Amino acid dipepetide frequency for Nonlabens ponticola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.845AlaAla: 5.845 ± 0.149	0.547AlaCys: 0.547 ± 0.026	4.413AlaAsp: 4.413 ± 0.13	3.396AlaGlu: 3.396 ± 0.077	3.39AlaPhe: 3.39 ± 0.066	5.22AlaGly: 5.22 ± 0.103	1.292AlaHis: 1.292 ± 0.044	5.445AlaIle: 5.445 ± 0.099	3.585AlaLys: 3.585 ± 0.091	6.367AlaLeu: 6.367 ± 0.116	1.867AlaMet: 1.867 ± 0.06	3.352AlaAsn: 3.352 ± 0.071	2.177AlaPro: 2.177 ± 0.06	3.551AlaGln: 3.551 ± 0.07	3.06AlaArg: 3.06 ± 0.07	4.594AlaSer: 4.594 ± 0.086	4.509AlaThr: 4.509 ± 0.092	5.001AlaVal: 5.001 ± 0.088	0.601AlaTrp: 0.601 ± 0.031	2.584AlaTyr: 2.584 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.467CysAla: 0.467 ± 0.023	0.101CysCys: 0.101 ± 0.013	0.409CysAsp: 0.409 ± 0.025	0.43CysGlu: 0.43 ± 0.026	0.316CysPhe: 0.316 ± 0.02	0.544CysGly: 0.544 ± 0.027	0.177CysHis: 0.177 ± 0.017	0.495CysIle: 0.495 ± 0.023	0.349CysLys: 0.349 ± 0.021	0.595CysLeu: 0.595 ± 0.026	0.12CysMet: 0.12 ± 0.011	0.309CysAsn: 0.309 ± 0.02	0.26CysPro: 0.26 ± 0.021	0.19CysGln: 0.19 ± 0.017	0.248CysArg: 0.248 ± 0.017	0.454CysSer: 0.454 ± 0.027	0.374CysThr: 0.374 ± 0.021	0.403CysVal: 0.403 ± 0.021	0.058CysTrp: 0.058 ± 0.009	0.277CysTyr: 0.277 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.82AspAla: 4.82 ± 0.135	0.372AspCys: 0.372 ± 0.02	5.401AspAsp: 5.401 ± 0.577	4.546AspGlu: 4.546 ± 0.141	3.568AspPhe: 3.568 ± 0.067	5.494AspGly: 5.494 ± 0.696	1.323AspHis: 1.323 ± 0.044	4.523AspIle: 4.523 ± 0.092	3.734AspLys: 3.734 ± 0.089	6.371AspLeu: 6.371 ± 0.093	1.379AspMet: 1.379 ± 0.047	3.737AspAsn: 3.737 ± 0.289	2.512AspPro: 2.512 ± 0.157	2.748AspGln: 2.748 ± 0.063	3.036AspArg: 3.036 ± 0.059	3.834AspSer: 3.834 ± 0.201	3.444AspThr: 3.444 ± 0.251	4.444AspVal: 4.444 ± 0.111	0.744AspTrp: 0.744 ± 0.031	3.256AspTyr: 3.256 ± 0.136	0.0AspXaa: 0.0 ± 0.0
Glu	4.019GluAla: 4.019 ± 0.086	0.318GluCys: 0.318 ± 0.019	4.209GluAsp: 4.209 ± 0.113	4.503GluGlu: 4.503 ± 0.106	2.905GluPhe: 2.905 ± 0.064	3.011GluGly: 3.011 ± 0.084	1.195GluHis: 1.195 ± 0.039	4.965GluIle: 4.965 ± 0.102	4.612GluLys: 4.612 ± 0.121	6.373GluLeu: 6.373 ± 0.105	1.628GluMet: 1.628 ± 0.052	3.988GluAsn: 3.988 ± 0.071	1.84GluPro: 1.84 ± 0.044	2.889GluGln: 2.889 ± 0.062	2.889GluArg: 2.889 ± 0.073	3.757GluSer: 3.757 ± 0.059	3.416GluThr: 3.416 ± 0.062	4.369GluVal: 4.369 ± 0.08	0.638GluTrp: 0.638 ± 0.03	2.405GluTyr: 2.405 ± 0.069	0.0GluXaa: 0.0 ± 0.0
Phe	3.24PheAla: 3.24 ± 0.072	0.321PheCys: 0.321 ± 0.019	3.399PheAsp: 3.399 ± 0.086	3.276PheGlu: 3.276 ± 0.061	2.334PhePhe: 2.334 ± 0.074	2.83PheGly: 2.83 ± 0.073	0.755PheHis: 0.755 ± 0.036	3.401PheIle: 3.401 ± 0.075	3.301PheLys: 3.301 ± 0.084	4.214PheLeu: 4.214 ± 0.088	1.113PheMet: 1.113 ± 0.041	2.922PheAsn: 2.922 ± 0.063	1.545PhePro: 1.545 ± 0.048	1.507PheGln: 1.507 ± 0.044	1.488PheArg: 1.488 ± 0.044	2.985PheSer: 2.985 ± 0.073	3.076PheThr: 3.076 ± 0.069	2.752PheVal: 2.752 ± 0.063	0.49PheTrp: 0.49 ± 0.023	2.076PheTyr: 2.076 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	4.495GlyAla: 4.495 ± 0.09	0.505GlyCys: 0.505 ± 0.028	4.503GlyAsp: 4.503 ± 0.341	3.656GlyGlu: 3.656 ± 0.074	3.481GlyPhe: 3.481 ± 0.071	4.518GlyGly: 4.518 ± 0.132	1.218GlyHis: 1.218 ± 0.041	5.339GlyIle: 5.339 ± 0.179	4.322GlyLys: 4.322 ± 0.101	5.528GlyLeu: 5.528 ± 0.096	1.679GlyMet: 1.679 ± 0.05	3.679GlyAsn: 3.679 ± 0.129	1.323GlyPro: 1.323 ± 0.043	2.049GlyGln: 2.049 ± 0.057	2.516GlyArg: 2.516 ± 0.067	4.481GlySer: 4.481 ± 0.111	4.351GlyThr: 4.351 ± 0.131	4.39GlyVal: 4.39 ± 0.084	0.711GlyTrp: 0.711 ± 0.034	2.829GlyTyr: 2.829 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.127HisAla: 1.127 ± 0.043	0.183HisCys: 0.183 ± 0.015	1.146HisAsp: 1.146 ± 0.044	1.19HisGlu: 1.19 ± 0.041	0.932HisPhe: 0.932 ± 0.04	1.21HisGly: 1.21 ± 0.043	0.56HisHis: 0.56 ± 0.027	1.309HisIle: 1.309 ± 0.047	1.176HisLys: 1.176 ± 0.042	1.833HisLeu: 1.833 ± 0.047	0.38HisMet: 0.38 ± 0.023	0.864HisAsn: 0.864 ± 0.035	0.828HisPro: 0.828 ± 0.035	0.722HisGln: 0.722 ± 0.031	0.788HisArg: 0.788 ± 0.032	1.012HisSer: 1.012 ± 0.037	0.932HisThr: 0.932 ± 0.033	1.15HisVal: 1.15 ± 0.043	0.202HisTrp: 0.202 ± 0.016	0.832HisTyr: 0.832 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.164IleAla: 6.164 ± 0.092	0.49IleCys: 0.49 ± 0.027	5.623IleAsp: 5.623 ± 0.134	5.157IleGlu: 5.157 ± 0.084	2.998IlePhe: 2.998 ± 0.065	4.69IleGly: 4.69 ± 0.078	1.299IleHis: 1.299 ± 0.046	5.247IleIle: 5.247 ± 0.099	4.942IleLys: 4.942 ± 0.098	6.29IleLeu: 6.29 ± 0.118	1.451IleMet: 1.451 ± 0.05	4.126IleAsn: 4.126 ± 0.084	3.013IlePro: 3.013 ± 0.089	2.319IleGln: 2.319 ± 0.046	2.301IleArg: 2.301 ± 0.06	4.66IleSer: 4.66 ± 0.092	4.63IleThr: 4.63 ± 0.109	4.591IleVal: 4.591 ± 0.086	0.642IleTrp: 0.642 ± 0.032	2.735IleTyr: 2.735 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	4.505LysAla: 4.505 ± 0.093	0.266LysCys: 0.266 ± 0.02	3.86LysAsp: 3.86 ± 0.09	4.821LysGlu: 4.821 ± 0.121	2.449LysPhe: 2.449 ± 0.069	3.512LysGly: 3.512 ± 0.092	1.231LysHis: 1.231 ± 0.044	4.347LysIle: 4.347 ± 0.103	5.054LysLys: 5.054 ± 0.117	5.661LysLeu: 5.661 ± 0.12	1.779LysMet: 1.779 ± 0.059	3.567LysAsn: 3.567 ± 0.087	2.162LysPro: 2.162 ± 0.061	2.452LysGln: 2.452 ± 0.066	2.758LysArg: 2.758 ± 0.073	4.051LysSer: 4.051 ± 0.091	3.557LysThr: 3.557 ± 0.085	3.893LysVal: 3.893 ± 0.091	0.621LysTrp: 0.621 ± 0.027	2.472LysTyr: 2.472 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	6.152LeuAla: 6.152 ± 0.114	0.66LeuCys: 0.66 ± 0.029	6.192LeuAsp: 6.192 ± 0.196	6.372LeuGlu: 6.372 ± 0.124	4.226LeuPhe: 4.226 ± 0.105	5.804LeuGly: 5.804 ± 0.104	1.581LeuHis: 1.581 ± 0.05	6.464LeuIle: 6.464 ± 0.134	6.405LeuLys: 6.405 ± 0.135	8.81LeuLeu: 8.81 ± 0.157	2.08LeuMet: 2.08 ± 0.057	4.914LeuAsn: 4.914 ± 0.086	3.574LeuPro: 3.574 ± 0.061	3.67LeuGln: 3.67 ± 0.084	3.835LeuArg: 3.835 ± 0.085	6.398LeuSer: 6.398 ± 0.114	5.048LeuThr: 5.048 ± 0.085	5.591LeuVal: 5.591 ± 0.103	0.818LeuTrp: 0.818 ± 0.032	3.049LeuTyr: 3.049 ± 0.079	0.0LeuXaa: 0.0 ± 0.0
Met	1.759MetAla: 1.759 ± 0.058	0.135MetCys: 0.135 ± 0.012	1.496MetAsp: 1.496 ± 0.049	1.411MetGlu: 1.411 ± 0.051	0.786MetPhe: 0.786 ± 0.034	1.394MetGly: 1.394 ± 0.047	0.4MetHis: 0.4 ± 0.021	1.794MetIle: 1.794 ± 0.06	1.982MetLys: 1.982 ± 0.053	2.067MetLeu: 2.067 ± 0.055	0.714MetMet: 0.714 ± 0.033	1.252MetAsn: 1.252 ± 0.043	0.875MetPro: 0.875 ± 0.039	0.99MetGln: 0.99 ± 0.036	1.174MetArg: 1.174 ± 0.041	1.622MetSer: 1.622 ± 0.046	1.348MetThr: 1.348 ± 0.041	1.43MetVal: 1.43 ± 0.042	0.142MetTrp: 0.142 ± 0.014	0.71MetTyr: 0.71 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.801AsnAla: 3.801 ± 0.076	0.348AsnCys: 0.348 ± 0.021	4.021AsnAsp: 4.021 ± 0.264	3.299AsnGlu: 3.299 ± 0.067	2.431AsnPhe: 2.431 ± 0.053	3.929AsnGly: 3.929 ± 0.159	0.946AsnHis: 0.946 ± 0.035	3.769AsnIle: 3.769 ± 0.087	3.224AsnLys: 3.224 ± 0.087	4.794AsnLeu: 4.794 ± 0.082	1.186AsnMet: 1.186 ± 0.039	3.181AsnAsn: 3.181 ± 0.094	2.561AsnPro: 2.561 ± 0.087	2.231AsnGln: 2.231 ± 0.058	2.332AsnArg: 2.332 ± 0.071	3.253AsnSer: 3.253 ± 0.073	3.067AsnThr: 3.067 ± 0.08	3.48AsnVal: 3.48 ± 0.075	0.678AsnTrp: 0.678 ± 0.032	2.534AsnTyr: 2.534 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	2.551ProAla: 2.551 ± 0.062	0.195ProCys: 0.195 ± 0.014	2.943ProAsp: 2.943 ± 0.238	2.697ProGlu: 2.697 ± 0.069	1.683ProPhe: 1.683 ± 0.043	2.052ProGly: 2.052 ± 0.06	0.603ProHis: 0.603 ± 0.027	2.53ProIle: 2.53 ± 0.053	1.808ProLys: 1.808 ± 0.059	2.947ProLeu: 2.947 ± 0.063	0.714ProMet: 0.714 ± 0.032	1.928ProAsn: 1.928 ± 0.092	0.721ProPro: 0.721 ± 0.031	1.491ProGln: 1.491 ± 0.039	1.143ProArg: 1.143 ± 0.039	2.173ProSer: 2.173 ± 0.052	1.922ProThr: 1.922 ± 0.058	2.574ProVal: 2.574 ± 0.057	0.343ProTrp: 0.343 ± 0.021	1.346ProTyr: 1.346 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.753GlnAla: 2.753 ± 0.061	0.174GlnCys: 0.174 ± 0.013	2.663GlnAsp: 2.663 ± 0.107	3.129GlnGlu: 3.129 ± 0.074	1.81GlnPhe: 1.81 ± 0.047	2.177GlnGly: 2.177 ± 0.052	0.736GlnHis: 0.736 ± 0.036	2.739GlnIle: 2.739 ± 0.066	2.17GlnLys: 2.17 ± 0.057	4.226GlnLeu: 4.226 ± 0.094	0.958GlnMet: 0.958 ± 0.036	1.814GlnAsn: 1.814 ± 0.054	1.407GlnPro: 1.407 ± 0.044	2.159GlnGln: 2.159 ± 0.061	1.791GlnArg: 1.791 ± 0.053	2.319GlnSer: 2.319 ± 0.051	2.03GlnThr: 2.03 ± 0.052	2.787GlnVal: 2.787 ± 0.054	0.447GlnTrp: 0.447 ± 0.026	1.426GlnTyr: 1.426 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	2.617ArgAla: 2.617 ± 0.067	0.214ArgCys: 0.214 ± 0.016	2.666ArgAsp: 2.666 ± 0.063	2.846ArgGlu: 2.846 ± 0.074	2.242ArgPhe: 2.242 ± 0.059	2.472ArgGly: 2.472 ± 0.057	0.711ArgHis: 0.711 ± 0.033	3.165ArgIle: 3.165 ± 0.071	3.03ArgLys: 3.03 ± 0.073	3.908ArgLeu: 3.908 ± 0.084	1.133ArgMet: 1.133 ± 0.038	2.357ArgAsn: 2.357 ± 0.065	1.252ArgPro: 1.252 ± 0.043	1.452ArgGln: 1.452 ± 0.05	1.87ArgArg: 1.87 ± 0.055	2.579ArgSer: 2.579 ± 0.077	2.132ArgThr: 2.132 ± 0.051	2.522ArgVal: 2.522 ± 0.061	0.448ArgTrp: 0.448 ± 0.026	1.833ArgTyr: 1.833 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	3.832SerAla: 3.832 ± 0.075	0.575SerCys: 0.575 ± 0.029	4.052SerAsp: 4.052 ± 0.177	3.091SerGlu: 3.091 ± 0.067	3.315SerPhe: 3.315 ± 0.067	4.753SerGly: 4.753 ± 0.107	1.181SerHis: 1.181 ± 0.044	5.182SerIle: 5.182 ± 0.086	3.884SerLys: 3.884 ± 0.101	5.86SerLeu: 5.86 ± 0.117	1.535SerMet: 1.535 ± 0.05	3.59SerAsn: 3.59 ± 0.086	1.999SerPro: 1.999 ± 0.053	2.73SerGln: 2.73 ± 0.069	2.949SerArg: 2.949 ± 0.067	4.241SerSer: 4.241 ± 0.083	3.636SerThr: 3.636 ± 0.078	3.814SerVal: 3.814 ± 0.075	0.724SerTrp: 0.724 ± 0.028	2.777SerTyr: 2.777 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	4.714ThrAla: 4.714 ± 0.076	0.324ThrCys: 0.324 ± 0.018	4.18ThrAsp: 4.18 ± 0.253	2.891ThrGlu: 2.891 ± 0.067	2.666ThrPhe: 2.666 ± 0.064	4.596ThrGly: 4.596 ± 0.119	0.955ThrHis: 0.955 ± 0.039	4.586ThrIle: 4.586 ± 0.094	2.482ThrLys: 2.482 ± 0.071	5.155ThrLeu: 5.155 ± 0.109	1.175ThrMet: 1.175 ± 0.04	2.862ThrAsn: 2.862 ± 0.084	2.361ThrPro: 2.361 ± 0.085	2.183ThrGln: 2.183 ± 0.059	2.238ThrArg: 2.238 ± 0.065	3.801ThrSer: 3.801 ± 0.074	3.922ThrThr: 3.922 ± 0.111	4.097ThrVal: 4.097 ± 0.089	0.512ThrTrp: 0.512 ± 0.027	2.364ThrTyr: 2.364 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	4.773ValAla: 4.773 ± 0.088	0.452ValCys: 0.452 ± 0.023	4.685ValAsp: 4.685 ± 0.163	4.21ValGlu: 4.21 ± 0.066	2.998ValPhe: 2.998 ± 0.065	4.01ValGly: 4.01 ± 0.089	1.15ValHis: 1.15 ± 0.042	5.016ValIle: 5.016 ± 0.084	3.771ValLys: 3.771 ± 0.087	5.791ValLeu: 5.791 ± 0.099	1.52ValMet: 1.52 ± 0.046	3.595ValAsn: 3.595 ± 0.072	2.336ValPro: 2.336 ± 0.059	2.203ValGln: 2.203 ± 0.052	2.519ValArg: 2.519 ± 0.067	4.373ValSer: 4.373 ± 0.113	3.895ValThr: 3.895 ± 0.076	4.587ValVal: 4.587 ± 0.088	0.543ValTrp: 0.543 ± 0.024	2.262ValTyr: 2.262 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.553TrpAla: 0.553 ± 0.03	0.091TrpCys: 0.091 ± 0.01	0.585TrpAsp: 0.585 ± 0.027	0.566TrpGlu: 0.566 ± 0.03	0.479TrpPhe: 0.479 ± 0.025	0.509TrpGly: 0.509 ± 0.027	0.224TrpHis: 0.224 ± 0.017	0.726TrpIle: 0.726 ± 0.033	0.694TrpLys: 0.694 ± 0.029	0.998TrpLeu: 0.998 ± 0.04	0.332TrpMet: 0.332 ± 0.02	0.716TrpAsn: 0.716 ± 0.034	0.253TrpPro: 0.253 ± 0.018	0.452TrpGln: 0.452 ± 0.022	0.452TrpArg: 0.452 ± 0.025	0.627TrpSer: 0.627 ± 0.024	0.551TrpThr: 0.551 ± 0.025	0.53TrpVal: 0.53 ± 0.029	0.152TrpTrp: 0.152 ± 0.016	0.474TrpTyr: 0.474 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.609TyrAla: 2.609 ± 0.069	0.304TyrCys: 0.304 ± 0.019	2.838TyrAsp: 2.838 ± 0.073	2.442TyrGlu: 2.442 ± 0.059	2.016TyrPhe: 2.016 ± 0.059	2.849TyrGly: 2.849 ± 0.074	0.843TyrHis: 0.843 ± 0.035	2.324TyrIle: 2.324 ± 0.056	2.492TyrLys: 2.492 ± 0.071	3.853TyrLeu: 3.853 ± 0.091	0.739TyrMet: 0.739 ± 0.034	2.311TyrAsn: 2.311 ± 0.06	1.365TyrPro: 1.365 ± 0.045	1.727TyrGln: 1.727 ± 0.051	2.065TyrArg: 2.065 ± 0.052	2.506TyrSer: 2.506 ± 0.06	2.225TyrThr: 2.225 ± 0.05	2.281TyrVal: 2.281 ± 0.051	0.449TyrTrp: 0.449 ± 0.023	1.65TyrTyr: 1.65 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2545 proteins (867875 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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