Amino acid dipepetide frequency for Arabis nemorensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.7AlaAla: 5.7 ± 0.032	1.154AlaCys: 1.154 ± 0.012	2.891AlaAsp: 2.891 ± 0.018	4.132AlaGlu: 4.132 ± 0.024	2.659AlaPhe: 2.659 ± 0.016	3.868AlaGly: 3.868 ± 0.022	1.174AlaHis: 1.174 ± 0.011	3.613AlaIle: 3.613 ± 0.022	4.011AlaLys: 4.011 ± 0.021	6.242AlaLeu: 6.242 ± 0.029	1.812AlaMet: 1.812 ± 0.013	2.446AlaAsn: 2.446 ± 0.016	2.532AlaPro: 2.532 ± 0.018	1.926AlaGln: 1.926 ± 0.015	3.316AlaArg: 3.316 ± 0.02	5.754AlaSer: 5.754 ± 0.03	3.601AlaThr: 3.601 ± 0.021	4.642AlaVal: 4.642 ± 0.023	0.715AlaTrp: 0.715 ± 0.009	1.746AlaTyr: 1.746 ± 0.014	0.049AlaXaa: 0.049 ± 0.002
Cys	0.895CysAla: 0.895 ± 0.009	0.494CysCys: 0.494 ± 0.008	0.891CysAsp: 0.891 ± 0.009	0.906CysGlu: 0.906 ± 0.01	0.916CysPhe: 0.916 ± 0.01	1.376CysGly: 1.376 ± 0.014	0.429CysHis: 0.429 ± 0.006	0.923CysIle: 0.923 ± 0.009	1.105CysLys: 1.105 ± 0.011	1.851CysLeu: 1.851 ± 0.012	0.396CysMet: 0.396 ± 0.006	0.783CysAsn: 0.783 ± 0.009	0.848CysPro: 0.848 ± 0.011	0.524CysGln: 0.524 ± 0.008	1.036CysArg: 1.036 ± 0.009	1.735CysSer: 1.735 ± 0.014	0.803CysThr: 0.803 ± 0.008	1.146CysVal: 1.146 ± 0.01	0.224CysTrp: 0.224 ± 0.005	0.557CysTyr: 0.557 ± 0.007	0.011CysXaa: 0.011 ± 0.001
Asp	3.241AspAla: 3.241 ± 0.019	0.935AspCys: 0.935 ± 0.011	3.559AspAsp: 3.559 ± 0.027	4.099AspGlu: 4.099 ± 0.02	2.39AspPhe: 2.39 ± 0.015	3.75AspGly: 3.75 ± 0.021	1.246AspHis: 1.246 ± 0.013	2.915AspIle: 2.915 ± 0.016	2.858AspLys: 2.858 ± 0.019	5.277AspLeu: 5.277 ± 0.023	1.357AspMet: 1.357 ± 0.012	2.025AspAsn: 2.025 ± 0.015	2.679AspPro: 2.679 ± 0.016	1.804AspGln: 1.804 ± 0.014	2.428AspArg: 2.428 ± 0.017	4.454AspSer: 4.454 ± 0.024	2.254AspThr: 2.254 ± 0.016	3.675AspVal: 3.675 ± 0.019	0.701AspTrp: 0.701 ± 0.01	1.578AspTyr: 1.578 ± 0.013	0.033AspXaa: 0.033 ± 0.002
Glu	4.889GluAla: 4.889 ± 0.028	0.866GluCys: 0.866 ± 0.01	4.112GluAsp: 4.112 ± 0.025	6.713GluGlu: 6.713 ± 0.039	2.475GluPhe: 2.475 ± 0.015	3.483GluGly: 3.483 ± 0.019	1.226GluHis: 1.226 ± 0.011	4.09GluIle: 4.09 ± 0.02	5.222GluLys: 5.222 ± 0.028	5.844GluLeu: 5.844 ± 0.026	1.895GluMet: 1.895 ± 0.014	3.192GluAsn: 3.192 ± 0.021	2.258GluPro: 2.258 ± 0.017	2.122GluGln: 2.122 ± 0.017	3.519GluArg: 3.519 ± 0.022	4.983GluSer: 4.983 ± 0.025	3.772GluThr: 3.772 ± 0.022	4.102GluVal: 4.102 ± 0.02	0.73GluTrp: 0.73 ± 0.009	1.64GluTyr: 1.64 ± 0.013	0.038GluXaa: 0.038 ± 0.002
Phe	2.544PheAla: 2.544 ± 0.016	0.876PheCys: 0.876 ± 0.01	2.428PheAsp: 2.428 ± 0.014	2.381PheGlu: 2.381 ± 0.014	1.956PhePhe: 1.956 ± 0.016	3.089PheGly: 3.089 ± 0.022	1.043PheHis: 1.043 ± 0.011	1.984PheIle: 1.984 ± 0.016	2.207PheLys: 2.207 ± 0.016	4.236PheLeu: 4.236 ± 0.023	1.001PheMet: 1.001 ± 0.01	1.696PheAsn: 1.696 ± 0.013	2.051PhePro: 2.051 ± 0.015	1.451PheGln: 1.451 ± 0.012	2.143PheArg: 2.143 ± 0.015	4.048PheSer: 4.048 ± 0.022	2.135PheThr: 2.135 ± 0.015	2.913PheVal: 2.913 ± 0.018	0.567PheTrp: 0.567 ± 0.007	1.245PheTyr: 1.245 ± 0.012	0.026PheXaa: 0.026 ± 0.002
Gly	3.521GlyAla: 3.521 ± 0.021	1.224GlyCys: 1.224 ± 0.012	3.508GlyAsp: 3.508 ± 0.017	3.893GlyGlu: 3.893 ± 0.019	3.324GlyPhe: 3.324 ± 0.021	5.33GlyGly: 5.33 ± 0.053	1.405GlyHis: 1.405 ± 0.014	3.515GlyIle: 3.515 ± 0.021	4.235GlyLys: 4.235 ± 0.021	5.818GlyLeu: 5.818 ± 0.027	1.46GlyMet: 1.46 ± 0.012	3.054GlyAsn: 3.054 ± 0.017	2.276GlyPro: 2.276 ± 0.017	1.937GlyGln: 1.937 ± 0.014	3.513GlyArg: 3.513 ± 0.021	5.895GlySer: 5.895 ± 0.03	3.193GlyThr: 3.193 ± 0.018	4.168GlyVal: 4.168 ± 0.028	0.855GlyTrp: 0.855 ± 0.009	2.084GlyTyr: 2.084 ± 0.019	0.053GlyXaa: 0.053 ± 0.002
His	1.184HisAla: 1.184 ± 0.012	0.488HisCys: 0.488 ± 0.007	1.087HisAsp: 1.087 ± 0.011	1.305HisGlu: 1.305 ± 0.011	0.953HisPhe: 0.953 ± 0.009	1.653HisGly: 1.653 ± 0.015	0.859HisHis: 0.859 ± 0.011	1.138HisIle: 1.138 ± 0.011	1.176HisLys: 1.176 ± 0.011	2.209HisLeu: 2.209 ± 0.017	0.568HisMet: 0.568 ± 0.007	0.919HisAsn: 0.919 ± 0.01	1.197HisPro: 1.197 ± 0.013	0.97HisGln: 0.97 ± 0.009	1.399HisArg: 1.399 ± 0.013	1.756HisSer: 1.756 ± 0.014	0.927HisThr: 0.927 ± 0.009	1.503HisVal: 1.503 ± 0.012	0.289HisTrp: 0.289 ± 0.005	0.688HisTyr: 0.688 ± 0.008	0.015HisXaa: 0.015 ± 0.001
Ile	3.513IleAla: 3.513 ± 0.02	1.081IleCys: 1.081 ± 0.01	2.985IleAsp: 2.985 ± 0.019	3.289IleGlu: 3.289 ± 0.019	2.187IlePhe: 2.187 ± 0.019	3.451IleGly: 3.451 ± 0.023	1.265IleHis: 1.265 ± 0.012	2.618IleIle: 2.618 ± 0.017	2.976IleLys: 2.976 ± 0.02	4.975IleLeu: 4.975 ± 0.022	1.133IleMet: 1.133 ± 0.01	2.145IleAsn: 2.145 ± 0.015	2.834IlePro: 2.834 ± 0.022	1.903IleGln: 1.903 ± 0.015	2.764IleArg: 2.764 ± 0.017	4.852IleSer: 4.852 ± 0.022	2.714IleThr: 2.714 ± 0.015	3.574IleVal: 3.574 ± 0.02	0.689IleTrp: 0.689 ± 0.008	1.475IleTyr: 1.475 ± 0.011	0.03IleXaa: 0.03 ± 0.002
Lys	4.064LysAla: 4.064 ± 0.022	0.957LysCys: 0.957 ± 0.012	3.308LysAsp: 3.308 ± 0.018	4.905LysGlu: 4.905 ± 0.028	2.157LysPhe: 2.157 ± 0.015	3.55LysGly: 3.55 ± 0.022	1.316LysHis: 1.316 ± 0.013	3.415LysIle: 3.415 ± 0.017	5.15LysLys: 5.15 ± 0.03	6.069LysLeu: 6.069 ± 0.027	1.575LysMet: 1.575 ± 0.013	2.76LysAsn: 2.76 ± 0.017	3.022LysPro: 3.022 ± 0.019	2.289LysGln: 2.289 ± 0.016	3.83LysArg: 3.83 ± 0.021	4.924LysSer: 4.924 ± 0.024	3.373LysThr: 3.373 ± 0.019	3.819LysVal: 3.819 ± 0.021	0.824LysTrp: 0.824 ± 0.009	1.552LysTyr: 1.552 ± 0.012	0.036LysXaa: 0.036 ± 0.002
Leu	6.205LeuAla: 6.205 ± 0.027	1.832LeuCys: 1.832 ± 0.014	5.018LeuAsp: 5.018 ± 0.022	6.321LeuGlu: 6.321 ± 0.026	3.79LeuPhe: 3.79 ± 0.022	5.634LeuGly: 5.634 ± 0.027	2.348LeuHis: 2.348 ± 0.016	4.623LeuIle: 4.623 ± 0.025	6.136LeuLys: 6.136 ± 0.027	9.513LeuLeu: 9.513 ± 0.042	2.253LeuMet: 2.253 ± 0.017	3.771LeuAsn: 3.771 ± 0.02	4.818LeuPro: 4.818 ± 0.025	3.832LeuGln: 3.832 ± 0.022	5.537LeuArg: 5.537 ± 0.027	8.318LeuSer: 8.318 ± 0.036	4.533LeuThr: 4.533 ± 0.026	6.486LeuVal: 6.486 ± 0.028	1.149LeuTrp: 1.149 ± 0.011	2.414LeuTyr: 2.414 ± 0.016	0.07LeuXaa: 0.07 ± 0.003
Met	2.059MetAla: 2.059 ± 0.016	0.331MetCys: 0.331 ± 0.005	1.424MetAsp: 1.424 ± 0.012	2.087MetGlu: 2.087 ± 0.013	0.935MetPhe: 0.935 ± 0.009	1.531MetGly: 1.531 ± 0.012	0.474MetHis: 0.474 ± 0.007	1.338MetIle: 1.338 ± 0.012	1.74MetLys: 1.74 ± 0.014	2.099MetLeu: 2.099 ± 0.017	0.747MetMet: 0.747 ± 0.011	1.08MetAsn: 1.08 ± 0.011	0.94MetPro: 0.94 ± 0.012	0.828MetGln: 0.828 ± 0.009	1.281MetArg: 1.281 ± 0.013	1.951MetSer: 1.951 ± 0.012	1.117MetThr: 1.117 ± 0.011	1.786MetVal: 1.786 ± 0.013	0.264MetTrp: 0.264 ± 0.005	0.62MetTyr: 0.62 ± 0.008	0.023MetXaa: 0.023 ± 0.002
Asn	2.55AsnAla: 2.55 ± 0.016	0.787AsnCys: 0.787 ± 0.01	2.025AsnAsp: 2.025 ± 0.014	2.492AsnGlu: 2.492 ± 0.015	1.74AsnPhe: 1.74 ± 0.014	3.301AsnGly: 3.301 ± 0.021	1.135AsnHis: 1.135 ± 0.01	2.319AsnIle: 2.319 ± 0.015	2.405AsnLys: 2.405 ± 0.016	4.443AsnLeu: 4.443 ± 0.025	1.07AsnMet: 1.07 ± 0.009	2.254AsnAsn: 2.254 ± 0.017	2.437AsnPro: 2.437 ± 0.017	1.734AsnGln: 1.734 ± 0.015	2.245AsnArg: 2.245 ± 0.017	3.679AsnSer: 3.679 ± 0.02	2.009AsnThr: 2.009 ± 0.016	2.869AsnVal: 2.869 ± 0.019	0.552AsnTrp: 0.552 ± 0.007	1.198AsnTyr: 1.198 ± 0.01	0.031AsnXaa: 0.031 ± 0.002
Pro	2.728ProAla: 2.728 ± 0.019	0.741ProCys: 0.741 ± 0.01	2.444ProAsp: 2.444 ± 0.017	3.358ProGlu: 3.358 ± 0.022	1.926ProPhe: 1.926 ± 0.014	2.608ProGly: 2.608 ± 0.016	0.985ProHis: 0.985 ± 0.01	2.243ProIle: 2.243 ± 0.016	2.78ProLys: 2.78 ± 0.019	4.151ProLeu: 4.151 ± 0.022	1.027ProMet: 1.027 ± 0.01	2.179ProAsn: 2.179 ± 0.017	3.772ProPro: 3.772 ± 0.058	1.68ProGln: 1.68 ± 0.015	2.52ProArg: 2.52 ± 0.016	4.885ProSer: 4.885 ± 0.022	2.549ProThr: 2.549 ± 0.017	3.215ProVal: 3.215 ± 0.019	0.607ProTrp: 0.607 ± 0.008	1.319ProTyr: 1.319 ± 0.014	0.043ProXaa: 0.043 ± 0.002
Gln	2.228GlnAla: 2.228 ± 0.016	0.529GlnCys: 0.529 ± 0.007	1.641GlnAsp: 1.641 ± 0.014	2.441GlnGlu: 2.441 ± 0.017	1.295GlnPhe: 1.295 ± 0.012	1.989GlnGly: 1.989 ± 0.015	0.779GlnHis: 0.779 ± 0.009	1.935GlnIle: 1.935 ± 0.014	2.193GlnLys: 2.193 ± 0.016	3.185GlnLeu: 3.185 ± 0.023	0.923GlnMet: 0.923 ± 0.01	1.67GlnAsn: 1.67 ± 0.013	1.611GlnPro: 1.611 ± 0.016	1.741GlnGln: 1.741 ± 0.019	2.171GlnArg: 2.171 ± 0.016	2.798GlnSer: 2.798 ± 0.019	1.8GlnThr: 1.8 ± 0.015	2.227GlnVal: 2.227 ± 0.015	0.45GlnTrp: 0.45 ± 0.007	0.881GlnTyr: 0.881 ± 0.01	0.024GlnXaa: 0.024 ± 0.002
Arg	3.146ArgAla: 3.146 ± 0.017	1.0ArgCys: 1.0 ± 0.011	2.868ArgAsp: 2.868 ± 0.015	3.561ArgGlu: 3.561 ± 0.021	2.522ArgPhe: 2.522 ± 0.017	3.276ArgGly: 3.276 ± 0.021	1.216ArgHis: 1.216 ± 0.011	2.999ArgIle: 2.999 ± 0.017	3.894ArgLys: 3.894 ± 0.019	5.136ArgLeu: 5.136 ± 0.025	1.324ArgMet: 1.324 ± 0.01	2.581ArgAsn: 2.581 ± 0.015	2.325ArgPro: 2.325 ± 0.017	1.809ArgGln: 1.809 ± 0.014	4.232ArgArg: 4.232 ± 0.029	4.695ArgSer: 4.695 ± 0.024	2.547ArgThr: 2.547 ± 0.016	3.529ArgVal: 3.529 ± 0.019	0.733ArgTrp: 0.733 ± 0.009	1.494ArgTyr: 1.494 ± 0.013	0.042ArgXaa: 0.042 ± 0.002
Ser	5.018SerAla: 5.018 ± 0.024	1.648SerCys: 1.648 ± 0.013	4.687SerAsp: 4.687 ± 0.024	5.067SerGlu: 5.067 ± 0.027	4.013SerPhe: 4.013 ± 0.02	6.109SerGly: 6.109 ± 0.031	1.975SerHis: 1.975 ± 0.017	4.32SerIle: 4.32 ± 0.023	5.032SerLys: 5.032 ± 0.024	8.717SerLeu: 8.717 ± 0.035	2.081SerMet: 2.081 ± 0.015	3.852SerAsn: 3.852 ± 0.021	4.748SerPro: 4.748 ± 0.031	2.945SerGln: 2.945 ± 0.019	4.723SerArg: 4.723 ± 0.024	11.132SerSer: 11.132 ± 0.052	4.491SerThr: 4.491 ± 0.022	5.624SerVal: 5.624 ± 0.02	1.139SerTrp: 1.139 ± 0.013	2.336SerTyr: 2.336 ± 0.016	0.083SerXaa: 0.083 ± 0.003
Thr	3.332ThrAla: 3.332 ± 0.021	0.929ThrCys: 0.929 ± 0.011	2.393ThrAsp: 2.393 ± 0.014	3.178ThrGlu: 3.178 ± 0.021	2.029ThrPhe: 2.029 ± 0.015	3.463ThrGly: 3.463 ± 0.024	1.031ThrHis: 1.031 ± 0.009	2.744ThrIle: 2.744 ± 0.019	3.011ThrLys: 3.011 ± 0.02	4.667ThrLeu: 4.667 ± 0.022	1.241ThrMet: 1.241 ± 0.011	2.171ThrAsn: 2.171 ± 0.013	2.531ThrPro: 2.531 ± 0.018	1.6ThrGln: 1.6 ± 0.012	2.65ThrArg: 2.65 ± 0.017	4.657ThrSer: 4.657 ± 0.025	3.209ThrThr: 3.209 ± 0.024	3.661ThrVal: 3.661 ± 0.02	0.662ThrTrp: 0.662 ± 0.008	1.383ThrTyr: 1.383 ± 0.012	0.045ThrXaa: 0.045 ± 0.002
Val	4.726ValAla: 4.726 ± 0.021	1.156ValCys: 1.156 ± 0.012	3.748ValAsp: 3.748 ± 0.019	4.579ValGlu: 4.579 ± 0.023	2.897ValPhe: 2.897 ± 0.017	3.919ValGly: 3.919 ± 0.024	1.428ValHis: 1.428 ± 0.012	3.523ValIle: 3.523 ± 0.018	4.228ValLys: 4.228 ± 0.022	6.251ValLeu: 6.251 ± 0.027	1.683ValMet: 1.683 ± 0.014	2.661ValAsn: 2.661 ± 0.016	3.135ValPro: 3.135 ± 0.017	2.094ValGln: 2.094 ± 0.016	3.23ValArg: 3.23 ± 0.018	5.895ValSer: 5.895 ± 0.026	3.561ValThr: 3.561 ± 0.02	5.128ValVal: 5.128 ± 0.026	0.789ValTrp: 0.789 ± 0.01	2.004ValTyr: 2.004 ± 0.016	0.051ValXaa: 0.051 ± 0.002
Trp	0.692TrpAla: 0.692 ± 0.008	0.227TrpCys: 0.227 ± 0.005	0.693TrpAsp: 0.693 ± 0.009	0.776TrpGlu: 0.776 ± 0.009	0.575TrpPhe: 0.575 ± 0.008	0.708TrpGly: 0.708 ± 0.009	0.259TrpHis: 0.259 ± 0.005	0.727TrpIle: 0.727 ± 0.008	0.928TrpLys: 0.928 ± 0.01	1.197TrpLeu: 1.197 ± 0.011	0.335TrpMet: 0.335 ± 0.006	0.699TrpAsn: 0.699 ± 0.009	0.471TrpPro: 0.471 ± 0.008	0.385TrpGln: 0.385 ± 0.007	0.866TrpArg: 0.866 ± 0.009	1.014TrpSer: 1.014 ± 0.01	0.641TrpThr: 0.641 ± 0.009	0.784TrpVal: 0.784 ± 0.008	0.242TrpTrp: 0.242 ± 0.005	0.345TrpTyr: 0.345 ± 0.006	0.008TrpXaa: 0.008 ± 0.001
Tyr	1.708TyrAla: 1.708 ± 0.014	0.582TyrCys: 0.582 ± 0.008	1.516TyrAsp: 1.516 ± 0.012	1.643TyrGlu: 1.643 ± 0.014	1.254TyrPhe: 1.254 ± 0.012	2.123TyrGly: 2.123 ± 0.018	0.669TyrHis: 0.669 ± 0.008	1.436TyrIle: 1.436 ± 0.011	1.571TyrLys: 1.571 ± 0.015	2.653TyrLeu: 2.653 ± 0.019	0.754TyrMet: 0.754 ± 0.009	1.303TyrAsn: 1.303 ± 0.013	1.235TyrPro: 1.235 ± 0.012	0.91TyrGln: 0.91 ± 0.009	1.485TyrArg: 1.485 ± 0.012	2.239TyrSer: 2.239 ± 0.014	1.318TyrThr: 1.318 ± 0.012	1.784TyrVal: 1.784 ± 0.016	0.383TyrTrp: 0.383 ± 0.007	0.975TyrTyr: 0.975 ± 0.014	0.016TyrXaa: 0.016 ± 0.001
Xaa	0.045XaaAla: 0.045 ± 0.002	0.013XaaCys: 0.013 ± 0.001	0.032XaaAsp: 0.032 ± 0.002	0.043XaaGlu: 0.043 ± 0.003	0.029XaaPhe: 0.029 ± 0.002	0.048XaaGly: 0.048 ± 0.002	0.019XaaHis: 0.019 ± 0.001	0.037XaaIle: 0.037 ± 0.001	0.036XaaLys: 0.036 ± 0.002	0.066XaaLeu: 0.066 ± 0.003	0.02XaaMet: 0.02 ± 0.001	0.033XaaAsn: 0.033 ± 0.002	0.04XaaPro: 0.04 ± 0.002	0.027XaaGln: 0.027 ± 0.001	0.042XaaArg: 0.042 ± 0.002	0.077XaaSer: 0.077 ± 0.003	0.041XaaThr: 0.041 ± 0.002	0.05XaaVal: 0.05 ± 0.002	0.008XaaTrp: 0.008 ± 0.001	0.022XaaTyr: 0.022 ± 0.001	6.236XaaXaa: 6.236 ± 0.097

Statistics based on 28762 proteins (10701967 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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