Amino acid dipepetide frequency for Lachnoanaerobaculum sp. ICM7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.099AlaAla: 5.099 ± 0.104
0.825AlaCys: 0.825 ± 0.035
4.062AlaAsp: 4.062 ± 0.073
3.682AlaGlu: 3.682 ± 0.073
2.928AlaPhe: 2.928 ± 0.063
5.403AlaGly: 5.403 ± 0.095
0.842AlaHis: 0.842 ± 0.033
5.567AlaIle: 5.567 ± 0.094
5.747AlaLys: 5.747 ± 0.089
6.244AlaLeu: 6.244 ± 0.092
2.133AlaMet: 2.133 ± 0.056
3.179AlaAsn: 3.179 ± 0.069
1.632AlaPro: 1.632 ± 0.056
1.453AlaGln: 1.453 ± 0.048
2.395AlaArg: 2.395 ± 0.051
3.712AlaSer: 3.712 ± 0.065
3.37AlaThr: 3.37 ± 0.091
4.852AlaVal: 4.852 ± 0.093
0.486AlaTrp: 0.486 ± 0.029
2.538AlaTyr: 2.538 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.744CysAla: 0.744 ± 0.036
0.178CysCys: 0.178 ± 0.015
0.751CysAsp: 0.751 ± 0.033
0.769CysGlu: 0.769 ± 0.029
0.554CysPhe: 0.554 ± 0.027
1.057CysGly: 1.057 ± 0.038
0.217CysHis: 0.217 ± 0.016
1.094CysIle: 1.094 ± 0.04
0.813CysLys: 0.813 ± 0.033
0.83CysLeu: 0.83 ± 0.031
0.325CysMet: 0.325 ± 0.02
0.516CysAsn: 0.516 ± 0.024
0.423CysPro: 0.423 ± 0.024
0.192CysGln: 0.192 ± 0.015
0.352CysArg: 0.352 ± 0.022
0.714CysSer: 0.714 ± 0.033
0.525CysThr: 0.525 ± 0.026
0.755CysVal: 0.755 ± 0.034
0.073CysTrp: 0.073 ± 0.009
0.421CysTyr: 0.421 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.895AspAla: 3.895 ± 0.067
0.652AspCys: 0.652 ± 0.027
3.616AspAsp: 3.616 ± 0.07
5.324AspGlu: 5.324 ± 0.093
3.249AspPhe: 3.249 ± 0.067
4.424AspGly: 4.424 ± 0.083
0.687AspHis: 0.687 ± 0.03
6.824AspIle: 6.824 ± 0.095
5.113AspLys: 5.113 ± 0.079
4.819AspLeu: 4.819 ± 0.074
2.055AspMet: 2.055 ± 0.055
3.296AspAsn: 3.296 ± 0.064
1.539AspPro: 1.539 ± 0.049
0.756AspGln: 0.756 ± 0.033
2.369AspArg: 2.369 ± 0.056
3.5AspSer: 3.5 ± 0.071
3.27AspThr: 3.27 ± 0.066
3.767AspVal: 3.767 ± 0.069
0.539AspTrp: 0.539 ± 0.027
2.92AspTyr: 2.92 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.785GluAla: 4.785 ± 0.091
0.716GluCys: 0.716 ± 0.03
4.534GluAsp: 4.534 ± 0.081
6.313GluGlu: 6.313 ± 0.101
2.995GluPhe: 2.995 ± 0.061
4.323GluGly: 4.323 ± 0.083
1.129GluHis: 1.129 ± 0.043
6.156GluIle: 6.156 ± 0.102
6.994GluLys: 6.994 ± 0.1
6.634GluLeu: 6.634 ± 0.116
2.046GluMet: 2.046 ± 0.051
5.35GluAsn: 5.35 ± 0.074
1.448GluPro: 1.448 ± 0.045
1.649GluGln: 1.649 ± 0.046
2.946GluArg: 2.946 ± 0.066
4.301GluSer: 4.301 ± 0.078
3.138GluThr: 3.138 ± 0.065
4.54GluVal: 4.54 ± 0.073
0.546GluTrp: 0.546 ± 0.025
3.543GluTyr: 3.543 ± 0.078
0.0GluXaa: 0.0 ± 0.0
Phe
2.968PheAla: 2.968 ± 0.065
0.6PheCys: 0.6 ± 0.027
3.308PheAsp: 3.308 ± 0.063
3.361PheGlu: 3.361 ± 0.067
2.149PhePhe: 2.149 ± 0.062
3.176PheGly: 3.176 ± 0.064
0.608PheHis: 0.608 ± 0.028
3.897PheIle: 3.897 ± 0.07
3.053PheLys: 3.053 ± 0.063
3.873PheLeu: 3.873 ± 0.071
1.262PheMet: 1.262 ± 0.041
2.272PheAsn: 2.272 ± 0.047
1.286PhePro: 1.286 ± 0.037
0.813PheGln: 0.813 ± 0.03
1.513PheArg: 1.513 ± 0.045
3.084PheSer: 3.084 ± 0.057
2.32PheThr: 2.32 ± 0.054
2.991PheVal: 2.991 ± 0.065
0.347PheTrp: 0.347 ± 0.02
1.828PheTyr: 1.828 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
4.428GlyAla: 4.428 ± 0.086
0.87GlyCys: 0.87 ± 0.038
3.769GlyAsp: 3.769 ± 0.071
4.822GlyGlu: 4.822 ± 0.085
3.338GlyPhe: 3.338 ± 0.062
4.547GlyGly: 4.547 ± 0.085
1.042GlyHis: 1.042 ± 0.038
6.491GlyIle: 6.491 ± 0.103
5.857GlyLys: 5.857 ± 0.093
5.558GlyLeu: 5.558 ± 0.077
2.118GlyMet: 2.118 ± 0.049
3.653GlyAsn: 3.653 ± 0.091
1.13GlyPro: 1.13 ± 0.041
1.464GlyGln: 1.464 ± 0.04
2.712GlyArg: 2.712 ± 0.07
4.327GlySer: 4.327 ± 0.075
3.449GlyThr: 3.449 ± 0.077
4.879GlyVal: 4.879 ± 0.09
0.657GlyTrp: 0.657 ± 0.033
3.052GlyTyr: 3.052 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
0.788HisAla: 0.788 ± 0.03
0.199HisCys: 0.199 ± 0.015
0.815HisAsp: 0.815 ± 0.038
0.895HisGlu: 0.895 ± 0.038
0.782HisPhe: 0.782 ± 0.029
1.065HisGly: 1.065 ± 0.04
0.321HisHis: 0.321 ± 0.034
1.404HisIle: 1.404 ± 0.042
0.898HisLys: 0.898 ± 0.033
1.204HisLeu: 1.204 ± 0.042
0.438HisMet: 0.438 ± 0.022
0.728HisAsn: 0.728 ± 0.034
0.639HisPro: 0.639 ± 0.026
0.345HisGln: 0.345 ± 0.023
0.598HisArg: 0.598 ± 0.024
0.892HisSer: 0.892 ± 0.035
0.777HisThr: 0.777 ± 0.028
0.808HisVal: 0.808 ± 0.032
0.125HisTrp: 0.125 ± 0.013
0.678HisTyr: 0.678 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.969IleAla: 5.969 ± 0.101
1.18IleCys: 1.18 ± 0.04
5.518IleAsp: 5.518 ± 0.085
6.284IleGlu: 6.284 ± 0.098
4.013IlePhe: 4.013 ± 0.083
5.596IleGly: 5.596 ± 0.095
1.2IleHis: 1.2 ± 0.036
7.347IleIle: 7.347 ± 0.121
7.011IleLys: 7.011 ± 0.117
7.835IleLeu: 7.835 ± 0.133
2.135IleMet: 2.135 ± 0.052
4.478IleAsn: 4.478 ± 0.073
3.048IlePro: 3.048 ± 0.068
1.768IleGln: 1.768 ± 0.045
3.316IleArg: 3.316 ± 0.062
6.41IleSer: 6.41 ± 0.095
4.289IleThr: 4.289 ± 0.074
5.59IleVal: 5.59 ± 0.089
0.634IleTrp: 0.634 ± 0.025
3.598IleTyr: 3.598 ± 0.067
0.0IleXaa: 0.0 ± 0.0
Lys
5.175LysAla: 5.175 ± 0.081
0.643LysCys: 0.643 ± 0.034
5.622LysAsp: 5.622 ± 0.1
7.644LysGlu: 7.644 ± 0.109
2.817LysPhe: 2.817 ± 0.053
4.394LysGly: 4.394 ± 0.075
1.079LysHis: 1.079 ± 0.029
6.493LysIle: 6.493 ± 0.096
7.73LysLys: 7.73 ± 0.12
6.731LysLeu: 6.731 ± 0.097
2.213LysMet: 2.213 ± 0.052
5.3LysAsn: 5.3 ± 0.084
2.005LysPro: 2.005 ± 0.051
1.972LysGln: 1.972 ± 0.06
3.485LysArg: 3.485 ± 0.068
5.025LysSer: 5.025 ± 0.075
3.975LysThr: 3.975 ± 0.071
4.953LysVal: 4.953 ± 0.075
0.601LysTrp: 0.601 ± 0.028
3.879LysTyr: 3.879 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
5.701LeuAla: 5.701 ± 0.077
1.097LeuCys: 1.097 ± 0.034
5.428LeuAsp: 5.428 ± 0.085
6.219LeuGlu: 6.219 ± 0.103
3.742LeuPhe: 3.742 ± 0.075
5.875LeuGly: 5.875 ± 0.094
1.304LeuHis: 1.304 ± 0.037
6.834LeuIle: 6.834 ± 0.104
7.093LeuLys: 7.093 ± 0.104
7.656LeuLeu: 7.656 ± 0.111
2.322LeuMet: 2.322 ± 0.057
4.644LeuAsn: 4.644 ± 0.074
3.185LeuPro: 3.185 ± 0.067
2.056LeuGln: 2.056 ± 0.044
3.266LeuArg: 3.266 ± 0.065
6.845LeuSer: 6.845 ± 0.088
4.214LeuThr: 4.214 ± 0.079
5.071LeuVal: 5.071 ± 0.091
0.608LeuTrp: 0.608 ± 0.029
3.299LeuTyr: 3.299 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.14MetAla: 2.14 ± 0.056
0.296MetCys: 0.296 ± 0.02
1.738MetAsp: 1.738 ± 0.04
2.092MetGlu: 2.092 ± 0.05
1.054MetPhe: 1.054 ± 0.037
1.86MetGly: 1.86 ± 0.052
0.429MetHis: 0.429 ± 0.025
2.296MetIle: 2.296 ± 0.059
2.381MetLys: 2.381 ± 0.05
2.575MetLeu: 2.575 ± 0.061
0.787MetMet: 0.787 ± 0.032
1.612MetAsn: 1.612 ± 0.043
1.044MetPro: 1.044 ± 0.037
0.84MetGln: 0.84 ± 0.028
1.078MetArg: 1.078 ± 0.037
1.87MetSer: 1.87 ± 0.05
1.41MetThr: 1.41 ± 0.041
1.777MetVal: 1.777 ± 0.044
0.196MetTrp: 0.196 ± 0.016
0.988MetTyr: 0.988 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.564AsnAla: 3.564 ± 0.079
0.502AsnCys: 0.502 ± 0.023
3.053AsnAsp: 3.053 ± 0.068
3.913AsnGlu: 3.913 ± 0.082
2.244AsnPhe: 2.244 ± 0.049
3.617AsnGly: 3.617 ± 0.076
0.744AsnHis: 0.744 ± 0.034
5.921AsnIle: 5.921 ± 0.096
4.356AsnLys: 4.356 ± 0.078
4.312AsnLeu: 4.312 ± 0.079
1.568AsnMet: 1.568 ± 0.05
3.088AsnAsn: 3.088 ± 0.07
2.068AsnPro: 2.068 ± 0.049
1.247AsnGln: 1.247 ± 0.039
2.031AsnArg: 2.031 ± 0.046
3.215AsnSer: 3.215 ± 0.067
3.256AsnThr: 3.256 ± 0.061
3.479AsnVal: 3.479 ± 0.063
0.433AsnTrp: 0.433 ± 0.023
2.288AsnTyr: 2.288 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
1.881ProAla: 1.881 ± 0.07
0.291ProCys: 0.291 ± 0.02
2.029ProAsp: 2.029 ± 0.049
2.475ProGlu: 2.475 ± 0.061
1.375ProPhe: 1.375 ± 0.041
1.816ProGly: 1.816 ± 0.051
0.478ProHis: 0.478 ± 0.023
2.285ProIle: 2.285 ± 0.053
2.176ProLys: 2.176 ± 0.05
2.347ProLeu: 2.347 ± 0.06
0.73ProMet: 0.73 ± 0.03
1.408ProAsn: 1.408 ± 0.046
0.591ProPro: 0.591 ± 0.027
0.697ProGln: 0.697 ± 0.031
0.8ProArg: 0.8 ± 0.032
1.812ProSer: 1.812 ± 0.053
1.638ProThr: 1.638 ± 0.051
2.506ProVal: 2.506 ± 0.057
0.272ProTrp: 0.272 ± 0.018
1.267ProTyr: 1.267 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
1.452GlnAla: 1.452 ± 0.046
0.2GlnCys: 0.2 ± 0.016
1.11GlnAsp: 1.11 ± 0.04
1.407GlnGlu: 1.407 ± 0.043
0.867GlnPhe: 0.867 ± 0.03
1.428GlnGly: 1.428 ± 0.046
0.281GlnHis: 0.281 ± 0.021
1.985GlnIle: 1.985 ± 0.046
1.934GlnLys: 1.934 ± 0.048
1.665GlnLeu: 1.665 ± 0.048
0.798GlnMet: 0.798 ± 0.028
1.45GlnAsn: 1.45 ± 0.041
0.519GlnPro: 0.519 ± 0.028
0.561GlnGln: 0.561 ± 0.028
1.01GlnArg: 1.01 ± 0.041
1.465GlnSer: 1.465 ± 0.043
1.286GlnThr: 1.286 ± 0.041
1.428GlnVal: 1.428 ± 0.048
0.2GlnTrp: 0.2 ± 0.017
0.924GlnTyr: 0.924 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
2.431ArgAla: 2.431 ± 0.052
0.393ArgCys: 0.393 ± 0.024
2.37ArgAsp: 2.37 ± 0.052
3.176ArgGlu: 3.176 ± 0.072
1.671ArgPhe: 1.671 ± 0.049
2.313ArgGly: 2.313 ± 0.054
0.571ArgHis: 0.571 ± 0.023
3.314ArgIle: 3.314 ± 0.064
3.123ArgLys: 3.123 ± 0.063
3.446ArgLeu: 3.446 ± 0.075
1.274ArgMet: 1.274 ± 0.039
1.974ArgAsn: 1.974 ± 0.048
1.036ArgPro: 1.036 ± 0.041
1.055ArgGln: 1.055 ± 0.034
1.539ArgArg: 1.539 ± 0.051
1.872ArgSer: 1.872 ± 0.047
1.644ArgThr: 1.644 ± 0.048
2.492ArgVal: 2.492 ± 0.053
0.316ArgTrp: 0.316 ± 0.019
1.74ArgTyr: 1.74 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
4.01SerAla: 4.01 ± 0.076
0.639SerCys: 0.639 ± 0.027
4.063SerAsp: 4.063 ± 0.085
4.433SerGlu: 4.433 ± 0.07
3.128SerPhe: 3.128 ± 0.066
5.25SerGly: 5.25 ± 0.093
0.948SerHis: 0.948 ± 0.042
5.406SerIle: 5.406 ± 0.091
5.152SerLys: 5.152 ± 0.088
5.731SerLeu: 5.731 ± 0.087
1.783SerMet: 1.783 ± 0.043
3.296SerAsn: 3.296 ± 0.066
1.833SerPro: 1.833 ± 0.05
1.441SerGln: 1.441 ± 0.039
2.214SerArg: 2.214 ± 0.054
4.127SerSer: 4.127 ± 0.092
3.194SerThr: 3.194 ± 0.083
4.256SerVal: 4.256 ± 0.075
0.503SerTrp: 0.503 ± 0.027
2.693SerTyr: 2.693 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
3.467ThrAla: 3.467 ± 0.068
0.483ThrCys: 0.483 ± 0.027
3.325ThrAsp: 3.325 ± 0.067
3.164ThrGlu: 3.164 ± 0.065
2.158ThrPhe: 2.158 ± 0.048
4.389ThrGly: 4.389 ± 0.081
0.755ThrHis: 0.755 ± 0.031
3.885ThrIle: 3.885 ± 0.072
3.595ThrLys: 3.595 ± 0.062
4.461ThrLeu: 4.461 ± 0.076
1.283ThrMet: 1.283 ± 0.04
2.451ThrAsn: 2.451 ± 0.053
1.956ThrPro: 1.956 ± 0.065
1.146ThrGln: 1.146 ± 0.039
1.626ThrArg: 1.626 ± 0.039
2.977ThrSer: 2.977 ± 0.061
2.976ThrThr: 2.976 ± 0.099
4.075ThrVal: 4.075 ± 0.094
0.414ThrTrp: 0.414 ± 0.024
2.058ThrTyr: 2.058 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
4.596ValAla: 4.596 ± 0.096
0.944ValCys: 0.944 ± 0.035
4.176ValAsp: 4.176 ± 0.066
4.653ValGlu: 4.653 ± 0.08
3.131ValPhe: 3.131 ± 0.053
4.338ValGly: 4.338 ± 0.072
0.904ValHis: 0.904 ± 0.033
5.376ValIle: 5.376 ± 0.075
4.87ValLys: 4.87 ± 0.084
6.237ValLeu: 6.237 ± 0.095
1.761ValMet: 1.761 ± 0.047
3.369ValAsn: 3.369 ± 0.061
1.991ValPro: 1.991 ± 0.051
1.303ValGln: 1.303 ± 0.039
2.384ValArg: 2.384 ± 0.055
4.71ValSer: 4.71 ± 0.071
3.228ValThr: 3.228 ± 0.086
4.538ValVal: 4.538 ± 0.091
0.508ValTrp: 0.508 ± 0.023
2.712ValTyr: 2.712 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.418TrpAla: 0.418 ± 0.024
0.125TrpCys: 0.125 ± 0.013
0.523TrpAsp: 0.523 ± 0.024
0.51TrpGlu: 0.51 ± 0.028
0.353TrpPhe: 0.353 ± 0.023
0.522TrpGly: 0.522 ± 0.026
0.153TrpHis: 0.153 ± 0.013
0.675TrpIle: 0.675 ± 0.032
0.66TrpLys: 0.66 ± 0.029
0.664TrpLeu: 0.664 ± 0.029
0.236TrpMet: 0.236 ± 0.019
0.474TrpAsn: 0.474 ± 0.023
0.149TrpPro: 0.149 ± 0.014
0.266TrpGln: 0.266 ± 0.019
0.31TrpArg: 0.31 ± 0.022
0.502TrpSer: 0.502 ± 0.025
0.336TrpThr: 0.336 ± 0.019
0.473TrpVal: 0.473 ± 0.027
0.093TrpTrp: 0.093 ± 0.01
0.448TrpTyr: 0.448 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.639TyrAla: 2.639 ± 0.053
0.47TyrCys: 0.47 ± 0.024
2.801TyrAsp: 2.801 ± 0.083
2.949TyrGlu: 2.949 ± 0.056
2.164TyrPhe: 2.164 ± 0.06
2.772TyrGly: 2.772 ± 0.064
0.709TyrHis: 0.709 ± 0.029
3.966TyrIle: 3.966 ± 0.075
3.178TyrLys: 3.178 ± 0.072
3.64TyrLeu: 3.64 ± 0.064
1.196TyrMet: 1.196 ± 0.038
2.359TyrAsn: 2.359 ± 0.06
1.348TyrPro: 1.348 ± 0.043
0.945TyrGln: 0.945 ± 0.032
1.807TyrArg: 1.807 ± 0.045
2.741TyrSer: 2.741 ± 0.063
2.347TyrThr: 2.347 ± 0.057
2.499TyrVal: 2.499 ± 0.056
0.342TyrTrp: 0.342 ± 0.02
1.975TyrTyr: 1.975 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2588 proteins (838843 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski