Amino acid dipepetide frequency for Streptococcus satellite phage Javan415

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.403AlaCys: 0.403 ± 0.32
4.428AlaAsp: 4.428 ± 1.57
2.818AlaGlu: 2.818 ± 1.317
2.013AlaPhe: 2.013 ± 0.901
2.818AlaGly: 2.818 ± 0.847
1.208AlaHis: 1.208 ± 0.929
4.428AlaIle: 4.428 ± 1.104
4.831AlaLys: 4.831 ± 1.445
4.026AlaLeu: 4.026 ± 1.025
3.221AlaMet: 3.221 ± 1.441
4.026AlaAsn: 4.026 ± 1.108
2.415AlaPro: 2.415 ± 0.74
0.805AlaGln: 0.805 ± 0.55
2.818AlaArg: 2.818 ± 0.795
3.221AlaSer: 3.221 ± 1.361
4.428AlaThr: 4.428 ± 1.219
3.623AlaVal: 3.623 ± 1.323
1.208AlaTrp: 1.208 ± 1.07
2.013AlaTyr: 2.013 ± 0.749
0.0AlaXaa: 0.0 ± 0.0
Cys
1.208CysAla: 1.208 ± 0.638
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.805CysGlu: 0.805 ± 0.697
1.208CysPhe: 1.208 ± 0.878
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.805CysIle: 0.805 ± 0.544
0.403CysLys: 0.403 ± 0.356
0.805CysLeu: 0.805 ± 0.471
0.403CysMet: 0.403 ± 0.346
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.403CysArg: 0.403 ± 0.399
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.403CysVal: 0.403 ± 0.399
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.623AspAla: 3.623 ± 1.479
1.208AspCys: 1.208 ± 0.536
4.026AspAsp: 4.026 ± 1.283
4.831AspGlu: 4.831 ± 1.776
2.818AspPhe: 2.818 ± 1.195
2.415AspGly: 2.415 ± 1.078
1.208AspHis: 1.208 ± 1.082
4.831AspIle: 4.831 ± 0.966
3.623AspLys: 3.623 ± 0.822
6.844AspLeu: 6.844 ± 1.416
2.013AspMet: 2.013 ± 0.545
4.026AspAsn: 4.026 ± 1.103
0.805AspPro: 0.805 ± 0.624
1.208AspGln: 1.208 ± 0.838
2.415AspArg: 2.415 ± 1.239
2.013AspSer: 2.013 ± 0.806
2.013AspThr: 2.013 ± 0.811
3.221AspVal: 3.221 ± 1.097
0.0AspTrp: 0.0 ± 0.0
4.428AspTyr: 4.428 ± 1.305
0.0AspXaa: 0.0 ± 0.0
Glu
5.233GluAla: 5.233 ± 1.08
0.403GluCys: 0.403 ± 0.472
3.623GluAsp: 3.623 ± 1.547
6.441GluGlu: 6.441 ± 1.878
3.623GluPhe: 3.623 ± 1.014
2.013GluGly: 2.013 ± 0.801
0.403GluHis: 0.403 ± 0.346
10.467GluIle: 10.467 ± 2.963
11.675GluLys: 11.675 ± 2.15
7.246GluLeu: 7.246 ± 1.793
0.805GluMet: 0.805 ± 0.451
4.428GluAsn: 4.428 ± 1.092
2.415GluPro: 2.415 ± 1.219
4.026GluGln: 4.026 ± 1.487
4.026GluArg: 4.026 ± 1.037
2.818GluSer: 2.818 ± 0.844
6.039GluThr: 6.039 ± 1.154
3.221GluVal: 3.221 ± 0.97
2.013GluTrp: 2.013 ± 0.684
4.831GluTyr: 4.831 ± 1.533
0.0GluXaa: 0.0 ± 0.0
Phe
1.61PheAla: 1.61 ± 0.995
0.0PheCys: 0.0 ± 0.0
2.415PheAsp: 2.415 ± 0.801
3.623PheGlu: 3.623 ± 1.204
2.013PhePhe: 2.013 ± 0.754
2.013PheGly: 2.013 ± 0.86
1.208PheHis: 1.208 ± 0.878
1.61PheIle: 1.61 ± 0.922
6.039PheLys: 6.039 ± 1.99
3.623PheLeu: 3.623 ± 0.964
1.208PheMet: 1.208 ± 0.606
2.818PheAsn: 2.818 ± 0.791
2.013PhePro: 2.013 ± 0.83
0.403PheGln: 0.403 ± 0.378
2.818PheArg: 2.818 ± 0.875
2.415PheSer: 2.415 ± 0.773
1.208PheThr: 1.208 ± 0.452
2.415PheVal: 2.415 ± 0.613
0.0PheTrp: 0.0 ± 0.0
2.415PheTyr: 2.415 ± 0.93
0.0PheXaa: 0.0 ± 0.0
Gly
1.61GlyAla: 1.61 ± 0.992
0.0GlyCys: 0.0 ± 0.0
2.818GlyAsp: 2.818 ± 0.82
2.013GlyGlu: 2.013 ± 0.825
3.623GlyPhe: 3.623 ± 0.653
2.013GlyGly: 2.013 ± 0.815
1.208GlyHis: 1.208 ± 0.452
4.831GlyIle: 4.831 ± 1.456
6.844GlyLys: 6.844 ± 1.326
4.831GlyLeu: 4.831 ± 0.931
1.61GlyMet: 1.61 ± 1.047
1.61GlyAsn: 1.61 ± 0.581
0.0GlyPro: 0.0 ± 0.0
0.805GlyGln: 0.805 ± 0.527
2.415GlyArg: 2.415 ± 0.953
1.208GlySer: 1.208 ± 0.725
3.221GlyThr: 3.221 ± 0.843
3.623GlyVal: 3.623 ± 0.956
0.403GlyTrp: 0.403 ± 0.436
5.233GlyTyr: 5.233 ± 0.818
0.0GlyXaa: 0.0 ± 0.0
His
1.61HisAla: 1.61 ± 0.698
0.403HisCys: 0.403 ± 0.436
0.805HisAsp: 0.805 ± 0.533
0.403HisGlu: 0.403 ± 0.356
1.208HisPhe: 1.208 ± 0.675
0.403HisGly: 0.403 ± 0.346
0.403HisHis: 0.403 ± 0.399
2.013HisIle: 2.013 ± 1.176
2.013HisLys: 2.013 ± 0.656
2.013HisLeu: 2.013 ± 0.941
0.805HisMet: 0.805 ± 0.657
0.403HisAsn: 0.403 ± 0.436
0.0HisPro: 0.0 ± 0.0
0.0HisGln: 0.0 ± 0.0
1.208HisArg: 1.208 ± 0.585
1.61HisSer: 1.61 ± 1.215
1.208HisThr: 1.208 ± 0.613
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.805HisTyr: 0.805 ± 0.705
0.0HisXaa: 0.0 ± 0.0
Ile
3.623IleAla: 3.623 ± 1.028
0.0IleCys: 0.0 ± 0.0
3.623IleAsp: 3.623 ± 1.466
9.259IleGlu: 9.259 ± 2.228
2.415IlePhe: 2.415 ± 0.672
3.221IleGly: 3.221 ± 1.1
0.805IleHis: 0.805 ± 0.44
5.233IleIle: 5.233 ± 0.634
6.441IleLys: 6.441 ± 1.37
4.831IleLeu: 4.831 ± 1.055
2.013IleMet: 2.013 ± 0.613
3.221IleAsn: 3.221 ± 1.086
2.013IlePro: 2.013 ± 0.786
1.61IleGln: 1.61 ± 0.712
3.623IleArg: 3.623 ± 1.357
5.636IleSer: 5.636 ± 1.303
5.233IleThr: 5.233 ± 1.076
4.026IleVal: 4.026 ± 1.34
0.805IleTrp: 0.805 ± 0.493
4.831IleTyr: 4.831 ± 1.418
0.0IleXaa: 0.0 ± 0.0
Lys
8.454LysAla: 8.454 ± 1.984
0.403LysCys: 0.403 ± 0.399
5.636LysAsp: 5.636 ± 1.441
10.467LysGlu: 10.467 ± 1.689
2.013LysPhe: 2.013 ± 0.857
6.441LysGly: 6.441 ± 2.117
1.208LysHis: 1.208 ± 0.442
5.636LysIle: 5.636 ± 1.141
7.649LysLys: 7.649 ± 1.552
6.441LysLeu: 6.441 ± 1.374
2.818LysMet: 2.818 ± 0.807
6.844LysAsn: 6.844 ± 1.939
3.623LysPro: 3.623 ± 1.13
3.221LysGln: 3.221 ± 0.997
6.039LysArg: 6.039 ± 1.665
4.428LysSer: 4.428 ± 1.023
5.233LysThr: 5.233 ± 1.394
6.039LysVal: 6.039 ± 1.331
0.403LysTrp: 0.403 ± 0.378
3.623LysTyr: 3.623 ± 0.98
0.0LysXaa: 0.0 ± 0.0
Leu
4.831LeuAla: 4.831 ± 0.704
0.403LeuCys: 0.403 ± 0.436
5.233LeuAsp: 5.233 ± 0.781
8.052LeuGlu: 8.052 ± 1.837
2.818LeuPhe: 2.818 ± 0.818
4.831LeuGly: 4.831 ± 1.447
2.013LeuHis: 2.013 ± 1.35
4.831LeuIle: 4.831 ± 1.437
8.454LeuLys: 8.454 ± 1.311
7.649LeuLeu: 7.649 ± 1.562
2.415LeuMet: 2.415 ± 0.754
3.623LeuAsn: 3.623 ± 1.123
4.026LeuPro: 4.026 ± 1.363
2.818LeuGln: 2.818 ± 0.945
4.026LeuArg: 4.026 ± 1.357
6.441LeuSer: 6.441 ± 1.586
5.636LeuThr: 5.636 ± 0.956
5.233LeuVal: 5.233 ± 1.909
0.805LeuTrp: 0.805 ± 0.366
3.623LeuTyr: 3.623 ± 0.864
0.0LeuXaa: 0.0 ± 0.0
Met
3.221MetAla: 3.221 ± 0.968
0.0MetCys: 0.0 ± 0.0
1.208MetAsp: 1.208 ± 0.442
5.233MetGlu: 5.233 ± 0.825
1.208MetPhe: 1.208 ± 0.539
0.805MetGly: 0.805 ± 0.565
0.0MetHis: 0.0 ± 0.0
0.805MetIle: 0.805 ± 0.653
1.61MetLys: 1.61 ± 0.615
2.818MetLeu: 2.818 ± 0.876
0.0MetMet: 0.0 ± 0.0
2.013MetAsn: 2.013 ± 1.123
0.403MetPro: 0.403 ± 0.399
0.0MetGln: 0.0 ± 0.0
0.403MetArg: 0.403 ± 0.399
0.403MetSer: 0.403 ± 0.32
1.61MetThr: 1.61 ± 0.837
2.013MetVal: 2.013 ± 0.966
0.403MetTrp: 0.403 ± 0.472
0.805MetTyr: 0.805 ± 0.56
0.0MetXaa: 0.0 ± 0.0
Asn
2.415AsnAla: 2.415 ± 0.875
0.0AsnCys: 0.0 ± 0.0
3.221AsnAsp: 3.221 ± 1.189
4.428AsnGlu: 4.428 ± 1.254
2.013AsnPhe: 2.013 ± 0.749
4.831AsnGly: 4.831 ± 1.522
2.013AsnHis: 2.013 ± 0.74
4.026AsnIle: 4.026 ± 0.94
8.454AsnLys: 8.454 ± 2.119
5.233AsnLeu: 5.233 ± 1.076
1.208AsnMet: 1.208 ± 0.756
4.831AsnAsn: 4.831 ± 1.393
2.415AsnPro: 2.415 ± 0.751
1.208AsnGln: 1.208 ± 0.674
4.428AsnArg: 4.428 ± 0.886
3.623AsnSer: 3.623 ± 1.41
2.415AsnThr: 2.415 ± 0.717
2.013AsnVal: 2.013 ± 1.017
0.805AsnTrp: 0.805 ± 0.459
3.221AsnTyr: 3.221 ± 1.175
0.0AsnXaa: 0.0 ± 0.0
Pro
2.013ProAla: 2.013 ± 0.705
0.403ProCys: 0.403 ± 0.399
1.208ProAsp: 1.208 ± 0.598
2.013ProGlu: 2.013 ± 0.89
1.208ProPhe: 1.208 ± 0.615
0.0ProGly: 0.0 ± 0.0
0.0ProHis: 0.0 ± 0.0
1.61ProIle: 1.61 ± 0.7
3.221ProLys: 3.221 ± 0.925
2.013ProLeu: 2.013 ± 0.537
0.805ProMet: 0.805 ± 0.487
2.013ProAsn: 2.013 ± 0.712
0.805ProPro: 0.805 ± 0.575
0.403ProGln: 0.403 ± 0.346
2.013ProArg: 2.013 ± 0.488
1.208ProSer: 1.208 ± 0.961
3.623ProThr: 3.623 ± 1.045
3.623ProVal: 3.623 ± 0.813
0.0ProTrp: 0.0 ± 0.0
2.013ProTyr: 2.013 ± 0.815
0.0ProXaa: 0.0 ± 0.0
Gln
2.013GlnAla: 2.013 ± 1.071
0.403GlnCys: 0.403 ± 0.346
1.208GlnAsp: 1.208 ± 0.674
2.013GlnGlu: 2.013 ± 0.632
1.208GlnPhe: 1.208 ± 0.452
1.61GlnGly: 1.61 ± 0.599
0.805GlnHis: 0.805 ± 0.503
1.61GlnIle: 1.61 ± 0.787
2.013GlnLys: 2.013 ± 1.048
5.233GlnLeu: 5.233 ± 1.123
0.403GlnMet: 0.403 ± 0.299
2.415GlnAsn: 2.415 ± 1.143
0.805GlnPro: 0.805 ± 0.624
0.403GlnGln: 0.403 ± 0.312
0.805GlnArg: 0.805 ± 0.469
1.61GlnSer: 1.61 ± 0.654
1.208GlnThr: 1.208 ± 0.779
1.208GlnVal: 1.208 ± 0.536
0.403GlnTrp: 0.403 ± 0.312
1.61GlnTyr: 1.61 ± 0.622
0.0GlnXaa: 0.0 ± 0.0
Arg
3.623ArgAla: 3.623 ± 1.669
0.0ArgCys: 0.0 ± 0.0
3.623ArgAsp: 3.623 ± 1.293
3.623ArgGlu: 3.623 ± 1.067
3.623ArgPhe: 3.623 ± 0.714
4.831ArgGly: 4.831 ± 1.398
0.403ArgHis: 0.403 ± 0.346
5.233ArgIle: 5.233 ± 1.278
3.623ArgLys: 3.623 ± 0.832
4.428ArgLeu: 4.428 ± 0.855
0.805ArgMet: 0.805 ± 0.51
4.026ArgAsn: 4.026 ± 0.819
0.805ArgPro: 0.805 ± 0.44
0.403ArgGln: 0.403 ± 0.346
2.013ArgArg: 2.013 ± 0.759
0.403ArgSer: 0.403 ± 0.32
2.818ArgThr: 2.818 ± 0.941
2.415ArgVal: 2.415 ± 0.902
0.403ArgTrp: 0.403 ± 0.403
2.818ArgTyr: 2.818 ± 1.362
0.0ArgXaa: 0.0 ± 0.0
Ser
0.805SerAla: 0.805 ± 0.487
0.403SerCys: 0.403 ± 0.436
2.818SerAsp: 2.818 ± 0.879
4.026SerGlu: 4.026 ± 1.536
1.208SerPhe: 1.208 ± 0.442
1.208SerGly: 1.208 ± 0.73
0.805SerHis: 0.805 ± 0.481
3.221SerIle: 3.221 ± 0.994
6.441SerLys: 6.441 ± 1.257
3.221SerLeu: 3.221 ± 0.808
0.403SerMet: 0.403 ± 0.32
2.415SerAsn: 2.415 ± 0.783
1.61SerPro: 1.61 ± 0.622
5.233SerGln: 5.233 ± 1.041
2.013SerArg: 2.013 ± 0.586
1.208SerSer: 1.208 ± 0.585
5.636SerThr: 5.636 ± 1.606
2.013SerVal: 2.013 ± 0.851
0.403SerTrp: 0.403 ± 0.312
3.221SerTyr: 3.221 ± 1.074
0.0SerXaa: 0.0 ± 0.0
Thr
3.221ThrAla: 3.221 ± 1.019
0.0ThrCys: 0.0 ± 0.0
4.428ThrAsp: 4.428 ± 1.429
4.428ThrGlu: 4.428 ± 1.338
4.428ThrPhe: 4.428 ± 1.163
4.026ThrGly: 4.026 ± 1.267
2.013ThrHis: 2.013 ± 0.845
4.026ThrIle: 4.026 ± 0.975
5.636ThrLys: 5.636 ± 1.264
6.441ThrLeu: 6.441 ± 1.462
0.403ThrMet: 0.403 ± 0.346
3.623ThrAsn: 3.623 ± 1.194
1.61ThrPro: 1.61 ± 0.654
0.805ThrGln: 0.805 ± 0.471
2.818ThrArg: 2.818 ± 0.883
1.61ThrSer: 1.61 ± 0.622
3.221ThrThr: 3.221 ± 0.842
7.649ThrVal: 7.649 ± 1.78
0.403ThrTrp: 0.403 ± 0.32
2.415ThrTyr: 2.415 ± 1.025
0.0ThrXaa: 0.0 ± 0.0
Val
3.623ValAla: 3.623 ± 0.754
0.805ValCys: 0.805 ± 0.55
1.61ValAsp: 1.61 ± 0.812
5.233ValGlu: 5.233 ± 1.074
2.415ValPhe: 2.415 ± 0.766
3.221ValGly: 3.221 ± 0.927
0.403ValHis: 0.403 ± 0.32
2.818ValIle: 2.818 ± 1.283
4.428ValLys: 4.428 ± 1.239
4.026ValLeu: 4.026 ± 1.297
2.415ValMet: 2.415 ± 0.843
6.039ValAsn: 6.039 ± 1.597
2.818ValPro: 2.818 ± 0.946
2.013ValGln: 2.013 ± 0.58
2.013ValArg: 2.013 ± 0.701
3.623ValSer: 3.623 ± 0.973
4.831ValThr: 4.831 ± 0.89
2.415ValVal: 2.415 ± 0.808
0.805ValTrp: 0.805 ± 0.567
2.818ValTyr: 2.818 ± 0.976
0.0ValXaa: 0.0 ± 0.0
Trp
0.805TrpAla: 0.805 ± 0.493
0.0TrpCys: 0.0 ± 0.0
0.403TrpAsp: 0.403 ± 0.378
2.013TrpGlu: 2.013 ± 0.756
0.0TrpPhe: 0.0 ± 0.0
1.61TrpGly: 1.61 ± 0.86
0.0TrpHis: 0.0 ± 0.0
0.403TrpIle: 0.403 ± 0.378
0.0TrpLys: 0.0 ± 0.0
1.208TrpLeu: 1.208 ± 0.489
0.403TrpMet: 0.403 ± 0.369
0.805TrpAsn: 0.805 ± 0.648
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.805TrpSer: 0.805 ± 0.487
0.0TrpThr: 0.0 ± 0.0
0.403TrpVal: 0.403 ± 0.312
0.0TrpTrp: 0.0 ± 0.0
0.403TrpTyr: 0.403 ± 0.312
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.208TyrAla: 1.208 ± 0.618
1.208TyrCys: 1.208 ± 0.564
5.233TyrAsp: 5.233 ± 1.073
4.026TyrGlu: 4.026 ± 1.064
0.805TyrPhe: 0.805 ± 0.44
1.61TyrGly: 1.61 ± 0.992
1.208TyrHis: 1.208 ± 0.452
4.026TyrIle: 4.026 ± 1.042
3.221TyrLys: 3.221 ± 1.051
5.233TyrLeu: 5.233 ± 0.961
0.403TyrMet: 0.403 ± 0.472
3.623TyrAsn: 3.623 ± 1.382
1.61TyrPro: 1.61 ± 0.877
3.623TyrGln: 3.623 ± 0.963
3.623TyrArg: 3.623 ± 0.951
4.026TyrSer: 4.026 ± 1.598
3.623TyrThr: 3.623 ± 1.003
2.818TyrVal: 2.818 ± 0.9
0.0TyrTrp: 0.0 ± 0.0
2.415TyrTyr: 2.415 ± 0.82
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 13 proteins (2485 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski