Amino acid dipepetide frequency for Influenza A virus (A/ruddy turnstone/Delaware/24/1990(mixed))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.785AlaAla: 4.785 ± 1.467
2.533AlaCys: 2.533 ± 0.749
1.407AlaAsp: 1.407 ± 0.581
3.659AlaGlu: 3.659 ± 0.827
3.659AlaPhe: 3.659 ± 0.633
5.348AlaGly: 5.348 ± 1.261
1.407AlaHis: 1.407 ± 0.683
3.096AlaIle: 3.096 ± 1.051
1.689AlaLys: 1.689 ± 0.789
7.036AlaLeu: 7.036 ± 1.282
2.252AlaMet: 2.252 ± 1.204
2.815AlaAsn: 2.815 ± 1.005
1.689AlaPro: 1.689 ± 0.564
1.407AlaGln: 1.407 ± 0.46
2.252AlaArg: 2.252 ± 0.624
7.599AlaSer: 7.599 ± 1.108
5.066AlaThr: 5.066 ± 0.924
4.222AlaVal: 4.222 ± 0.666
0.563AlaTrp: 0.563 ± 0.42
1.689AlaTyr: 1.689 ± 0.523
0.0AlaXaa: 0.0 ± 0.0
Cys
0.844CysAla: 0.844 ± 0.44
0.0CysCys: 0.0 ± 0.0
1.126CysAsp: 1.126 ± 0.577
0.844CysGlu: 0.844 ± 0.457
1.689CysPhe: 1.689 ± 0.6
0.844CysGly: 0.844 ± 0.527
1.407CysHis: 1.407 ± 0.519
2.815CysIle: 2.815 ± 1.089
0.844CysLys: 0.844 ± 0.473
1.407CysLeu: 1.407 ± 0.443
1.126CysMet: 1.126 ± 0.452
1.689CysAsn: 1.689 ± 0.558
0.563CysPro: 0.563 ± 0.288
0.281CysGln: 0.281 ± 0.231
1.407CysArg: 1.407 ± 0.61
1.97CysSer: 1.97 ± 0.639
0.844CysThr: 0.844 ± 0.365
1.689CysVal: 1.689 ± 0.454
0.0CysTrp: 0.0 ± 0.0
1.126CysTyr: 1.126 ± 0.52
0.0CysXaa: 0.0 ± 0.0
Asp
2.815AspAla: 2.815 ± 0.475
0.563AspCys: 0.563 ± 0.432
2.252AspAsp: 2.252 ± 0.801
3.096AspGlu: 3.096 ± 0.748
0.844AspPhe: 0.844 ± 0.332
4.222AspGly: 4.222 ± 0.996
0.281AspHis: 0.281 ± 0.231
1.126AspIle: 1.126 ± 0.601
1.97AspLys: 1.97 ± 0.568
4.503AspLeu: 4.503 ± 1.02
1.689AspMet: 1.689 ± 0.604
3.377AspAsn: 3.377 ± 0.576
4.222AspPro: 4.222 ± 1.071
1.97AspGln: 1.97 ± 1.075
2.815AspArg: 2.815 ± 0.702
3.377AspSer: 3.377 ± 0.787
1.689AspThr: 1.689 ± 0.73
3.096AspVal: 3.096 ± 0.454
0.281AspTrp: 0.281 ± 0.231
1.407AspTyr: 1.407 ± 0.308
0.0AspXaa: 0.0 ± 0.0
Glu
2.252GluAla: 2.252 ± 1.214
2.815GluCys: 2.815 ± 1.104
5.066GluAsp: 5.066 ± 0.81
5.066GluGlu: 5.066 ± 1.53
0.844GluPhe: 0.844 ± 0.495
5.066GluGly: 5.066 ± 1.038
0.563GluHis: 0.563 ± 0.339
5.629GluIle: 5.629 ± 1.145
2.252GluLys: 2.252 ± 1.299
5.629GluLeu: 5.629 ± 1.307
1.97GluMet: 1.97 ± 0.596
4.785GluAsn: 4.785 ± 1.06
1.126GluPro: 1.126 ± 0.765
3.94GluGln: 3.94 ± 1.504
5.91GluArg: 5.91 ± 1.492
3.94GluSer: 3.94 ± 0.849
3.94GluThr: 3.94 ± 0.585
5.629GluVal: 5.629 ± 1.819
1.126GluTrp: 1.126 ± 0.858
1.126GluTyr: 1.126 ± 0.532
0.0GluXaa: 0.0 ± 0.0
Phe
2.252PheAla: 2.252 ± 0.641
0.563PheCys: 0.563 ± 0.319
2.252PheAsp: 2.252 ± 0.601
3.94PheGlu: 3.94 ± 1.42
1.97PhePhe: 1.97 ± 0.553
1.689PheGly: 1.689 ± 0.361
0.844PheHis: 0.844 ± 0.457
1.407PheIle: 1.407 ± 0.435
2.533PheLys: 2.533 ± 0.691
2.533PheLeu: 2.533 ± 0.642
0.563PheMet: 0.563 ± 0.547
0.563PheAsn: 0.563 ± 0.319
0.0PhePro: 0.0 ± 0.0
3.096PheGln: 3.096 ± 0.814
1.407PheArg: 1.407 ± 0.308
2.815PheSer: 2.815 ± 0.867
2.533PheThr: 2.533 ± 0.373
2.533PheVal: 2.533 ± 0.907
0.844PheTrp: 0.844 ± 0.365
0.844PheTyr: 0.844 ± 0.383
0.0PheXaa: 0.0 ± 0.0
Gly
5.629GlyAla: 5.629 ± 0.723
0.563GlyCys: 0.563 ± 0.288
2.533GlyAsp: 2.533 ± 0.52
3.096GlyGlu: 3.096 ± 0.854
3.377GlyPhe: 3.377 ± 1.316
3.377GlyGly: 3.377 ± 1.055
1.689GlyHis: 1.689 ± 0.656
4.503GlyIle: 4.503 ± 1.039
5.066GlyLys: 5.066 ± 0.683
5.348GlyLeu: 5.348 ± 1.598
2.533GlyMet: 2.533 ± 0.714
5.066GlyAsn: 5.066 ± 0.521
3.377GlyPro: 3.377 ± 0.673
1.97GlyGln: 1.97 ± 0.626
6.755GlyArg: 6.755 ± 1.517
6.192GlySer: 6.192 ± 0.743
4.503GlyThr: 4.503 ± 0.782
5.348GlyVal: 5.348 ± 0.467
1.97GlyTrp: 1.97 ± 0.675
2.815GlyTyr: 2.815 ± 0.616
0.0GlyXaa: 0.0 ± 0.0
His
0.563HisAla: 0.563 ± 0.288
0.281HisCys: 0.281 ± 0.231
1.407HisAsp: 1.407 ± 0.687
0.563HisGlu: 0.563 ± 0.421
0.563HisPhe: 0.563 ± 0.424
0.563HisGly: 0.563 ± 0.421
0.563HisHis: 0.563 ± 0.462
1.407HisIle: 1.407 ± 0.807
1.689HisLys: 1.689 ± 0.613
1.126HisLeu: 1.126 ± 0.532
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
1.407HisPro: 1.407 ± 0.423
1.126HisGln: 1.126 ± 0.477
1.407HisArg: 1.407 ± 0.894
1.689HisSer: 1.689 ± 0.69
0.844HisThr: 0.844 ± 0.422
0.563HisVal: 0.563 ± 0.42
0.0HisTrp: 0.0 ± 0.0
0.563HisTyr: 0.563 ± 0.319
0.0HisXaa: 0.0 ± 0.0
Ile
4.785IleAla: 4.785 ± 0.812
1.407IleCys: 1.407 ± 0.75
3.377IleAsp: 3.377 ± 1.129
5.348IleGlu: 5.348 ± 0.928
1.97IlePhe: 1.97 ± 0.704
4.503IleGly: 4.503 ± 0.886
0.563IleHis: 0.563 ± 0.319
4.503IleIle: 4.503 ± 1.053
1.689IleLys: 1.689 ± 0.39
8.725IleLeu: 8.725 ± 1.241
1.689IleMet: 1.689 ± 0.569
1.689IleAsn: 1.689 ± 0.39
1.97IlePro: 1.97 ± 0.835
1.407IleGln: 1.407 ± 0.46
7.881IleArg: 7.881 ± 1.483
4.503IleSer: 4.503 ± 1.21
4.222IleThr: 4.222 ± 0.978
3.659IleVal: 3.659 ± 0.689
1.689IleTrp: 1.689 ± 0.591
3.659IleTyr: 3.659 ± 0.774
0.0IleXaa: 0.0 ± 0.0
Lys
2.252LysAla: 2.252 ± 0.822
1.689LysCys: 1.689 ± 0.89
2.815LysAsp: 2.815 ± 0.488
2.252LysGlu: 2.252 ± 0.68
1.407LysPhe: 1.407 ± 0.402
3.096LysGly: 3.096 ± 0.651
0.281LysHis: 0.281 ± 0.256
3.096LysIle: 3.096 ± 1.12
1.126LysLys: 1.126 ± 0.531
3.096LysLeu: 3.096 ± 0.998
2.252LysMet: 2.252 ± 0.899
1.407LysAsn: 1.407 ± 0.844
1.126LysPro: 1.126 ± 0.477
1.97LysGln: 1.97 ± 1.215
3.94LysArg: 3.94 ± 1.077
2.815LysSer: 2.815 ± 0.838
2.815LysThr: 2.815 ± 0.821
2.252LysVal: 2.252 ± 0.907
1.126LysTrp: 1.126 ± 0.471
1.97LysTyr: 1.97 ± 0.586
0.0LysXaa: 0.0 ± 0.0
Leu
3.377LeuAla: 3.377 ± 0.723
2.252LeuCys: 2.252 ± 0.783
1.97LeuAsp: 1.97 ± 0.768
6.192LeuGlu: 6.192 ± 1.636
1.407LeuPhe: 1.407 ± 0.795
3.659LeuGly: 3.659 ± 1.164
1.689LeuHis: 1.689 ± 0.738
9.006LeuIle: 9.006 ± 0.94
6.755LeuLys: 6.755 ± 1.795
5.066LeuLeu: 5.066 ± 0.976
2.815LeuMet: 2.815 ± 0.589
4.503LeuAsn: 4.503 ± 0.692
2.815LeuPro: 2.815 ± 1.157
2.533LeuGln: 2.533 ± 1.079
3.94LeuArg: 3.94 ± 0.934
5.066LeuSer: 5.066 ± 1.488
5.066LeuThr: 5.066 ± 1.205
4.785LeuVal: 4.785 ± 0.769
1.689LeuTrp: 1.689 ± 0.666
1.97LeuTyr: 1.97 ± 0.494
0.0LeuXaa: 0.0 ± 0.0
Met
2.533MetAla: 2.533 ± 0.923
1.689MetCys: 1.689 ± 1.017
3.096MetAsp: 3.096 ± 1.216
3.94MetGlu: 3.94 ± 1.546
0.281MetPhe: 0.281 ± 0.239
2.533MetGly: 2.533 ± 1.252
0.0MetHis: 0.0 ± 0.0
1.97MetIle: 1.97 ± 0.598
0.281MetLys: 0.281 ± 0.231
0.563MetLeu: 0.563 ± 0.388
1.407MetMet: 1.407 ± 0.649
1.407MetAsn: 1.407 ± 0.748
0.563MetPro: 0.563 ± 0.42
1.689MetGln: 1.689 ± 0.746
3.377MetArg: 3.377 ± 0.83
3.096MetSer: 3.096 ± 0.677
1.97MetThr: 1.97 ± 0.93
3.659MetVal: 3.659 ± 1.274
0.281MetTrp: 0.281 ± 0.231
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
6.192AsnAla: 6.192 ± 0.885
0.844AsnCys: 0.844 ± 0.333
3.096AsnAsp: 3.096 ± 0.646
3.096AsnGlu: 3.096 ± 0.758
1.407AsnPhe: 1.407 ± 0.356
7.599AsnGly: 7.599 ± 1.718
0.0AsnHis: 0.0 ± 0.0
4.503AsnIle: 4.503 ± 1.049
1.689AsnLys: 1.689 ± 0.39
3.377AsnLeu: 3.377 ± 0.589
1.126AsnMet: 1.126 ± 0.646
5.066AsnAsn: 5.066 ± 1.436
3.659AsnPro: 3.659 ± 0.816
2.252AsnGln: 2.252 ± 0.545
2.815AsnArg: 2.815 ± 0.95
3.377AsnSer: 3.377 ± 0.686
4.503AsnThr: 4.503 ± 1.109
0.844AsnVal: 0.844 ± 0.495
1.407AsnTrp: 1.407 ± 0.61
0.281AsnTyr: 0.281 ± 0.256
0.0AsnXaa: 0.0 ± 0.0
Pro
2.533ProAla: 2.533 ± 0.68
0.563ProCys: 0.563 ± 0.319
0.844ProAsp: 0.844 ± 0.476
2.252ProGlu: 2.252 ± 0.539
2.815ProPhe: 2.815 ± 0.495
1.689ProGly: 1.689 ± 0.294
0.281ProHis: 0.281 ± 0.231
3.096ProIle: 3.096 ± 0.507
1.97ProLys: 1.97 ± 0.666
3.659ProLeu: 3.659 ± 1.251
0.0ProMet: 0.0 ± 0.0
4.222ProAsn: 4.222 ± 0.928
0.281ProPro: 0.281 ± 0.362
0.281ProGln: 0.281 ± 0.239
2.533ProArg: 2.533 ± 0.887
4.785ProSer: 4.785 ± 1.239
2.533ProThr: 2.533 ± 0.968
1.126ProVal: 1.126 ± 0.696
0.0ProTrp: 0.0 ± 0.0
1.407ProTyr: 1.407 ± 0.568
0.0ProXaa: 0.0 ± 0.0
Gln
5.066GlnAla: 5.066 ± 1.468
0.281GlnCys: 0.281 ± 0.256
1.126GlnAsp: 1.126 ± 0.549
2.252GlnGlu: 2.252 ± 0.75
0.281GlnPhe: 0.281 ± 0.34
3.096GlnGly: 3.096 ± 1.072
1.126GlnHis: 1.126 ± 0.462
3.659GlnIle: 3.659 ± 0.723
2.533GlnLys: 2.533 ± 1.237
2.533GlnLeu: 2.533 ± 1.323
3.377GlnMet: 3.377 ± 1.613
3.659GlnAsn: 3.659 ± 0.838
0.844GlnPro: 0.844 ± 0.332
1.407GlnGln: 1.407 ± 0.518
4.503GlnArg: 4.503 ± 1.415
1.97GlnSer: 1.97 ± 0.793
1.126GlnThr: 1.126 ± 0.46
1.689GlnVal: 1.689 ± 0.629
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
4.503ArgAla: 4.503 ± 1.378
0.281ArgCys: 0.281 ± 0.231
2.815ArgAsp: 2.815 ± 0.573
5.348ArgGlu: 5.348 ± 0.758
2.252ArgPhe: 2.252 ± 0.829
8.444ArgGly: 8.444 ± 1.452
1.407ArgHis: 1.407 ± 0.519
3.096ArgIle: 3.096 ± 0.708
1.407ArgLys: 1.407 ± 0.844
4.785ArgLeu: 4.785 ± 0.908
6.473ArgMet: 6.473 ± 1.87
3.659ArgAsn: 3.659 ± 1.262
3.94ArgPro: 3.94 ± 0.639
3.377ArgGln: 3.377 ± 0.812
5.629ArgArg: 5.629 ± 1.543
6.192ArgSer: 6.192 ± 0.964
6.755ArgThr: 6.755 ± 1.459
2.252ArgVal: 2.252 ± 0.409
0.281ArgTrp: 0.281 ± 0.34
0.844ArgTyr: 0.844 ± 0.405
0.0ArgXaa: 0.0 ± 0.0
Ser
5.066SerAla: 5.066 ± 1.422
3.659SerCys: 3.659 ± 0.857
2.815SerAsp: 2.815 ± 0.928
3.659SerGlu: 3.659 ± 1.307
3.659SerPhe: 3.659 ± 1.223
7.599SerGly: 7.599 ± 1.406
0.844SerHis: 0.844 ± 0.457
4.222SerIle: 4.222 ± 0.795
2.252SerLys: 2.252 ± 1.26
5.91SerLeu: 5.91 ± 1.585
0.563SerMet: 0.563 ± 0.424
4.785SerAsn: 4.785 ± 1.036
2.252SerPro: 2.252 ± 0.804
3.659SerGln: 3.659 ± 0.936
4.503SerArg: 4.503 ± 0.755
9.851SerSer: 9.851 ± 2.408
5.629SerThr: 5.629 ± 1.158
5.066SerVal: 5.066 ± 1.518
2.252SerTrp: 2.252 ± 1.438
2.252SerTyr: 2.252 ± 0.532
0.0SerXaa: 0.0 ± 0.0
Thr
2.252ThrAla: 2.252 ± 0.439
0.844ThrCys: 0.844 ± 0.457
3.377ThrAsp: 3.377 ± 0.994
6.473ThrGlu: 6.473 ± 1.073
2.252ThrPhe: 2.252 ± 0.725
5.348ThrGly: 5.348 ± 0.876
1.407ThrHis: 1.407 ± 0.46
5.91ThrIle: 5.91 ± 1.141
2.533ThrLys: 2.533 ± 0.412
3.94ThrLeu: 3.94 ± 0.982
1.407ThrMet: 1.407 ± 0.656
4.785ThrAsn: 4.785 ± 0.801
1.407ThrPro: 1.407 ± 0.496
2.252ThrGln: 2.252 ± 0.825
4.785ThrArg: 4.785 ± 1.173
2.815ThrSer: 2.815 ± 1.079
3.659ThrThr: 3.659 ± 1.669
3.94ThrVal: 3.94 ± 1.673
0.563ThrTrp: 0.563 ± 0.462
1.97ThrTyr: 1.97 ± 0.668
0.0ThrXaa: 0.0 ± 0.0
Val
4.503ValAla: 4.503 ± 0.932
1.689ValCys: 1.689 ± 0.66
1.407ValAsp: 1.407 ± 0.884
3.94ValGlu: 3.94 ± 0.979
2.815ValPhe: 2.815 ± 0.834
4.222ValGly: 4.222 ± 1.13
0.281ValHis: 0.281 ± 0.231
3.377ValIle: 3.377 ± 1.072
3.096ValLys: 3.096 ± 0.562
3.659ValLeu: 3.659 ± 0.746
1.689ValMet: 1.689 ± 0.509
1.97ValAsn: 1.97 ± 1.023
4.785ValPro: 4.785 ± 0.58
4.503ValGln: 4.503 ± 1.267
2.533ValArg: 2.533 ± 0.902
4.785ValSer: 4.785 ± 1.599
3.096ValThr: 3.096 ± 0.951
1.97ValVal: 1.97 ± 0.636
1.126ValTrp: 1.126 ± 0.38
0.844ValTyr: 0.844 ± 0.365
0.0ValXaa: 0.0 ± 0.0
Trp
1.407TrpAla: 1.407 ± 0.308
0.0TrpCys: 0.0 ± 0.0
0.563TrpAsp: 0.563 ± 0.319
1.407TrpGlu: 1.407 ± 0.638
0.281TrpPhe: 0.281 ± 0.362
0.281TrpGly: 0.281 ± 0.231
1.407TrpHis: 1.407 ± 0.515
1.407TrpIle: 1.407 ± 0.605
0.281TrpLys: 0.281 ± 0.239
1.97TrpLeu: 1.97 ± 0.625
1.126TrpMet: 1.126 ± 0.678
0.563TrpAsn: 0.563 ± 0.42
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.97TrpArg: 1.97 ± 0.689
1.97TrpSer: 1.97 ± 0.915
1.126TrpThr: 1.126 ± 0.477
0.281TrpVal: 0.281 ± 0.256
0.0TrpTrp: 0.0 ± 0.0
0.563TrpTyr: 0.563 ± 0.288
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.563TyrAla: 0.563 ± 0.319
0.0TyrCys: 0.0 ± 0.0
2.252TyrAsp: 2.252 ± 0.947
2.252TyrGlu: 2.252 ± 0.958
1.407TyrPhe: 1.407 ± 0.483
2.533TyrGly: 2.533 ± 0.567
0.281TyrHis: 0.281 ± 0.231
1.407TyrIle: 1.407 ± 0.668
1.126TyrLys: 1.126 ± 0.324
1.689TyrLeu: 1.689 ± 0.471
0.0TyrMet: 0.0 ± 0.0
1.407TyrAsn: 1.407 ± 0.438
0.844TyrPro: 0.844 ± 0.495
1.407TyrGln: 1.407 ± 0.417
3.377TyrArg: 3.377 ± 0.965
1.689TyrSer: 1.689 ± 0.399
0.0TyrThr: 0.0 ± 0.0
1.689TyrVal: 1.689 ± 0.521
1.407TyrTrp: 1.407 ± 0.308
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (3554 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski