Amino acid dipepetide frequency for Chitinibacter sp. 2T18

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.492AlaAla: 13.492 ± 0.175
1.175AlaCys: 1.175 ± 0.03
5.667AlaAsp: 5.667 ± 0.087
6.623AlaGlu: 6.623 ± 0.096
3.476AlaPhe: 3.476 ± 0.062
8.161AlaGly: 8.161 ± 0.111
2.319AlaHis: 2.319 ± 0.046
6.337AlaIle: 6.337 ± 0.076
5.478AlaLys: 5.478 ± 0.097
12.1AlaLeu: 12.1 ± 0.134
3.112AlaMet: 3.112 ± 0.055
4.038AlaAsn: 4.038 ± 0.061
4.333AlaPro: 4.333 ± 0.095
5.989AlaGln: 5.989 ± 0.108
5.482AlaArg: 5.482 ± 0.074
6.346AlaSer: 6.346 ± 0.102
5.334AlaThr: 5.334 ± 0.099
6.804AlaVal: 6.804 ± 0.085
1.513AlaTrp: 1.513 ± 0.049
2.464AlaTyr: 2.464 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.943CysAla: 0.943 ± 0.031
0.119CysCys: 0.119 ± 0.01
0.563CysAsp: 0.563 ± 0.027
0.541CysGlu: 0.541 ± 0.024
0.351CysPhe: 0.351 ± 0.019
0.925CysGly: 0.925 ± 0.034
0.303CysHis: 0.303 ± 0.018
0.534CysIle: 0.534 ± 0.023
0.379CysLys: 0.379 ± 0.02
0.957CysLeu: 0.957 ± 0.029
0.213CysMet: 0.213 ± 0.014
0.359CysAsn: 0.359 ± 0.019
0.509CysPro: 0.509 ± 0.025
0.399CysGln: 0.399 ± 0.022
0.509CysArg: 0.509 ± 0.021
0.61CysSer: 0.61 ± 0.028
0.493CysThr: 0.493 ± 0.02
0.641CysVal: 0.641 ± 0.028
0.124CysTrp: 0.124 ± 0.01
0.266CysTyr: 0.266 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
5.705AspAla: 5.705 ± 0.079
0.575AspCys: 0.575 ± 0.026
2.621AspAsp: 2.621 ± 0.067
3.459AspGlu: 3.459 ± 0.061
2.347AspPhe: 2.347 ± 0.051
4.037AspGly: 4.037 ± 0.08
1.05AspHis: 1.05 ± 0.032
2.98AspIle: 2.98 ± 0.062
2.243AspLys: 2.243 ± 0.058
5.598AspLeu: 5.598 ± 0.086
1.17AspMet: 1.17 ± 0.033
1.528AspAsn: 1.528 ± 0.039
2.352AspPro: 2.352 ± 0.053
2.201AspGln: 2.201 ± 0.045
2.518AspArg: 2.518 ± 0.053
2.533AspSer: 2.533 ± 0.051
2.507AspThr: 2.507 ± 0.073
3.721AspVal: 3.721 ± 0.065
0.961AspTrp: 0.961 ± 0.038
1.735AspTyr: 1.735 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
6.022GluAla: 6.022 ± 0.1
0.497GluCys: 0.497 ± 0.023
2.204GluAsp: 2.204 ± 0.044
2.709GluGlu: 2.709 ± 0.065
2.068GluPhe: 2.068 ± 0.044
3.194GluGly: 3.194 ± 0.066
1.425GluHis: 1.425 ± 0.037
3.661GluIle: 3.661 ± 0.071
2.811GluLys: 2.811 ± 0.062
6.7GluLeu: 6.7 ± 0.098
1.653GluMet: 1.653 ± 0.043
1.969GluAsn: 1.969 ± 0.043
1.95GluPro: 1.95 ± 0.045
3.486GluGln: 3.486 ± 0.066
3.716GluArg: 3.716 ± 0.071
2.904GluSer: 2.904 ± 0.048
2.763GluThr: 2.763 ± 0.059
4.012GluVal: 4.012 ± 0.063
0.79GluTrp: 0.79 ± 0.029
1.56GluTyr: 1.56 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
4.336PheAla: 4.336 ± 0.072
0.475PheCys: 0.475 ± 0.022
2.461PheAsp: 2.461 ± 0.046
2.2PheGlu: 2.2 ± 0.049
1.526PhePhe: 1.526 ± 0.046
3.092PheGly: 3.092 ± 0.061
0.767PheHis: 0.767 ± 0.028
2.067PheIle: 2.067 ± 0.053
1.527PheLys: 1.527 ± 0.039
3.187PheLeu: 3.187 ± 0.057
0.864PheMet: 0.864 ± 0.03
1.531PheAsn: 1.531 ± 0.041
1.376PhePro: 1.376 ± 0.031
1.211PheGln: 1.211 ± 0.034
1.663PheArg: 1.663 ± 0.04
2.64PheSer: 2.64 ± 0.054
2.019PheThr: 2.019 ± 0.047
2.543PheVal: 2.543 ± 0.05
0.575PheTrp: 0.575 ± 0.028
1.065PheTyr: 1.065 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
6.438GlyAla: 6.438 ± 0.096
0.778GlyCys: 0.778 ± 0.03
3.626GlyAsp: 3.626 ± 0.069
4.407GlyGlu: 4.407 ± 0.072
3.191GlyPhe: 3.191 ± 0.062
5.332GlyGly: 5.332 ± 0.089
1.646GlyHis: 1.646 ± 0.039
4.36GlyIle: 4.36 ± 0.066
3.955GlyLys: 3.955 ± 0.079
7.673GlyLeu: 7.673 ± 0.097
2.17GlyMet: 2.17 ± 0.047
2.561GlyAsn: 2.561 ± 0.067
1.792GlyPro: 1.792 ± 0.044
3.447GlyGln: 3.447 ± 0.066
3.701GlyArg: 3.701 ± 0.071
4.018GlySer: 4.018 ± 0.076
3.398GlyThr: 3.398 ± 0.075
5.629GlyVal: 5.629 ± 0.079
1.111GlyTrp: 1.111 ± 0.034
2.2GlyTyr: 2.2 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
2.268HisAla: 2.268 ± 0.053
0.294HisCys: 0.294 ± 0.016
1.196HisAsp: 1.196 ± 0.035
1.248HisGlu: 1.248 ± 0.034
1.018HisPhe: 1.018 ± 0.031
1.735HisGly: 1.735 ± 0.052
0.699HisHis: 0.699 ± 0.032
1.299HisIle: 1.299 ± 0.036
0.762HisLys: 0.762 ± 0.029
2.431HisLeu: 2.431 ± 0.05
0.473HisMet: 0.473 ± 0.023
0.715HisAsn: 0.715 ± 0.023
1.259HisPro: 1.259 ± 0.039
1.048HisGln: 1.048 ± 0.035
1.16HisArg: 1.16 ± 0.033
1.243HisSer: 1.243 ± 0.036
1.097HisThr: 1.097 ± 0.033
1.312HisVal: 1.312 ± 0.038
0.421HisTrp: 0.421 ± 0.02
0.736HisTyr: 0.736 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
7.321IleAla: 7.321 ± 0.099
0.597IleCys: 0.597 ± 0.023
3.731IleAsp: 3.731 ± 0.063
4.11IleGlu: 4.11 ± 0.075
1.786IlePhe: 1.786 ± 0.045
4.553IleGly: 4.553 ± 0.08
1.13IleHis: 1.13 ± 0.035
2.75IleIle: 2.75 ± 0.058
2.664IleLys: 2.664 ± 0.056
5.118IleLeu: 5.118 ± 0.081
1.144IleMet: 1.144 ± 0.031
2.549IleAsn: 2.549 ± 0.049
2.481IlePro: 2.481 ± 0.045
1.976IleGln: 1.976 ± 0.048
2.901IleArg: 2.901 ± 0.054
3.823IleSer: 3.823 ± 0.059
3.169IleThr: 3.169 ± 0.062
3.864IleVal: 3.864 ± 0.062
0.73IleTrp: 0.73 ± 0.029
1.455IleTyr: 1.455 ± 0.041
0.0IleXaa: 0.0 ± 0.0
Lys
4.881LysAla: 4.881 ± 0.097
0.247LysCys: 0.247 ± 0.016
2.229LysAsp: 2.229 ± 0.06
2.209LysGlu: 2.209 ± 0.055
1.339LysPhe: 1.339 ± 0.037
2.794LysGly: 2.794 ± 0.058
0.938LysHis: 0.938 ± 0.029
2.818LysIle: 2.818 ± 0.058
2.365LysLys: 2.365 ± 0.061
5.24LysLeu: 5.24 ± 0.075
1.386LysMet: 1.386 ± 0.041
1.896LysAsn: 1.896 ± 0.047
2.454LysPro: 2.454 ± 0.058
2.266LysGln: 2.266 ± 0.049
2.302LysArg: 2.302 ± 0.048
2.609LysSer: 2.609 ± 0.052
2.715LysThr: 2.715 ± 0.047
3.195LysVal: 3.195 ± 0.062
0.556LysTrp: 0.556 ± 0.022
1.124LysTyr: 1.124 ± 0.032
0.0LysXaa: 0.0 ± 0.0
Leu
13.646LeuAla: 13.646 ± 0.155
1.027LeuCys: 1.027 ± 0.034
5.93LeuAsp: 5.93 ± 0.092
5.519LeuGlu: 5.519 ± 0.085
3.741LeuPhe: 3.741 ± 0.077
7.851LeuGly: 7.851 ± 0.104
2.314LeuHis: 2.314 ± 0.055
6.442LeuIle: 6.442 ± 0.092
5.113LeuLys: 5.113 ± 0.076
11.868LeuLeu: 11.868 ± 0.154
2.765LeuMet: 2.765 ± 0.057
4.41LeuAsn: 4.41 ± 0.072
5.521LeuPro: 5.521 ± 0.07
4.809LeuGln: 4.809 ± 0.073
5.784LeuArg: 5.784 ± 0.099
7.121LeuSer: 7.121 ± 0.095
5.515LeuThr: 5.515 ± 0.081
6.707LeuVal: 6.707 ± 0.088
1.228LeuTrp: 1.228 ± 0.039
2.407LeuTyr: 2.407 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
2.795MetAla: 2.795 ± 0.053
0.172MetCys: 0.172 ± 0.013
1.165MetAsp: 1.165 ± 0.035
1.006MetGlu: 1.006 ± 0.031
0.783MetPhe: 0.783 ± 0.032
1.842MetGly: 1.842 ± 0.048
0.55MetHis: 0.55 ± 0.022
1.347MetIle: 1.347 ± 0.039
1.368MetLys: 1.368 ± 0.036
2.968MetLeu: 2.968 ± 0.064
0.723MetMet: 0.723 ± 0.028
1.094MetAsn: 1.094 ± 0.038
1.389MetPro: 1.389 ± 0.038
1.359MetGln: 1.359 ± 0.036
1.384MetArg: 1.384 ± 0.039
1.882MetSer: 1.882 ± 0.041
1.43MetThr: 1.43 ± 0.034
1.663MetVal: 1.663 ± 0.045
0.206MetTrp: 0.206 ± 0.014
0.462MetTyr: 0.462 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.864AsnAla: 3.864 ± 0.066
0.321AsnCys: 0.321 ± 0.02
2.036AsnAsp: 2.036 ± 0.051
2.041AsnGlu: 2.041 ± 0.049
1.252AsnPhe: 1.252 ± 0.035
2.865AsnGly: 2.865 ± 0.058
0.795AsnHis: 0.795 ± 0.029
2.067AsnIle: 2.067 ± 0.051
1.57AsnLys: 1.57 ± 0.038
3.739AsnLeu: 3.739 ± 0.06
0.89AsnMet: 0.89 ± 0.031
1.39AsnAsn: 1.39 ± 0.042
2.267AsnPro: 2.267 ± 0.053
1.901AsnGln: 1.901 ± 0.05
2.022AsnArg: 2.022 ± 0.047
2.058AsnSer: 2.058 ± 0.061
2.088AsnThr: 2.088 ± 0.051
2.375AsnVal: 2.375 ± 0.052
0.612AsnTrp: 0.612 ± 0.026
1.119AsnTyr: 1.119 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
4.932ProAla: 4.932 ± 0.084
0.345ProCys: 0.345 ± 0.019
2.598ProAsp: 2.598 ± 0.05
3.124ProGlu: 3.124 ± 0.056
1.697ProPhe: 1.697 ± 0.04
2.482ProGly: 2.482 ± 0.057
1.022ProHis: 1.022 ± 0.033
2.402ProIle: 2.402 ± 0.047
2.046ProLys: 2.046 ± 0.048
4.453ProLeu: 4.453 ± 0.063
1.08ProMet: 1.08 ± 0.035
1.804ProAsn: 1.804 ± 0.044
1.695ProPro: 1.695 ± 0.044
2.045ProGln: 2.045 ± 0.05
1.801ProArg: 1.801 ± 0.051
2.741ProSer: 2.741 ± 0.054
2.617ProThr: 2.617 ± 0.089
3.37ProVal: 3.37 ± 0.074
0.608ProTrp: 0.608 ± 0.025
1.167ProTyr: 1.167 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
5.574GlnAla: 5.574 ± 0.089
0.429GlnCys: 0.429 ± 0.023
1.899GlnAsp: 1.899 ± 0.041
2.02GlnGlu: 2.02 ± 0.045
1.82GlnPhe: 1.82 ± 0.037
3.005GlnGly: 3.005 ± 0.063
1.259GlnHis: 1.259 ± 0.038
3.18GlnIle: 3.18 ± 0.058
1.938GlnLys: 1.938 ± 0.051
6.157GlnLeu: 6.157 ± 0.103
1.316GlnMet: 1.316 ± 0.037
1.604GlnAsn: 1.604 ± 0.045
1.952GlnPro: 1.952 ± 0.05
3.083GlnGln: 3.083 ± 0.081
2.823GlnArg: 2.823 ± 0.064
2.782GlnSer: 2.782 ± 0.061
2.429GlnThr: 2.429 ± 0.052
3.174GlnVal: 3.174 ± 0.057
0.728GlnTrp: 0.728 ± 0.028
1.479GlnTyr: 1.479 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
4.891ArgAla: 4.891 ± 0.083
0.497ArgCys: 0.497 ± 0.024
2.884ArgAsp: 2.884 ± 0.053
3.428ArgGlu: 3.428 ± 0.072
2.381ArgPhe: 2.381 ± 0.044
3.157ArgGly: 3.157 ± 0.059
1.343ArgHis: 1.343 ± 0.037
3.278ArgIle: 3.278 ± 0.069
2.193ArgLys: 2.193 ± 0.05
6.044ArgLeu: 6.044 ± 0.094
1.365ArgMet: 1.365 ± 0.039
1.92ArgAsn: 1.92 ± 0.05
1.959ArgPro: 1.959 ± 0.047
2.809ArgGln: 2.809 ± 0.061
3.029ArgArg: 3.029 ± 0.062
2.766ArgSer: 2.766 ± 0.054
2.42ArgThr: 2.42 ± 0.046
3.612ArgVal: 3.612 ± 0.057
0.84ArgTrp: 0.84 ± 0.035
1.796ArgTyr: 1.796 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
6.263SerAla: 6.263 ± 0.093
0.562SerCys: 0.562 ± 0.023
3.062SerAsp: 3.062 ± 0.049
3.249SerGlu: 3.249 ± 0.066
2.243SerPhe: 2.243 ± 0.053
4.738SerGly: 4.738 ± 0.075
1.361SerHis: 1.361 ± 0.032
3.37SerIle: 3.37 ± 0.063
2.717SerLys: 2.717 ± 0.056
6.385SerLeu: 6.385 ± 0.091
1.38SerMet: 1.38 ± 0.038
2.431SerAsn: 2.431 ± 0.053
2.591SerPro: 2.591 ± 0.049
2.762SerGln: 2.762 ± 0.059
3.058SerArg: 3.058 ± 0.05
3.854SerSer: 3.854 ± 0.085
3.164SerThr: 3.164 ± 0.064
3.809SerVal: 3.809 ± 0.066
0.876SerTrp: 0.876 ± 0.032
1.663SerTyr: 1.663 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
5.513ThrAla: 5.513 ± 0.099
0.435ThrCys: 0.435 ± 0.022
2.43ThrAsp: 2.43 ± 0.056
2.579ThrGlu: 2.579 ± 0.045
1.753ThrPhe: 1.753 ± 0.041
4.078ThrGly: 4.078 ± 0.074
1.161ThrHis: 1.161 ± 0.037
2.953ThrIle: 2.953 ± 0.058
1.696ThrLys: 1.696 ± 0.04
6.384ThrLeu: 6.384 ± 0.096
1.185ThrMet: 1.185 ± 0.032
1.591ThrAsn: 1.591 ± 0.042
3.447ThrPro: 3.447 ± 0.094
2.53ThrGln: 2.53 ± 0.05
2.565ThrArg: 2.565 ± 0.05
2.899ThrSer: 2.899 ± 0.063
2.819ThrThr: 2.819 ± 0.066
3.743ThrVal: 3.743 ± 0.08
0.646ThrTrp: 0.646 ± 0.027
1.21ThrTyr: 1.21 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
7.56ValAla: 7.56 ± 0.1
0.721ValCys: 0.721 ± 0.026
3.594ValAsp: 3.594 ± 0.069
3.824ValGlu: 3.824 ± 0.056
2.557ValPhe: 2.557 ± 0.052
4.748ValGly: 4.748 ± 0.075
1.303ValHis: 1.303 ± 0.039
4.096ValIle: 4.096 ± 0.06
3.212ValLys: 3.212 ± 0.064
7.464ValLeu: 7.464 ± 0.093
1.873ValMet: 1.873 ± 0.043
2.529ValAsn: 2.529 ± 0.056
2.786ValPro: 2.786 ± 0.057
2.638ValGln: 2.638 ± 0.048
3.508ValArg: 3.508 ± 0.07
4.256ValSer: 4.256 ± 0.069
3.664ValThr: 3.664 ± 0.099
5.154ValVal: 5.154 ± 0.081
0.867ValTrp: 0.867 ± 0.03
1.586ValTyr: 1.586 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.183TrpAla: 1.183 ± 0.038
0.169TrpCys: 0.169 ± 0.013
0.563TrpAsp: 0.563 ± 0.023
0.536TrpGlu: 0.536 ± 0.024
0.561TrpPhe: 0.561 ± 0.024
0.861TrpGly: 0.861 ± 0.032
0.419TrpHis: 0.419 ± 0.02
0.696TrpIle: 0.696 ± 0.03
0.534TrpLys: 0.534 ± 0.022
2.159TrpLeu: 2.159 ± 0.058
0.328TrpMet: 0.328 ± 0.017
0.493TrpAsn: 0.493 ± 0.022
0.618TrpPro: 0.618 ± 0.029
1.13TrpGln: 1.13 ± 0.043
0.995TrpArg: 0.995 ± 0.033
0.759TrpSer: 0.759 ± 0.03
0.568TrpThr: 0.568 ± 0.027
0.955TrpVal: 0.955 ± 0.031
0.262TrpTrp: 0.262 ± 0.019
0.34TrpTyr: 0.34 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.617TyrAla: 2.617 ± 0.048
0.302TyrCys: 0.302 ± 0.019
1.381TyrAsp: 1.381 ± 0.04
1.267TyrGlu: 1.267 ± 0.036
1.234TyrPhe: 1.234 ± 0.04
1.982TyrGly: 1.982 ± 0.048
0.606TyrHis: 0.606 ± 0.022
1.211TyrIle: 1.211 ± 0.029
0.994TyrLys: 0.994 ± 0.038
3.092TyrLeu: 3.092 ± 0.055
0.497TyrMet: 0.497 ± 0.023
0.862TyrAsn: 0.862 ± 0.032
1.301TyrPro: 1.301 ± 0.037
1.561TyrGln: 1.561 ± 0.047
1.691TyrArg: 1.691 ± 0.044
1.694TyrSer: 1.694 ± 0.05
1.41TyrThr: 1.41 ± 0.055
1.659TyrVal: 1.659 ± 0.038
0.474TyrTrp: 0.474 ± 0.021
0.764TyrTyr: 0.764 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3281 proteins (1045249 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski