Amino acid dipepetide frequency for Woodchuck hepatitis B virus (isolate 7) (WHV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.228AlaAla: 4.228 ± 1.65
2.114AlaCys: 2.114 ± 0.93
1.691AlaAsp: 1.691 ± 1.159
0.846AlaGlu: 0.846 ± 0.453
1.268AlaPhe: 1.268 ± 0.869
3.805AlaGly: 3.805 ± 1.16
0.423AlaHis: 0.423 ± 0.29
2.114AlaIle: 2.114 ± 0.899
0.0AlaLys: 0.0 ± 0.0
9.725AlaLeu: 9.725 ± 1.568
0.0AlaMet: 0.0 ± 0.0
2.537AlaAsn: 2.537 ± 0.94
2.114AlaPro: 2.114 ± 1.52
3.805AlaGln: 3.805 ± 1.371
5.074AlaArg: 5.074 ± 0.831
4.228AlaSer: 4.228 ± 2.127
2.96AlaThr: 2.96 ± 1.322
2.114AlaVal: 2.114 ± 0.785
2.96AlaTrp: 2.96 ± 0.841
2.114AlaTyr: 2.114 ± 0.747
0.0AlaXaa: 0.0 ± 0.0
Cys
0.423CysAla: 0.423 ± 0.464
3.383CysCys: 3.383 ± 1.714
0.0CysAsp: 0.0 ± 0.0
0.846CysGlu: 0.846 ± 0.58
0.423CysPhe: 0.423 ± 0.464
1.268CysGly: 1.268 ± 0.869
0.0CysHis: 0.0 ± 0.0
0.423CysIle: 0.423 ± 0.29
1.268CysLys: 1.268 ± 0.742
5.92CysLeu: 5.92 ± 1.358
1.268CysMet: 1.268 ± 0.956
1.268CysAsn: 1.268 ± 0.742
2.96CysPro: 2.96 ± 1.448
0.423CysGln: 0.423 ± 0.464
1.691CysArg: 1.691 ± 0.857
2.114CysSer: 2.114 ± 0.899
5.074CysThr: 5.074 ± 1.761
1.268CysVal: 1.268 ± 0.723
2.537CysTrp: 2.537 ± 0.703
0.423CysTyr: 0.423 ± 0.29
0.0CysXaa: 0.0 ± 0.0
Asp
1.268AspAla: 1.268 ± 0.869
0.0AspCys: 0.0 ± 0.0
0.846AspAsp: 0.846 ± 0.58
1.268AspGlu: 1.268 ± 1.007
1.691AspPhe: 1.691 ± 0.768
0.846AspGly: 0.846 ± 0.615
0.0AspHis: 0.0 ± 0.0
1.268AspIle: 1.268 ± 0.842
1.691AspLys: 1.691 ± 0.732
5.074AspLeu: 5.074 ± 1.163
1.268AspMet: 1.268 ± 0.742
0.846AspAsn: 0.846 ± 0.58
3.383AspPro: 3.383 ± 1.641
1.268AspGln: 1.268 ± 0.986
0.423AspArg: 0.423 ± 0.29
1.268AspSer: 1.268 ± 1.04
2.114AspThr: 2.114 ± 1.599
1.268AspVal: 1.268 ± 0.603
3.383AspTrp: 3.383 ± 1.53
0.423AspTyr: 0.423 ± 0.29
0.0AspXaa: 0.0 ± 0.0
Glu
0.423GluAla: 0.423 ± 0.29
1.268GluCys: 1.268 ± 0.742
0.846GluAsp: 0.846 ± 0.58
3.383GluGlu: 3.383 ± 1.547
2.114GluPhe: 2.114 ± 1.52
0.423GluGly: 0.423 ± 0.464
3.383GluHis: 3.383 ± 1.536
0.423GluIle: 0.423 ± 0.423
1.268GluLys: 1.268 ± 0.869
4.228GluLeu: 4.228 ± 1.378
0.846GluMet: 0.846 ± 0.615
0.0GluAsn: 0.0 ± 0.0
0.423GluPro: 0.423 ± 0.29
0.846GluGln: 0.846 ± 0.811
1.691GluArg: 1.691 ± 0.575
1.268GluSer: 1.268 ± 0.603
1.268GluThr: 1.268 ± 0.742
0.423GluVal: 0.423 ± 0.29
1.268GluTrp: 1.268 ± 0.742
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
3.383PheAla: 3.383 ± 1.634
0.423PheCys: 0.423 ± 0.29
0.0PheAsp: 0.0 ± 0.0
0.423PheGlu: 0.423 ± 0.423
2.96PhePhe: 2.96 ± 0.505
3.383PheGly: 3.383 ± 2.438
2.114PheHis: 2.114 ± 1.188
3.383PheIle: 3.383 ± 1.174
0.846PheLys: 0.846 ± 0.58
8.034PheLeu: 8.034 ± 2.249
0.423PheMet: 0.423 ± 0.29
1.268PheAsn: 1.268 ± 0.499
5.92PhePro: 5.92 ± 0.828
2.114PheGln: 2.114 ± 1.017
2.537PheArg: 2.537 ± 0.661
3.805PheSer: 3.805 ± 1.355
2.114PheThr: 2.114 ± 0.564
2.96PheVal: 2.96 ± 1.498
1.268PheTrp: 1.268 ± 0.742
0.846PheTyr: 0.846 ± 0.58
0.0PheXaa: 0.0 ± 0.0
Gly
1.691GlyAla: 1.691 ± 0.768
0.423GlyCys: 0.423 ± 0.464
2.114GlyAsp: 2.114 ± 1.101
0.846GlyGlu: 0.846 ± 0.58
2.96GlyPhe: 2.96 ± 1.357
4.228GlyGly: 4.228 ± 1.323
1.268GlyHis: 1.268 ± 0.869
5.497GlyIle: 5.497 ± 1.403
0.846GlyLys: 0.846 ± 0.58
8.034GlyLeu: 8.034 ± 1.735
0.846GlyMet: 0.846 ± 0.755
3.383GlyAsn: 3.383 ± 1.53
4.228GlyPro: 4.228 ± 1.256
2.96GlyGln: 2.96 ± 0.505
2.114GlyArg: 2.114 ± 0.862
3.383GlySer: 3.383 ± 1.26
2.114GlyThr: 2.114 ± 0.996
2.96GlyVal: 2.96 ± 1.322
0.846GlyTrp: 0.846 ± 0.575
0.846GlyTyr: 0.846 ± 0.58
0.0GlyXaa: 0.0 ± 0.0
His
0.846HisAla: 0.846 ± 0.453
1.268HisCys: 1.268 ± 0.735
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.846HisPhe: 0.846 ± 0.58
0.0HisGly: 0.0 ± 0.0
1.268HisHis: 1.268 ± 0.735
1.268HisIle: 1.268 ± 0.869
1.268HisLys: 1.268 ± 0.603
8.457HisLeu: 8.457 ± 1.788
0.0HisMet: 0.0 ± 0.0
2.96HisAsn: 2.96 ± 1.232
1.268HisPro: 1.268 ± 0.499
0.0HisGln: 0.0 ± 0.0
0.846HisArg: 0.846 ± 0.58
0.0HisSer: 0.0 ± 0.0
3.383HisThr: 3.383 ± 2.246
1.691HisVal: 1.691 ± 0.768
0.846HisTrp: 0.846 ± 0.58
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.074IleAla: 5.074 ± 0.949
0.846IleCys: 0.846 ± 0.58
1.691IleAsp: 1.691 ± 1.043
0.0IleGlu: 0.0 ± 0.0
3.383IlePhe: 3.383 ± 1.329
0.423IleGly: 0.423 ± 0.29
0.846IleHis: 0.846 ± 0.58
2.537IleIle: 2.537 ± 1.117
2.537IleLys: 2.537 ± 0.807
5.497IleLeu: 5.497 ± 1.171
1.268IleMet: 1.268 ± 0.513
1.691IleAsn: 1.691 ± 1.138
6.342IlePro: 6.342 ± 2.813
1.691IleGln: 1.691 ± 1.159
2.96IleArg: 2.96 ± 2.391
5.074IleSer: 5.074 ± 1.323
3.383IleThr: 3.383 ± 1.571
1.691IleVal: 1.691 ± 0.677
3.805IleTrp: 3.805 ± 2.225
