Amino acid dipepetide frequency for Wolbachia endosymbiont wVitA of Nasonia vitripennis phage WOVitA1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.068AlaAla: 6.068 ± 0.801
0.796AlaCys: 0.796 ± 0.175
3.382AlaAsp: 3.382 ± 0.445
5.073AlaGlu: 5.073 ± 0.509
1.691AlaPhe: 1.691 ± 0.301
3.631AlaGly: 3.631 ± 0.375
0.995AlaHis: 0.995 ± 0.166
5.272AlaIle: 5.272 ± 0.513
7.311AlaLys: 7.311 ± 0.728
6.515AlaLeu: 6.515 ± 0.598
1.442AlaMet: 1.442 ± 0.222
4.625AlaAsn: 4.625 ± 0.645
1.243AlaPro: 1.243 ± 0.3
2.089AlaGln: 2.089 ± 0.345
3.034AlaArg: 3.034 ± 0.311
3.482AlaSer: 3.482 ± 0.386
2.586AlaThr: 2.586 ± 0.406
5.322AlaVal: 5.322 ± 0.578
0.647AlaTrp: 0.647 ± 0.155
1.89AlaTyr: 1.89 ± 0.326
0.0AlaXaa: 0.0 ± 0.0
Cys
0.746CysAla: 0.746 ± 0.204
0.05CysCys: 0.05 ± 0.045
0.298CysAsp: 0.298 ± 0.111
0.796CysGlu: 0.796 ± 0.217
0.497CysPhe: 0.497 ± 0.211
0.696CysGly: 0.696 ± 0.197
0.249CysHis: 0.249 ± 0.083
0.647CysIle: 0.647 ± 0.208
0.597CysLys: 0.597 ± 0.142
0.995CysLeu: 0.995 ± 0.237
0.099CysMet: 0.099 ± 0.067
0.448CysAsn: 0.448 ± 0.172
0.298CysPro: 0.298 ± 0.113
0.298CysGln: 0.298 ± 0.124
0.846CysArg: 0.846 ± 0.185
0.796CysSer: 0.796 ± 0.211
0.895CysThr: 0.895 ± 0.22
0.696CysVal: 0.696 ± 0.166
0.05CysTrp: 0.05 ± 0.054
0.249CysTyr: 0.249 ± 0.104
0.0CysXaa: 0.0 ± 0.0
Asp
2.487AspAla: 2.487 ± 0.237
0.497AspCys: 0.497 ± 0.17
2.338AspAsp: 2.338 ± 0.322
4.277AspGlu: 4.277 ± 0.389
1.84AspPhe: 1.84 ± 0.299
2.785AspGly: 2.785 ± 0.285
0.895AspHis: 0.895 ± 0.246
5.919AspIle: 5.919 ± 0.623
3.83AspLys: 3.83 ± 0.345
4.178AspLeu: 4.178 ± 0.477
0.945AspMet: 0.945 ± 0.257
2.437AspAsn: 2.437 ± 0.331
1.592AspPro: 1.592 ± 0.336
2.338AspGln: 2.338 ± 0.409
1.791AspArg: 1.791 ± 0.356
3.084AspSer: 3.084 ± 0.449
2.238AspThr: 2.238 ± 0.34
3.73AspVal: 3.73 ± 0.377
0.597AspTrp: 0.597 ± 0.144
2.238AspTyr: 2.238 ± 0.351
0.0AspXaa: 0.0 ± 0.0
Glu
4.576GluAla: 4.576 ± 0.389
0.647GluCys: 0.647 ± 0.181
3.73GluAsp: 3.73 ± 0.474
6.714GluGlu: 6.714 ± 0.662
2.984GluPhe: 2.984 ± 0.393
4.675GluGly: 4.675 ± 0.544
1.144GluHis: 1.144 ± 0.251
7.958GluIle: 7.958 ± 0.713
8.107GluLys: 8.107 ± 0.618
8.604GluLeu: 8.604 ± 0.605
2.039GluMet: 2.039 ± 0.324
4.924GluAsn: 4.924 ± 0.494
1.592GluPro: 1.592 ± 0.346
2.238GluGln: 2.238 ± 0.4
4.178GluArg: 4.178 ± 0.524
4.526GluSer: 4.526 ± 0.475
2.636GluThr: 2.636 ± 0.279
6.068GluVal: 6.068 ± 0.521
0.547GluTrp: 0.547 ± 0.201
2.984GluTyr: 2.984 ± 0.483
0.0GluXaa: 0.0 ± 0.0
Phe
2.586PheAla: 2.586 ± 0.279
0.448PheCys: 0.448 ± 0.116
2.039PheAsp: 2.039 ± 0.411
2.487PheGlu: 2.487 ± 0.304
1.741PhePhe: 1.741 ± 0.271
1.94PheGly: 1.94 ± 0.293
0.547PheHis: 0.547 ± 0.155
2.636PheIle: 2.636 ± 0.341
1.94PheLys: 1.94 ± 0.276
3.084PheLeu: 3.084 ± 0.437
0.696PheMet: 0.696 ± 0.176
2.089PheAsn: 2.089 ± 0.262
1.044PhePro: 1.044 ± 0.299
1.094PheGln: 1.094 ± 0.218
1.691PheArg: 1.691 ± 0.224
2.785PheSer: 2.785 ± 0.397
2.139PheThr: 2.139 ± 0.357
2.089PheVal: 2.089 ± 0.343
0.149PheTrp: 0.149 ± 0.084
1.592PheTyr: 1.592 ± 0.255
0.0PheXaa: 0.0 ± 0.0
Gly
4.725GlyAla: 4.725 ± 0.741
0.597GlyCys: 0.597 ± 0.174
2.288GlyAsp: 2.288 ± 0.389
5.073GlyGlu: 5.073 ± 0.876
2.487GlyPhe: 2.487 ± 0.364
3.283GlyGly: 3.283 ± 0.44
1.741GlyHis: 1.741 ± 0.638
5.073GlyIle: 5.073 ± 0.57
6.018GlyLys: 6.018 ± 0.614
3.83GlyLeu: 3.83 ± 0.459
1.393GlyMet: 1.393 ± 0.269
3.631GlyAsn: 3.631 ± 0.442
0.746GlyPro: 0.746 ± 0.185
1.741GlyGln: 1.741 ± 0.312
2.835GlyArg: 2.835 ± 0.35
4.377GlySer: 4.377 ± 0.425
3.233GlyThr: 3.233 ± 0.496
4.377GlyVal: 4.377 ± 0.489
0.497GlyTrp: 0.497 ± 0.159
3.084GlyTyr: 3.084 ± 0.535
0.0GlyXaa: 0.0 ± 0.0
His
0.995HisAla: 0.995 ± 0.198
0.448HisCys: 0.448 ± 0.151
1.144HisAsp: 1.144 ± 0.215
0.746HisGlu: 0.746 ± 0.253
1.343HisPhe: 1.343 ± 0.336
1.343HisGly: 1.343 ± 0.31
0.298HisHis: 0.298 ± 0.122
1.791HisIle: 1.791 ± 0.377
1.144HisLys: 1.144 ± 0.279
3.133HisLeu: 3.133 ± 0.68
0.249HisMet: 0.249 ± 0.139
1.144HisAsn: 1.144 ± 0.206
0.597HisPro: 0.597 ± 0.173
0.746HisGln: 0.746 ± 0.212
0.647HisArg: 0.647 ± 0.213
1.343HisSer: 1.343 ± 0.228
1.144HisThr: 1.144 ± 0.185
1.393HisVal: 1.393 ± 0.284
0.099HisTrp: 0.099 ± 0.064
0.995HisTyr: 0.995 ± 0.27
0.0HisXaa: 0.0 ± 0.0
Ile
6.714IleAla: 6.714 ± 0.713
0.945IleCys: 0.945 ± 0.262
4.924IleAsp: 4.924 ± 0.579
7.61IleGlu: 7.61 ± 0.756
1.989IlePhe: 1.989 ± 0.297
4.526IleGly: 4.526 ± 0.618
1.343IleHis: 1.343 ± 0.231
5.869IleIle: 5.869 ± 0.604
7.61IleLys: 7.61 ± 0.733
6.167IleLeu: 6.167 ± 0.646
1.144IleMet: 1.144 ± 0.203
5.272IleAsn: 5.272 ± 0.732
2.537IlePro: 2.537 ± 0.39
1.691IleGln: 1.691 ± 0.323
3.73IleArg: 3.73 ± 0.414
4.874IleSer: 4.874 ± 0.489
5.421IleThr: 5.421 ± 0.59
5.073IleVal: 5.073 ± 0.493
0.647IleTrp: 0.647 ± 0.181
2.835IleTyr: 2.835 ± 0.376
0.0IleXaa: 0.0 ± 0.0
Lys
6.018LysAla: 6.018 ± 0.727
0.846LysCys: 0.846 ± 0.176
4.675LysAsp: 4.675 ± 0.643
8.256LysGlu: 8.256 ± 0.78
3.034LysPhe: 3.034 ± 0.421
6.416LysGly: 6.416 ± 0.696
1.393LysHis: 1.393 ± 0.283
7.262LysIle: 7.262 ± 0.797
6.416LysLys: 6.416 ± 0.638
7.51LysLeu: 7.51 ± 0.749
1.592LysMet: 1.592 ± 0.279
4.974LysAsn: 4.974 ± 0.458
2.188LysPro: 2.188 ± 0.357
2.288LysGln: 2.288 ± 0.318
4.277LysArg: 4.277 ± 0.576
6.515LysSer: 6.515 ± 0.547
4.576LysThr: 4.576 ± 0.425
6.864LysVal: 6.864 ± 0.55
1.094LysTrp: 1.094 ± 0.295
2.437LysTyr: 2.437 ± 0.336
0.0LysXaa: 0.0 ± 0.0
Leu
6.018LeuAla: 6.018 ± 0.633
0.995LeuCys: 0.995 ± 0.251
4.974LeuAsp: 4.974 ± 0.675
7.56LeuGlu: 7.56 ± 0.655
2.686LeuPhe: 2.686 ± 0.27
4.675LeuGly: 4.675 ± 0.495
4.775LeuHis: 4.775 ± 1.124
6.068LeuIle: 6.068 ± 0.551
9.301LeuLys: 9.301 ± 0.804
11.837LeuLeu: 11.837 ± 1.313
1.542LeuMet: 1.542 ± 0.287
4.874LeuAsn: 4.874 ± 0.559
3.133LeuPro: 3.133 ± 0.462
3.382LeuGln: 3.382 ± 0.509
3.83LeuArg: 3.83 ± 0.458
8.754LeuSer: 8.754 ± 0.671
4.228LeuThr: 4.228 ± 0.572
5.372LeuVal: 5.372 ± 0.56
0.796LeuTrp: 0.796 ± 0.213
2.437LeuTyr: 2.437 ± 0.388
0.0LeuXaa: 0.0 ± 0.0
Met
0.945MetAla: 0.945 ± 0.192
0.149MetCys: 0.149 ± 0.081
0.398MetAsp: 0.398 ± 0.168
1.343MetGlu: 1.343 ± 0.247
0.895MetPhe: 0.895 ± 0.219
0.796MetGly: 0.796 ± 0.216
0.298MetHis: 0.298 ± 0.097
1.044MetIle: 1.044 ± 0.221
1.741MetLys: 1.741 ± 0.235
2.238MetLeu: 2.238 ± 0.263
0.298MetMet: 0.298 ± 0.105
0.895MetAsn: 0.895 ± 0.15
0.746MetPro: 0.746 ± 0.221
0.846MetGln: 0.846 ± 0.22
0.696MetArg: 0.696 ± 0.185
1.343MetSer: 1.343 ± 0.346
0.895MetThr: 0.895 ± 0.238
1.094MetVal: 1.094 ± 0.222
0.199MetTrp: 0.199 ± 0.098
0.398MetTyr: 0.398 ± 0.167
0.0MetXaa: 0.0 ± 0.0
Asn
4.924AsnAla: 4.924 ± 1.035
0.846AsnCys: 0.846 ± 0.166
2.885AsnAsp: 2.885 ± 0.399
3.084AsnGlu: 3.084 ± 0.399
2.188AsnPhe: 2.188 ± 0.325
3.879AsnGly: 3.879 ± 0.888
1.343AsnHis: 1.343 ± 0.279
5.769AsnIle: 5.769 ± 0.697
5.222AsnLys: 5.222 ± 0.687
5.62AsnLeu: 5.62 ± 0.658
0.547AsnMet: 0.547 ± 0.176
4.327AsnAsn: 4.327 ± 0.544
2.039AsnPro: 2.039 ± 0.264
2.089AsnGln: 2.089 ± 0.332
2.636AsnArg: 2.636 ± 0.423
3.83AsnSer: 3.83 ± 0.413
2.586AsnThr: 2.586 ± 0.473
4.078AsnVal: 4.078 ± 0.765
0.696AsnTrp: 0.696 ± 0.194
1.989AsnTyr: 1.989 ± 0.251
0.0AsnXaa: 0.0 ± 0.0
Pro
1.989ProAla: 1.989 ± 0.41
0.298ProCys: 0.298 ± 0.127
1.442ProAsp: 1.442 ± 0.255
2.437ProGlu: 2.437 ± 0.379
1.094ProPhe: 1.094 ± 0.297
2.238ProGly: 2.238 ± 0.437
0.647ProHis: 0.647 ± 0.215
2.736ProIle: 2.736 ± 0.493
2.238ProLys: 2.238 ± 0.286
5.073ProLeu: 5.073 ± 1.049
0.348ProMet: 0.348 ± 0.123
1.492ProAsn: 1.492 ± 0.277
0.846ProPro: 0.846 ± 0.288
0.746ProGln: 0.746 ± 0.188
0.945ProArg: 0.945 ± 0.231
1.542ProSer: 1.542 ± 0.246
0.846ProThr: 0.846 ± 0.259
1.592ProVal: 1.592 ± 0.372
0.348ProTrp: 0.348 ± 0.134
0.995ProTyr: 0.995 ± 0.204
0.0ProXaa: 0.0 ± 0.0
Gln
1.492GlnAla: 1.492 ± 0.338
0.199GlnCys: 0.199 ± 0.093
1.293GlnAsp: 1.293 ± 0.265
2.835GlnGlu: 2.835 ± 0.522
1.044GlnPhe: 1.044 ± 0.209
2.387GlnGly: 2.387 ± 0.31
0.696GlnHis: 0.696 ± 0.17
1.989GlnIle: 1.989 ± 0.312
3.133GlnLys: 3.133 ± 0.361
3.183GlnLeu: 3.183 ± 0.553
0.647GlnMet: 0.647 ± 0.191
2.089GlnAsn: 2.089 ± 0.547
0.796GlnPro: 0.796 ± 0.23
0.846GlnGln: 0.846 ± 0.239
1.343GlnArg: 1.343 ± 0.219
2.188GlnSer: 2.188 ± 0.418
1.691GlnThr: 1.691 ± 0.252
1.94GlnVal: 1.94 ± 0.301
0.249GlnTrp: 0.249 ± 0.142
0.945GlnTyr: 0.945 ± 0.193
0.0GlnXaa: 0.0 ± 0.0
Arg
2.736ArgAla: 2.736 ± 0.313
0.298ArgCys: 0.298 ± 0.126
2.586ArgAsp: 2.586 ± 0.333
4.526ArgGlu: 4.526 ± 0.558
1.84ArgPhe: 1.84 ± 0.4
3.034ArgGly: 3.034 ± 0.356
0.746ArgHis: 0.746 ± 0.184
3.432ArgIle: 3.432 ± 0.483
3.631ArgLys: 3.631 ± 0.494
3.78ArgLeu: 3.78 ± 0.577
0.746ArgMet: 0.746 ± 0.177
3.034ArgAsn: 3.034 ± 0.468
1.542ArgPro: 1.542 ± 0.336
1.243ArgGln: 1.243 ± 0.297
2.835ArgArg: 2.835 ± 0.432
3.283ArgSer: 3.283 ± 0.495
2.487ArgThr: 2.487 ± 0.3
2.487ArgVal: 2.487 ± 0.473
0.547ArgTrp: 0.547 ± 0.178
1.194ArgTyr: 1.194 ± 0.268
0.0ArgXaa: 0.0 ± 0.0
Ser
3.73SerAla: 3.73 ± 0.436
0.348SerCys: 0.348 ± 0.133
3.084SerAsp: 3.084 ± 0.373
5.322SerGlu: 5.322 ± 0.595
2.288SerPhe: 2.288 ± 0.248
5.272SerGly: 5.272 ± 0.408
1.243SerHis: 1.243 ± 0.307
5.62SerIle: 5.62 ± 0.561
6.118SerLys: 6.118 ± 0.496
6.764SerLeu: 6.764 ± 0.611
1.293SerMet: 1.293 ± 0.303
4.078SerAsn: 4.078 ± 0.494
2.089SerPro: 2.089 ± 0.351
1.94SerGln: 1.94 ± 0.311
3.233SerArg: 3.233 ± 0.331
4.576SerSer: 4.576 ± 0.55
3.78SerThr: 3.78 ± 0.386
3.482SerVal: 3.482 ± 0.488
0.995SerTrp: 0.995 ± 0.245
2.039SerTyr: 2.039 ± 0.355
0.0SerXaa: 0.0 ± 0.0
Thr
3.68ThrAla: 3.68 ± 0.603
0.597ThrCys: 0.597 ± 0.183
1.94ThrAsp: 1.94 ± 0.377
3.034ThrGlu: 3.034 ± 0.353
1.592ThrPhe: 1.592 ± 0.355
2.934ThrGly: 2.934 ± 0.469
0.796ThrHis: 0.796 ± 0.151
3.879ThrIle: 3.879 ± 0.535
3.432ThrLys: 3.432 ± 0.398
4.725ThrLeu: 4.725 ± 0.515
0.597ThrMet: 0.597 ± 0.155
2.636ThrAsn: 2.636 ± 0.414
4.327ThrPro: 4.327 ± 1.008
1.542ThrGln: 1.542 ± 0.247
1.691ThrArg: 1.691 ± 0.277
3.631ThrSer: 3.631 ± 0.48
2.984ThrThr: 2.984 ± 0.377
3.482ThrVal: 3.482 ± 0.352
0.547ThrTrp: 0.547 ± 0.208
1.542ThrTyr: 1.542 ± 0.206
0.0ThrXaa: 0.0 ± 0.0
Val
3.183ValAla: 3.183 ± 0.402
0.746ValCys: 0.746 ± 0.243
4.427ValAsp: 4.427 ± 0.399
6.118ValGlu: 6.118 ± 0.532
1.989ValPhe: 1.989 ± 0.29
3.382ValGly: 3.382 ± 0.381
0.746ValHis: 0.746 ± 0.173
4.874ValIle: 4.874 ± 0.388
7.311ValLys: 7.311 ± 0.606
6.515ValLeu: 6.515 ± 0.605
1.044ValMet: 1.044 ± 0.227
5.471ValAsn: 5.471 ± 0.997
1.343ValPro: 1.343 ± 0.321
1.84ValGln: 1.84 ± 0.304
3.581ValArg: 3.581 ± 0.499
3.581ValSer: 3.581 ± 0.345
3.084ValThr: 3.084 ± 0.376
4.128ValVal: 4.128 ± 0.48
0.497ValTrp: 0.497 ± 0.166
1.094ValTyr: 1.094 ± 0.189
0.0ValXaa: 0.0 ± 0.0
Trp
0.597TrpAla: 0.597 ± 0.224
0.099TrpCys: 0.099 ± 0.072
0.199TrpAsp: 0.199 ± 0.114
0.448TrpGlu: 0.448 ± 0.144
0.348TrpPhe: 0.348 ± 0.125
0.398TrpGly: 0.398 ± 0.144
0.398TrpHis: 0.398 ± 0.158
0.746TrpIle: 0.746 ± 0.155
0.995TrpLys: 0.995 ± 0.205
0.746TrpLeu: 0.746 ± 0.256
0.05TrpMet: 0.05 ± 0.049
0.497TrpAsn: 0.497 ± 0.166
0.348TrpPro: 0.348 ± 0.135
0.448TrpGln: 0.448 ± 0.158
0.597TrpArg: 0.597 ± 0.164
0.846TrpSer: 0.846 ± 0.213
0.746TrpThr: 0.746 ± 0.208
0.547TrpVal: 0.547 ± 0.185
0.05TrpTrp: 0.05 ± 0.052
0.249TrpTyr: 0.249 ± 0.111
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.885TyrAla: 2.885 ± 0.385
0.398TyrCys: 0.398 ± 0.137
1.989TyrAsp: 1.989 ± 0.236
3.133TyrGlu: 3.133 ± 0.541
1.243TyrPhe: 1.243 ± 0.276
2.736TyrGly: 2.736 ± 0.564
0.497TyrHis: 0.497 ± 0.116
2.338TyrIle: 2.338 ± 0.352
2.537TyrLys: 2.537 ± 0.384
2.736TyrLeu: 2.736 ± 0.309
0.497TyrMet: 0.497 ± 0.187
1.641TyrAsn: 1.641 ± 0.283
0.846TyrPro: 0.846 ± 0.185
1.542TyrGln: 1.542 ± 0.278
1.592TyrArg: 1.592 ± 0.3
1.94TyrSer: 1.94 ± 0.324
1.393TyrThr: 1.393 ± 0.271
1.144TyrVal: 1.144 ± 0.226
0.099TyrTrp: 0.099 ± 0.059
1.293TyrTyr: 1.293 ± 0.239
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 63 proteins (20107 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski