 0.344
2.29GluPhe: 2.29 ± 0.242
1.464GluGly: 1.464 ± 0.197
0.826GluHis: 0.826 ± 0.151
5.878GluIle: 5.878 ± 0.398
5.288GluLys: 5.288 ± 0.335
4.863GluLeu: 4.863 ± 0.388
1.464GluMet: 1.464 ± 0.179
4.249GluAsn: 4.249 ± 0.347
1.44GluPro: 1.44 ± 0.189
1.251GluGln: 1.251 ± 0.153
1.889GluArg: 1.889 ± 0.256
3.517GluSer: 3.517 ± 0.354
3.092GluThr: 3.092 ± 0.238
2.431GluVal: 2.431 ± 0.259
0.496GluTrp: 0.496 ± 0.11
3.234GluTyr: 3.234 ± 0.271
0.0GluXaa: 0.0 ± 0.0
Phe
1.369PheAla: 1.369 ± 0.194
1.298PheCys: 1.298 ± 0.187
2.998PheAsp: 2.998 ± 0.275
2.833PheGlu: 2.833 ± 0.235
3.376PhePhe: 3.376 ± 0.341
2.455PheGly: 2.455 ± 0.24
0.85PheHis: 0.85 ± 0.131
5.736PheIle: 5.736 ± 0.393
5.123PheLys: 5.123 ± 0.344
6.232PheLeu: 6.232 ± 0.449
1.18PheMet: 1.18 ± 0.161
5.548PheAsn: 5.548 ± 0.393
1.865PhePro: 1.865 ± 0.182
1.039PheGln: 1.039 ± 0.148
1.416PheArg: 1.416 ± 0.182
5.382PheSer: 5.382 ± 0.385
2.786PheThr: 2.786 ± 0.207
4.06PheVal: 4.06 ± 0.341
0.496PheTrp: 0.496 ± 0.108
3.092PheTyr: 3.092 ± 0.261
0.0PheXaa: 0.0 ± 0.0
Gly
1.251GlyAla: 1.251 ± 0.208
0.755GlyCys: 0.755 ± 0.148
2.266GlyAsp: 2.266 ± 0.212
2.03GlyGlu: 2.03 ± 0.211
2.29GlyPhe: 2.29 ± 0.286
2.007GlyGly: 2.007 ± 0.231
0.472GlyHis: 0.472 ± 0.092
3.022GlyIle: 3.022 ± 0.312
3.942GlyLys: 3.942 ± 0.35
2.738GlyLeu: 2.738 ± 0.206
0.732GlyMet: 0.732 ± 0.128
3.069GlyAsn: 3.069 ± 0.231
0.637GlyPro: 0.637 ± 0.116
0.519GlyGln: 0.519 ± 0.097
1.487GlyArg: 1.487 ± 0.212
2.502GlySer: 2.502 ± 0.257
1.511GlyThr: 1.511 ± 0.193
2.904GlyVal: 2.904 ± 0.234
0.189GlyTrp: 0.189 ± 0.066
2.361GlyTyr: 2.361 ± 0.213
0.0GlyXaa: 0.0 ± 0.0
His
0.519HisAla: 0.519 ± 0.122
0.567HisCys: 0.567 ± 0.118
0.991HisAsp: 0.991 ± 0.157
0.708HisGlu: 0.708 ± 0.128
0.968HisPhe: 0.968 ± 0.129
0.708HisGly: 0.708 ± 0.124
0.378HisHis: 0.378 ± 0.096
1.77HisIle: 1.77 ± 0.172
1.204HisLys: 1.204 ± 0.142
1.7HisLeu: 1.7 ± 0.228
0.685HisMet: 0.685 ± 0.13
1.039HisAsn: 1.039 ± 0.146
0.449HisPro: 0.449 ± 0.116
0.401HisGln: 0.401 ± 0.097
0.33HisArg: 0.33 ± 0.082
1.157HisSer: 1.157 ± 0.138
0.614HisThr: 0.614 ± 0.132
1.605HisVal: 1.605 ± 0.192
0.189HisTrp: 0.189 ± 0.07
0.803HisTyr: 0.803 ± 0.145
0.0HisXaa: 0.0 ± 0.0
Ile
2.927IleAla: 2.927 ± 0.255
2.29IleCys: 2.29 ± 0.233
5.736IleAsp: 5.736 ± 0.331
4.344IleGlu: 4.344 ± 0.371
5.76IlePhe: 5.76 ± 0.344
3.022IleGly: 3.022 ± 0.237
1.77IleHis: 1.77 ± 0.208
9.419IleIle: 9.419 ± 0.589
9.136IleLys: 9.136 ± 0.488
8.829IleLeu: 8.829 ± 0.52
2.219IleMet: 2.219 ± 0.244
9.419IleAsn: 9.419 ± 0.559
2.927IlePro: 2.927 ± 0.252
1.77IleGln: 1.77 ± 0.19
2.88IleArg: 2.88 ± 0.264
9.301IleSer: 9.301 ± 0.39
5.689IleThr: 5.689 ± 0.374
5.524IleVal: 5.524 ± 0.344
0.496IleTrp: 0.496 ± 0.108
4.131IleTyr: 4.131 ± 0.406
0.0IleXaa: 0.0 ± 0.0
Lys
1.889LysAla: 1.889 ± 0.231
1.983LysCys: 1.983 ± 0.216
4.627LysAsp: 4.627 ± 0.277
4.816LysGlu: 4.816 ± 0.327
4.178LysPhe: 4.178 ± 0.32
2.431LysGly: 2.431 ± 0.213
1.629LysHis: 1.629 ± 0.206
10.104LysIle: 10.104 ± 0.542
11.496LysLys: 11.496 ± 0.674
8.333LysLeu: 8.333 ± 0.447
2.077LysMet: 2.077 ± 0.239
8.616LysAsn: 8.616 ± 0.475
2.29LysPro: 2.29 ± 0.247
2.361LysGln: 2.361 ± 0.227
3.447LysArg: 3.447 ± 0.254
6.846LysSer: 6.846 ± 0.399
5.548LysThr: 5.548 ± 0.374
5.099LysVal: 5.099 ± 0.348
0.708LysTrp: 0.708 ± 0.123
5.17LysTyr: 5.17 ± 0.384
0.0LysXaa: 0.0 ± 0.0
Leu
2.762LeuAla: 2.762 ± 0.226
1.534LeuCys: 1.534 ± 0.222
4.698LeuAsp: 4.698 ± 0.359
4.698LeuGlu: 4.698 ± 0.351
5.595LeuPhe: 5.595 ± 0.431
3.14LeuGly: 3.14 ± 0.288
1.511LeuHis: 1.511 ± 0.22
8.168LeuIle: 8.168 ± 0.435
9.325LeuLys: 9.325 ± 0.517
8.475LeuLeu: 8.475 ± 0.509
2.243LeuMet: 2.243 ± 0.232
7.224LeuAsn: 7.224 ± 0.378
2.904LeuPro: 2.904 ± 0.257
1.794LeuGln: 1.794 ± 0.229
3.045LeuArg: 3.045 ± 0.262
8.38LeuSer: 8.38 ± 0.344
5.288LeuThr: 5.288 ± 0.347
5.642LeuVal: 5.642 ± 0.424
0.401LeuTrp: 0.401 ± 0.101
3.966LeuTyr: 3.966 ± 0.359
0.0LeuXaa: 0.0 ± 0.0
Met
0.897MetAla: 0.897 ± 0.142
0.543MetCys: 0.543 ± 0.1
1.416MetAsp: 1.416 ± 0.199
1.346MetGlu: 1.346 ± 0.17
2.03MetPhe: 2.03 ± 0.214
0.991MetGly: 0.991 ± 0.139
0.378MetHis: 0.378 ± 0.093
2.313MetIle: 2.313 ± 0.221
1.629MetLys: 1.629 ± 0.216
2.55MetLeu: 2.55 ± 0.221
0.543MetMet: 0.543 ± 0.116
1.676MetAsn: 1.676 ± 0.183
0.85MetPro: 0.85 ± 0.132
0.59MetGln: 0.59 ± 0.098
0.685MetArg: 0.685 ± 0.141
2.101MetSer: 2.101 ± 0.272
1.322MetThr: 1.322 ± 0.16
1.204MetVal: 1.204 ± 0.163
0.094MetTrp: 0.094 ± 0.05
1.298MetTyr: 1.298 ± 0.199
0.0MetXaa: 0.0 ± 0.0
Asn
1.747AsnAla: 1.747 ± 0.189
1.558AsnCys: 1.558 ± 0.198
5.17AsnAsp: 5.17 ± 0.394
4.58AsnGlu: 4.58 ± 0.328
4.58AsnPhe: 4.58 ± 0.341
3.281AsnGly: 3.281 ± 0.34
1.251AsnHis: 1.251 ± 0.193
8.357AsnIle: 8.357 ± 0.456
7.79AsnLys: 7.79 ± 0.377
6.633AsnLeu: 6.633 ± 0.436
2.148AsnMet: 2.148 ± 0.213
7.955AsnAsn: 7.955 ± 0.503
2.715AsnPro: 2.715 ± 0.326
1.204AsnGln: 1.204 ± 0.155
2.337AsnArg: 2.337 ± 0.245
5.807AsnSer: 5.807 ± 0.365
3.966AsnThr: 3.966 ± 0.302
6.728AsnVal: 6.728 ± 0.434
0.401AsnTrp: 0.401 ± 0.082
3.895AsnTyr: 3.895 ± 0.276
0.0AsnXaa: 0.0 ± 0.0
Pro
0.519ProAla: 0.519 ± 0.106
0.661ProCys: 0.661 ± 0.106
1.534ProAsp: 1.534 ± 0.192
1.841ProGlu: 1.841 ± 0.201
2.054ProPhe: 2.054 ± 0.282
1.086ProGly: 1.086 ± 0.165
0.543ProHis: 0.543 ± 0.109
2.691ProIle: 2.691 ± 0.234
2.526ProLys: 2.526 ± 0.227
2.856ProLeu: 2.856 ± 0.313
0.685ProMet: 0.685 ± 0.123
2.172ProAsn: 2.172 ± 0.213
1.086ProPro: 1.086 ± 0.223
0.661ProGln: 0.661 ± 0.125
0.897ProArg: 0.897 ± 0.165
2.597ProSer: 2.597 ± 0.26
1.511ProThr: 1.511 ± 0.207
1.511ProVal: 1.511 ± 0.23
0.189ProTrp: 0.189 ± 0.067
1.204ProTyr: 1.204 ± 0.152
0.0ProXaa: 0.0 ± 0.0
Gln
0.401GlnAla: 0.401 ± 0.109
0.307GlnCys: 0.307 ± 0.093
0.991GlnAsp: 0.991 ± 0.152
1.18GlnGlu: 1.18 ± 0.157
0.779GlnPhe: 0.779 ± 0.15
0.543GlnGly: 0.543 ± 0.105
0.307GlnHis: 0.307 ± 0.088
1.605GlnIle: 1.605 ± 0.22
2.054GlnLys: 2.054 ± 0.181
2.125GlnLeu: 2.125 ± 0.196
0.567GlnMet: 0.567 ± 0.107
1.44GlnAsn: 1.44 ± 0.187
0.519GlnPro: 0.519 ± 0.124
0.614GlnGln: 0.614 ± 0.132
0.873GlnArg: 0.873 ± 0.143
1.582GlnSer: 1.582 ± 0.185
1.298GlnThr: 1.298 ± 0.166
1.157GlnVal: 1.157 ± 0.2
0.189GlnTrp: 0.189 ± 0.069
0.921GlnTyr: 0.921 ± 0.137
0.0GlnXaa: 0.0 ± 0.0
Arg
0.85ArgAla: 0.85 ± 0.138
0.873ArgCys: 0.873 ± 0.156
2.172ArgAsp: 2.172 ± 0.198
1.676ArgGlu: 1.676 ± 0.217
2.054ArgPhe: 2.054 ± 0.18
1.346ArgGly: 1.346 ± 0.22
0.85ArgHis: 0.85 ± 0.133
2.243ArgIle: 2.243 ± 0.221
2.479ArgLys: 2.479 ± 0.246
3.234ArgLeu: 3.234 ± 0.275
0.732ArgMet: 0.732 ± 0.118
1.794ArgAsn: 1.794 ± 0.203
0.779ArgPro: 0.779 ± 0.159
0.991ArgGln: 0.991 ± 0.14
1.228ArgArg: 1.228 ± 0.18
2.431ArgSer: 2.431 ± 0.225
1.346ArgThr: 1.346 ± 0.191
1.983ArgVal: 1.983 ± 0.252
0.212ArgTrp: 0.212 ± 0.093
1.936ArgTyr: 1.936 ± 0.227
0.0ArgXaa: 0.0 ± 0.0
Ser
2.455SerAla: 2.455 ± 0.276
1.865SerCys: 1.865 ± 0.223
4.391SerAsp: 4.391 ± 0.403
4.296SerGlu: 4.296 ± 0.371
5.264SerPhe: 5.264 ± 0.372
3.022SerGly: 3.022 ± 0.243
1.464SerHis: 1.464 ± 0.196
7.106SerIle: 7.106 ± 0.385
7.625SerLys: 7.625 ± 0.379
7.932SerLeu: 7.932 ± 0.4
2.03SerMet: 2.03 ± 0.183
6.161SerAsn: 6.161 ± 0.356
2.219SerPro: 2.219 ± 0.268
1.818SerGln: 1.818 ± 0.259
2.29SerArg: 2.29 ± 0.293
7.247SerSer: 7.247 ± 0.518
4.462SerThr: 4.462 ± 0.365
5.807SerVal: 5.807 ± 0.359
0.637SerTrp: 0.637 ± 0.129
3.966SerTyr: 3.966 ± 0.335
0.0SerXaa: 0.0 ± 0.0
Thr
1.369ThrAla: 1.369 ± 0.161
1.582ThrCys: 1.582 ± 0.221
2.856ThrAsp: 2.856 ± 0.248
2.904ThrGlu: 2.904 ± 0.275
3.423ThrPhe: 3.423 ± 0.257
2.077ThrGly: 2.077 ± 0.214
1.228ThrHis: 1.228 ± 0.177
5.028ThrIle: 5.028 ± 0.321
4.438ThrLys: 4.438 ± 0.32
4.887ThrLeu: 4.887 ± 0.314
1.133ThrMet: 1.133 ± 0.194
3.399ThrAsn: 3.399 ± 0.276
1.676ThrPro: 1.676 ± 0.252
0.708ThrGln: 0.708 ± 0.139
1.487ThrArg: 1.487 ± 0.183
4.367ThrSer: 4.367 ± 0.392
2.927ThrThr: 2.927 ± 0.314
4.155ThrVal: 4.155 ± 0.334
0.283ThrTrp: 0.283 ± 0.074
2.526ThrTyr: 2.526 ± 0.243
0.0ThrXaa: 0.0 ± 0.0
Val
1.983ValAla: 1.983 ± 0.216
1.818ValCys: 1.818 ± 0.225
3.919ValAsp: 3.919 ± 0.265
3.163ValGlu: 3.163 ± 0.301
4.58ValPhe: 4.58 ± 0.346
2.054ValGly: 2.054 ± 0.229
0.873ValHis: 0.873 ± 0.152
6.256ValIle: 6.256 ± 0.455
6.751ValLys: 6.751 ± 0.44
6.303ValLeu: 6.303 ± 0.304
1.393ValMet: 1.393 ± 0.15
6.303ValAsn: 6.303 ± 0.431
2.03ValPro: 2.03 ± 0.192
1.015ValGln: 1.015 ± 0.166
1.983ValArg: 1.983 ± 0.208
5.642ValSer: 5.642 ± 0.38
3.423ValThr: 3.423 ± 0.352
4.037ValVal: 4.037 ± 0.307
0.33ValTrp: 0.33 ± 0.087
3.683ValTyr: 3.683 ± 0.285
0.0ValXaa: 0.0 ± 0.0
Trp
0.189TrpAla: 0.189 ± 0.063
0.142TrpCys: 0.142 ± 0.055
0.212TrpAsp: 0.212 ± 0.072
0.283TrpGlu: 0.283 ± 0.082
0.567TrpPhe: 0.567 ± 0.105
0.212TrpGly: 0.212 ± 0.066
0.047TrpHis: 0.047 ± 0.03
0.779TrpIle: 0.779 ± 0.128
0.873TrpLys: 0.873 ± 0.148
0.449TrpLeu: 0.449 ± 0.113
0.378TrpMet: 0.378 ± 0.099
0.307TrpAsn: 0.307 ± 0.087
0.236TrpPro: 0.236 ± 0.074
0.094TrpGln: 0.094 ± 0.043
0.212TrpArg: 0.212 ± 0.078
0.543TrpSer: 0.543 ± 0.126
0.189TrpThr: 0.189 ± 0.065
0.472TrpVal: 0.472 ± 0.104
0.047TrpTrp: 0.047 ± 0.034
0.236TrpTyr: 0.236 ± 0.065
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.393TyrAla: 1.393 ± 0.284
1.228TyrCys: 1.228 ± 0.183
3.163TyrAsp: 3.163 ± 0.338
2.313TyrGlu: 2.313 ± 0.242
3.258TyrPhe: 3.258 ± 0.223
2.597TyrGly: 2.597 ± 0.282
0.921TyrHis: 0.921 ± 0.149
4.934TyrIle: 4.934 ± 0.312
3.47TyrLys: 3.47 ± 0.275
4.485TyrLeu: 4.485 ± 0.312
1.275TyrMet: 1.275 ± 0.179
3.848TyrAsn: 3.848 ± 0.346
1.794TyrPro: 1.794 ± 0.201
0.968TyrGln: 0.968 ± 0.163
1.558TyrArg: 1.558 ± 0.185
4.202TyrSer: 4.202 ± 0.291
2.101TyrThr: 2.101 ± 0.203
4.226TyrVal: 4.226 ± 0.275
0.33TyrTrp: 0.33 ± 0.099
2.219TyrTyr: 2.219 ± 0.224
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 140 proteins (42362 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski