Amino acid dipepetide frequency for Maliponia aquimaris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.968AlaAla: 17.968 ± 0.166	1.237AlaCys: 1.237 ± 0.033	6.97AlaAsp: 6.97 ± 0.063	8.677AlaGlu: 8.677 ± 0.095	4.326AlaPhe: 4.326 ± 0.061	11.017AlaGly: 11.017 ± 0.107	2.4AlaHis: 2.4 ± 0.043	5.382AlaIle: 5.382 ± 0.063	3.107AlaLys: 3.107 ± 0.054	15.135AlaLeu: 15.135 ± 0.133	3.713AlaMet: 3.713 ± 0.052	2.479AlaAsn: 2.479 ± 0.041	6.542AlaPro: 6.542 ± 0.102	4.78AlaGln: 4.78 ± 0.064	10.243AlaArg: 10.243 ± 0.111	5.3AlaSer: 5.3 ± 0.061	6.152AlaThr: 6.152 ± 0.072	8.848AlaVal: 8.848 ± 0.084	1.701AlaTrp: 1.701 ± 0.036	2.549AlaTyr: 2.549 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	1.216CysAla: 1.216 ± 0.031	0.124CysCys: 0.124 ± 0.009	0.635CysAsp: 0.635 ± 0.021	0.42CysGlu: 0.42 ± 0.019	0.34CysPhe: 0.34 ± 0.012	1.018CysGly: 1.018 ± 0.029	0.287CysHis: 0.287 ± 0.014	0.417CysIle: 0.417 ± 0.017	0.205CysLys: 0.205 ± 0.01	0.969CysLeu: 0.969 ± 0.025	0.167CysMet: 0.167 ± 0.01	0.212CysAsn: 0.212 ± 0.012	0.551CysPro: 0.551 ± 0.019	0.228CysGln: 0.228 ± 0.012	0.648CysArg: 0.648 ± 0.024	0.416CysSer: 0.416 ± 0.018	0.52CysThr: 0.52 ± 0.022	0.642CysVal: 0.642 ± 0.021	0.127CysTrp: 0.127 ± 0.01	0.217CysTyr: 0.217 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.361AspAla: 7.361 ± 0.072	0.542AspCys: 0.542 ± 0.019	3.422AspAsp: 3.422 ± 0.077	3.33AspGlu: 3.33 ± 0.056	2.233AspPhe: 2.233 ± 0.043	5.724AspGly: 5.724 ± 0.073	1.311AspHis: 1.311 ± 0.028	2.841AspIle: 2.841 ± 0.041	1.593AspLys: 1.593 ± 0.034	6.752AspLeu: 6.752 ± 0.072	1.615AspMet: 1.615 ± 0.031	1.268AspAsn: 1.268 ± 0.027	4.05AspPro: 4.05 ± 0.059	1.647AspGln: 1.647 ± 0.032	4.753AspArg: 4.753 ± 0.059	2.366AspSer: 2.366 ± 0.043	3.332AspThr: 3.332 ± 0.054	4.02AspVal: 4.02 ± 0.053	1.284AspTrp: 1.284 ± 0.033	1.528AspTyr: 1.528 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	8.349GluAla: 8.349 ± 0.105	0.338GluCys: 0.338 ± 0.017	3.276GluAsp: 3.276 ± 0.051	3.127GluGlu: 3.127 ± 0.06	1.679GluPhe: 1.679 ± 0.033	4.919GluGly: 4.919 ± 0.052	1.057GluHis: 1.057 ± 0.027	3.497GluIle: 3.497 ± 0.049	1.767GluLys: 1.767 ± 0.038	4.656GluLeu: 4.656 ± 0.06	1.723GluMet: 1.723 ± 0.035	1.38GluAsn: 1.38 ± 0.032	2.492GluPro: 2.492 ± 0.045	1.79GluGln: 1.79 ± 0.035	4.26GluArg: 4.26 ± 0.066	2.134GluSer: 2.134 ± 0.039	3.771GluThr: 3.771 ± 0.059	4.429GluVal: 4.429 ± 0.05	0.683GluTrp: 0.683 ± 0.022	0.941GluTyr: 0.941 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.549PheAla: 4.549 ± 0.056	0.424PheCys: 0.424 ± 0.016	2.947PheAsp: 2.947 ± 0.037	2.116PheGlu: 2.116 ± 0.038	1.376PhePhe: 1.376 ± 0.038	3.615PheGly: 3.615 ± 0.054	0.758PheHis: 0.758 ± 0.025	1.42PheIle: 1.42 ± 0.036	0.766PheLys: 0.766 ± 0.021	3.307PheLeu: 3.307 ± 0.049	0.814PheMet: 0.814 ± 0.027	0.928PheAsn: 0.928 ± 0.024	1.535PhePro: 1.535 ± 0.033	0.958PheGln: 0.958 ± 0.022	2.338PheArg: 2.338 ± 0.042	1.891PheSer: 1.891 ± 0.038	2.018PheThr: 2.018 ± 0.036	2.726PheVal: 2.726 ± 0.046	0.579PheTrp: 0.579 ± 0.024	0.894PheTyr: 0.894 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.62GlyAla: 10.62 ± 0.095	0.885GlyCys: 0.885 ± 0.024	4.949GlyAsp: 4.949 ± 0.074	4.473GlyGlu: 4.473 ± 0.054	3.712GlyPhe: 3.712 ± 0.052	7.898GlyGly: 7.898 ± 0.112	2.048GlyHis: 2.048 ± 0.039	4.231GlyIle: 4.231 ± 0.066	2.992GlyLys: 2.992 ± 0.052	9.666GlyLeu: 9.666 ± 0.092	2.584GlyMet: 2.584 ± 0.047	2.195GlyAsn: 2.195 ± 0.064	4.144GlyPro: 4.144 ± 0.057	3.148GlyGln: 3.148 ± 0.047	6.057GlyArg: 6.057 ± 0.067	4.172GlySer: 4.172 ± 0.082	5.057GlyThr: 5.057 ± 0.079	6.576GlyVal: 6.576 ± 0.071	1.587GlyTrp: 1.587 ± 0.033	2.322GlyTyr: 2.322 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.416HisAla: 2.416 ± 0.044	0.247HisCys: 0.247 ± 0.012	1.311HisAsp: 1.311 ± 0.033	1.033HisGlu: 1.033 ± 0.025	0.811HisPhe: 0.811 ± 0.024	2.076HisGly: 2.076 ± 0.043	0.589HisHis: 0.589 ± 0.022	0.854HisIle: 0.854 ± 0.025	0.485HisLys: 0.485 ± 0.018	2.24HisLeu: 2.24 ± 0.04	0.524HisMet: 0.524 ± 0.019	0.418HisAsn: 0.418 ± 0.017	1.415HisPro: 1.415 ± 0.031	0.535HisGln: 0.535 ± 0.02	1.453HisArg: 1.453 ± 0.033	0.86HisSer: 0.86 ± 0.022	0.854HisThr: 0.854 ± 0.024	1.648HisVal: 1.648 ± 0.031	0.377HisTrp: 0.377 ± 0.019	0.521HisTyr: 0.521 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.743IleAla: 6.743 ± 0.068	0.558IleCys: 0.558 ± 0.02	3.354IleAsp: 3.354 ± 0.049	3.094IleGlu: 3.094 ± 0.048	1.543IlePhe: 1.543 ± 0.036	4.497IleGly: 4.497 ± 0.062	0.889IleHis: 0.889 ± 0.025	1.713IleIle: 1.713 ± 0.043	1.177IleLys: 1.177 ± 0.025	4.521IleLeu: 4.521 ± 0.065	0.947IleMet: 0.947 ± 0.026	1.13IleAsn: 1.13 ± 0.03	2.224IlePro: 2.224 ± 0.043	1.082IleGln: 1.082 ± 0.025	3.097IleArg: 3.097 ± 0.046	2.442IleSer: 2.442 ± 0.04	2.696IleThr: 2.696 ± 0.044	3.723IleVal: 3.723 ± 0.056	0.633IleTrp: 0.633 ± 0.022	1.013IleTyr: 1.013 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.653LysAla: 3.653 ± 0.066	0.168LysCys: 0.168 ± 0.011	1.617LysAsp: 1.617 ± 0.037	1.265LysGlu: 1.265 ± 0.032	0.762LysPhe: 0.762 ± 0.021	2.51LysGly: 2.51 ± 0.054	0.527LysHis: 0.527 ± 0.02	1.29LysIle: 1.29 ± 0.03	0.987LysLys: 0.987 ± 0.029	2.561LysLeu: 2.561 ± 0.046	0.697LysMet: 0.697 ± 0.023	0.619LysAsn: 0.619 ± 0.017	1.731LysPro: 1.731 ± 0.034	0.765LysGln: 0.765 ± 0.023	2.0LysArg: 2.0 ± 0.039	1.504LysSer: 1.504 ± 0.036	1.725LysThr: 1.725 ± 0.031	2.144LysVal: 2.144 ± 0.043	0.339LysTrp: 0.339 ± 0.014	0.558LysTyr: 0.558 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.85LeuAla: 13.85 ± 0.125	1.057LeuCys: 1.057 ± 0.027	6.349LeuAsp: 6.349 ± 0.065	5.284LeuGlu: 5.284 ± 0.075	3.49LeuPhe: 3.49 ± 0.061	8.799LeuGly: 8.799 ± 0.085	2.061LeuHis: 2.061 ± 0.043	4.764LeuIle: 4.764 ± 0.064	2.966LeuLys: 2.966 ± 0.052	9.256LeuLeu: 9.256 ± 0.111	2.71LeuMet: 2.71 ± 0.049	2.455LeuAsn: 2.455 ± 0.042	5.982LeuPro: 5.982 ± 0.071	2.588LeuGln: 2.588 ± 0.044	7.736LeuArg: 7.736 ± 0.09	6.345LeuSer: 6.345 ± 0.073	6.447LeuThr: 6.447 ± 0.077	7.303LeuVal: 7.303 ± 0.073	1.458LeuTrp: 1.458 ± 0.036	1.993LeuTyr: 1.993 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	3.474MetAla: 3.474 ± 0.049	0.184MetCys: 0.184 ± 0.011	1.418MetAsp: 1.418 ± 0.03	1.192MetGlu: 1.192 ± 0.027	0.764MetPhe: 0.764 ± 0.023	2.196MetGly: 2.196 ± 0.039	0.469MetHis: 0.469 ± 0.018	1.42MetIle: 1.42 ± 0.036	0.991MetLys: 0.991 ± 0.025	2.549MetLeu: 2.549 ± 0.041	0.765MetMet: 0.765 ± 0.024	0.732MetAsn: 0.732 ± 0.021	1.577MetPro: 1.577 ± 0.034	0.997MetGln: 0.997 ± 0.025	1.882MetArg: 1.882 ± 0.036	1.598MetSer: 1.598 ± 0.032	2.169MetThr: 2.169 ± 0.033	1.848MetVal: 1.848 ± 0.041	0.231MetTrp: 0.231 ± 0.012	0.339MetTyr: 0.339 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.931AsnAla: 2.931 ± 0.043	0.245AsnCys: 0.245 ± 0.014	1.42AsnAsp: 1.42 ± 0.047	0.984AsnGlu: 0.984 ± 0.027	0.832AsnPhe: 0.832 ± 0.022	2.223AsnGly: 2.223 ± 0.052	0.458AsnHis: 0.458 ± 0.017	1.155AsnIle: 1.155 ± 0.032	0.554AsnLys: 0.554 ± 0.022	2.285AsnLeu: 2.285 ± 0.047	0.605AsnMet: 0.605 ± 0.021	0.579AsnAsn: 0.579 ± 0.023	1.732AsnPro: 1.732 ± 0.039	0.595AsnGln: 0.595 ± 0.02	1.659AsnArg: 1.659 ± 0.034	1.053AsnSer: 1.053 ± 0.036	1.235AsnThr: 1.235 ± 0.031	1.657AsnVal: 1.657 ± 0.036	0.395AsnTrp: 0.395 ± 0.016	0.581AsnTyr: 0.581 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.424ProAla: 6.424 ± 0.083	0.409ProCys: 0.409 ± 0.015	4.188ProAsp: 4.188 ± 0.06	4.352ProGlu: 4.352 ± 0.065	1.922ProPhe: 1.922 ± 0.039	5.285ProGly: 5.285 ± 0.057	1.102ProHis: 1.102 ± 0.025	2.094ProIle: 2.094 ± 0.036	1.436ProLys: 1.436 ± 0.036	5.008ProLeu: 5.008 ± 0.063	1.353ProMet: 1.353 ± 0.033	1.197ProAsn: 1.197 ± 0.026	2.724ProPro: 2.724 ± 0.05	1.871ProGln: 1.871 ± 0.035	3.385ProArg: 3.385 ± 0.052	2.374ProSer: 2.374 ± 0.038	2.414ProThr: 2.414 ± 0.039	4.636ProVal: 4.636 ± 0.064	0.757ProTrp: 0.757 ± 0.022	1.152ProTyr: 1.152 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.278GlnAla: 4.278 ± 0.06	0.204GlnCys: 0.204 ± 0.012	1.879GlnAsp: 1.879 ± 0.035	1.467GlnGlu: 1.467 ± 0.032	0.987GlnPhe: 0.987 ± 0.025	2.75GlnGly: 2.75 ± 0.046	0.593GlnHis: 0.593 ± 0.021	1.774GlnIle: 1.774 ± 0.034	0.921GlnLys: 0.921 ± 0.03	2.769GlnLeu: 2.769 ± 0.043	1.014GlnMet: 1.014 ± 0.029	0.734GlnAsn: 0.734 ± 0.02	1.621GlnPro: 1.621 ± 0.033	1.039GlnGln: 1.039 ± 0.029	2.208GlnArg: 2.208 ± 0.041	1.53GlnSer: 1.53 ± 0.034	1.695GlnThr: 1.695 ± 0.033	2.623GlnVal: 2.623 ± 0.038	0.36GlnTrp: 0.36 ± 0.015	0.561GlnTyr: 0.561 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.123ArgAla: 9.123 ± 0.103	0.555ArgCys: 0.555 ± 0.021	4.603ArgAsp: 4.603 ± 0.065	3.859ArgGlu: 3.859 ± 0.052	2.782ArgPhe: 2.782 ± 0.047	5.137ArgGly: 5.137 ± 0.066	1.761ArgHis: 1.761 ± 0.037	3.952ArgIle: 3.952 ± 0.056	2.194ArgLys: 2.194 ± 0.041	8.199ArgLeu: 8.199 ± 0.09	2.104ArgMet: 2.104 ± 0.034	1.682ArgAsn: 1.682 ± 0.036	3.77ArgPro: 3.77 ± 0.054	2.469ArgGln: 2.469 ± 0.045	5.712ArgArg: 5.712 ± 0.077	3.186ArgSer: 3.186 ± 0.043	3.307ArgThr: 3.307 ± 0.047	5.158ArgVal: 5.158 ± 0.06	1.057ArgTrp: 1.057 ± 0.028	1.626ArgTyr: 1.626 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	5.628SerAla: 5.628 ± 0.074	0.467SerCys: 0.467 ± 0.017	2.965SerAsp: 2.965 ± 0.039	2.553SerGlu: 2.553 ± 0.042	2.13SerPhe: 2.13 ± 0.038	5.454SerGly: 5.454 ± 0.085	0.993SerHis: 0.993 ± 0.024	2.2SerIle: 2.2 ± 0.036	1.186SerLys: 1.186 ± 0.029	4.79SerLeu: 4.79 ± 0.062	1.227SerMet: 1.227 ± 0.028	1.121SerAsn: 1.121 ± 0.027	2.539SerPro: 2.539 ± 0.041	1.381SerGln: 1.381 ± 0.031	3.269SerArg: 3.269 ± 0.047	2.216SerSer: 2.216 ± 0.041	2.281SerThr: 2.281 ± 0.04	3.605SerVal: 3.605 ± 0.052	0.727SerTrp: 0.727 ± 0.026	1.231SerTyr: 1.231 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.605ThrAla: 6.605 ± 0.064	0.565ThrCys: 0.565 ± 0.021	3.13ThrAsp: 3.13 ± 0.052	2.965ThrGlu: 2.965 ± 0.051	1.918ThrPhe: 1.918 ± 0.04	5.757ThrGly: 5.757 ± 0.072	1.101ThrHis: 1.101 ± 0.028	2.413ThrIle: 2.413 ± 0.049	1.182ThrLys: 1.182 ± 0.035	6.317ThrLeu: 6.317 ± 0.078	1.242ThrMet: 1.242 ± 0.03	1.153ThrAsn: 1.153 ± 0.033	3.668ThrPro: 3.668 ± 0.053	1.639ThrGln: 1.639 ± 0.031	4.01ThrArg: 4.01 ± 0.05	2.549ThrSer: 2.549 ± 0.039	2.754ThrThr: 2.754 ± 0.048	4.502ThrVal: 4.502 ± 0.073	0.778ThrTrp: 0.778 ± 0.025	1.252ThrTyr: 1.252 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	9.254ValAla: 9.254 ± 0.093	0.729ValCys: 0.729 ± 0.024	4.116ValAsp: 4.116 ± 0.056	4.2ValGlu: 4.2 ± 0.058	2.966ValPhe: 2.966 ± 0.044	5.299ValGly: 5.299 ± 0.074	1.367ValHis: 1.367 ± 0.033	4.066ValIle: 4.066 ± 0.058	1.947ValLys: 1.947 ± 0.037	7.944ValLeu: 7.944 ± 0.079	2.055ValMet: 2.055 ± 0.04	1.928ValAsn: 1.928 ± 0.039	3.961ValPro: 3.961 ± 0.056	2.219ValGln: 2.219 ± 0.036	4.726ValArg: 4.726 ± 0.055	4.172ValSer: 4.172 ± 0.053	5.043ValThr: 5.043 ± 0.076	5.766ValVal: 5.766 ± 0.074	1.034ValTrp: 1.034 ± 0.028	1.553ValTyr: 1.553 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.436TrpAla: 1.436 ± 0.034	0.167TrpCys: 0.167 ± 0.01	0.829TrpAsp: 0.829 ± 0.025	0.698TrpGlu: 0.698 ± 0.022	0.542TrpPhe: 0.542 ± 0.021	1.08TrpGly: 1.08 ± 0.027	0.39TrpHis: 0.39 ± 0.016	0.71TrpIle: 0.71 ± 0.021	0.427TrpLys: 0.427 ± 0.019	1.744TrpLeu: 1.744 ± 0.037	0.442TrpMet: 0.442 ± 0.015	0.409TrpAsn: 0.409 ± 0.016	0.791TrpPro: 0.791 ± 0.025	0.657TrpGln: 0.657 ± 0.02	1.203TrpArg: 1.203 ± 0.029	0.781TrpSer: 0.781 ± 0.027	0.894TrpThr: 0.894 ± 0.023	0.932TrpVal: 0.932 ± 0.028	0.236TrpTrp: 0.236 ± 0.014	0.323TrpTyr: 0.323 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.647TyrAla: 2.647 ± 0.041	0.256TyrCys: 0.256 ± 0.013	1.596TyrAsp: 1.596 ± 0.034	1.181TyrGlu: 1.181 ± 0.029	0.841TyrPhe: 0.841 ± 0.022	2.062TyrGly: 2.062 ± 0.043	0.506TyrHis: 0.506 ± 0.018	0.886TyrIle: 0.886 ± 0.027	0.537TyrLys: 0.537 ± 0.019	2.224TyrLeu: 2.224 ± 0.04	0.493TyrMet: 0.493 ± 0.016	0.558TyrAsn: 0.558 ± 0.018	1.031TyrPro: 1.031 ± 0.024	0.616TyrGln: 0.616 ± 0.022	1.6TyrArg: 1.6 ± 0.036	1.078TyrSer: 1.078 ± 0.029	1.136TyrThr: 1.136 ± 0.032	1.558TyrVal: 1.558 ± 0.034	0.35TyrTrp: 0.35 ± 0.016	0.586TyrTyr: 0.586 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5072 proteins (1572961 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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