Amino acid dipepetide frequency for Candidimonas sp. SYP-B2681

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.709AlaAla: 13.709 ± 0.154
1.186AlaCys: 1.186 ± 0.03
5.696AlaAsp: 5.696 ± 0.074
5.71AlaGlu: 5.71 ± 0.078
3.818AlaPhe: 3.818 ± 0.063
9.315AlaGly: 9.315 ± 0.1
2.266AlaHis: 2.266 ± 0.041
6.4AlaIle: 6.4 ± 0.076
3.904AlaLys: 3.904 ± 0.075
12.652AlaLeu: 12.652 ± 0.142
3.293AlaMet: 3.293 ± 0.052
3.194AlaAsn: 3.194 ± 0.056
4.693AlaPro: 4.693 ± 0.077
4.893AlaGln: 4.893 ± 0.07
7.037AlaArg: 7.037 ± 0.086
6.71AlaSer: 6.71 ± 0.075
5.577AlaThr: 5.577 ± 0.068
7.844AlaVal: 7.844 ± 0.092
1.553AlaTrp: 1.553 ± 0.037
2.677AlaTyr: 2.677 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
1.029CysAla: 1.029 ± 0.029
0.133CysCys: 0.133 ± 0.013
0.515CysAsp: 0.515 ± 0.024
0.472CysGlu: 0.472 ± 0.022
0.343CysPhe: 0.343 ± 0.017
0.95CysGly: 0.95 ± 0.033
0.247CysHis: 0.247 ± 0.016
0.466CysIle: 0.466 ± 0.019
0.252CysLys: 0.252 ± 0.014
0.867CysLeu: 0.867 ± 0.03
0.25CysMet: 0.25 ± 0.016
0.29CysAsn: 0.29 ± 0.016
0.493CysPro: 0.493 ± 0.021
0.303CysGln: 0.303 ± 0.017
0.524CysArg: 0.524 ± 0.023
0.575CysSer: 0.575 ± 0.024
0.48CysThr: 0.48 ± 0.021
0.731CysVal: 0.731 ± 0.025
0.119CysTrp: 0.119 ± 0.01
0.224CysTyr: 0.224 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
5.77AspAla: 5.77 ± 0.081
0.447AspCys: 0.447 ± 0.022
2.731AspAsp: 2.731 ± 0.057
3.056AspGlu: 3.056 ± 0.055
2.141AspPhe: 2.141 ± 0.045
3.983AspGly: 3.983 ± 0.073
1.204AspHis: 1.204 ± 0.036
3.206AspIle: 3.206 ± 0.052
1.841AspLys: 1.841 ± 0.045
5.504AspLeu: 5.504 ± 0.068
1.295AspMet: 1.295 ± 0.033
1.499AspAsn: 1.499 ± 0.037
2.882AspPro: 2.882 ± 0.049
1.825AspGln: 1.825 ± 0.037
3.094AspArg: 3.094 ± 0.051
2.784AspSer: 2.784 ± 0.054
2.789AspThr: 2.789 ± 0.053
4.23AspVal: 4.23 ± 0.063
0.866AspTrp: 0.866 ± 0.026
1.561AspTyr: 1.561 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
5.686GluAla: 5.686 ± 0.082
0.41GluCys: 0.41 ± 0.021
2.191GluAsp: 2.191 ± 0.047
2.525GluGlu: 2.525 ± 0.065
1.937GluPhe: 1.937 ± 0.041
3.578GluGly: 3.578 ± 0.058
1.425GluHis: 1.425 ± 0.037
3.161GluIle: 3.161 ± 0.056
2.267GluLys: 2.267 ± 0.049
5.726GluLeu: 5.726 ± 0.075
1.312GluMet: 1.312 ± 0.035
1.773GluAsn: 1.773 ± 0.044
2.458GluPro: 2.458 ± 0.057
2.569GluGln: 2.569 ± 0.051
4.015GluArg: 4.015 ± 0.066
3.112GluSer: 3.112 ± 0.054
2.755GluThr: 2.755 ± 0.048
3.663GluVal: 3.663 ± 0.059
0.72GluTrp: 0.72 ± 0.027
1.26GluTyr: 1.26 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
3.885PheAla: 3.885 ± 0.065
0.419PheCys: 0.419 ± 0.02
2.464PheAsp: 2.464 ± 0.051
2.047PheGlu: 2.047 ± 0.045
1.484PhePhe: 1.484 ± 0.046
3.341PheGly: 3.341 ± 0.064
0.731PheHis: 0.731 ± 0.028
2.059PheIle: 2.059 ± 0.045
1.307PheLys: 1.307 ± 0.036
3.356PheLeu: 3.356 ± 0.063
0.879PheMet: 0.879 ± 0.031
1.321PheAsn: 1.321 ± 0.039
1.708PhePro: 1.708 ± 0.043
1.18PheGln: 1.18 ± 0.031
1.839PheArg: 1.839 ± 0.044
2.631PheSer: 2.631 ± 0.062
2.076PheThr: 2.076 ± 0.045
2.758PheVal: 2.758 ± 0.054
0.528PheTrp: 0.528 ± 0.026
0.977PheTyr: 0.977 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
7.857GlyAla: 7.857 ± 0.101
0.782GlyCys: 0.782 ± 0.029
3.71GlyAsp: 3.71 ± 0.059
3.939GlyGlu: 3.939 ± 0.062
3.195GlyPhe: 3.195 ± 0.06
6.198GlyGly: 6.198 ± 0.088
1.872GlyHis: 1.872 ± 0.042
4.826GlyIle: 4.826 ± 0.07
3.541GlyLys: 3.541 ± 0.06
8.59GlyLeu: 8.59 ± 0.109
2.436GlyMet: 2.436 ± 0.052
2.338GlyAsn: 2.338 ± 0.059
3.018GlyPro: 3.018 ± 0.054
3.057GlyGln: 3.057 ± 0.054
4.811GlyArg: 4.811 ± 0.065
4.867GlySer: 4.867 ± 0.07
4.472GlyThr: 4.472 ± 0.065
6.312GlyVal: 6.312 ± 0.082
1.291GlyTrp: 1.291 ± 0.037
2.431GlyTyr: 2.431 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.552HisAla: 2.552 ± 0.051
0.273HisCys: 0.273 ± 0.014
1.194HisAsp: 1.194 ± 0.038
1.22HisGlu: 1.22 ± 0.029
0.865HisPhe: 0.865 ± 0.028
1.98HisGly: 1.98 ± 0.048
0.619HisHis: 0.619 ± 0.027
1.262HisIle: 1.262 ± 0.033
0.692HisLys: 0.692 ± 0.023
2.065HisLeu: 2.065 ± 0.047
0.532HisMet: 0.532 ± 0.025
0.676HisAsn: 0.676 ± 0.025
1.414HisPro: 1.414 ± 0.039
0.811HisGln: 0.811 ± 0.025
1.318HisArg: 1.318 ± 0.038
1.236HisSer: 1.236 ± 0.034
1.133HisThr: 1.133 ± 0.029
1.646HisVal: 1.646 ± 0.038
0.336HisTrp: 0.336 ± 0.016
0.661HisTyr: 0.661 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
6.822IleAla: 6.822 ± 0.083
0.529IleCys: 0.529 ± 0.02
3.535IleAsp: 3.535 ± 0.055
3.593IleGlu: 3.593 ± 0.058
1.879IlePhe: 1.879 ± 0.051
4.753IleGly: 4.753 ± 0.064
1.064IleHis: 1.064 ± 0.032
2.651IleIle: 2.651 ± 0.056
2.142IleLys: 2.142 ± 0.05
4.808IleLeu: 4.808 ± 0.067
1.199IleMet: 1.199 ± 0.033
1.935IleAsn: 1.935 ± 0.041
2.707IlePro: 2.707 ± 0.052
1.841IleGln: 1.841 ± 0.04
3.023IleArg: 3.023 ± 0.054
3.598IleSer: 3.598 ± 0.056
3.077IleThr: 3.077 ± 0.051
4.434IleVal: 4.434 ± 0.067
0.636IleTrp: 0.636 ± 0.024
1.225IleTyr: 1.225 ± 0.031
0.0IleXaa: 0.0 ± 0.0
Lys
4.08LysAla: 4.08 ± 0.076
0.19LysCys: 0.19 ± 0.013
1.868LysAsp: 1.868 ± 0.046
1.923LysGlu: 1.923 ± 0.046
1.062LysPhe: 1.062 ± 0.029
2.699LysGly: 2.699 ± 0.056
0.791LysHis: 0.791 ± 0.029
1.97LysIle: 1.97 ± 0.046
1.729LysLys: 1.729 ± 0.05
3.767LysLeu: 3.767 ± 0.06
0.935LysMet: 0.935 ± 0.026
1.276LysAsn: 1.276 ± 0.035
2.166LysPro: 2.166 ± 0.047
1.542LysGln: 1.542 ± 0.042
2.39LysArg: 2.39 ± 0.044
2.162LysSer: 2.162 ± 0.045
2.213LysThr: 2.213 ± 0.048
2.776LysVal: 2.776 ± 0.052
0.487LysTrp: 0.487 ± 0.019
0.802LysTyr: 0.802 ± 0.028
0.0LysXaa: 0.0 ± 0.0
Leu
13.105LeuAla: 13.105 ± 0.129
1.054LeuCys: 1.054 ± 0.03
5.758LeuAsp: 5.758 ± 0.075
5.257LeuGlu: 5.257 ± 0.076
3.845LeuPhe: 3.845 ± 0.078
8.433LeuGly: 8.433 ± 0.107
2.327LeuHis: 2.327 ± 0.049
5.671LeuIle: 5.671 ± 0.077
3.844LeuLys: 3.844 ± 0.065
10.929LeuLeu: 10.929 ± 0.159
2.533LeuMet: 2.533 ± 0.056
3.421LeuAsn: 3.421 ± 0.053
5.616LeuPro: 5.616 ± 0.072
3.857LeuGln: 3.857 ± 0.07
6.628LeuArg: 6.628 ± 0.089
6.979LeuSer: 6.979 ± 0.088
5.663LeuThr: 5.663 ± 0.078
7.49LeuVal: 7.49 ± 0.089
1.186LeuTrp: 1.186 ± 0.036
2.303LeuTyr: 2.303 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
3.006MetAla: 3.006 ± 0.054
0.193MetCys: 0.193 ± 0.011
1.156MetAsp: 1.156 ± 0.034
1.115MetGlu: 1.115 ± 0.031
0.809MetPhe: 0.809 ± 0.026
1.977MetGly: 1.977 ± 0.045
0.532MetHis: 0.532 ± 0.02
1.226MetIle: 1.226 ± 0.034
1.083MetLys: 1.083 ± 0.032
2.97MetLeu: 2.97 ± 0.059
0.703MetMet: 0.703 ± 0.026
0.934MetAsn: 0.934 ± 0.028
1.482MetPro: 1.482 ± 0.034
1.16MetGln: 1.16 ± 0.034
1.649MetArg: 1.649 ± 0.04
1.791MetSer: 1.791 ± 0.038
1.602MetThr: 1.602 ± 0.037
1.941MetVal: 1.941 ± 0.044
0.254MetTrp: 0.254 ± 0.014
0.445MetTyr: 0.445 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.411AsnAla: 3.411 ± 0.057
0.292AsnCys: 0.292 ± 0.018
1.675AsnAsp: 1.675 ± 0.04
1.647AsnGlu: 1.647 ± 0.037
1.141AsnPhe: 1.141 ± 0.032
2.579AsnGly: 2.579 ± 0.054
0.659AsnHis: 0.659 ± 0.024
1.845AsnIle: 1.845 ± 0.041
1.202AsnLys: 1.202 ± 0.035
2.991AsnLeu: 2.991 ± 0.049
0.78AsnMet: 0.78 ± 0.029
0.995AsnAsn: 0.995 ± 0.032
2.043AsnPro: 2.043 ± 0.043
1.093AsnGln: 1.093 ± 0.032
1.897AsnArg: 1.897 ± 0.038
1.658AsnSer: 1.658 ± 0.038
1.759AsnThr: 1.759 ± 0.039
2.305AsnVal: 2.305 ± 0.044
0.504AsnTrp: 0.504 ± 0.021
0.802AsnTyr: 0.802 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
5.486ProAla: 5.486 ± 0.082
0.367ProCys: 0.367 ± 0.019
3.364ProAsp: 3.364 ± 0.047
3.513ProGlu: 3.513 ± 0.058
1.909ProPhe: 1.909 ± 0.039
3.992ProGly: 3.992 ± 0.066
1.134ProHis: 1.134 ± 0.03
2.516ProIle: 2.516 ± 0.048
1.667ProLys: 1.667 ± 0.035
4.861ProLeu: 4.861 ± 0.068
1.248ProMet: 1.248 ± 0.03
1.486ProAsn: 1.486 ± 0.044
2.128ProPro: 2.128 ± 0.045
1.839ProGln: 1.839 ± 0.046
2.342ProArg: 2.342 ± 0.049
2.959ProSer: 2.959 ± 0.051
2.531ProThr: 2.531 ± 0.049
4.146ProVal: 4.146 ± 0.063
0.732ProTrp: 0.732 ± 0.026
1.386ProTyr: 1.386 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
5.06GlnAla: 5.06 ± 0.082
0.309GlnCys: 0.309 ± 0.018
1.777GlnAsp: 1.777 ± 0.04
1.933GlnGlu: 1.933 ± 0.045
1.314GlnPhe: 1.314 ± 0.033
2.944GlnGly: 2.944 ± 0.05
1.014GlnHis: 1.014 ± 0.03
2.193GlnIle: 2.193 ± 0.04
1.38GlnLys: 1.38 ± 0.038
4.064GlnLeu: 4.064 ± 0.07
1.021GlnMet: 1.021 ± 0.029
1.184GlnAsn: 1.184 ± 0.032
1.77GlnPro: 1.77 ± 0.041
1.938GlnGln: 1.938 ± 0.045
2.795GlnArg: 2.795 ± 0.05
2.209GlnSer: 2.209 ± 0.046
2.06GlnThr: 2.06 ± 0.043
2.851GlnVal: 2.851 ± 0.052
0.628GlnTrp: 0.628 ± 0.023
0.956GlnTyr: 0.956 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
6.04ArgAla: 6.04 ± 0.073
0.523ArgCys: 0.523 ± 0.023
3.175ArgAsp: 3.175 ± 0.054
3.327ArgGlu: 3.327 ± 0.058
2.452ArgPhe: 2.452 ± 0.048
3.895ArgGly: 3.895 ± 0.057
1.556ArgHis: 1.556 ± 0.039
3.695ArgIle: 3.695 ± 0.05
2.298ArgLys: 2.298 ± 0.045
7.068ArgLeu: 7.068 ± 0.08
1.694ArgMet: 1.694 ± 0.037
2.056ArgAsn: 2.056 ± 0.043
2.867ArgPro: 2.867 ± 0.048
2.792ArgGln: 2.792 ± 0.052
4.213ArgArg: 4.213 ± 0.075
3.728ArgSer: 3.728 ± 0.058
2.847ArgThr: 2.847 ± 0.058
4.358ArgVal: 4.358 ± 0.077
0.927ArgTrp: 0.927 ± 0.026
1.923ArgTyr: 1.923 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
6.463SerAla: 6.463 ± 0.076
0.541SerCys: 0.541 ± 0.023
3.151SerAsp: 3.151 ± 0.045
2.889SerGlu: 2.889 ± 0.056
2.393SerPhe: 2.393 ± 0.041
5.697SerGly: 5.697 ± 0.082
1.357SerHis: 1.357 ± 0.032
3.382SerIle: 3.382 ± 0.055
2.082SerLys: 2.082 ± 0.048
6.483SerLeu: 6.483 ± 0.093
1.733SerMet: 1.733 ± 0.038
1.881SerAsn: 1.881 ± 0.042
3.013SerPro: 3.013 ± 0.049
2.209SerGln: 2.209 ± 0.043
3.714SerArg: 3.714 ± 0.059
3.817SerSer: 3.817 ± 0.065
3.312SerThr: 3.312 ± 0.046
4.515SerVal: 4.515 ± 0.069
0.91SerTrp: 0.91 ± 0.031
1.51SerTyr: 1.51 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
5.639ThrAla: 5.639 ± 0.07
0.422ThrCys: 0.422 ± 0.017
2.74ThrAsp: 2.74 ± 0.048
2.65ThrGlu: 2.65 ± 0.047
1.855ThrPhe: 1.855 ± 0.038
4.609ThrGly: 4.609 ± 0.073
1.238ThrHis: 1.238 ± 0.033
2.924ThrIle: 2.924 ± 0.054
1.466ThrLys: 1.466 ± 0.04
6.405ThrLeu: 6.405 ± 0.08
1.293ThrMet: 1.293 ± 0.038
1.414ThrAsn: 1.414 ± 0.037
3.306ThrPro: 3.306 ± 0.062
1.984ThrGln: 1.984 ± 0.042
3.118ThrArg: 3.118 ± 0.048
3.163ThrSer: 3.163 ± 0.053
2.907ThrThr: 2.907 ± 0.053
4.209ThrVal: 4.209 ± 0.062
0.68ThrTrp: 0.68 ± 0.023
1.209ThrTyr: 1.209 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
8.64ValAla: 8.64 ± 0.093
0.751ValCys: 0.751 ± 0.03
3.953ValAsp: 3.953 ± 0.059
3.907ValGlu: 3.907 ± 0.06
2.912ValPhe: 2.912 ± 0.059
5.461ValGly: 5.461 ± 0.073
1.56ValHis: 1.56 ± 0.036
4.14ValIle: 4.14 ± 0.07
2.769ValLys: 2.769 ± 0.063
8.196ValLeu: 8.196 ± 0.102
1.935ValMet: 1.935 ± 0.042
2.439ValAsn: 2.439 ± 0.044
3.86ValPro: 3.86 ± 0.054
2.815ValGln: 2.815 ± 0.057
4.233ValArg: 4.233 ± 0.059
4.853ValSer: 4.853 ± 0.071
3.897ValThr: 3.897 ± 0.064
6.25ValVal: 6.25 ± 0.076
0.921ValTrp: 0.921 ± 0.031
1.707ValTyr: 1.707 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.201TrpAla: 1.201 ± 0.033
0.142TrpCys: 0.142 ± 0.011
0.591TrpAsp: 0.591 ± 0.023
0.551TrpGlu: 0.551 ± 0.024
0.587TrpPhe: 0.587 ± 0.026
0.926TrpGly: 0.926 ± 0.032
0.376TrpHis: 0.376 ± 0.015
0.731TrpIle: 0.731 ± 0.028
0.484TrpLys: 0.484 ± 0.023
1.983TrpLeu: 1.983 ± 0.047
0.422TrpMet: 0.422 ± 0.02
0.489TrpAsn: 0.489 ± 0.02
0.662TrpPro: 0.662 ± 0.024
0.695TrpGln: 0.695 ± 0.028
1.075TrpArg: 1.075 ± 0.034
0.811TrpSer: 0.811 ± 0.031
0.686TrpThr: 0.686 ± 0.027
0.91TrpVal: 0.91 ± 0.029
0.222TrpTrp: 0.222 ± 0.015
0.328TrpTyr: 0.328 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.686TyrAla: 2.686 ± 0.052
0.3TyrCys: 0.3 ± 0.017
1.46TyrAsp: 1.46 ± 0.036
1.268TyrGlu: 1.268 ± 0.032
1.048TyrPhe: 1.048 ± 0.031
2.236TyrGly: 2.236 ± 0.039
0.513TyrHis: 0.513 ± 0.022
1.126TyrIle: 1.126 ± 0.033
0.879TyrLys: 0.879 ± 0.029
2.615TyrLeu: 2.615 ± 0.055
0.535TyrMet: 0.535 ± 0.023
0.677TyrAsn: 0.677 ± 0.024
1.318TyrPro: 1.318 ± 0.033
0.997TyrGln: 0.997 ± 0.03
1.719TyrArg: 1.719 ± 0.041
1.412TyrSer: 1.412 ± 0.034
1.395TyrThr: 1.395 ± 0.037
1.83TyrVal: 1.83 ± 0.041
0.371TyrTrp: 0.371 ± 0.017
0.685TyrTyr: 0.685 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3632 proteins (1176441 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski