Amino acid dipepetide frequency for Pelotomaculum propionicicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.917AlaAla: 9.917 ± 0.145	1.179AlaCys: 1.179 ± 0.038	4.087AlaAsp: 4.087 ± 0.07	5.761AlaGlu: 5.761 ± 0.078	3.053AlaPhe: 3.053 ± 0.059	8.971AlaGly: 8.971 ± 0.124	1.26AlaHis: 1.26 ± 0.037	4.916AlaIle: 4.916 ± 0.083	4.296AlaLys: 4.296 ± 0.065	8.878AlaLeu: 8.878 ± 0.107	2.232AlaMet: 2.232 ± 0.049	2.633AlaAsn: 2.633 ± 0.05	2.922AlaPro: 2.922 ± 0.061	2.664AlaGln: 2.664 ± 0.056	5.468AlaArg: 5.468 ± 0.081	4.26AlaSer: 4.26 ± 0.065	3.48AlaThr: 3.48 ± 0.068	7.565AlaVal: 7.565 ± 0.099	0.826AlaTrp: 0.826 ± 0.033	2.402AlaTyr: 2.402 ± 0.048	0.001AlaXaa: 0.001 ± 0.001
Cys	0.981CysAla: 0.981 ± 0.032	0.263CysCys: 0.263 ± 0.016	0.609CysAsp: 0.609 ± 0.024	0.683CysGlu: 0.683 ± 0.026	0.543CysPhe: 0.543 ± 0.022	1.473CysGly: 1.473 ± 0.045	0.268CysHis: 0.268 ± 0.014	0.649CysIle: 0.649 ± 0.026	0.567CysLys: 0.567 ± 0.023	1.324CysLeu: 1.324 ± 0.037	0.286CysMet: 0.286 ± 0.015	0.46CysAsn: 0.46 ± 0.023	0.815CysPro: 0.815 ± 0.034	0.366CysGln: 0.366 ± 0.02	0.91CysArg: 0.91 ± 0.03	0.797CysSer: 0.797 ± 0.029	0.561CysThr: 0.561 ± 0.027	0.799CysVal: 0.799 ± 0.031	0.133CysTrp: 0.133 ± 0.011	0.396CysTyr: 0.396 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.568AspAla: 3.568 ± 0.059	0.621AspCys: 0.621 ± 0.026	2.212AspAsp: 2.212 ± 0.054	3.422AspGlu: 3.422 ± 0.072	2.323AspPhe: 2.323 ± 0.052	3.619AspGly: 3.619 ± 0.069	0.848AspHis: 0.848 ± 0.025	3.937AspIle: 3.937 ± 0.064	2.813AspLys: 2.813 ± 0.052	5.573AspLeu: 5.573 ± 0.07	1.281AspMet: 1.281 ± 0.037	1.823AspAsn: 1.823 ± 0.041	2.435AspPro: 2.435 ± 0.054	1.638AspGln: 1.638 ± 0.045	2.895AspArg: 2.895 ± 0.055	2.565AspSer: 2.565 ± 0.052	2.415AspThr: 2.415 ± 0.054	3.366AspVal: 3.366 ± 0.061	0.61AspTrp: 0.61 ± 0.025	2.032AspTyr: 2.032 ± 0.048	0.001AspXaa: 0.001 ± 0.001
Glu	6.001GluAla: 6.001 ± 0.091	0.633GluCys: 0.633 ± 0.027	3.156GluAsp: 3.156 ± 0.061	5.629GluGlu: 5.629 ± 0.091	2.247GluPhe: 2.247 ± 0.048	4.361GluGly: 4.361 ± 0.069	1.173GluHis: 1.173 ± 0.036	5.52GluIle: 5.52 ± 0.081	5.429GluLys: 5.429 ± 0.073	6.739GluLeu: 6.739 ± 0.098	2.094GluMet: 2.094 ± 0.049	2.954GluAsn: 2.954 ± 0.055	2.18GluPro: 2.18 ± 0.05	2.672GluGln: 2.672 ± 0.052	3.705GluArg: 3.705 ± 0.065	3.022GluSer: 3.022 ± 0.051	3.174GluThr: 3.174 ± 0.05	4.938GluVal: 4.938 ± 0.065	0.578GluTrp: 0.578 ± 0.023	2.174GluTyr: 2.174 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.024PheAla: 3.024 ± 0.06	0.629PheCys: 0.629 ± 0.022	2.078PheAsp: 2.078 ± 0.042	2.258PheGlu: 2.258 ± 0.045	1.89PhePhe: 1.89 ± 0.043	2.889PheGly: 2.889 ± 0.054	0.712PheHis: 0.712 ± 0.027	2.862PheIle: 2.862 ± 0.048	2.272PheLys: 2.272 ± 0.046	4.144PheLeu: 4.144 ± 0.068	0.973PheMet: 0.973 ± 0.034	1.754PheAsn: 1.754 ± 0.043	1.7PhePro: 1.7 ± 0.038	1.126PheGln: 1.126 ± 0.034	1.841PheArg: 1.841 ± 0.043	2.607PheSer: 2.607 ± 0.052	2.249PheThr: 2.249 ± 0.045	2.449PheVal: 2.449 ± 0.05	0.484PheTrp: 0.484 ± 0.024	1.431PheTyr: 1.431 ± 0.041	0.002PheXaa: 0.002 ± 0.002
Gly	6.487GlyAla: 6.487 ± 0.099	1.176GlyCys: 1.176 ± 0.033	3.759GlyAsp: 3.759 ± 0.071	4.985GlyGlu: 4.985 ± 0.065	3.274GlyPhe: 3.274 ± 0.058	6.18GlyGly: 6.18 ± 0.103	1.434GlyHis: 1.434 ± 0.039	5.605GlyIle: 5.605 ± 0.077	5.017GlyLys: 5.017 ± 0.071	7.964GlyLeu: 7.964 ± 0.095	2.19GlyMet: 2.19 ± 0.048	2.623GlyAsn: 2.623 ± 0.048	2.465GlyPro: 2.465 ± 0.052	2.782GlyGln: 2.782 ± 0.061	4.658GlyArg: 4.658 ± 0.067	4.622GlySer: 4.622 ± 0.066	3.956GlyThr: 3.956 ± 0.073	5.927GlyVal: 5.927 ± 0.082	0.883GlyTrp: 0.883 ± 0.031	2.811GlyTyr: 2.811 ± 0.056	0.003GlyXaa: 0.003 ± 0.002
His	1.196HisAla: 1.196 ± 0.036	0.307HisCys: 0.307 ± 0.018	0.779HisAsp: 0.779 ± 0.027	0.925HisGlu: 0.925 ± 0.033	0.806HisPhe: 0.806 ± 0.028	1.355HisGly: 1.355 ± 0.036	0.421HisHis: 0.421 ± 0.024	1.128HisIle: 1.128 ± 0.034	0.83HisLys: 0.83 ± 0.028	1.861HisLeu: 1.861 ± 0.048	0.392HisMet: 0.392 ± 0.017	0.641HisAsn: 0.641 ± 0.022	1.004HisPro: 1.004 ± 0.032	0.563HisGln: 0.563 ± 0.024	0.999HisArg: 0.999 ± 0.031	1.001HisSer: 1.001 ± 0.032	0.879HisThr: 0.879 ± 0.03	1.027HisVal: 1.027 ± 0.035	0.206HisTrp: 0.206 ± 0.013	0.643HisTyr: 0.643 ± 0.023	0.001HisXaa: 0.001 ± 0.001
Ile	5.642IleAla: 5.642 ± 0.067	0.902IleCys: 0.902 ± 0.03	3.579IleAsp: 3.579 ± 0.065	4.501IleGlu: 4.501 ± 0.072	2.71IlePhe: 2.71 ± 0.056	4.752IleGly: 4.752 ± 0.064	1.009IleHis: 1.009 ± 0.035	5.081IleIle: 5.081 ± 0.081	4.486IleLys: 4.486 ± 0.073	6.381IleLeu: 6.381 ± 0.086	1.652IleMet: 1.652 ± 0.04	3.1IleAsn: 3.1 ± 0.057	3.243IlePro: 3.243 ± 0.06	1.815IleGln: 1.815 ± 0.039	3.393IleArg: 3.393 ± 0.055	4.438IleSer: 4.438 ± 0.068	3.903IleThr: 3.903 ± 0.07	4.573IleVal: 4.573 ± 0.079	0.591IleTrp: 0.591 ± 0.024	2.16IleTyr: 2.16 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.702LysAla: 4.702 ± 0.065	0.567LysCys: 0.567 ± 0.023	3.111LysAsp: 3.111 ± 0.058	4.989LysGlu: 4.989 ± 0.067	1.768LysPhe: 1.768 ± 0.043	4.04LysGly: 4.04 ± 0.063	0.986LysHis: 0.986 ± 0.029	4.442LysIle: 4.442 ± 0.068	4.624LysLys: 4.624 ± 0.085	5.25LysLeu: 5.25 ± 0.071	1.678LysMet: 1.678 ± 0.04	2.745LysAsn: 2.745 ± 0.054	2.324LysPro: 2.324 ± 0.052	2.044LysGln: 2.044 ± 0.046	2.947LysArg: 2.947 ± 0.055	3.06LysSer: 3.06 ± 0.056	3.373LysThr: 3.373 ± 0.068	4.343LysVal: 4.343 ± 0.068	0.531LysTrp: 0.531 ± 0.02	2.009LysTyr: 2.009 ± 0.041	0.001LysXaa: 0.001 ± 0.001
Leu	10.373LeuAla: 10.373 ± 0.124	1.172LeuCys: 1.172 ± 0.031	5.271LeuAsp: 5.271 ± 0.068	6.849LeuGlu: 6.849 ± 0.079	3.861LeuPhe: 3.861 ± 0.073	7.426LeuGly: 7.426 ± 0.091	1.587LeuHis: 1.587 ± 0.039	6.288LeuIle: 6.288 ± 0.078	6.454LeuLys: 6.454 ± 0.085	10.27LeuLeu: 10.27 ± 0.127	2.173LeuMet: 2.173 ± 0.04	3.931LeuAsn: 3.931 ± 0.055	4.834LeuPro: 4.834 ± 0.077	3.069LeuGln: 3.069 ± 0.057	5.316LeuArg: 5.316 ± 0.09	6.398LeuSer: 6.398 ± 0.094	5.405LeuThr: 5.405 ± 0.07	7.261LeuVal: 7.261 ± 0.091	0.888LeuTrp: 0.888 ± 0.033	2.859LeuTyr: 2.859 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	2.487MetAla: 2.487 ± 0.047	0.243MetCys: 0.243 ± 0.017	1.285MetAsp: 1.285 ± 0.035	1.744MetGlu: 1.744 ± 0.043	0.906MetPhe: 0.906 ± 0.032	1.912MetGly: 1.912 ± 0.044	0.393MetHis: 0.393 ± 0.018	1.639MetIle: 1.639 ± 0.04	1.562MetLys: 1.562 ± 0.038	2.486MetLeu: 2.486 ± 0.046	0.613MetMet: 0.613 ± 0.03	0.979MetAsn: 0.979 ± 0.032	1.31MetPro: 1.31 ± 0.037	0.76MetGln: 0.76 ± 0.029	1.312MetArg: 1.312 ± 0.034	1.582MetSer: 1.582 ± 0.041	1.267MetThr: 1.267 ± 0.029	1.924MetVal: 1.924 ± 0.047	0.18MetTrp: 0.18 ± 0.011	0.566MetTyr: 0.566 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	2.575AsnAla: 2.575 ± 0.042	0.574AsnCys: 0.574 ± 0.025	1.667AsnAsp: 1.667 ± 0.042	2.211AsnGlu: 2.211 ± 0.047	1.49AsnPhe: 1.49 ± 0.038	2.742AsnGly: 2.742 ± 0.055	0.665AsnHis: 0.665 ± 0.022	3.045AsnIle: 3.045 ± 0.061	2.327AsnLys: 2.327 ± 0.054	4.179AsnLeu: 4.179 ± 0.07	1.025AsnMet: 1.025 ± 0.037	1.776AsnAsn: 1.776 ± 0.041	2.207AsnPro: 2.207 ± 0.049	1.279AsnGln: 1.279 ± 0.038	2.082AsnArg: 2.082 ± 0.038	2.193AsnSer: 2.193 ± 0.046	2.038AsnThr: 2.038 ± 0.05	2.515AsnVal: 2.515 ± 0.051	0.463AsnTrp: 0.463 ± 0.023	1.415AsnTyr: 1.415 ± 0.04	0.0AsnXaa: 0.0 ± 0.0
Pro	4.242ProAla: 4.242 ± 0.084	0.505ProCys: 0.505 ± 0.022	2.696ProAsp: 2.696 ± 0.057	3.711ProGlu: 3.711 ± 0.06	1.708ProPhe: 1.708 ± 0.041	4.289ProGly: 4.289 ± 0.072	0.739ProHis: 0.739 ± 0.03	1.847ProIle: 1.847 ± 0.039	1.812ProLys: 1.812 ± 0.042	4.055ProLeu: 4.055 ± 0.062	0.806ProMet: 0.806 ± 0.026	1.263ProAsn: 1.263 ± 0.033	1.778ProPro: 1.778 ± 0.048	1.361ProGln: 1.361 ± 0.039	1.957ProArg: 1.957 ± 0.047	2.097ProSer: 2.097 ± 0.045	1.736ProThr: 1.736 ± 0.042	4.296ProVal: 4.296 ± 0.06	0.437ProTrp: 0.437 ± 0.021	1.407ProTyr: 1.407 ± 0.038	0.002ProXaa: 0.002 ± 0.002
Gln	3.267GlnAla: 3.267 ± 0.067	0.327GlnCys: 0.327 ± 0.019	1.544GlnAsp: 1.544 ± 0.041	2.475GlnGlu: 2.475 ± 0.053	1.111GlnPhe: 1.111 ± 0.035	2.359GlnGly: 2.359 ± 0.052	0.498GlnHis: 0.498 ± 0.022	2.2GlnIle: 2.2 ± 0.043	2.229GlnLys: 2.229 ± 0.046	3.055GlnLeu: 3.055 ± 0.051	0.936GlnMet: 0.936 ± 0.029	1.281GlnAsn: 1.281 ± 0.035	1.302GlnPro: 1.302 ± 0.038	1.281GlnGln: 1.281 ± 0.045	1.796GlnArg: 1.796 ± 0.041	1.702GlnSer: 1.702 ± 0.04	1.453GlnThr: 1.453 ± 0.036	2.694GlnVal: 2.694 ± 0.054	0.333GlnTrp: 0.333 ± 0.019	1.02GlnTyr: 1.02 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	4.021ArgAla: 4.021 ± 0.065	0.67ArgCys: 0.67 ± 0.025	2.85ArgAsp: 2.85 ± 0.056	4.517ArgGlu: 4.517 ± 0.073	2.248ArgPhe: 2.248 ± 0.05	3.707ArgGly: 3.707 ± 0.063	1.078ArgHis: 1.078 ± 0.031	3.69ArgIle: 3.69 ± 0.064	3.132ArgLys: 3.132 ± 0.052	6.003ArgLeu: 6.003 ± 0.094	1.441ArgMet: 1.441 ± 0.038	1.945ArgAsn: 1.945 ± 0.045	2.247ArgPro: 2.247 ± 0.05	2.484ArgGln: 2.484 ± 0.055	3.588ArgArg: 3.588 ± 0.079	2.769ArgSer: 2.769 ± 0.051	2.467ArgThr: 2.467 ± 0.048	4.042ArgVal: 4.042 ± 0.065	0.643ArgTrp: 0.643 ± 0.027	1.925ArgTyr: 1.925 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.307SerAla: 4.307 ± 0.074	0.815SerCys: 0.815 ± 0.032	2.716SerAsp: 2.716 ± 0.052	3.332SerGlu: 3.332 ± 0.045	2.58SerPhe: 2.58 ± 0.052	5.307SerGly: 5.307 ± 0.097	1.022SerHis: 1.022 ± 0.031	3.657SerIle: 3.657 ± 0.054	2.798SerLys: 2.798 ± 0.057	6.257SerLeu: 6.257 ± 0.089	1.453SerMet: 1.453 ± 0.034	1.872SerAsn: 1.872 ± 0.047	2.525SerPro: 2.525 ± 0.051	1.835SerGln: 1.835 ± 0.044	3.188SerArg: 3.188 ± 0.06	3.401SerSer: 3.401 ± 0.076	2.657SerThr: 2.657 ± 0.053	3.912SerVal: 3.912 ± 0.061	0.577SerTrp: 0.577 ± 0.026	1.934SerTyr: 1.934 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	4.632ThrAla: 4.632 ± 0.077	0.681ThrCys: 0.681 ± 0.024	2.4ThrAsp: 2.4 ± 0.052	2.884ThrGlu: 2.884 ± 0.061	1.823ThrPhe: 1.823 ± 0.045	5.437ThrGly: 5.437 ± 0.072	0.849ThrHis: 0.849 ± 0.028	3.307ThrIle: 3.307 ± 0.06	2.154ThrLys: 2.154 ± 0.047	4.695ThrLeu: 4.695 ± 0.079	1.182ThrMet: 1.182 ± 0.033	1.697ThrAsn: 1.697 ± 0.038	2.487ThrPro: 2.487 ± 0.058	1.239ThrGln: 1.239 ± 0.035	2.645ThrArg: 2.645 ± 0.051	2.723ThrSer: 2.723 ± 0.058	2.584ThrThr: 2.584 ± 0.061	4.306ThrVal: 4.306 ± 0.07	0.531ThrTrp: 0.531 ± 0.022	1.517ThrTyr: 1.517 ± 0.04	0.001ThrXaa: 0.001 ± 0.001
Val	6.282ValAla: 6.282 ± 0.082	0.979ValCys: 0.979 ± 0.034	3.879ValAsp: 3.879 ± 0.071	4.942ValGlu: 4.942 ± 0.068	3.136ValPhe: 3.136 ± 0.051	4.719ValGly: 4.719 ± 0.072	1.118ValHis: 1.118 ± 0.033	5.467ValIle: 5.467 ± 0.079	4.551ValLys: 4.551 ± 0.072	7.767ValLeu: 7.767 ± 0.096	1.837ValMet: 1.837 ± 0.043	3.107ValAsn: 3.107 ± 0.055	3.079ValPro: 3.079 ± 0.057	2.195ValGln: 2.195 ± 0.05	4.034ValArg: 4.034 ± 0.069	4.431ValSer: 4.431 ± 0.063	4.093ValThr: 4.093 ± 0.07	5.829ValVal: 5.829 ± 0.084	0.689ValTrp: 0.689 ± 0.025	2.298ValTyr: 2.298 ± 0.045	0.001ValXaa: 0.001 ± 0.001
Trp	0.744TrpAla: 0.744 ± 0.024	0.122TrpCys: 0.122 ± 0.011	0.571TrpAsp: 0.571 ± 0.022	0.729TrpGlu: 0.729 ± 0.027	0.387TrpPhe: 0.387 ± 0.02	0.774TrpGly: 0.774 ± 0.03	0.215TrpHis: 0.215 ± 0.015	0.528TrpIle: 0.528 ± 0.022	0.467TrpLys: 0.467 ± 0.024	1.211TrpLeu: 1.211 ± 0.039	0.244TrpMet: 0.244 ± 0.014	0.403TrpAsn: 0.403 ± 0.019	0.4TrpPro: 0.4 ± 0.02	0.465TrpGln: 0.465 ± 0.019	0.635TrpArg: 0.635 ± 0.026	0.576TrpSer: 0.576 ± 0.026	0.44TrpThr: 0.44 ± 0.021	0.711TrpVal: 0.711 ± 0.026	0.152TrpTrp: 0.152 ± 0.012	0.313TrpTyr: 0.313 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.318TyrAla: 2.318 ± 0.039	0.518TyrCys: 0.518 ± 0.025	1.749TyrAsp: 1.749 ± 0.049	1.833TyrGlu: 1.833 ± 0.042	1.511TyrPhe: 1.511 ± 0.042	2.487TyrGly: 2.487 ± 0.052	0.688TyrHis: 0.688 ± 0.027	2.104TyrIle: 2.104 ± 0.047	1.715TyrLys: 1.715 ± 0.044	3.591TyrLeu: 3.591 ± 0.062	0.657TyrMet: 0.657 ± 0.025	1.48TyrAsn: 1.48 ± 0.042	1.489TyrPro: 1.489 ± 0.041	1.225TyrGln: 1.225 ± 0.035	2.098TyrArg: 2.098 ± 0.049	1.902TyrSer: 1.902 ± 0.047	1.643TyrThr: 1.643 ± 0.039	1.953TyrVal: 1.953 ± 0.042	0.351TyrTrp: 0.351 ± 0.017	1.242TyrTyr: 1.242 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.002XaaHis: 0.002 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.002XaaVal: 0.002 ± 0.002	0.002XaaTrp: 0.002 ± 0.002	0.0XaaTyr: 0.0 ± 0.0	0.006XaaXaa: 0.006 ± 0.004

Statistics based on 3787 proteins (1096290 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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