2.114IleTyr: 2.114 ± 0.828
0.0IleXaa: 0.0 ± 0.0
Lys
0.846LysAla: 0.846 ± 0.58
0.423LysCys: 0.423 ± 0.464
0.846LysAsp: 0.846 ± 0.927
0.846LysGlu: 0.846 ± 0.811
0.423LysPhe: 0.423 ± 0.29
2.114LysGly: 2.114 ± 0.554
1.691LysHis: 1.691 ± 0.587
2.96LysIle: 2.96 ± 0.716
0.423LysLys: 0.423 ± 0.29
3.805LysLeu: 3.805 ± 1.251
0.0LysMet: 0.0 ± 0.0
2.537LysAsn: 2.537 ± 0.844
3.383LysPro: 3.383 ± 1.415
0.846LysGln: 0.846 ± 0.361
0.846LysArg: 0.846 ± 0.58
3.383LysSer: 3.383 ± 2.318
1.691LysThr: 1.691 ± 1.159
1.268LysVal: 1.268 ± 0.842
0.846LysTrp: 0.846 ± 0.453
0.423LysTyr: 0.423 ± 0.29
0.0LysXaa: 0.0 ± 0.0
Leu
5.92LeuAla: 5.92 ± 1.715
3.805LeuCys: 3.805 ± 0.945
6.342LeuAsp: 6.342 ± 0.516
1.268LeuGlu: 1.268 ± 0.869
2.537LeuPhe: 2.537 ± 0.537
7.611LeuGly: 7.611 ± 1.581
2.537LeuHis: 2.537 ± 1.739
9.302LeuIle: 9.302 ± 3.361
2.114LeuLys: 2.114 ± 0.95
22.833LeuLeu: 22.833 ± 5.386
0.846LeuMet: 0.846 ± 0.444
5.92LeuAsn: 5.92 ± 1.352
8.879LeuPro: 8.879 ± 0.648
7.611LeuGln: 7.611 ± 1.954
5.92LeuArg: 5.92 ± 1.162
10.994LeuSer: 10.994 ± 1.065
7.611LeuThr: 7.611 ± 1.502
10.148LeuVal: 10.148 ± 2.039
6.342LeuTrp: 6.342 ± 0.653
3.383LeuTyr: 3.383 ± 1.571
0.0LeuXaa: 0.0 ± 0.0
Met
0.423MetAla: 0.423 ± 0.464
0.0MetCys: 0.0 ± 0.0
1.691MetAsp: 1.691 ± 0.896
0.0MetGlu: 0.0 ± 0.0
0.0MetPhe: 0.0 ± 0.0
1.691MetGly: 1.691 ± 0.732
0.846MetHis: 0.846 ± 0.58
1.268MetIle: 1.268 ± 0.742
0.846MetLys: 0.846 ± 0.615
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.846MetPro: 0.846 ± 0.453
0.0MetGln: 0.0 ± 0.0
0.423MetArg: 0.423 ± 0.464
2.114MetSer: 2.114 ± 0.95
0.0MetThr: 0.0 ± 0.0
0.846MetVal: 0.846 ± 0.58
0.0MetTrp: 0.0 ± 0.0
2.96MetTyr: 2.96 ± 1.448
0.0MetXaa: 0.0 ± 0.0
Asn
2.96AsnAla: 2.96 ± 1.387
3.805AsnCys: 3.805 ± 1.245
1.268AsnAsp: 1.268 ± 0.735
0.423AsnGlu: 0.423 ± 0.29
2.96AsnPhe: 2.96 ± 1.084
2.114AsnGly: 2.114 ± 0.554
2.114AsnHis: 2.114 ± 0.899
2.114AsnIle: 2.114 ± 0.613
0.846AsnLys: 0.846 ± 0.58
5.074AsnLeu: 5.074 ± 1.323
0.0AsnMet: 0.0 ± 0.0
2.537AsnAsn: 2.537 ± 1.271
2.114AsnPro: 2.114 ± 0.821
3.805AsnGln: 3.805 ± 1.445
1.691AsnArg: 1.691 ± 0.835
4.651AsnSer: 4.651 ± 1.9
1.268AsnThr: 1.268 ± 0.499
0.423AsnVal: 0.423 ± 0.29
0.423AsnTrp: 0.423 ± 0.29
2.96AsnTyr: 2.96 ± 0.858
0.0AsnXaa: 0.0 ± 0.0
Pro
6.342ProAla: 6.342 ± 1.505
1.691ProCys: 1.691 ± 0.774
1.268ProAsp: 1.268 ± 0.842
4.228ProGlu: 4.228 ± 0.546
4.228ProPhe: 4.228 ± 0.846
3.383ProGly: 3.383 ± 1.415
2.537ProHis: 2.537 ± 0.679
4.651ProIle: 4.651 ± 1.181
2.114ProLys: 2.114 ± 0.821
8.034ProLeu: 8.034 ± 0.69
0.846ProMet: 0.846 ± 0.543
2.114ProAsn: 2.114 ± 0.899
9.302ProPro: 9.302 ± 3.214
2.114ProGln: 2.114 ± 0.769
5.497ProArg: 5.497 ± 2.261
7.611ProSer: 7.611 ± 2.453
8.879ProThr: 8.879 ± 3.495
4.228ProVal: 4.228 ± 1.23
0.846ProTrp: 0.846 ± 0.58
4.228ProTyr: 4.228 ± 1.563
0.0ProXaa: 0.0 ± 0.0
Gln
1.691GlnAla: 1.691 ± 1.141
1.691GlnCys: 1.691 ± 0.587
1.691GlnAsp: 1.691 ± 0.587
1.691GlnGlu: 1.691 ± 0.677
2.537GlnPhe: 2.537 ± 0.661
2.114GlnGly: 2.114 ± 1.21
2.537GlnHis: 2.537 ± 0.546
0.846GlnIle: 0.846 ± 0.361
1.268GlnLys: 1.268 ± 0.499
3.805GlnLeu: 3.805 ± 1.559
0.0GlnMet: 0.0 ± 0.0
3.805GlnAsn: 3.805 ± 1.371
2.537GlnPro: 2.537 ± 0.717
1.691GlnGln: 1.691 ± 0.732
0.423GlnArg: 0.423 ± 0.29
4.651GlnSer: 4.651 ± 2.227
5.92GlnThr: 5.92 ± 1.698
2.114GlnVal: 2.114 ± 0.95
2.114GlnTrp: 2.114 ± 0.554
0.423GlnTyr: 0.423 ± 0.29
0.0GlnXaa: 0.0 ± 0.0
Arg
0.846ArgAla: 0.846 ± 0.811
0.423ArgCys: 0.423 ± 0.29
2.96ArgAsp: 2.96 ± 2.234
1.268ArgGlu: 1.268 ± 0.735
3.383ArgPhe: 3.383 ± 1.174
2.96ArgGly: 2.96 ± 0.845
0.846ArgHis: 0.846 ± 0.453
1.691ArgIle: 1.691 ± 1.159
2.114ArgLys: 2.114 ± 0.996
5.074ArgLeu: 5.074 ± 2.413
0.0ArgMet: 0.0 ± 0.0
2.537ArgAsn: 2.537 ± 1.739
2.96ArgPro: 2.96 ± 1.179
5.497ArgGln: 5.497 ± 1.105
11.839ArgArg: 11.839 ± 7.336
3.805ArgSer: 3.805 ± 2.204
4.651ArgThr: 4.651 ± 2.259
1.268ArgVal: 1.268 ± 0.869
1.268ArgTrp: 1.268 ± 0.742
1.268ArgTyr: 1.268 ± 0.499
0.0ArgXaa: 0.0 ± 0.0
Ser
5.92SerAla: 5.92 ± 1.602
2.537SerCys: 2.537 ± 0.703
1.691SerAsp: 1.691 ± 0.907
2.114SerGlu: 2.114 ± 0.899
3.805SerPhe: 3.805 ± 0.478
2.96SerGly: 2.96 ± 1.423
0.846SerHis: 0.846 ± 0.58
2.537SerIle: 2.537 ± 0.978
1.691SerLys: 1.691 ± 0.774
8.034SerLeu: 8.034 ± 1.148
0.846SerMet: 0.846 ± 0.58
3.383SerAsn: 3.383 ± 1.571
13.108SerPro: 13.108 ± 2.475
4.228SerGln: 4.228 ± 1.116
5.92SerArg: 5.92 ± 2.681
12.262SerSer: 12.262 ± 2.737
5.074SerThr: 5.074 ± 0.761
2.96SerVal: 2.96 ± 1.219
3.805SerTrp: 3.805 ± 1.16
1.691SerTyr: 1.691 ± 0.768
0.0SerXaa: 0.0 ± 0.0
Thr
5.92ThrAla: 5.92 ± 1.781
4.651ThrCys: 4.651 ± 2.048
0.846ThrAsp: 0.846 ± 0.58
2.114ThrGlu: 2.114 ± 1.235
3.805ThrPhe: 3.805 ± 1.156
5.92ThrGly: 5.92 ± 0.961
0.846ThrHis: 0.846 ± 0.361
5.497ThrIle: 5.497 ± 1.171
3.805ThrLys: 3.805 ± 0.478
3.805ThrLeu: 3.805 ± 0.938
1.268ThrMet: 1.268 ± 0.522
1.268ThrAsn: 1.268 ± 0.499
5.92ThrPro: 5.92 ± 1.425
0.423ThrGln: 0.423 ± 0.29
2.114ThrArg: 2.114 ± 1.449
7.188ThrSer: 7.188 ± 0.975
8.457ThrThr: 8.457 ± 4.05
5.074ThrVal: 5.074 ± 1.334
2.114ThrTrp: 2.114 ± 0.613
1.691ThrTyr: 1.691 ± 0.721
0.0ThrXaa: 0.0 ± 0.0
Val
2.114ValAla: 2.114 ± 1.449
2.537ValCys: 2.537 ± 0.703
2.96ValAsp: 2.96 ± 0.676
0.0ValGlu: 0.0 ± 0.0
2.96ValPhe: 2.96 ± 0.937
1.268ValGly: 1.268 ± 0.499
0.846ValHis: 0.846 ± 0.58
1.268ValIle: 1.268 ± 0.735
0.423ValLys: 0.423 ± 0.29
6.765ValLeu: 6.765 ± 1.822
0.0ValMet: 0.0 ± 0.0
4.228ValAsn: 4.228 ± 1.341
5.074ValPro: 5.074 ± 1.205
2.114ValGln: 2.114 ± 0.899
3.383ValArg: 3.383 ± 1.536
4.651ValSer: 4.651 ± 0.715
1.268ValThr: 1.268 ± 0.499
3.383ValVal: 3.383 ± 1.096
0.846ValTrp: 0.846 ± 0.811
2.96ValTyr: 2.96 ± 1.306
0.0ValXaa: 0.0 ± 0.0
Trp
3.383TrpAla: 3.383 ± 1.174
0.0TrpCys: 0.0 ± 0.0
0.846TrpAsp: 0.846 ± 0.811
2.537TrpGlu: 2.537 ± 0.552
3.805TrpPhe: 3.805 ± 1.245
3.805TrpGly: 3.805 ± 0.786
0.423TrpHis: 0.423 ± 0.464
2.114TrpIle: 2.114 ± 0.899
1.268TrpLys: 1.268 ± 0.742
4.228TrpLeu: 4.228 ± 0.967
3.383TrpMet: 3.383 ± 1.499
0.423TrpAsn: 0.423 ± 0.423
2.537TrpPro: 2.537 ± 0.717
0.423TrpGln: 0.423 ± 0.423
0.423TrpArg: 0.423 ± 0.29
0.423TrpSer: 0.423 ± 0.29
3.805TrpThr: 3.805 ± 1.16
1.691TrpVal: 1.691 ± 0.587
3.383TrpTrp: 3.383 ± 1.53
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.423TyrAla: 0.423 ± 0.29
1.691TyrCys: 1.691 ± 0.587
0.0TyrAsp: 0.0 ± 0.0
1.691TyrGlu: 1.691 ± 0.768
2.114TyrPhe: 2.114 ± 0.554
1.268TyrGly: 1.268 ± 0.52
0.846TyrHis: 0.846 ± 0.58
2.114TyrIle: 2.114 ± 1.108
2.96TyrLys: 2.96 ± 0.845
5.497TyrLeu: 5.497 ± 1.616
0.423TyrMet: 0.423 ± 0.29
0.846TyrAsn: 0.846 ± 0.58
0.846TyrPro: 0.846 ± 0.361
1.691TyrGln: 1.691 ± 0.677
0.846TyrArg: 0.846 ± 0.811
2.537TyrSer: 2.537 ± 1.739
1.691TyrThr: 1.691 ± 1.011
1.268TyrVal: 1.268 ± 0.869
0.0TyrTrp: 0.0 ± 0.0
0.423TyrTyr: 0.423 ± 0.423
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2366 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski