Amino acid dipepetide frequency for Streptococcus satellite phage Javan537

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.276AlaAla: 2.276 ± 1.27
0.379AlaCys: 0.379 ± 0.39
2.276AlaAsp: 2.276 ± 0.913
6.07AlaGlu: 6.07 ± 1.439
3.035AlaPhe: 3.035 ± 1.465
2.276AlaGly: 2.276 ± 0.762
1.138AlaHis: 1.138 ± 0.605
6.07AlaIle: 6.07 ± 1.439
6.829AlaLys: 6.829 ± 1.443
6.07AlaLeu: 6.07 ± 1.831
1.517AlaMet: 1.517 ± 0.694
5.69AlaAsn: 5.69 ± 1.581
1.138AlaPro: 1.138 ± 0.731
2.656AlaGln: 2.656 ± 0.879
3.794AlaArg: 3.794 ± 1.219
2.656AlaSer: 2.656 ± 0.892
3.794AlaThr: 3.794 ± 1.161
1.897AlaVal: 1.897 ± 0.761
0.379AlaTrp: 0.379 ± 0.344
2.656AlaTyr: 2.656 ± 0.757
0.0AlaXaa: 0.0 ± 0.0
Cys
0.759CysAla: 0.759 ± 0.473
0.0CysCys: 0.0 ± 0.0
0.379CysAsp: 0.379 ± 0.325
0.379CysGlu: 0.379 ± 0.344
0.379CysPhe: 0.379 ± 0.334
0.759CysGly: 0.759 ± 0.525
0.0CysHis: 0.0 ± 0.0
0.379CysIle: 0.379 ± 0.366
0.759CysLys: 0.759 ± 0.533
0.379CysLeu: 0.379 ± 0.39
0.379CysMet: 0.379 ± 0.366
0.759CysAsn: 0.759 ± 0.471
1.517CysPro: 1.517 ± 0.74
0.0CysGln: 0.0 ± 0.0
0.379CysArg: 0.379 ± 0.344
0.0CysSer: 0.0 ± 0.0
0.379CysThr: 0.379 ± 0.476
0.379CysVal: 0.379 ± 0.314
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.517AspAla: 1.517 ± 0.516
0.379AspCys: 0.379 ± 0.366
1.138AspAsp: 1.138 ± 0.53
6.829AspGlu: 6.829 ± 2.337
4.173AspPhe: 4.173 ± 0.779
3.035AspGly: 3.035 ± 1.247
0.379AspHis: 0.379 ± 0.396
4.932AspIle: 4.932 ± 1.404
4.932AspLys: 4.932 ± 1.277
4.932AspLeu: 4.932 ± 0.976
0.759AspMet: 0.759 ± 0.554
5.311AspAsn: 5.311 ± 1.409
1.138AspPro: 1.138 ± 0.597
0.379AspGln: 0.379 ± 0.344
2.656AspArg: 2.656 ± 1.069
2.656AspSer: 2.656 ± 0.831
3.794AspThr: 3.794 ± 0.901
1.517AspVal: 1.517 ± 0.803
0.379AspTrp: 0.379 ± 0.314
1.897AspTyr: 1.897 ± 0.714
0.0AspXaa: 0.0 ± 0.0
Glu
7.587GluAla: 7.587 ± 1.73
0.759GluCys: 0.759 ± 0.576
2.656GluAsp: 2.656 ± 1.146
6.449GluGlu: 6.449 ± 1.653
3.035GluPhe: 3.035 ± 1.475
1.517GluGly: 1.517 ± 0.778
0.759GluHis: 0.759 ± 0.445
6.829GluIle: 6.829 ± 1.596
6.829GluLys: 6.829 ± 1.711
12.519GluLeu: 12.519 ± 1.866
1.897GluMet: 1.897 ± 0.872
4.173GluAsn: 4.173 ± 0.92
1.897GluPro: 1.897 ± 0.883
3.414GluGln: 3.414 ± 0.893
4.932GluArg: 4.932 ± 1.453
2.656GluSer: 2.656 ± 0.866
6.07GluThr: 6.07 ± 1.381
5.69GluVal: 5.69 ± 1.89
0.0GluTrp: 0.0 ± 0.0
3.035GluTyr: 3.035 ± 1.006
0.0GluXaa: 0.0 ± 0.0
Phe
1.897PheAla: 1.897 ± 0.822
0.0PheCys: 0.0 ± 0.0
3.035PheAsp: 3.035 ± 1.238
3.035PheGlu: 3.035 ± 1.179
1.138PhePhe: 1.138 ± 0.633
1.517PheGly: 1.517 ± 0.573
0.379PheHis: 0.379 ± 0.344
5.311PheIle: 5.311 ± 1.209
4.173PheLys: 4.173 ± 1.152
4.932PheLeu: 4.932 ± 1.137
1.517PheMet: 1.517 ± 0.591
3.035PheAsn: 3.035 ± 1.332
1.138PhePro: 1.138 ± 0.748
1.897PheGln: 1.897 ± 0.84
0.759PheArg: 0.759 ± 0.574
1.897PheSer: 1.897 ± 0.679
3.035PheThr: 3.035 ± 1.223
1.517PheVal: 1.517 ± 0.904
1.138PheTrp: 1.138 ± 0.699
1.517PheTyr: 1.517 ± 0.595
0.0PheXaa: 0.0 ± 0.0
Gly
1.897GlyAla: 1.897 ± 0.729
0.379GlyCys: 0.379 ± 0.344
1.517GlyAsp: 1.517 ± 0.781
2.656GlyGlu: 2.656 ± 0.885
3.414GlyPhe: 3.414 ± 1.206
1.897GlyGly: 1.897 ± 0.591
0.379GlyHis: 0.379 ± 0.344
3.035GlyIle: 3.035 ± 1.074
4.173GlyLys: 4.173 ± 1.58
4.552GlyLeu: 4.552 ± 0.933
2.276GlyMet: 2.276 ± 0.988
2.276GlyAsn: 2.276 ± 0.852
0.0GlyPro: 0.0 ± 0.0
1.138GlyGln: 1.138 ± 0.659
1.897GlyArg: 1.897 ± 0.738
1.138GlySer: 1.138 ± 0.766
1.517GlyThr: 1.517 ± 0.697
3.794GlyVal: 3.794 ± 1.366
0.379GlyTrp: 0.379 ± 0.314
4.932GlyTyr: 4.932 ± 1.338
0.0GlyXaa: 0.0 ± 0.0
His
1.138HisAla: 1.138 ± 0.495
0.0HisCys: 0.0 ± 0.0
1.517HisAsp: 1.517 ± 0.794
1.517HisGlu: 1.517 ± 0.68
0.759HisPhe: 0.759 ± 0.687
1.138HisGly: 1.138 ± 0.495
0.379HisHis: 0.379 ± 0.39
1.138HisIle: 1.138 ± 0.628
1.897HisLys: 1.897 ± 0.953
1.517HisLeu: 1.517 ± 0.504
0.0HisMet: 0.0 ± 0.0
0.759HisAsn: 0.759 ± 0.502
0.0HisPro: 0.0 ± 0.0
0.759HisGln: 0.759 ± 0.502
1.138HisArg: 1.138 ± 0.564
0.759HisSer: 0.759 ± 0.472
1.517HisThr: 1.517 ± 0.743
0.379HisVal: 0.379 ± 0.344
0.0HisTrp: 0.0 ± 0.0
1.897HisTyr: 1.897 ± 0.643
0.0HisXaa: 0.0 ± 0.0
Ile
4.173IleAla: 4.173 ± 1.269
1.897IleCys: 1.897 ± 0.692
4.932IleAsp: 4.932 ± 1.414
8.346IleGlu: 8.346 ± 1.763
1.138IlePhe: 1.138 ± 0.566
1.138IleGly: 1.138 ± 0.575
1.517IleHis: 1.517 ± 0.637
3.414IleIle: 3.414 ± 1.242
7.208IleLys: 7.208 ± 1.733
6.449IleLeu: 6.449 ± 1.656
0.379IleMet: 0.379 ± 0.348
3.794IleAsn: 3.794 ± 0.626
3.794IlePro: 3.794 ± 1.061
3.794IleGln: 3.794 ± 1.048
1.138IleArg: 1.138 ± 0.771
4.932IleSer: 4.932 ± 1.693
4.932IleThr: 4.932 ± 0.947
2.276IleVal: 2.276 ± 1.054
0.0IleTrp: 0.0 ± 0.0
3.414IleTyr: 3.414 ± 1.112
0.0IleXaa: 0.0 ± 0.0
Lys
8.725LysAla: 8.725 ± 2.541
0.379LysCys: 0.379 ± 0.334
3.414LysAsp: 3.414 ± 0.871
9.863LysGlu: 9.863 ± 1.93
3.794LysPhe: 3.794 ± 1.01
3.035LysGly: 3.035 ± 1.057
1.138LysHis: 1.138 ± 0.505
4.932LysIle: 4.932 ± 1.99
7.967LysLys: 7.967 ± 2.297
6.829LysLeu: 6.829 ± 1.258
2.276LysMet: 2.276 ± 0.736
6.07LysAsn: 6.07 ± 1.27
1.897LysPro: 1.897 ± 1.256
3.414LysGln: 3.414 ± 0.922
6.829LysArg: 6.829 ± 1.456
7.587LysSer: 7.587 ± 1.714
5.311LysThr: 5.311 ± 1.281
5.311LysVal: 5.311 ± 1.379
0.0LysTrp: 0.0 ± 0.0
3.414LysTyr: 3.414 ± 1.286
0.0LysXaa: 0.0 ± 0.0
Leu
6.07LeuAla: 6.07 ± 1.593
0.0LeuCys: 0.0 ± 0.0
10.622LeuAsp: 10.622 ± 1.543
8.346LeuGlu: 8.346 ± 1.907
3.035LeuPhe: 3.035 ± 1.322
4.932LeuGly: 4.932 ± 1.203
1.897LeuHis: 1.897 ± 0.723
3.414LeuIle: 3.414 ± 1.06
11.381LeuLys: 11.381 ± 2.056
7.967LeuLeu: 7.967 ± 1.642
1.897LeuMet: 1.897 ± 0.572
4.552LeuAsn: 4.552 ± 1.623
2.656LeuPro: 2.656 ± 0.951
3.035LeuGln: 3.035 ± 0.849
3.035LeuArg: 3.035 ± 1.155
7.208LeuSer: 7.208 ± 1.341
6.829LeuThr: 6.829 ± 1.468
4.173LeuVal: 4.173 ± 1.287
0.379LeuTrp: 0.379 ± 0.476
3.414LeuTyr: 3.414 ± 0.89
0.0LeuXaa: 0.0 ± 0.0
Met
2.276MetAla: 2.276 ± 0.968
0.0MetCys: 0.0 ± 0.0
1.517MetAsp: 1.517 ± 0.647
1.897MetGlu: 1.897 ± 0.861
0.0MetPhe: 0.0 ± 0.0
0.379MetGly: 0.379 ± 0.369
0.0MetHis: 0.0 ± 0.0
1.517MetIle: 1.517 ± 0.838
1.138MetLys: 1.138 ± 0.702
1.897MetLeu: 1.897 ± 0.721
0.0MetMet: 0.0 ± 0.0
1.517MetAsn: 1.517 ± 0.788
1.138MetPro: 1.138 ± 0.566
0.759MetGln: 0.759 ± 0.466
1.138MetArg: 1.138 ± 0.574
0.0MetSer: 0.0 ± 0.0
4.173MetThr: 4.173 ± 1.255
2.276MetVal: 2.276 ± 0.848
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
3.794AsnAla: 3.794 ± 1.537
0.759AsnCys: 0.759 ± 0.443
1.897AsnAsp: 1.897 ± 0.835
4.932AsnGlu: 4.932 ± 1.44
1.897AsnPhe: 1.897 ± 0.715
4.173AsnGly: 4.173 ± 1.208
1.138AsnHis: 1.138 ± 0.718
4.932AsnIle: 4.932 ± 1.327
4.173AsnLys: 4.173 ± 0.842
3.414AsnLeu: 3.414 ± 1.278
0.379AsnMet: 0.379 ± 0.658
6.449AsnAsn: 6.449 ± 1.62
1.517AsnPro: 1.517 ± 0.556
2.656AsnGln: 2.656 ± 1.349
3.035AsnArg: 3.035 ± 1.263
4.552AsnSer: 4.552 ± 1.315
7.967AsnThr: 7.967 ± 1.439
2.276AsnVal: 2.276 ± 0.726
1.138AsnTrp: 1.138 ± 0.63
4.552AsnTyr: 4.552 ± 1.262
0.0AsnXaa: 0.0 ± 0.0
Pro
2.276ProAla: 2.276 ± 0.638
0.0ProCys: 0.0 ± 0.0
0.759ProAsp: 0.759 ± 0.603
0.759ProGlu: 0.759 ± 0.565
1.897ProPhe: 1.897 ± 0.957
1.517ProGly: 1.517 ± 0.793
0.759ProHis: 0.759 ± 0.623
1.897ProIle: 1.897 ± 1.078
2.276ProLys: 2.276 ± 1.289
1.138ProLeu: 1.138 ± 0.7
0.759ProMet: 0.759 ± 0.507
2.276ProAsn: 2.276 ± 0.716
1.517ProPro: 1.517 ± 0.814
1.138ProGln: 1.138 ± 0.582
3.035ProArg: 3.035 ± 0.88
1.138ProSer: 1.138 ± 0.819
3.414ProThr: 3.414 ± 0.994
2.276ProVal: 2.276 ± 0.748
0.0ProTrp: 0.0 ± 0.0
1.897ProTyr: 1.897 ± 0.541
0.0ProXaa: 0.0 ± 0.0
Gln
4.552GlnAla: 4.552 ± 1.201
1.138GlnCys: 1.138 ± 0.566
1.897GlnAsp: 1.897 ± 0.746
2.656GlnGlu: 2.656 ± 1.733
2.276GlnPhe: 2.276 ± 0.989
1.897GlnGly: 1.897 ± 0.693
0.379GlnHis: 0.379 ± 0.344
1.897GlnIle: 1.897 ± 0.989
2.656GlnLys: 2.656 ± 0.804
3.414GlnLeu: 3.414 ± 1.318
0.379GlnMet: 0.379 ± 0.327
1.897GlnAsn: 1.897 ± 0.731
2.276GlnPro: 2.276 ± 0.914
2.276GlnGln: 2.276 ± 0.857
1.897GlnArg: 1.897 ± 0.691
3.035GlnSer: 3.035 ± 0.766
2.656GlnThr: 2.656 ± 0.89
0.759GlnVal: 0.759 ± 0.516
0.0GlnTrp: 0.0 ± 0.0
1.138GlnTyr: 1.138 ± 0.451
0.0GlnXaa: 0.0 ± 0.0
Arg
2.276ArgAla: 2.276 ± 0.719
0.0ArgCys: 0.0 ± 0.0
3.035ArgAsp: 3.035 ± 0.82
1.897ArgGlu: 1.897 ± 0.841
1.517ArgPhe: 1.517 ± 0.741
2.276ArgGly: 2.276 ± 0.875
1.897ArgHis: 1.897 ± 0.54
3.414ArgIle: 3.414 ± 1.063
5.311ArgLys: 5.311 ± 1.149
2.276ArgLeu: 2.276 ± 0.912
1.517ArgMet: 1.517 ± 0.884
4.552ArgAsn: 4.552 ± 1.176
1.897ArgPro: 1.897 ± 0.743
1.897ArgGln: 1.897 ± 0.843
2.656ArgArg: 2.656 ± 1.167
3.035ArgSer: 3.035 ± 0.912
2.276ArgThr: 2.276 ± 0.942
2.276ArgVal: 2.276 ± 0.945
1.517ArgTrp: 1.517 ± 0.818
3.035ArgTyr: 3.035 ± 0.916
0.0ArgXaa: 0.0 ± 0.0
Ser
4.173SerAla: 4.173 ± 1.168
0.0SerCys: 0.0 ± 0.0
2.656SerAsp: 2.656 ± 1.018
2.276SerGlu: 2.276 ± 0.769
2.656SerPhe: 2.656 ± 0.982
1.897SerGly: 1.897 ± 0.736
1.517SerHis: 1.517 ± 0.724
4.173SerIle: 4.173 ± 1.22
5.69SerLys: 5.69 ± 1.035
4.173SerLeu: 4.173 ± 1.07
1.138SerMet: 1.138 ± 0.405
3.035SerAsn: 3.035 ± 1.071
2.656SerPro: 2.656 ± 1.077
1.897SerGln: 1.897 ± 0.791
2.656SerArg: 2.656 ± 1.193
1.138SerSer: 1.138 ± 0.54
4.932SerThr: 4.932 ± 1.615
2.276SerVal: 2.276 ± 0.898
0.759SerTrp: 0.759 ± 0.687
3.794SerTyr: 3.794 ± 1.093
0.0SerXaa: 0.0 ± 0.0
Thr
4.552ThrAla: 4.552 ± 1.037
0.0ThrCys: 0.0 ± 0.0
3.414ThrAsp: 3.414 ± 1.34
5.69ThrGlu: 5.69 ± 1.797
4.932ThrPhe: 4.932 ± 2.073
4.932ThrGly: 4.932 ± 0.972
2.276ThrHis: 2.276 ± 1.269
6.829ThrIle: 6.829 ± 1.165
4.552ThrLys: 4.552 ± 1.363
8.725ThrLeu: 8.725 ± 1.465
1.897ThrMet: 1.897 ± 1.207
4.173ThrAsn: 4.173 ± 1.263
1.517ThrPro: 1.517 ± 0.638
2.656ThrGln: 2.656 ± 1.135
2.276ThrArg: 2.276 ± 0.847
2.656ThrSer: 2.656 ± 0.77
4.932ThrThr: 4.932 ± 1.426
3.035ThrVal: 3.035 ± 0.856
0.0ThrTrp: 0.0 ± 0.0
3.414ThrTyr: 3.414 ± 1.221
0.0ThrXaa: 0.0 ± 0.0
Val
0.759ValAla: 0.759 ± 0.497
0.759ValCys: 0.759 ± 0.628
2.656ValAsp: 2.656 ± 0.9
5.311ValGlu: 5.311 ± 1.409
1.138ValPhe: 1.138 ± 0.495
2.656ValGly: 2.656 ± 0.833
1.897ValHis: 1.897 ± 0.748
3.035ValIle: 3.035 ± 0.944
4.552ValLys: 4.552 ± 1.287
4.552ValLeu: 4.552 ± 0.897
1.138ValMet: 1.138 ± 0.719
1.517ValAsn: 1.517 ± 0.869
1.138ValPro: 1.138 ± 0.515
1.517ValGln: 1.517 ± 1.055
1.517ValArg: 1.517 ± 0.779
3.794ValSer: 3.794 ± 1.315
3.414ValThr: 3.414 ± 1.233
1.517ValVal: 1.517 ± 0.711
0.0ValTrp: 0.0 ± 0.0
2.656ValTyr: 2.656 ± 0.752
0.0ValXaa: 0.0 ± 0.0
Trp
0.379TrpAla: 0.379 ± 0.373
0.0TrpCys: 0.0 ± 0.0
0.379TrpAsp: 0.379 ± 0.344
0.759TrpGlu: 0.759 ± 0.49
0.0TrpPhe: 0.0 ± 0.0
0.379TrpGly: 0.379 ± 0.369
0.379TrpHis: 0.379 ± 0.334
0.0TrpIle: 0.0 ± 0.0
1.138TrpLys: 1.138 ± 0.559
0.379TrpLeu: 0.379 ± 0.476
0.0TrpMet: 0.0 ± 0.0
0.379TrpAsn: 0.379 ± 0.314
0.379TrpPro: 0.379 ± 0.385
0.379TrpGln: 0.379 ± 0.334
0.379TrpArg: 0.379 ± 0.39
0.379TrpSer: 0.379 ± 0.344
0.0TrpThr: 0.0 ± 0.0
0.759TrpVal: 0.759 ± 0.471
0.379TrpTrp: 0.379 ± 0.344
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.517TyrAla: 1.517 ± 0.648
1.138TyrCys: 1.138 ± 0.534
3.035TyrAsp: 3.035 ± 1.257
3.035TyrGlu: 3.035 ± 1.084
2.656TyrPhe: 2.656 ± 1.207
1.897TyrGly: 1.897 ± 0.813
0.0TyrHis: 0.0 ± 0.0
1.517TyrIle: 1.517 ± 0.677
4.552TyrLys: 4.552 ± 1.842
8.725TyrLeu: 8.725 ± 2.2
1.138TyrMet: 1.138 ± 0.6
3.794TyrAsn: 3.794 ± 1.724
1.517TyrPro: 1.517 ± 0.635
3.414TyrGln: 3.414 ± 1.038
3.414TyrArg: 3.414 ± 1.261
2.276TyrSer: 2.276 ± 0.799
1.517TyrThr: 1.517 ± 1.016
1.138TyrVal: 1.138 ± 0.827
0.379TyrTrp: 0.379 ± 0.369
3.414TyrTyr: 3.414 ± 1.138
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 18 proteins (2637 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski