Amino acid dipepetide frequency for Streptococcus phage Javan101

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.451AlaAla: 4.451 ± 0.872
0.685AlaCys: 0.685 ± 0.254
3.852AlaAsp: 3.852 ± 0.558
3.681AlaGlu: 3.681 ± 0.744
2.311AlaPhe: 2.311 ± 0.41
5.051AlaGly: 5.051 ± 0.756
1.027AlaHis: 1.027 ± 0.304
4.708AlaIle: 4.708 ± 0.978
5.65AlaLys: 5.65 ± 0.544
6.078AlaLeu: 6.078 ± 1.2
2.397AlaMet: 2.397 ± 0.44
3.338AlaAsn: 3.338 ± 0.533
1.37AlaPro: 1.37 ± 0.332
3.338AlaGln: 3.338 ± 0.488
3.681AlaArg: 3.681 ± 0.572
4.28AlaSer: 4.28 ± 0.691
5.222AlaThr: 5.222 ± 0.764
4.879AlaVal: 4.879 ± 0.728
0.599AlaTrp: 0.599 ± 0.178
3.681AlaTyr: 3.681 ± 0.518
0.0AlaXaa: 0.0 ± 0.0
Cys
0.257CysAla: 0.257 ± 0.177
0.171CysCys: 0.171 ± 0.113
0.428CysAsp: 0.428 ± 0.178
0.685CysGlu: 0.685 ± 0.268
0.086CysPhe: 0.086 ± 0.092
1.027CysGly: 1.027 ± 0.376
0.257CysHis: 0.257 ± 0.136
0.428CysIle: 0.428 ± 0.176
0.342CysLys: 0.342 ± 0.229
0.942CysLeu: 0.942 ± 0.286
0.086CysMet: 0.086 ± 0.073
0.257CysAsn: 0.257 ± 0.151
0.428CysPro: 0.428 ± 0.169
0.685CysGln: 0.685 ± 0.203
0.856CysArg: 0.856 ± 0.239
0.599CysSer: 0.599 ± 0.214
0.257CysThr: 0.257 ± 0.12
0.428CysVal: 0.428 ± 0.152
0.0CysTrp: 0.0 ± 0.0
0.685CysTyr: 0.685 ± 0.263
0.0CysXaa: 0.0 ± 0.0
Asp
3.082AspAla: 3.082 ± 0.503
0.599AspCys: 0.599 ± 0.174
3.51AspAsp: 3.51 ± 0.865
4.622AspGlu: 4.622 ± 0.671
2.996AspPhe: 2.996 ± 0.385
4.708AspGly: 4.708 ± 0.662
1.626AspHis: 1.626 ± 0.37
3.595AspIle: 3.595 ± 0.415
4.537AspLys: 4.537 ± 0.483
6.506AspLeu: 6.506 ± 0.914
2.054AspMet: 2.054 ± 0.317
2.14AspAsn: 2.14 ± 0.461
1.455AspPro: 1.455 ± 0.471
1.883AspGln: 1.883 ± 0.39
2.054AspArg: 2.054 ± 0.62
2.91AspSer: 2.91 ± 0.465
3.082AspThr: 3.082 ± 0.405
3.167AspVal: 3.167 ± 0.573
0.856AspTrp: 0.856 ± 0.231
3.338AspTyr: 3.338 ± 0.61
0.0AspXaa: 0.0 ± 0.0
Glu
5.821GluAla: 5.821 ± 0.786
0.685GluCys: 0.685 ± 0.275
4.109GluAsp: 4.109 ± 0.658
6.848GluGlu: 6.848 ± 0.94
2.397GluPhe: 2.397 ± 0.412
5.564GluGly: 5.564 ± 0.52
1.113GluHis: 1.113 ± 0.246
3.253GluIle: 3.253 ± 0.593
5.907GluLys: 5.907 ± 0.753
8.132GluLeu: 8.132 ± 0.905
2.054GluMet: 2.054 ± 0.544
3.338GluAsn: 3.338 ± 0.519
1.969GluPro: 1.969 ± 0.442
3.938GluGln: 3.938 ± 0.64
2.226GluArg: 2.226 ± 0.461
3.253GluSer: 3.253 ± 0.558
4.622GluThr: 4.622 ± 0.645
4.537GluVal: 4.537 ± 0.518
0.77GluTrp: 0.77 ± 0.312
1.284GluTyr: 1.284 ± 0.252
0.0GluXaa: 0.0 ± 0.0
Phe
1.712PheAla: 1.712 ± 0.485
0.685PheCys: 0.685 ± 0.228
2.739PheAsp: 2.739 ± 0.447
2.568PheGlu: 2.568 ± 0.556
1.37PhePhe: 1.37 ± 0.464
3.082PheGly: 3.082 ± 0.478
0.77PheHis: 0.77 ± 0.296
1.883PheIle: 1.883 ± 0.413
3.082PheLys: 3.082 ± 0.558
2.568PheLeu: 2.568 ± 0.553
0.856PheMet: 0.856 ± 0.298
1.798PheAsn: 1.798 ± 0.264
0.599PhePro: 0.599 ± 0.229
1.798PheGln: 1.798 ± 0.363
1.455PheArg: 1.455 ± 0.277
2.482PheSer: 2.482 ± 0.442
2.311PheThr: 2.311 ± 0.371
1.626PheVal: 1.626 ± 0.344
0.599PheTrp: 0.599 ± 0.197
2.054PheTyr: 2.054 ± 0.423
0.0PheXaa: 0.0 ± 0.0
Gly
3.51GlyAla: 3.51 ± 0.612
0.086GlyCys: 0.086 ± 0.082
4.28GlyAsp: 4.28 ± 0.592
4.28GlyGlu: 4.28 ± 0.561
2.397GlyPhe: 2.397 ± 0.489
5.393GlyGly: 5.393 ± 0.927
2.14GlyHis: 2.14 ± 0.548
5.136GlyIle: 5.136 ± 0.673
5.992GlyLys: 5.992 ± 0.761
6.078GlyLeu: 6.078 ± 0.751
1.883GlyMet: 1.883 ± 0.333
3.424GlyAsn: 3.424 ± 0.549
0.77GlyPro: 0.77 ± 0.196
2.996GlyGln: 2.996 ± 0.499
3.852GlyArg: 3.852 ± 0.609
4.451GlySer: 4.451 ± 1.113
4.708GlyThr: 4.708 ± 0.718
4.879GlyVal: 4.879 ± 0.77
0.685GlyTrp: 0.685 ± 0.223
2.568GlyTyr: 2.568 ± 0.467
0.0GlyXaa: 0.0 ± 0.0
His
1.027HisAla: 1.027 ± 0.213
0.171HisCys: 0.171 ± 0.104
1.37HisAsp: 1.37 ± 0.342
0.856HisGlu: 0.856 ± 0.259
1.198HisPhe: 1.198 ± 0.381
1.113HisGly: 1.113 ± 0.335
0.77HisHis: 0.77 ± 0.263
1.284HisIle: 1.284 ± 0.299
1.113HisLys: 1.113 ± 0.24
2.311HisLeu: 2.311 ± 0.377
0.428HisMet: 0.428 ± 0.214
1.198HisAsn: 1.198 ± 0.229
1.113HisPro: 1.113 ± 0.351
0.77HisGln: 0.77 ± 0.303
1.37HisArg: 1.37 ± 0.331
1.284HisSer: 1.284 ± 0.256
0.856HisThr: 0.856 ± 0.334
1.284HisVal: 1.284 ± 0.328
0.171HisTrp: 0.171 ± 0.128
0.599HisTyr: 0.599 ± 0.299
0.0HisXaa: 0.0 ± 0.0
Ile
4.965IleAla: 4.965 ± 0.419
0.514IleCys: 0.514 ± 0.204
4.794IleAsp: 4.794 ± 0.517
3.51IleGlu: 3.51 ± 0.499
1.37IlePhe: 1.37 ± 0.436
3.938IleGly: 3.938 ± 0.651
0.856IleHis: 0.856 ± 0.277
2.91IleIle: 2.91 ± 0.474
5.051IleLys: 5.051 ± 0.909
5.393IleLeu: 5.393 ± 0.67
1.198IleMet: 1.198 ± 0.339
2.054IleAsn: 2.054 ± 0.514
1.798IlePro: 1.798 ± 0.377
2.311IleGln: 2.311 ± 0.379
2.482IleArg: 2.482 ± 0.473
4.28IleSer: 4.28 ± 0.814
4.109IleThr: 4.109 ± 0.729
3.167IleVal: 3.167 ± 0.55
1.284IleTrp: 1.284 ± 0.347
2.054IleTyr: 2.054 ± 0.399
0.0IleXaa: 0.0 ± 0.0
Lys
7.276LysAla: 7.276 ± 0.777
0.599LysCys: 0.599 ± 0.225
3.852LysAsp: 3.852 ± 0.667
5.136LysGlu: 5.136 ± 0.412
1.969LysPhe: 1.969 ± 0.284
5.65LysGly: 5.65 ± 0.52
1.883LysHis: 1.883 ± 0.394
4.194LysIle: 4.194 ± 0.564
4.708LysLys: 4.708 ± 0.704
5.735LysLeu: 5.735 ± 0.835
1.712LysMet: 1.712 ± 0.394
2.568LysAsn: 2.568 ± 0.498
2.568LysPro: 2.568 ± 0.412
3.51LysGln: 3.51 ± 0.519
5.222LysArg: 5.222 ± 0.809
4.28LysSer: 4.28 ± 0.5
4.708LysThr: 4.708 ± 0.637
4.965LysVal: 4.965 ± 0.788
0.942LysTrp: 0.942 ± 0.219
1.969LysTyr: 1.969 ± 0.408
0.0LysXaa: 0.0 ± 0.0
Leu
6.848LeuAla: 6.848 ± 0.796
0.599LeuCys: 0.599 ± 0.223
4.879LeuAsp: 4.879 ± 0.602
7.79LeuGlu: 7.79 ± 0.726
2.739LeuPhe: 2.739 ± 0.477
6.163LeuGly: 6.163 ± 0.656
1.198LeuHis: 1.198 ± 0.337
4.366LeuIle: 4.366 ± 0.617
7.019LeuLys: 7.019 ± 0.726
7.875LeuLeu: 7.875 ± 0.773
2.226LeuMet: 2.226 ± 0.387
3.938LeuAsn: 3.938 ± 0.565
3.766LeuPro: 3.766 ± 0.667
3.766LeuGln: 3.766 ± 0.583
3.766LeuArg: 3.766 ± 0.604
7.533LeuSer: 7.533 ± 0.851
7.191LeuThr: 7.191 ± 0.648
6.163LeuVal: 6.163 ± 0.806
0.77LeuTrp: 0.77 ± 0.196
3.852LeuTyr: 3.852 ± 0.791
0.0LeuXaa: 0.0 ± 0.0
Met
2.482MetAla: 2.482 ± 0.427
0.086MetCys: 0.086 ± 0.076
1.37MetAsp: 1.37 ± 0.36
1.455MetGlu: 1.455 ± 0.417
0.856MetPhe: 0.856 ± 0.238
1.883MetGly: 1.883 ± 0.491
0.0MetHis: 0.0 ± 0.0
1.284MetIle: 1.284 ± 0.375
1.626MetLys: 1.626 ± 0.368
1.37MetLeu: 1.37 ± 0.393
0.685MetMet: 0.685 ± 0.26
0.685MetAsn: 0.685 ± 0.217
0.514MetPro: 0.514 ± 0.186
0.514MetGln: 0.514 ± 0.177
1.284MetArg: 1.284 ± 0.329
2.14MetSer: 2.14 ± 0.42
3.082MetThr: 3.082 ± 0.503
1.541MetVal: 1.541 ± 0.296
0.086MetTrp: 0.086 ± 0.082
0.428MetTyr: 0.428 ± 0.206
0.0MetXaa: 0.0 ± 0.0
Asn
3.766AsnAla: 3.766 ± 0.588
0.342AsnCys: 0.342 ± 0.229
1.712AsnAsp: 1.712 ± 0.366
2.739AsnGlu: 2.739 ± 0.441
1.712AsnPhe: 1.712 ± 0.457
4.451AsnGly: 4.451 ± 0.847
0.77AsnHis: 0.77 ± 0.28
1.969AsnIle: 1.969 ± 0.373
2.996AsnLys: 2.996 ± 0.51
3.253AsnLeu: 3.253 ± 0.465
0.77AsnMet: 0.77 ± 0.285
1.712AsnAsn: 1.712 ± 0.569
1.969AsnPro: 1.969 ± 0.354
2.226AsnGln: 2.226 ± 0.436
1.969AsnArg: 1.969 ± 0.324
3.424AsnSer: 3.424 ± 0.424
2.739AsnThr: 2.739 ± 0.587
2.226AsnVal: 2.226 ± 0.451
1.027AsnTrp: 1.027 ± 0.367
0.942AsnTyr: 0.942 ± 0.288
0.0AsnXaa: 0.0 ± 0.0
Pro
1.198ProAla: 1.198 ± 0.328
0.257ProCys: 0.257 ± 0.131
2.054ProAsp: 2.054 ± 0.514
2.311ProGlu: 2.311 ± 0.541
1.113ProPhe: 1.113 ± 0.354
1.198ProGly: 1.198 ± 0.366
0.942ProHis: 0.942 ± 0.248
1.883ProIle: 1.883 ± 0.381
2.482ProLys: 2.482 ± 0.379
2.654ProLeu: 2.654 ± 0.337
0.342ProMet: 0.342 ± 0.155
1.798ProAsn: 1.798 ± 0.428
0.942ProPro: 0.942 ± 0.362
1.455ProGln: 1.455 ± 0.322
1.113ProArg: 1.113 ± 0.274
2.568ProSer: 2.568 ± 0.487
2.226ProThr: 2.226 ± 0.429
1.969ProVal: 1.969 ± 0.397
0.428ProTrp: 0.428 ± 0.188
1.626ProTyr: 1.626 ± 0.354
0.0ProXaa: 0.0 ± 0.0
Gln
3.852GlnAla: 3.852 ± 0.763
0.342GlnCys: 0.342 ± 0.172
1.969GlnAsp: 1.969 ± 0.396
3.766GlnGlu: 3.766 ± 0.622
1.798GlnPhe: 1.798 ± 0.432
2.397GlnGly: 2.397 ± 0.433
0.685GlnHis: 0.685 ± 0.226
2.568GlnIle: 2.568 ± 0.357
3.338GlnLys: 3.338 ± 0.443
4.879GlnLeu: 4.879 ± 0.565
1.284GlnMet: 1.284 ± 0.337
2.054GlnAsn: 2.054 ± 0.419
1.541GlnPro: 1.541 ± 0.382
1.969GlnGln: 1.969 ± 0.528
1.541GlnArg: 1.541 ± 0.369
2.739GlnSer: 2.739 ± 0.417
3.167GlnThr: 3.167 ± 0.486
3.167GlnVal: 3.167 ± 0.471
0.685GlnTrp: 0.685 ± 0.265
0.599GlnTyr: 0.599 ± 0.224
0.0GlnXaa: 0.0 ± 0.0
Arg
2.654ArgAla: 2.654 ± 0.51
0.685ArgCys: 0.685 ± 0.356
2.226ArgAsp: 2.226 ± 0.533
3.595ArgGlu: 3.595 ± 0.45
1.712ArgPhe: 1.712 ± 0.485
2.311ArgGly: 2.311 ± 0.43
1.113ArgHis: 1.113 ± 0.33
2.054ArgIle: 2.054 ± 0.446
3.938ArgLys: 3.938 ± 0.733
5.136ArgLeu: 5.136 ± 0.615
0.599ArgMet: 0.599 ± 0.223
2.14ArgAsn: 2.14 ± 0.429
1.455ArgPro: 1.455 ± 0.335
3.51ArgGln: 3.51 ± 0.413
2.739ArgArg: 2.739 ± 0.608
2.91ArgSer: 2.91 ± 0.368
1.969ArgThr: 1.969 ± 0.493
3.595ArgVal: 3.595 ± 0.672
0.856ArgTrp: 0.856 ± 0.283
1.712ArgTyr: 1.712 ± 0.383
0.0ArgXaa: 0.0 ± 0.0
Ser
5.307SerAla: 5.307 ± 0.673
0.342SerCys: 0.342 ± 0.155
4.366SerAsp: 4.366 ± 0.712
4.622SerGlu: 4.622 ± 0.732
2.654SerPhe: 2.654 ± 0.422
4.879SerGly: 4.879 ± 0.761
1.883SerHis: 1.883 ± 0.38
4.28SerIle: 4.28 ± 0.906
4.366SerLys: 4.366 ± 0.698
5.907SerLeu: 5.907 ± 0.776
1.284SerMet: 1.284 ± 0.39
2.739SerAsn: 2.739 ± 0.567
1.969SerPro: 1.969 ± 0.484
2.482SerGln: 2.482 ± 0.446
2.996SerArg: 2.996 ± 0.452
5.307SerSer: 5.307 ± 0.934
4.28SerThr: 4.28 ± 0.856
4.537SerVal: 4.537 ± 0.458
1.541SerTrp: 1.541 ± 0.317
2.397SerTyr: 2.397 ± 0.455
0.0SerXaa: 0.0 ± 0.0
Thr
4.965ThrAla: 4.965 ± 0.671
0.428ThrCys: 0.428 ± 0.189
3.595ThrAsp: 3.595 ± 0.581
4.28ThrGlu: 4.28 ± 0.494
3.253ThrPhe: 3.253 ± 0.714
3.766ThrGly: 3.766 ± 0.651
0.942ThrHis: 0.942 ± 0.241
5.479ThrIle: 5.479 ± 1.191
5.051ThrLys: 5.051 ± 0.531
5.992ThrLeu: 5.992 ± 0.907
1.027ThrMet: 1.027 ± 0.263
2.739ThrAsn: 2.739 ± 0.383
2.996ThrPro: 2.996 ± 0.633
2.482ThrGln: 2.482 ± 0.488
2.226ThrArg: 2.226 ± 0.411
5.564ThrSer: 5.564 ± 0.707
5.222ThrThr: 5.222 ± 0.656
5.907ThrVal: 5.907 ± 0.77
1.027ThrTrp: 1.027 ± 0.263
2.397ThrTyr: 2.397 ± 0.378
0.0ThrXaa: 0.0 ± 0.0
Val
3.424ValAla: 3.424 ± 0.508
0.514ValCys: 0.514 ± 0.18
3.595ValAsp: 3.595 ± 0.583
5.393ValGlu: 5.393 ± 0.645
2.14ValPhe: 2.14 ± 0.449
3.766ValGly: 3.766 ± 0.576
1.027ValHis: 1.027 ± 0.23
4.451ValIle: 4.451 ± 0.68
3.595ValLys: 3.595 ± 0.49
7.191ValLeu: 7.191 ± 0.73
1.198ValMet: 1.198 ± 0.445
2.226ValAsn: 2.226 ± 0.386
2.054ValPro: 2.054 ± 0.479
1.883ValGln: 1.883 ± 0.269
3.338ValArg: 3.338 ± 0.531
5.051ValSer: 5.051 ± 0.622
5.992ValThr: 5.992 ± 0.836
3.852ValVal: 3.852 ± 0.615
1.455ValTrp: 1.455 ± 0.384
2.654ValTyr: 2.654 ± 0.564
0.0ValXaa: 0.0 ± 0.0
Trp
0.856TrpAla: 0.856 ± 0.262
0.257TrpCys: 0.257 ± 0.136
0.856TrpAsp: 0.856 ± 0.289
1.113TrpGlu: 1.113 ± 0.244
0.856TrpPhe: 0.856 ± 0.331
0.599TrpGly: 0.599 ± 0.177
0.257TrpHis: 0.257 ± 0.142
0.685TrpIle: 0.685 ± 0.258
0.599TrpLys: 0.599 ± 0.239
1.284TrpLeu: 1.284 ± 0.243
0.428TrpMet: 0.428 ± 0.157
1.284TrpAsn: 1.284 ± 0.387
0.086TrpPro: 0.086 ± 0.081
0.77TrpGln: 0.77 ± 0.219
0.942TrpArg: 0.942 ± 0.286
1.113TrpSer: 1.113 ± 0.31
0.942TrpThr: 0.942 ± 0.319
0.942TrpVal: 0.942 ± 0.236
0.257TrpTrp: 0.257 ± 0.118
0.171TrpTyr: 0.171 ± 0.123
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.825TyrAla: 2.825 ± 0.429
0.856TyrCys: 0.856 ± 0.351
3.167TyrAsp: 3.167 ± 0.761
2.568TyrGlu: 2.568 ± 0.42
1.113TyrPhe: 1.113 ± 0.275
2.568TyrGly: 2.568 ± 0.514
1.027TyrHis: 1.027 ± 0.272
1.626TyrIle: 1.626 ± 0.448
2.054TyrLys: 2.054 ± 0.447
3.167TyrLeu: 3.167 ± 0.679
0.77TyrMet: 0.77 ± 0.26
1.37TyrAsn: 1.37 ± 0.282
1.198TyrPro: 1.198 ± 0.276
2.054TyrGln: 2.054 ± 0.426
1.798TyrArg: 1.798 ± 0.291
1.969TyrSer: 1.969 ± 0.434
2.654TyrThr: 2.654 ± 0.427
1.969TyrVal: 1.969 ± 0.299
0.257TyrTrp: 0.257 ± 0.155
1.027TyrTyr: 1.027 ± 0.343
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 39 proteins (11683 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski