Amino acid dipepetide frequency for Candidatus Marinamargulisbacteria bacterium SCGC AG-343-D04

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.83AlaAla: 3.83 ± 0.154
0.776AlaCys: 0.776 ± 0.04
2.693AlaAsp: 2.693 ± 0.096
3.071AlaGlu: 3.071 ± 0.097
2.701AlaPhe: 2.701 ± 0.085
3.313AlaGly: 3.313 ± 0.111
1.278AlaHis: 1.278 ± 0.051
4.69AlaIle: 4.69 ± 0.11
3.847AlaLys: 3.847 ± 0.102
6.055AlaLeu: 6.055 ± 0.13
1.226AlaMet: 1.226 ± 0.054
2.339AlaAsn: 2.339 ± 0.075
1.758AlaPro: 1.758 ± 0.064
2.19AlaGln: 2.19 ± 0.093
1.927AlaArg: 1.927 ± 0.072
4.409AlaSer: 4.409 ± 0.105
2.893AlaThr: 2.893 ± 0.092
3.439AlaVal: 3.439 ± 0.101
0.405AlaTrp: 0.405 ± 0.028
1.985AlaTyr: 1.985 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.676CysAla: 0.676 ± 0.039
0.254CysCys: 0.254 ± 0.025
0.842CysAsp: 0.842 ± 0.051
0.773CysGlu: 0.773 ± 0.041
0.734CysPhe: 0.734 ± 0.044
0.92CysGly: 0.92 ± 0.046
0.393CysHis: 0.393 ± 0.03
1.187CysIle: 1.187 ± 0.058
0.8CysLys: 0.8 ± 0.045
1.592CysLeu: 1.592 ± 0.064
0.279CysMet: 0.279 ± 0.025
0.536CysAsn: 0.536 ± 0.039
0.606CysPro: 0.606 ± 0.039
0.459CysGln: 0.459 ± 0.032
0.476CysArg: 0.476 ± 0.033
1.156CysSer: 1.156 ± 0.053
0.585CysThr: 0.585 ± 0.042
1.009CysVal: 1.009 ± 0.052
0.095CysTrp: 0.095 ± 0.015
0.409CysTyr: 0.409 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
2.99AspAla: 2.99 ± 0.081
0.769AspCys: 0.769 ± 0.045
3.098AspAsp: 3.098 ± 0.095
3.425AspGlu: 3.425 ± 0.1
2.906AspPhe: 2.906 ± 0.083
2.916AspGly: 2.916 ± 0.118
1.334AspHis: 1.334 ± 0.054
5.431AspIle: 5.431 ± 0.101
3.371AspLys: 3.371 ± 0.092
5.567AspLeu: 5.567 ± 0.123
1.185AspMet: 1.185 ± 0.059
2.444AspAsn: 2.444 ± 0.091
2.248AspPro: 2.248 ± 0.07
2.097AspGln: 2.097 ± 0.078
1.946AspArg: 1.946 ± 0.075
4.55AspSer: 4.55 ± 0.135
2.947AspThr: 2.947 ± 0.077
3.751AspVal: 3.751 ± 0.124
0.428AspTrp: 0.428 ± 0.031
2.372AspTyr: 2.372 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
3.851GluAla: 3.851 ± 0.125
1.044GluCys: 1.044 ± 0.05
3.687GluAsp: 3.687 ± 0.101
4.725GluGlu: 4.725 ± 0.15
2.728GluPhe: 2.728 ± 0.084
3.888GluGly: 3.888 ± 0.108
1.448GluHis: 1.448 ± 0.057
4.477GluIle: 4.477 ± 0.1
6.299GluLys: 6.299 ± 0.13
6.2GluLeu: 6.2 ± 0.127
1.284GluMet: 1.284 ± 0.06
3.456GluAsn: 3.456 ± 0.083
1.408GluPro: 1.408 ± 0.054
2.387GluGln: 2.387 ± 0.097
2.368GluArg: 2.368 ± 0.086
5.089GluSer: 5.089 ± 0.105
3.402GluThr: 3.402 ± 0.09
3.445GluVal: 3.445 ± 0.108
0.575GluTrp: 0.575 ± 0.043
2.078GluTyr: 2.078 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
2.095PheAla: 2.095 ± 0.064
0.753PheCys: 0.753 ± 0.043
2.868PheAsp: 2.868 ± 0.088
2.966PheGlu: 2.966 ± 0.083
3.098PhePhe: 3.098 ± 0.098
2.93PheGly: 2.93 ± 0.09
1.135PheHis: 1.135 ± 0.055
3.894PheIle: 3.894 ± 0.1
3.704PheLys: 3.704 ± 0.095
5.025PheLeu: 5.025 ± 0.129
1.069PheMet: 1.069 ± 0.043
2.777PheAsn: 2.777 ± 0.077
1.907PhePro: 1.907 ± 0.068
1.795PheGln: 1.795 ± 0.069
1.63PheArg: 1.63 ± 0.058
5.455PheSer: 5.455 ± 0.126
2.467PheThr: 2.467 ± 0.071
2.742PheVal: 2.742 ± 0.11
0.44PheTrp: 0.44 ± 0.029
1.934PheTyr: 1.934 ± 0.066
0.0PheXaa: 0.0 ± 0.0
Gly
3.658GlyAla: 3.658 ± 0.097
0.825GlyCys: 0.825 ± 0.037
3.216GlyAsp: 3.216 ± 0.104
3.125GlyGlu: 3.125 ± 0.103
3.166GlyPhe: 3.166 ± 0.102
3.919GlyGly: 3.919 ± 0.12
1.477GlyHis: 1.477 ± 0.058
5.001GlyIle: 5.001 ± 0.114
4.262GlyLys: 4.262 ± 0.106
5.817GlyLeu: 5.817 ± 0.124
1.456GlyMet: 1.456 ± 0.064
2.684GlyAsn: 2.684 ± 0.097
1.584GlyPro: 1.584 ± 0.06
1.791GlyGln: 1.791 ± 0.056
2.192GlyArg: 2.192 ± 0.081
4.264GlySer: 4.264 ± 0.098
3.005GlyThr: 3.005 ± 0.106
4.457GlyVal: 4.457 ± 0.113
0.529GlyTrp: 0.529 ± 0.034
2.209GlyTyr: 2.209 ± 0.078
0.0GlyXaa: 0.0 ± 0.0
His
1.264HisAla: 1.264 ± 0.056
0.401HisCys: 0.401 ± 0.036
1.226HisAsp: 1.226 ± 0.056
1.276HisGlu: 1.276 ± 0.053
1.553HisPhe: 1.553 ± 0.065
1.233HisGly: 1.233 ± 0.062
0.916HisHis: 0.916 ± 0.056
2.103HisIle: 2.103 ± 0.072
1.47HisLys: 1.47 ± 0.066
2.548HisLeu: 2.548 ± 0.085
0.447HisMet: 0.447 ± 0.026
0.991HisAsn: 0.991 ± 0.052
1.181HisPro: 1.181 ± 0.055
0.945HisGln: 0.945 ± 0.044
0.873HisArg: 0.873 ± 0.05
2.076HisSer: 2.076 ± 0.082
1.164HisThr: 1.164 ± 0.05
1.534HisVal: 1.534 ± 0.061
0.219HisTrp: 0.219 ± 0.019
1.257HisTyr: 1.257 ± 0.058
0.0HisXaa: 0.0 ± 0.0
Ile
4.384IleAla: 4.384 ± 0.106
1.051IleCys: 1.051 ± 0.054
4.847IleAsp: 4.847 ± 0.108
5.292IleGlu: 5.292 ± 0.117
3.631IlePhe: 3.631 ± 0.112
4.649IleGly: 4.649 ± 0.128
2.093IleHis: 2.093 ± 0.071
5.939IleIle: 5.939 ± 0.17
6.367IleLys: 6.367 ± 0.157
6.949IleLeu: 6.949 ± 0.17
1.454IleMet: 1.454 ± 0.053
4.275IleAsn: 4.275 ± 0.125
3.361IlePro: 3.361 ± 0.09
3.29IleGln: 3.29 ± 0.08
2.864IleArg: 2.864 ± 0.081
6.978IleSer: 6.978 ± 0.164
4.471IleThr: 4.471 ± 0.112
4.461IleVal: 4.461 ± 0.107
0.49IleTrp: 0.49 ± 0.032
2.368IleTyr: 2.368 ± 0.076
0.0IleXaa: 0.0 ± 0.0
Lys
4.434LysAla: 4.434 ± 0.112
0.881LysCys: 0.881 ± 0.047
4.645LysAsp: 4.645 ± 0.113
7.031LysGlu: 7.031 ± 0.163
2.085LysPhe: 2.085 ± 0.063
4.351LysGly: 4.351 ± 0.113
1.929LysHis: 1.929 ± 0.072
5.172LysIle: 5.172 ± 0.129
8.355LysLys: 8.355 ± 0.214
5.809LysLeu: 5.809 ± 0.122
1.696LysMet: 1.696 ± 0.06
4.372LysAsn: 4.372 ± 0.152
2.333LysPro: 2.333 ± 0.077
3.377LysGln: 3.377 ± 0.098
3.332LysArg: 3.332 ± 0.094
5.424LysSer: 5.424 ± 0.097
4.8LysThr: 4.8 ± 0.135
4.14LysVal: 4.14 ± 0.101
0.713LysTrp: 0.713 ± 0.045
2.227LysTyr: 2.227 ± 0.076
0.0LysXaa: 0.0 ± 0.0
Leu
5.261LeuAla: 5.261 ± 0.135
1.425LeuCys: 1.425 ± 0.062
5.518LeuAsp: 5.518 ± 0.13
6.43LeuGlu: 6.43 ± 0.146
5.364LeuPhe: 5.364 ± 0.144
6.061LeuGly: 6.061 ± 0.14
2.271LeuHis: 2.271 ± 0.073
7.224LeuIle: 7.224 ± 0.164
7.974LeuLys: 7.974 ± 0.165
9.571LeuLeu: 9.571 ± 0.189
2.043LeuMet: 2.043 ± 0.07
5.313LeuAsn: 5.313 ± 0.136
3.565LeuPro: 3.565 ± 0.099
3.21LeuGln: 3.21 ± 0.093
3.437LeuArg: 3.437 ± 0.11
9.738LeuSer: 9.738 ± 0.181
5.522LeuThr: 5.522 ± 0.1
5.094LeuVal: 5.094 ± 0.107
0.722LeuTrp: 0.722 ± 0.04
3.232LeuTyr: 3.232 ± 0.091
0.0LeuXaa: 0.0 ± 0.0
Met
1.326MetAla: 1.326 ± 0.058
0.184MetCys: 0.184 ± 0.018
1.059MetAsp: 1.059 ± 0.045
1.144MetGlu: 1.144 ± 0.053
0.895MetPhe: 0.895 ± 0.045
1.477MetGly: 1.477 ± 0.056
0.403MetHis: 0.403 ± 0.034
1.81MetIle: 1.81 ± 0.062
1.781MetLys: 1.781 ± 0.067
1.828MetLeu: 1.828 ± 0.062
0.556MetMet: 0.556 ± 0.038
1.173MetAsn: 1.173 ± 0.052
0.701MetPro: 0.701 ± 0.034
0.62MetGln: 0.62 ± 0.034
0.651MetArg: 0.651 ± 0.036
1.663MetSer: 1.663 ± 0.059
1.371MetThr: 1.371 ± 0.046
1.29MetVal: 1.29 ± 0.054
0.147MetTrp: 0.147 ± 0.018
0.697MetTyr: 0.697 ± 0.055
0.0MetXaa: 0.0 ± 0.0
Asn
2.668AsnAla: 2.668 ± 0.075
0.614AsnCys: 0.614 ± 0.036
2.393AsnAsp: 2.393 ± 0.069
3.032AsnGlu: 3.032 ± 0.088
2.025AsnPhe: 2.025 ± 0.066
2.428AsnGly: 2.428 ± 0.093
1.206AsnHis: 1.206 ± 0.056
4.523AsnIle: 4.523 ± 0.144
3.851AsnLys: 3.851 ± 0.115
4.026AsnLeu: 4.026 ± 0.11
1.069AsnMet: 1.069 ± 0.044
2.494AsnAsn: 2.494 ± 0.116
2.67AsnPro: 2.67 ± 0.097
1.942AsnGln: 1.942 ± 0.077
1.971AsnArg: 1.971 ± 0.066
3.594AsnSer: 3.594 ± 0.116
3.139AsnThr: 3.139 ± 0.102
2.841AsnVal: 2.841 ± 0.103
0.381AsnTrp: 0.381 ± 0.029
1.652AsnTyr: 1.652 ± 0.072
0.0AsnXaa: 0.0 ± 0.0
Pro
1.752ProAla: 1.752 ± 0.074
0.387ProCys: 0.387 ± 0.03
2.101ProAsp: 2.101 ± 0.078
2.684ProGlu: 2.684 ± 0.072
2.099ProPhe: 2.099 ± 0.082
1.923ProGly: 1.923 ± 0.072
0.982ProHis: 0.982 ± 0.047
2.823ProIle: 2.823 ± 0.087
2.647ProLys: 2.647 ± 0.079
3.828ProLeu: 3.828 ± 0.099
0.583ProMet: 0.583 ± 0.034
1.768ProAsn: 1.768 ± 0.074
1.319ProPro: 1.319 ± 0.075
1.317ProGln: 1.317 ± 0.062
1.133ProArg: 1.133 ± 0.051
3.243ProSer: 3.243 ± 0.105
2.213ProThr: 2.213 ± 0.075
2.31ProVal: 2.31 ± 0.074
0.308ProTrp: 0.308 ± 0.026
1.392ProTyr: 1.392 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
2.126GlnAla: 2.126 ± 0.075
0.608GlnCys: 0.608 ± 0.038
2.151GlnAsp: 2.151 ± 0.063
2.631GlnGlu: 2.631 ± 0.084
1.874GlnPhe: 1.874 ± 0.066
2.074GlnGly: 2.074 ± 0.08
1.046GlnHis: 1.046 ± 0.059
2.202GlnIle: 2.202 ± 0.065
3.392GlnLys: 3.392 ± 0.092
3.935GlnLeu: 3.935 ± 0.11
0.699GlnMet: 0.699 ± 0.043
1.847GlnAsn: 1.847 ± 0.067
0.926GlnPro: 0.926 ± 0.044
1.665GlnGln: 1.665 ± 0.076
1.609GlnArg: 1.609 ± 0.063
2.881GlnSer: 2.881 ± 0.081
1.977GlnThr: 1.977 ± 0.064
1.861GlnVal: 1.861 ± 0.07
0.378GlnTrp: 0.378 ± 0.028
1.402GlnTyr: 1.402 ± 0.062
0.0GlnXaa: 0.0 ± 0.0
Arg
1.946ArgAla: 1.946 ± 0.074
0.542ArgCys: 0.542 ± 0.036
1.938ArgAsp: 1.938 ± 0.063
2.355ArgGlu: 2.355 ± 0.093
2.114ArgPhe: 2.114 ± 0.067
1.992ArgGly: 1.992 ± 0.075
0.984ArgHis: 0.984 ± 0.052
2.672ArgIle: 2.672 ± 0.073
2.821ArgLys: 2.821 ± 0.093
3.9ArgLeu: 3.9 ± 0.116
0.802ArgMet: 0.802 ± 0.046
1.667ArgAsn: 1.667 ± 0.062
1.344ArgPro: 1.344 ± 0.055
1.45ArgGln: 1.45 ± 0.064
1.514ArgArg: 1.514 ± 0.066
2.639ArgSer: 2.639 ± 0.075
1.547ArgThr: 1.547 ± 0.062
2.511ArgVal: 2.511 ± 0.077
0.304ArgTrp: 0.304 ± 0.025
1.677ArgTyr: 1.677 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
3.971SerAla: 3.971 ± 0.092
1.09SerCys: 1.09 ± 0.049
4.481SerAsp: 4.481 ± 0.142
4.732SerGlu: 4.732 ± 0.118
5.098SerPhe: 5.098 ± 0.131
4.839SerGly: 4.839 ± 0.13
2.0SerHis: 2.0 ± 0.083
7.627SerIle: 7.627 ± 0.178
5.671SerLys: 5.671 ± 0.135
9.197SerLeu: 9.197 ± 0.19
1.71SerMet: 1.71 ± 0.061
3.396SerAsn: 3.396 ± 0.103
3.485SerPro: 3.485 ± 0.115
3.077SerGln: 3.077 ± 0.094
3.017SerArg: 3.017 ± 0.083
8.014SerSer: 8.014 ± 0.231
4.678SerThr: 4.678 ± 0.101
4.847SerVal: 4.847 ± 0.12
0.724SerTrp: 0.724 ± 0.043
2.904SerTyr: 2.904 ± 0.08
0.0SerXaa: 0.0 ± 0.0
Thr
3.102ThrAla: 3.102 ± 0.079
0.734ThrCys: 0.734 ± 0.039
2.877ThrAsp: 2.877 ± 0.094
3.009ThrGlu: 3.009 ± 0.08
2.953ThrPhe: 2.953 ± 0.089
3.319ThrGly: 3.319 ± 0.085
1.537ThrHis: 1.537 ± 0.06
4.295ThrIle: 4.295 ± 0.113
3.421ThrLys: 3.421 ± 0.111
6.831ThrLeu: 6.831 ± 0.13
0.949ThrMet: 0.949 ± 0.048
2.056ThrAsn: 2.056 ± 0.071
2.688ThrPro: 2.688 ± 0.093
2.275ThrGln: 2.275 ± 0.071
1.82ThrArg: 1.82 ± 0.074
4.258ThrSer: 4.258 ± 0.106
3.1ThrThr: 3.1 ± 0.094
3.363ThrVal: 3.363 ± 0.092
0.405ThrTrp: 0.405 ± 0.033
1.917ThrTyr: 1.917 ± 0.076
0.0ThrXaa: 0.0 ± 0.0
Val
3.245ValAla: 3.245 ± 0.097
0.788ValCys: 0.788 ± 0.043
3.741ValAsp: 3.741 ± 0.125
3.681ValGlu: 3.681 ± 0.095
3.234ValPhe: 3.234 ± 0.099
3.813ValGly: 3.813 ± 0.138
1.222ValHis: 1.222 ± 0.047
4.713ValIle: 4.713 ± 0.111
3.995ValLys: 3.995 ± 0.102
6.043ValLeu: 6.043 ± 0.142
1.336ValMet: 1.336 ± 0.056
2.775ValAsn: 2.775 ± 0.096
2.039ValPro: 2.039 ± 0.071
1.787ValGln: 1.787 ± 0.074
2.124ValArg: 2.124 ± 0.079
5.41ValSer: 5.41 ± 0.172
3.185ValThr: 3.185 ± 0.097
3.96ValVal: 3.96 ± 0.112
0.422ValTrp: 0.422 ± 0.031
1.977ValTyr: 1.977 ± 0.073
0.0ValXaa: 0.0 ± 0.0
Trp
0.432TrpAla: 0.432 ± 0.031
0.136TrpCys: 0.136 ± 0.015
0.426TrpAsp: 0.426 ± 0.034
0.488TrpGlu: 0.488 ± 0.031
0.449TrpPhe: 0.449 ± 0.033
0.556TrpGly: 0.556 ± 0.034
0.172TrpHis: 0.172 ± 0.019
0.707TrpIle: 0.707 ± 0.04
0.647TrpLys: 0.647 ± 0.035
0.724TrpLeu: 0.724 ± 0.041
0.25TrpMet: 0.25 ± 0.027
0.432TrpAsn: 0.432 ± 0.033
0.248TrpPro: 0.248 ± 0.021
0.221TrpGln: 0.221 ± 0.022
0.292TrpArg: 0.292 ± 0.024
0.515TrpSer: 0.515 ± 0.033
0.459TrpThr: 0.459 ± 0.03
0.529TrpVal: 0.529 ± 0.039
0.083TrpTrp: 0.083 ± 0.014
0.333TrpTyr: 0.333 ± 0.037
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.816TyrAla: 1.816 ± 0.056
0.521TyrCys: 0.521 ± 0.035
1.969TyrAsp: 1.969 ± 0.069
1.971TyrGlu: 1.971 ± 0.062
1.979TyrPhe: 1.979 ± 0.069
2.035TyrGly: 2.035 ± 0.067
0.852TyrHis: 0.852 ± 0.047
2.724TyrIle: 2.724 ± 0.087
2.432TyrLys: 2.432 ± 0.084
3.528TyrLeu: 3.528 ± 0.107
0.678TyrMet: 0.678 ± 0.035
1.725TyrAsn: 1.725 ± 0.069
1.441TyrPro: 1.441 ± 0.054
1.39TyrGln: 1.39 ± 0.061
1.543TyrArg: 1.543 ± 0.072
3.199TyrSer: 3.199 ± 0.105
1.985TyrThr: 1.985 ± 0.073
1.905TyrVal: 1.905 ± 0.064
0.331TyrTrp: 0.331 ± 0.031
1.293TyrTyr: 1.293 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1416 proteins (483552 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski