Amino acid dipepetide frequency for Fowlpox virus (strain NVSL) (FPV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.722AlaAla: 1.722 ± 0.198
0.855AlaCys: 0.855 ± 0.1
2.428AlaAsp: 2.428 ± 0.182
1.375AlaGlu: 1.375 ± 0.138
1.325AlaPhe: 1.325 ± 0.11
1.4AlaGly: 1.4 ± 0.162
0.409AlaHis: 0.409 ± 0.069
4.249AlaIle: 4.249 ± 0.268
2.279AlaLys: 2.279 ± 0.151
3.183AlaLeu: 3.183 ± 0.189
0.892AlaMet: 0.892 ± 0.124
2.502AlaAsn: 2.502 ± 0.155
0.718AlaPro: 0.718 ± 0.111
0.471AlaGln: 0.471 ± 0.074
1.449AlaArg: 1.449 ± 0.143
2.366AlaSer: 2.366 ± 0.155
2.093AlaThr: 2.093 ± 0.159
2.75AlaVal: 2.75 ± 0.204
0.211AlaTrp: 0.211 ± 0.056
1.66AlaTyr: 1.66 ± 0.17
0.0AlaXaa: 0.0 ± 0.0
Cys
0.681CysAla: 0.681 ± 0.083
0.644CysCys: 0.644 ± 0.109
1.201CysAsp: 1.201 ± 0.126
1.09CysGlu: 1.09 ± 0.114
1.028CysPhe: 1.028 ± 0.11
1.102CysGly: 1.102 ± 0.128
0.347CysHis: 0.347 ± 0.064
2.428CysIle: 2.428 ± 0.183
1.932CysLys: 1.932 ± 0.15
1.598CysLeu: 1.598 ± 0.144
0.83CysMet: 0.83 ± 0.098
1.759CysAsn: 1.759 ± 0.142
0.793CysPro: 0.793 ± 0.084
0.235CysGln: 0.235 ± 0.049
0.929CysArg: 0.929 ± 0.096
1.548CysSer: 1.548 ± 0.167
1.016CysThr: 1.016 ± 0.102
1.263CysVal: 1.263 ± 0.128
0.161CysTrp: 0.161 ± 0.045
1.412CysTyr: 1.412 ± 0.164
0.0CysXaa: 0.0 ± 0.0
Asp
2.242AspAla: 2.242 ± 0.173
0.966AspCys: 0.966 ± 0.113
4.608AspAsp: 4.608 ± 0.374
3.53AspGlu: 3.53 ± 0.211
2.737AspPhe: 2.737 ± 0.199
2.576AspGly: 2.576 ± 0.224
1.152AspHis: 1.152 ± 0.122
8.237AspIle: 8.237 ± 0.36
5.252AspLys: 5.252 ± 0.296
4.694AspLeu: 4.694 ± 0.229
1.635AspMet: 1.635 ± 0.137
4.645AspAsn: 4.645 ± 0.275
1.821AspPro: 1.821 ± 0.174
0.979AspGln: 0.979 ± 0.121
2.391AspArg: 2.391 ± 0.22
4.385AspSer: 4.385 ± 0.251
4.199AspThr: 4.199 ± 0.281
3.815AspVal: 3.815 ± 0.225
0.421AspTrp: 0.421 ± 0.075
3.716AspTyr: 3.716 ± 0.235
0.0AspXaa: 0.0 ± 0.0
Glu
1.982GluAla: 1.982 ± 0.162
1.115GluCys: 1.115 ± 0.12
3.493GluAsp: 3.493 ± 0.228
3.889GluGlu: 3.889 ± 0.25
2.106GluPhe: 2.106 ± 0.162
1.833GluGly: 1.833 ± 0.146
1.102GluHis: 1.102 ± 0.104
5.066GluIle: 5.066 ± 0.308
4.905GluLys: 4.905 ± 0.271
6.404GluLeu: 6.404 ± 0.325
1.239GluMet: 1.239 ± 0.132
3.988GluAsn: 3.988 ± 0.235
1.387GluPro: 1.387 ± 0.149
1.214GluGln: 1.214 ± 0.13
1.895GluArg: 1.895 ± 0.17
3.865GluSer: 3.865 ± 0.233
3.171GluThr: 3.171 ± 0.184
2.985GluVal: 2.985 ± 0.197
0.372GluTrp: 0.372 ± 0.07
3.964GluTyr: 3.964 ± 0.231
0.012GluXaa: 0.012 ± 0.011
Phe
0.879PheAla: 0.879 ± 0.097
0.966PheCys: 0.966 ± 0.108
2.477PheAsp: 2.477 ± 0.183
2.093PheGlu: 2.093 ± 0.179
1.784PhePhe: 1.784 ± 0.193
1.524PheGly: 1.524 ± 0.117
0.768PheHis: 0.768 ± 0.105
4.682PheIle: 4.682 ± 0.261
3.406PheLys: 3.406 ± 0.202
3.728PheLeu: 3.728 ± 0.238
1.189PheMet: 1.189 ± 0.109
3.159PheAsn: 3.159 ± 0.218
1.573PhePro: 1.573 ± 0.123
0.78PheGln: 0.78 ± 0.105
1.462PheArg: 1.462 ± 0.143
3.815PheSer: 3.815 ± 0.23
2.898PheThr: 2.898 ± 0.198
2.638PheVal: 2.638 ± 0.164
0.434PheTrp: 0.434 ± 0.068
2.291PheTyr: 2.291 ± 0.15
0.0PheXaa: 0.0 ± 0.0
Gly
2.279GlyAla: 2.279 ± 0.28
0.917GlyCys: 0.917 ± 0.114
2.527GlyAsp: 2.527 ± 0.163
1.87GlyGlu: 1.87 ± 0.155
1.907GlyPhe: 1.907 ± 0.163
1.808GlyGly: 1.808 ± 0.229
0.656GlyHis: 0.656 ± 0.097
4.323GlyIle: 4.323 ± 0.225
3.097GlyLys: 3.097 ± 0.195
2.626GlyLeu: 2.626 ± 0.202
0.904GlyMet: 0.904 ± 0.091
3.196GlyAsn: 3.196 ± 0.223
0.768GlyPro: 0.768 ± 0.107
0.632GlyGln: 0.632 ± 0.086
2.019GlyArg: 2.019 ± 0.167
3.109GlySer: 3.109 ± 0.282
2.155GlyThr: 2.155 ± 0.169
2.155GlyVal: 2.155 ± 0.149
0.26GlyTrp: 0.26 ± 0.066
2.824GlyTyr: 2.824 ± 0.186
0.0GlyXaa: 0.0 ± 0.0
His
0.879HisAla: 0.879 ± 0.089
0.495HisCys: 0.495 ± 0.066
1.177HisAsp: 1.177 ± 0.127
0.966HisGlu: 0.966 ± 0.108
0.694HisPhe: 0.694 ± 0.108
1.177HisGly: 1.177 ± 0.153
0.458HisHis: 0.458 ± 0.078
2.044HisIle: 2.044 ± 0.158
1.548HisLys: 1.548 ± 0.13
1.561HisLeu: 1.561 ± 0.14
0.458HisMet: 0.458 ± 0.076
1.412HisAsn: 1.412 ± 0.143
0.718HisPro: 0.718 ± 0.087
0.458HisGln: 0.458 ± 0.065
0.966HisArg: 0.966 ± 0.101
1.412HisSer: 1.412 ± 0.133
1.04HisThr: 1.04 ± 0.093
1.263HisVal: 1.263 ± 0.127
0.161HisTrp: 0.161 ± 0.042
1.301HisTyr: 1.301 ± 0.14
0.0HisXaa: 0.0 ± 0.0
Ile
3.419IleAla: 3.419 ± 0.186
1.969IleCys: 1.969 ± 0.159
6.874IleAsp: 6.874 ± 0.306
5.884IleGlu: 5.884 ± 0.298
4.038IlePhe: 4.038 ± 0.276
3.542IleGly: 3.542 ± 0.174
2.081IleHis: 2.081 ± 0.171
8.906IleIle: 8.906 ± 0.402
9.067IleLys: 9.067 ± 0.513
9.228IleLeu: 9.228 ± 0.41
2.552IleMet: 2.552 ± 0.185
8.77IleAsn: 8.77 ± 0.364
3.22IlePro: 3.22 ± 0.197
1.969IleGln: 1.969 ± 0.152
4.087IleArg: 4.087 ± 0.248
8.348IleSer: 8.348 ± 0.333
5.958IleThr: 5.958 ± 0.292
5.202IleVal: 5.202 ± 0.242
0.446IleTrp: 0.446 ± 0.082
4.794IleTyr: 4.794 ± 0.251
0.0IleXaa: 0.0 ± 0.0
Lys
2.242LysAla: 2.242 ± 0.159
1.759LysCys: 1.759 ± 0.148
5.71LysAsp: 5.71 ± 0.307
5.537LysGlu: 5.537 ± 0.298
3.258LysPhe: 3.258 ± 0.243
2.96LysGly: 2.96 ± 0.206
2.069LysHis: 2.069 ± 0.139
7.308LysIle: 7.308 ± 0.357
7.221LysLys: 7.221 ± 0.367
7.258LysLeu: 7.258 ± 0.369
2.106LysMet: 2.106 ± 0.143
6.243LysAsn: 6.243 ± 0.329
2.353LysPro: 2.353 ± 0.198
2.304LysGln: 2.304 ± 0.202
3.097LysArg: 3.097 ± 0.204
5.549LysSer: 5.549 ± 0.234
4.571LysThr: 4.571 ± 0.234
4.41LysVal: 4.41 ± 0.211
0.607LysTrp: 0.607 ± 0.093
5.685LysTyr: 5.685 ± 0.275
0.0LysXaa: 0.0 ± 0.0
Leu
3.208LeuAla: 3.208 ± 0.202
1.994LeuCys: 1.994 ± 0.168
5.933LeuAsp: 5.933 ± 0.273
5.698LeuGlu: 5.698 ± 0.226
4.125LeuPhe: 4.125 ± 0.261
3.381LeuGly: 3.381 ± 0.211
2.775LeuHis: 2.775 ± 0.302
7.469LeuIle: 7.469 ± 0.297
7.345LeuLys: 7.345 ± 0.308
10.578LeuLeu: 10.578 ± 0.631
2.118LeuMet: 2.118 ± 0.131
4.93LeuAsn: 4.93 ± 0.298
3.32LeuPro: 3.32 ± 0.203
2.254LeuGln: 2.254 ± 0.146
3.481LeuArg: 3.481 ± 0.226
7.667LeuSer: 7.667 ± 0.337
4.447LeuThr: 4.447 ± 0.299
4.855LeuVal: 4.855 ± 0.238
0.396LeuTrp: 0.396 ± 0.078
5.116LeuTyr: 5.116 ± 0.269
0.0LeuXaa: 0.0 ± 0.0
Met
1.102MetAla: 1.102 ± 0.116
0.557MetCys: 0.557 ± 0.087
1.685MetAsp: 1.685 ± 0.125
1.784MetGlu: 1.784 ± 0.148
1.35MetPhe: 1.35 ± 0.118
1.016MetGly: 1.016 ± 0.101
0.495MetHis: 0.495 ± 0.094
2.13MetIle: 2.13 ± 0.174
2.242MetLys: 2.242 ± 0.178
2.799MetLeu: 2.799 ± 0.195
0.681MetMet: 0.681 ± 0.088
1.499MetAsn: 1.499 ± 0.132
0.694MetPro: 0.694 ± 0.098
0.495MetGln: 0.495 ± 0.061
0.817MetArg: 0.817 ± 0.106
2.056MetSer: 2.056 ± 0.149
1.065MetThr: 1.065 ± 0.116
1.362MetVal: 1.362 ± 0.116
0.124MetTrp: 0.124 ± 0.037
1.598MetTyr: 1.598 ± 0.156
0.0MetXaa: 0.0 ± 0.0
Asn
2.341AsnAla: 2.341 ± 0.225
1.35AsnCys: 1.35 ± 0.146
4.335AsnAsp: 4.335 ± 0.252
3.629AsnGlu: 3.629 ± 0.23
2.675AsnPhe: 2.675 ± 0.216
2.911AsnGly: 2.911 ± 0.189
1.35AsnHis: 1.35 ± 0.15
9.5AsnIle: 9.5 ± 0.427
6.391AsnLys: 6.391 ± 0.302
4.732AsnLeu: 4.732 ± 0.251
2.18AsnMet: 2.18 ± 0.181
6.045AsnAsn: 6.045 ± 0.333
2.031AsnPro: 2.031 ± 0.142
1.362AsnGln: 1.362 ± 0.132
3.171AsnArg: 3.171 ± 0.182
5.227AsnSer: 5.227 ± 0.233
5.239AsnThr: 5.239 ± 0.297
3.803AsnVal: 3.803 ± 0.23
0.446AsnTrp: 0.446 ± 0.07
3.629AsnTyr: 3.629 ± 0.22
0.0AsnXaa: 0.0 ± 0.0
Pro
0.632ProAla: 0.632 ± 0.117
0.718ProCys: 0.718 ± 0.097
2.279ProAsp: 2.279 ± 0.167
2.069ProGlu: 2.069 ± 0.179
1.598ProPhe: 1.598 ± 0.124
1.14ProGly: 1.14 ± 0.126
0.446ProHis: 0.446 ± 0.086
2.96ProIle: 2.96 ± 0.202
2.155ProLys: 2.155 ± 0.22
3.852ProLeu: 3.852 ± 0.308
0.632ProMet: 0.632 ± 0.082
2.168ProAsn: 2.168 ± 0.15
1.412ProPro: 1.412 ± 0.257
0.644ProGln: 0.644 ± 0.118
1.313ProArg: 1.313 ± 0.147
2.391ProSer: 2.391 ± 0.234
1.226ProThr: 1.226 ± 0.13
1.982ProVal: 1.982 ± 0.176
0.285ProTrp: 0.285 ± 0.053
1.61ProTyr: 1.61 ± 0.144
0.0ProXaa: 0.0 ± 0.0
Gln
0.718GlnAla: 0.718 ± 0.105
0.471GlnCys: 0.471 ± 0.069
1.338GlnAsp: 1.338 ± 0.109
1.313GlnGlu: 1.313 ± 0.147
0.718GlnPhe: 0.718 ± 0.119
0.867GlnGly: 0.867 ± 0.125
0.409GlnHis: 0.409 ± 0.082
1.474GlnIle: 1.474 ± 0.132
1.524GlnLys: 1.524 ± 0.131
2.391GlnLeu: 2.391 ± 0.14
0.508GlnMet: 0.508 ± 0.082
1.177GlnAsn: 1.177 ± 0.128
0.508GlnPro: 0.508 ± 0.09
0.731GlnGln: 0.731 ± 0.11
0.879GlnArg: 0.879 ± 0.116
1.672GlnSer: 1.672 ± 0.165
0.879GlnThr: 0.879 ± 0.098
1.016GlnVal: 1.016 ± 0.108
0.124GlnTrp: 0.124 ± 0.036
1.189GlnTyr: 1.189 ± 0.134
0.0GlnXaa: 0.0 ± 0.0
Arg
1.201ArgAla: 1.201 ± 0.132
1.04ArgCys: 1.04 ± 0.117
2.341ArgAsp: 2.341 ± 0.169
1.932ArgGlu: 1.932 ± 0.167
1.821ArgPhe: 1.821 ± 0.154
1.858ArgGly: 1.858 ± 0.162
1.065ArgHis: 1.065 ± 0.134
3.406ArgIle: 3.406 ± 0.212
3.357ArgLys: 3.357 ± 0.224
3.765ArgLeu: 3.765 ± 0.195
0.966ArgMet: 0.966 ± 0.106
3.208ArgAsn: 3.208 ± 0.218
1.065ArgPro: 1.065 ± 0.148
1.016ArgGln: 1.016 ± 0.118
2.205ArgArg: 2.205 ± 0.227
3.369ArgSer: 3.369 ± 0.213
2.341ArgThr: 2.341 ± 0.184
2.168ArgVal: 2.168 ± 0.162
0.471ArgTrp: 0.471 ± 0.066
2.725ArgTyr: 2.725 ± 0.186
0.0ArgXaa: 0.0 ± 0.0
Ser
2.353SerAla: 2.353 ± 0.182
1.746SerCys: 1.746 ± 0.127
4.756SerAsp: 4.756 ± 0.27
3.753SerGlu: 3.753 ± 0.198
3.654SerPhe: 3.654 ± 0.208
3.344SerGly: 3.344 ± 0.248
1.338SerHis: 1.338 ± 0.144
8.609SerIle: 8.609 ± 0.313
6.627SerLys: 6.627 ± 0.297
6.986SerLeu: 6.986 ± 0.33
1.883SerMet: 1.883 ± 0.149
5.14SerAsn: 5.14 ± 0.274
2.539SerPro: 2.539 ± 0.204
1.35SerGln: 1.35 ± 0.131
3.394SerArg: 3.394 ± 0.212
7.407SerSer: 7.407 ± 0.577
4.583SerThr: 4.583 ± 0.284
4.992SerVal: 4.992 ± 0.248
0.458SerTrp: 0.458 ± 0.068
3.976SerTyr: 3.976 ± 0.216
0.0SerXaa: 0.0 ± 0.0
Thr
2.279ThrAla: 2.279 ± 0.154
1.697ThrCys: 1.697 ± 0.182
3.629ThrAsp: 3.629 ± 0.179
3.282ThrGlu: 3.282 ± 0.202
2.304ThrPhe: 2.304 ± 0.17
2.527ThrGly: 2.527 ± 0.182
0.979ThrHis: 0.979 ± 0.093
5.537ThrIle: 5.537 ± 0.244
4.261ThrLys: 4.261 ± 0.252
4.595ThrLeu: 4.595 ± 0.233
1.412ThrMet: 1.412 ± 0.138
3.481ThrAsn: 3.481 ± 0.194
2.836ThrPro: 2.836 ± 0.222
1.016ThrGln: 1.016 ± 0.115
2.477ThrArg: 2.477 ± 0.162
5.054ThrSer: 5.054 ± 0.32
3.183ThrThr: 3.183 ± 0.231
3.555ThrVal: 3.555 ± 0.24
0.595ThrTrp: 0.595 ± 0.091
2.539ThrTyr: 2.539 ± 0.165
0.0ThrXaa: 0.0 ± 0.0
Val
1.833ValAla: 1.833 ± 0.181
1.239ValCys: 1.239 ± 0.122
3.381ValAsp: 3.381 ± 0.174
3.01ValGlu: 3.01 ± 0.178
2.626ValPhe: 2.626 ± 0.18
1.746ValGly: 1.746 ± 0.157
0.917ValHis: 0.917 ± 0.102
5.784ValIle: 5.784 ± 0.277
4.509ValLys: 4.509 ± 0.221
5.537ValLeu: 5.537 ± 0.291
1.511ValMet: 1.511 ± 0.142
4.348ValAsn: 4.348 ± 0.279
1.969ValPro: 1.969 ± 0.154
0.867ValGln: 0.867 ± 0.124
2.539ValArg: 2.539 ± 0.178
5.153ValSer: 5.153 ± 0.22
3.258ValThr: 3.258 ± 0.249
2.985ValVal: 2.985 ± 0.209
0.272ValTrp: 0.272 ± 0.055
3.22ValTyr: 3.22 ± 0.225
0.0ValXaa: 0.0 ± 0.0
Trp
0.211TrpAla: 0.211 ± 0.068
0.198TrpCys: 0.198 ± 0.052
0.334TrpAsp: 0.334 ± 0.057
0.421TrpGlu: 0.421 ± 0.074
0.347TrpPhe: 0.347 ± 0.062
0.099TrpGly: 0.099 ± 0.039
0.062TrpHis: 0.062 ± 0.032
0.892TrpIle: 0.892 ± 0.113
0.582TrpLys: 0.582 ± 0.087
0.706TrpLeu: 0.706 ± 0.089
0.347TrpMet: 0.347 ± 0.063
0.409TrpAsn: 0.409 ± 0.071
0.223TrpPro: 0.223 ± 0.051
0.111TrpGln: 0.111 ± 0.037
0.235TrpArg: 0.235 ± 0.056
0.322TrpSer: 0.322 ± 0.058
0.372TrpThr: 0.372 ± 0.069
0.372TrpVal: 0.372 ± 0.079
0.062TrpTrp: 0.062 ± 0.03
0.359TrpTyr: 0.359 ± 0.072
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.13TyrAla: 2.13 ± 0.173
1.301TyrCys: 1.301 ± 0.121
3.493TyrAsp: 3.493 ± 0.188
2.861TyrGlu: 2.861 ± 0.188
2.452TyrPhe: 2.452 ± 0.187
3.22TyrGly: 3.22 ± 0.218
1.313TyrHis: 1.313 ± 0.125
5.351TyrIle: 5.351 ± 0.274
4.546TyrLys: 4.546 ± 0.259
4.868TyrLeu: 4.868 ± 0.265
1.499TyrMet: 1.499 ± 0.123
4.273TyrAsn: 4.273 ± 0.239
1.561TyrPro: 1.561 ± 0.149
1.016TyrGln: 1.016 ± 0.123
2.502TyrArg: 2.502 ± 0.185
4.174TyrSer: 4.174 ± 0.196
3.542TyrThr: 3.542 ± 0.233
3.146TyrVal: 3.146 ± 0.2
0.359TyrTrp: 0.359 ± 0.064
3.468TyrTyr: 3.468 ± 0.23
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.012XaaArg: 0.012 ± 0.011
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 251 proteins (80735 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski