Amino acid dipepetide frequency for Sphingorhabdus sp. JK6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.216AlaAla: 13.216 ± 0.169	0.918AlaCys: 0.918 ± 0.037	6.604AlaAsp: 6.604 ± 0.079	7.043AlaGlu: 7.043 ± 0.105	3.926AlaPhe: 3.926 ± 0.067	9.275AlaGly: 9.275 ± 0.14	1.851AlaHis: 1.851 ± 0.05	6.806AlaIle: 6.806 ± 0.109	5.494AlaLys: 5.494 ± 0.094	11.232AlaLeu: 11.232 ± 0.129	3.524AlaMet: 3.524 ± 0.067	3.641AlaAsn: 3.641 ± 0.073	4.513AlaPro: 4.513 ± 0.08	3.972AlaGln: 3.972 ± 0.076	5.999AlaArg: 5.999 ± 0.094	6.462AlaSer: 6.462 ± 0.102	5.472AlaThr: 5.472 ± 0.093	7.206AlaVal: 7.206 ± 0.098	1.171AlaTrp: 1.171 ± 0.038	2.41AlaTyr: 2.41 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.852CysAla: 0.852 ± 0.032	0.098CysCys: 0.098 ± 0.01	0.612CysAsp: 0.612 ± 0.023	0.479CysGlu: 0.479 ± 0.024	0.321CysPhe: 0.321 ± 0.019	0.867CysGly: 0.867 ± 0.035	0.223CysHis: 0.223 ± 0.019	0.465CysIle: 0.465 ± 0.022	0.283CysLys: 0.283 ± 0.018	0.719CysLeu: 0.719 ± 0.027	0.18CysMet: 0.18 ± 0.016	0.286CysAsn: 0.286 ± 0.016	0.424CysPro: 0.424 ± 0.025	0.258CysGln: 0.258 ± 0.018	0.455CysArg: 0.455 ± 0.022	0.502CysSer: 0.502 ± 0.023	0.385CysThr: 0.385 ± 0.02	0.566CysVal: 0.566 ± 0.026	0.112CysTrp: 0.112 ± 0.011	0.195CysTyr: 0.195 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.442AspAla: 6.442 ± 0.093	0.512AspCys: 0.512 ± 0.024	3.797AspAsp: 3.797 ± 0.072	4.01AspGlu: 4.01 ± 0.069	2.362AspPhe: 2.362 ± 0.047	5.7AspGly: 5.7 ± 0.083	1.328AspHis: 1.328 ± 0.041	3.95AspIle: 3.95 ± 0.068	2.68AspLys: 2.68 ± 0.057	5.388AspLeu: 5.388 ± 0.07	1.77AspMet: 1.77 ± 0.045	2.067AspAsn: 2.067 ± 0.05	3.228AspPro: 3.228 ± 0.063	2.245AspGln: 2.245 ± 0.052	3.81AspArg: 3.81 ± 0.06	2.823AspSer: 2.823 ± 0.056	2.624AspThr: 2.624 ± 0.051	4.048AspVal: 4.048 ± 0.068	1.083AspTrp: 1.083 ± 0.038	1.766AspTyr: 1.766 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	6.908GluAla: 6.908 ± 0.111	0.367GluCys: 0.367 ± 0.019	3.245GluAsp: 3.245 ± 0.064	3.738GluGlu: 3.738 ± 0.077	2.024GluPhe: 2.024 ± 0.05	4.257GluGly: 4.257 ± 0.068	1.214GluHis: 1.214 ± 0.038	4.011GluIle: 4.011 ± 0.074	3.506GluLys: 3.506 ± 0.067	5.393GluLeu: 5.393 ± 0.08	1.877GluMet: 1.877 ± 0.047	2.426GluAsn: 2.426 ± 0.052	2.431GluPro: 2.431 ± 0.054	2.52GluGln: 2.52 ± 0.058	4.007GluArg: 4.007 ± 0.083	2.681GluSer: 2.681 ± 0.048	3.53GluThr: 3.53 ± 0.065	3.572GluVal: 3.572 ± 0.08	0.802GluTrp: 0.802 ± 0.032	1.388GluTyr: 1.388 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	4.599PheAla: 4.599 ± 0.066	0.409PheCys: 0.409 ± 0.021	2.854PheAsp: 2.854 ± 0.065	2.343PheGlu: 2.343 ± 0.049	1.577PhePhe: 1.577 ± 0.047	4.057PheGly: 4.057 ± 0.077	0.756PheHis: 0.756 ± 0.034	2.023PheIle: 2.023 ± 0.058	1.309PheLys: 1.309 ± 0.034	3.419PheLeu: 3.419 ± 0.075	0.92PheMet: 0.92 ± 0.037	1.402PheAsn: 1.402 ± 0.049	1.565PhePro: 1.565 ± 0.042	1.02PheGln: 1.02 ± 0.031	2.04PheArg: 2.04 ± 0.044	2.607PheSer: 2.607 ± 0.061	2.05PheThr: 2.05 ± 0.054	2.67PheVal: 2.67 ± 0.057	0.59PheTrp: 0.59 ± 0.027	1.055PheTyr: 1.055 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.397GlyAla: 8.397 ± 0.127	0.803GlyCys: 0.803 ± 0.03	4.94GlyAsp: 4.94 ± 0.079	4.796GlyGlu: 4.796 ± 0.075	3.717GlyPhe: 3.717 ± 0.072	7.86GlyGly: 7.86 ± 0.222	1.662GlyHis: 1.662 ± 0.043	4.937GlyIle: 4.937 ± 0.091	4.468GlyLys: 4.468 ± 0.074	8.101GlyLeu: 8.101 ± 0.099	2.353GlyMet: 2.353 ± 0.057	3.028GlyAsn: 3.028 ± 0.109	3.245GlyPro: 3.245 ± 0.055	3.008GlyGln: 3.008 ± 0.055	4.658GlyArg: 4.658 ± 0.07	5.181GlySer: 5.181 ± 0.103	4.621GlyThr: 4.621 ± 0.119	5.451GlyVal: 5.451 ± 0.081	1.425GlyTrp: 1.425 ± 0.037	2.441GlyTyr: 2.441 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.744HisAla: 1.744 ± 0.047	0.272HisCys: 0.272 ± 0.018	1.181HisAsp: 1.181 ± 0.041	1.046HisGlu: 1.046 ± 0.033	0.868HisPhe: 0.868 ± 0.031	1.692HisGly: 1.692 ± 0.052	0.55HisHis: 0.55 ± 0.03	1.216HisIle: 1.216 ± 0.04	0.751HisLys: 0.751 ± 0.029	1.765HisLeu: 1.765 ± 0.046	0.475HisMet: 0.475 ± 0.024	0.611HisAsn: 0.611 ± 0.026	1.213HisPro: 1.213 ± 0.036	0.608HisGln: 0.608 ± 0.025	1.151HisArg: 1.151 ± 0.039	1.115HisSer: 1.115 ± 0.037	0.641HisThr: 0.641 ± 0.029	1.253HisVal: 1.253 ± 0.037	0.316HisTrp: 0.316 ± 0.019	0.57HisTyr: 0.57 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.869IleAla: 7.869 ± 0.105	0.656IleCys: 0.656 ± 0.027	4.361IleAsp: 4.361 ± 0.067	4.083IleGlu: 4.083 ± 0.075	2.408IlePhe: 2.408 ± 0.056	5.607IleGly: 5.607 ± 0.092	0.983IleHis: 0.983 ± 0.032	3.729IleIle: 3.729 ± 0.068	2.305IleLys: 2.305 ± 0.048	5.103IleLeu: 5.103 ± 0.074	1.397IleMet: 1.397 ± 0.047	2.158IleAsn: 2.158 ± 0.06	2.611IlePro: 2.611 ± 0.058	1.467IleGln: 1.467 ± 0.038	2.975IleArg: 2.975 ± 0.056	3.93IleSer: 3.93 ± 0.075	3.381IleThr: 3.381 ± 0.082	4.116IleVal: 4.116 ± 0.067	0.86IleTrp: 0.86 ± 0.033	1.358IleTyr: 1.358 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	5.017LysAla: 5.017 ± 0.09	0.282LysCys: 0.282 ± 0.019	2.387LysAsp: 2.387 ± 0.055	2.292LysGlu: 2.292 ± 0.055	1.548LysPhe: 1.548 ± 0.042	3.2LysGly: 3.2 ± 0.058	0.83LysHis: 0.83 ± 0.027	2.954LysIle: 2.954 ± 0.058	2.351LysLys: 2.351 ± 0.059	4.56LysLeu: 4.56 ± 0.08	1.398LysMet: 1.398 ± 0.04	1.581LysAsn: 1.581 ± 0.037	2.569LysPro: 2.569 ± 0.069	1.583LysGln: 1.583 ± 0.047	2.776LysArg: 2.776 ± 0.059	2.848LysSer: 2.848 ± 0.066	2.637LysThr: 2.637 ± 0.059	2.788LysVal: 2.788 ± 0.064	0.662LysTrp: 0.662 ± 0.026	1.098LysTyr: 1.098 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	11.11LeuAla: 11.11 ± 0.135	0.762LeuCys: 0.762 ± 0.029	5.81LeuAsp: 5.81 ± 0.087	5.411LeuGlu: 5.411 ± 0.094	3.856LeuPhe: 3.856 ± 0.076	7.504LeuGly: 7.504 ± 0.098	1.647LeuHis: 1.647 ± 0.045	5.583LeuIle: 5.583 ± 0.086	4.128LeuLys: 4.128 ± 0.075	8.541LeuLeu: 8.541 ± 0.147	2.366LeuMet: 2.366 ± 0.058	3.109LeuAsn: 3.109 ± 0.067	4.729LeuPro: 4.729 ± 0.078	2.708LeuGln: 2.708 ± 0.055	5.236LeuArg: 5.236 ± 0.076	6.378LeuSer: 6.378 ± 0.097	5.177LeuThr: 5.177 ± 0.073	6.417LeuVal: 6.417 ± 0.096	1.116LeuTrp: 1.116 ± 0.039	1.99LeuTyr: 1.99 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.278MetAla: 3.278 ± 0.059	0.173MetCys: 0.173 ± 0.015	1.38MetAsp: 1.38 ± 0.039	1.511MetGlu: 1.511 ± 0.044	0.85MetPhe: 0.85 ± 0.032	2.093MetGly: 2.093 ± 0.05	0.474MetHis: 0.474 ± 0.019	1.802MetIle: 1.802 ± 0.048	1.321MetLys: 1.321 ± 0.04	2.717MetLeu: 2.717 ± 0.06	0.832MetMet: 0.832 ± 0.03	0.945MetAsn: 0.945 ± 0.035	1.473MetPro: 1.473 ± 0.043	0.963MetGln: 0.963 ± 0.033	1.706MetArg: 1.706 ± 0.041	1.604MetSer: 1.604 ± 0.043	1.907MetThr: 1.907 ± 0.049	1.799MetVal: 1.799 ± 0.049	0.236MetTrp: 0.236 ± 0.017	0.328MetTyr: 0.328 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.752AsnAla: 3.752 ± 0.094	0.323AsnCys: 0.323 ± 0.019	2.007AsnAsp: 2.007 ± 0.044	1.762AsnGlu: 1.762 ± 0.045	1.457AsnPhe: 1.457 ± 0.049	3.237AsnGly: 3.237 ± 0.084	0.643AsnHis: 0.643 ± 0.029	2.413AsnIle: 2.413 ± 0.06	1.225AsnLys: 1.225 ± 0.04	3.25AsnLeu: 3.25 ± 0.069	0.973AsnMet: 0.973 ± 0.033	1.277AsnAsn: 1.277 ± 0.047	2.106AsnPro: 2.106 ± 0.046	1.167AsnGln: 1.167 ± 0.035	2.132AsnArg: 2.132 ± 0.048	2.076AsnSer: 2.076 ± 0.053	1.388AsnThr: 1.388 ± 0.045	2.384AsnVal: 2.384 ± 0.067	0.552AsnTrp: 0.552 ± 0.025	0.91AsnTyr: 0.91 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	4.895ProAla: 4.895 ± 0.088	0.289ProCys: 0.289 ± 0.018	3.661ProAsp: 3.661 ± 0.067	3.699ProGlu: 3.699 ± 0.065	1.924ProPhe: 1.924 ± 0.05	3.814ProGly: 3.814 ± 0.062	0.921ProHis: 0.921 ± 0.031	2.67ProIle: 2.67 ± 0.053	2.163ProLys: 2.163 ± 0.052	4.236ProLeu: 4.236 ± 0.065	1.237ProMet: 1.237 ± 0.039	1.584ProAsn: 1.584 ± 0.044	2.122ProPro: 2.122 ± 0.082	1.557ProGln: 1.557 ± 0.042	2.018ProArg: 2.018 ± 0.05	2.578ProSer: 2.578 ± 0.055	2.293ProThr: 2.293 ± 0.062	3.748ProVal: 3.748 ± 0.065	0.572ProTrp: 0.572 ± 0.026	1.075ProTyr: 1.075 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.609GlnAla: 3.609 ± 0.065	0.292GlnCys: 0.292 ± 0.018	1.64GlnAsp: 1.64 ± 0.043	1.667GlnGlu: 1.667 ± 0.04	1.38GlnPhe: 1.38 ± 0.039	2.331GlnGly: 2.331 ± 0.05	0.634GlnHis: 0.634 ± 0.027	2.239GlnIle: 2.239 ± 0.048	1.601GlnLys: 1.601 ± 0.047	3.269GlnLeu: 3.269 ± 0.073	1.029GlnMet: 1.029 ± 0.038	1.269GlnAsn: 1.269 ± 0.037	1.625GlnPro: 1.625 ± 0.038	1.365GlnGln: 1.365 ± 0.039	2.136GlnArg: 2.136 ± 0.048	2.211GlnSer: 2.211 ± 0.046	1.843GlnThr: 1.843 ± 0.05	2.044GlnVal: 2.044 ± 0.046	0.486GlnTrp: 0.486 ± 0.021	0.874GlnTyr: 0.874 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	5.646ArgAla: 5.646 ± 0.073	0.432ArgCys: 0.432 ± 0.022	3.571ArgAsp: 3.571 ± 0.075	3.405ArgGlu: 3.405 ± 0.068	2.589ArgPhe: 2.589 ± 0.06	3.854ArgGly: 3.854 ± 0.065	1.204ArgHis: 1.204 ± 0.034	3.679ArgIle: 3.679 ± 0.068	2.815ArgLys: 2.815 ± 0.058	5.937ArgLeu: 5.937 ± 0.095	1.543ArgMet: 1.543 ± 0.051	2.061ArgAsn: 2.061 ± 0.053	2.604ArgPro: 2.604 ± 0.048	2.028ArgGln: 2.028 ± 0.049	3.415ArgArg: 3.415 ± 0.082	3.226ArgSer: 3.226 ± 0.058	2.758ArgThr: 2.758 ± 0.053	3.579ArgVal: 3.579 ± 0.054	0.884ArgTrp: 0.884 ± 0.033	1.679ArgTyr: 1.679 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	6.311SerAla: 6.311 ± 0.102	0.479SerCys: 0.479 ± 0.022	3.84SerAsp: 3.84 ± 0.063	3.458SerGlu: 3.458 ± 0.063	2.544SerPhe: 2.544 ± 0.054	6.108SerGly: 6.108 ± 0.103	1.033SerHis: 1.033 ± 0.032	3.428SerIle: 3.428 ± 0.065	2.505SerLys: 2.505 ± 0.056	5.451SerLeu: 5.451 ± 0.083	1.509SerMet: 1.509 ± 0.043	2.106SerAsn: 2.106 ± 0.053	2.735SerPro: 2.735 ± 0.051	1.994SerGln: 1.994 ± 0.043	3.284SerArg: 3.284 ± 0.063	3.628SerSer: 3.628 ± 0.076	2.769SerThr: 2.769 ± 0.072	4.026SerVal: 4.026 ± 0.069	0.758SerTrp: 0.758 ± 0.027	1.553SerTyr: 1.553 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.832ThrAla: 5.832 ± 0.089	0.35ThrCys: 0.35 ± 0.018	3.112ThrAsp: 3.112 ± 0.055	2.863ThrGlu: 2.863 ± 0.057	1.832ThrPhe: 1.832 ± 0.051	5.267ThrGly: 5.267 ± 0.113	0.952ThrHis: 0.952 ± 0.033	3.348ThrIle: 3.348 ± 0.064	2.09ThrLys: 2.09 ± 0.044	5.016ThrLeu: 5.016 ± 0.078	1.28ThrMet: 1.28 ± 0.038	1.778ThrAsn: 1.778 ± 0.052	2.929ThrPro: 2.929 ± 0.06	1.574ThrGln: 1.574 ± 0.04	2.806ThrArg: 2.806 ± 0.06	3.036ThrSer: 3.036 ± 0.078	2.728ThrThr: 2.728 ± 0.065	3.811ThrVal: 3.811 ± 0.075	0.541ThrTrp: 0.541 ± 0.025	1.108ThrTyr: 1.108 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	7.592ValAla: 7.592 ± 0.086	0.497ValCys: 0.497 ± 0.023	4.269ValAsp: 4.269 ± 0.068	4.285ValGlu: 4.285 ± 0.071	2.414ValPhe: 2.414 ± 0.05	5.309ValGly: 5.309 ± 0.094	1.284ValHis: 1.284 ± 0.041	4.045ValIle: 4.045 ± 0.063	2.84ValLys: 2.84 ± 0.059	5.593ValLeu: 5.593 ± 0.084	1.788ValMet: 1.788 ± 0.047	2.375ValAsn: 2.375 ± 0.067	3.278ValPro: 3.278 ± 0.063	2.038ValGln: 2.038 ± 0.046	3.691ValArg: 3.691 ± 0.063	4.27ValSer: 4.27 ± 0.074	4.166ValThr: 4.166 ± 0.07	4.568ValVal: 4.568 ± 0.079	0.753ValTrp: 0.753 ± 0.033	1.344ValTyr: 1.344 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.138TrpAla: 1.138 ± 0.037	0.111TrpCys: 0.111 ± 0.011	0.709TrpAsp: 0.709 ± 0.026	0.699TrpGlu: 0.699 ± 0.029	0.553TrpPhe: 0.553 ± 0.024	0.867TrpGly: 0.867 ± 0.032	0.315TrpHis: 0.315 ± 0.017	0.787TrpIle: 0.787 ± 0.027	0.631TrpLys: 0.631 ± 0.025	1.62TrpLeu: 1.62 ± 0.049	0.419TrpMet: 0.419 ± 0.021	0.517TrpAsn: 0.517 ± 0.026	0.608TrpPro: 0.608 ± 0.028	0.617TrpGln: 0.617 ± 0.023	0.983TrpArg: 0.983 ± 0.029	0.859TrpSer: 0.859 ± 0.029	0.806TrpThr: 0.806 ± 0.033	0.822TrpVal: 0.822 ± 0.027	0.215TrpTrp: 0.215 ± 0.015	0.275TrpTyr: 0.275 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.526TyrAla: 2.526 ± 0.056	0.256TyrCys: 0.256 ± 0.016	1.656TyrAsp: 1.656 ± 0.048	1.306TyrGlu: 1.306 ± 0.036	1.115TyrPhe: 1.115 ± 0.036	2.194TyrGly: 2.194 ± 0.05	0.534TyrHis: 0.534 ± 0.021	1.273TyrIle: 1.273 ± 0.038	0.891TyrLys: 0.891 ± 0.03	2.266TyrLeu: 2.266 ± 0.045	0.521TyrMet: 0.521 ± 0.024	0.817TyrAsn: 0.817 ± 0.031	1.05TyrPro: 1.05 ± 0.034	0.852TyrGln: 0.852 ± 0.037	1.633TyrArg: 1.633 ± 0.046	1.503TyrSer: 1.503 ± 0.041	1.076TyrThr: 1.076 ± 0.039	1.533TyrVal: 1.533 ± 0.04	0.417TyrTrp: 0.417 ± 0.022	0.686TyrTyr: 0.686 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3022 proteins (940177 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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