Amino acid dipepetide frequency for Cloacibacterium normanense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.226AlaAla: 4.226 ± 0.1	0.495AlaCys: 0.495 ± 0.028	3.318AlaAsp: 3.318 ± 0.068	4.946AlaGlu: 4.946 ± 0.096	3.309AlaPhe: 3.309 ± 0.07	4.058AlaGly: 4.058 ± 0.092	1.062AlaHis: 1.062 ± 0.043	4.897AlaIle: 4.897 ± 0.082	5.383AlaLys: 5.383 ± 0.088	5.703AlaLeu: 5.703 ± 0.1	1.597AlaMet: 1.597 ± 0.048	3.396AlaAsn: 3.396 ± 0.075	1.788AlaPro: 1.788 ± 0.055	2.688AlaGln: 2.688 ± 0.062	1.925AlaArg: 1.925 ± 0.049	3.575AlaSer: 3.575 ± 0.075	3.41AlaThr: 3.41 ± 0.076	4.037AlaVal: 4.037 ± 0.085	0.564AlaTrp: 0.564 ± 0.026	2.208AlaTyr: 2.208 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.456CysAla: 0.456 ± 0.022	0.096CysCys: 0.096 ± 0.014	0.387CysAsp: 0.387 ± 0.022	0.482CysGlu: 0.482 ± 0.025	0.41CysPhe: 0.41 ± 0.023	0.663CysGly: 0.663 ± 0.037	0.171CysHis: 0.171 ± 0.017	0.546CysIle: 0.546 ± 0.03	0.478CysLys: 0.478 ± 0.022	0.572CysLeu: 0.572 ± 0.027	0.142CysMet: 0.142 ± 0.013	0.402CysAsn: 0.402 ± 0.024	0.287CysPro: 0.287 ± 0.024	0.191CysGln: 0.191 ± 0.016	0.221CysArg: 0.221 ± 0.018	0.457CysSer: 0.457 ± 0.03	0.389CysThr: 0.389 ± 0.023	0.418CysVal: 0.418 ± 0.024	0.046CysTrp: 0.046 ± 0.007	0.248CysTyr: 0.248 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.546AspAla: 3.546 ± 0.072	0.389AspCys: 0.389 ± 0.021	2.496AspAsp: 2.496 ± 0.059	4.094AspGlu: 4.094 ± 0.085	4.166AspPhe: 4.166 ± 0.076	3.243AspGly: 3.243 ± 0.075	0.738AspHis: 0.738 ± 0.03	3.772AspIle: 3.772 ± 0.082	4.155AspLys: 4.155 ± 0.077	5.038AspLeu: 5.038 ± 0.094	0.952AspMet: 0.952 ± 0.036	2.666AspAsn: 2.666 ± 0.059	1.267AspPro: 1.267 ± 0.042	1.48AspGln: 1.48 ± 0.045	1.721AspArg: 1.721 ± 0.051	2.578AspSer: 2.578 ± 0.06	2.11AspThr: 2.11 ± 0.052	3.374AspVal: 3.374 ± 0.075	0.739AspTrp: 0.739 ± 0.032	2.62AspTyr: 2.62 ± 0.067	0.0AspXaa: 0.0 ± 0.0
Glu	4.13GluAla: 4.13 ± 0.081	0.324GluCys: 0.324 ± 0.02	3.498GluAsp: 3.498 ± 0.078	5.953GluGlu: 5.953 ± 0.128	3.565GluPhe: 3.565 ± 0.071	3.59GluGly: 3.59 ± 0.069	1.12GluHis: 1.12 ± 0.042	6.916GluIle: 6.916 ± 0.104	8.364GluLys: 8.364 ± 0.127	6.093GluLeu: 6.093 ± 0.097	1.858GluMet: 1.858 ± 0.051	6.354GluAsn: 6.354 ± 0.106	1.526GluPro: 1.526 ± 0.04	2.334GluGln: 2.334 ± 0.058	2.406GluArg: 2.406 ± 0.068	3.035GluSer: 3.035 ± 0.059	3.736GluThr: 3.736 ± 0.071	4.485GluVal: 4.485 ± 0.087	0.59GluTrp: 0.59 ± 0.028	2.473GluTyr: 2.473 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.567PheAla: 3.567 ± 0.061	0.457PheCys: 0.457 ± 0.025	3.134PheAsp: 3.134 ± 0.071	3.697PheGlu: 3.697 ± 0.07	3.206PhePhe: 3.206 ± 0.082	4.103PheGly: 4.103 ± 0.074	0.956PheHis: 0.956 ± 0.033	3.988PheIle: 3.988 ± 0.082	3.819PheLys: 3.819 ± 0.074	5.691PheLeu: 5.691 ± 0.093	1.206PheMet: 1.206 ± 0.036	3.319PheAsn: 3.319 ± 0.075	2.018PhePro: 2.018 ± 0.058	1.791PheGln: 1.791 ± 0.058	1.808PheArg: 1.808 ± 0.052	4.358PheSer: 4.358 ± 0.091	3.165PheThr: 3.165 ± 0.058	3.515PheVal: 3.515 ± 0.071	0.704PheTrp: 0.704 ± 0.033	2.454PheTyr: 2.454 ± 0.067	0.0PheXaa: 0.0 ± 0.0
Gly	4.036GlyAla: 4.036 ± 0.091	0.509GlyCys: 0.509 ± 0.035	3.007GlyAsp: 3.007 ± 0.067	3.705GlyGlu: 3.705 ± 0.061	3.706GlyPhe: 3.706 ± 0.07	4.27GlyGly: 4.27 ± 0.12	1.018GlyHis: 1.018 ± 0.038	5.491GlyIle: 5.491 ± 0.084	5.779GlyLys: 5.779 ± 0.092	5.256GlyLeu: 5.256 ± 0.083	1.504GlyMet: 1.504 ± 0.044	3.996GlyAsn: 3.996 ± 0.079	1.1GlyPro: 1.1 ± 0.043	1.687GlyGln: 1.687 ± 0.051	1.964GlyArg: 1.964 ± 0.056	3.56GlySer: 3.56 ± 0.076	3.688GlyThr: 3.688 ± 0.088	4.13GlyVal: 4.13 ± 0.08	0.648GlyTrp: 0.648 ± 0.031	2.609GlyTyr: 2.609 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	0.964HisAla: 0.964 ± 0.036	0.191HisCys: 0.191 ± 0.015	0.767HisAsp: 0.767 ± 0.034	1.07HisGlu: 1.07 ± 0.041	1.139HisPhe: 1.139 ± 0.044	0.99HisGly: 0.99 ± 0.04	0.569HisHis: 0.569 ± 0.034	1.219HisIle: 1.219 ± 0.039	1.198HisLys: 1.198 ± 0.043	1.781HisLeu: 1.781 ± 0.048	0.277HisMet: 0.277 ± 0.022	0.846HisAsn: 0.846 ± 0.036	0.834HisPro: 0.834 ± 0.034	0.897HisGln: 0.897 ± 0.033	0.641HisArg: 0.641 ± 0.028	1.052HisSer: 1.052 ± 0.032	0.772HisThr: 0.772 ± 0.028	0.769HisVal: 0.769 ± 0.032	0.22HisTrp: 0.22 ± 0.016	0.816HisTyr: 0.816 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.281IleAla: 5.281 ± 0.081	0.587IleCys: 0.587 ± 0.026	4.378IleAsp: 4.378 ± 0.074	5.435IleGlu: 5.435 ± 0.091	4.535IlePhe: 4.535 ± 0.098	4.895IleGly: 4.895 ± 0.072	1.339IleHis: 1.339 ± 0.042	6.089IleIle: 6.089 ± 0.123	6.156IleLys: 6.156 ± 0.087	7.743IleLeu: 7.743 ± 0.128	1.295IleMet: 1.295 ± 0.037	4.849IleAsn: 4.849 ± 0.088	3.294IlePro: 3.294 ± 0.064	2.522IleGln: 2.522 ± 0.066	2.297IleArg: 2.297 ± 0.053	6.172IleSer: 6.172 ± 0.089	4.443IleThr: 4.443 ± 0.087	4.409IleVal: 4.409 ± 0.072	0.715IleTrp: 0.715 ± 0.027	3.002IleTyr: 3.002 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	4.875LysAla: 4.875 ± 0.091	0.379LysCys: 0.379 ± 0.021	4.637LysAsp: 4.637 ± 0.072	6.78LysGlu: 6.78 ± 0.11	4.134LysPhe: 4.134 ± 0.073	4.451LysGly: 4.451 ± 0.075	1.35LysHis: 1.35 ± 0.043	8.115LysIle: 8.115 ± 0.127	8.138LysLys: 8.138 ± 0.118	7.165LysLeu: 7.165 ± 0.107	2.452LysMet: 2.452 ± 0.054	7.152LysAsn: 7.152 ± 0.111	2.692LysPro: 2.692 ± 0.069	2.594LysGln: 2.594 ± 0.066	2.523LysArg: 2.523 ± 0.054	5.086LysSer: 5.086 ± 0.083	5.116LysThr: 5.116 ± 0.085	5.127LysVal: 5.127 ± 0.087	0.697LysTrp: 0.697 ± 0.032	3.406LysTyr: 3.406 ± 0.074	0.0LysXaa: 0.0 ± 0.0
Leu	5.897LeuAla: 5.897 ± 0.098	0.597LeuCys: 0.597 ± 0.026	4.71LeuAsp: 4.71 ± 0.084	6.755LeuGlu: 6.755 ± 0.109	4.759LeuPhe: 4.759 ± 0.103	6.051LeuGly: 6.051 ± 0.094	1.547LeuHis: 1.547 ± 0.044	6.518LeuIle: 6.518 ± 0.106	8.257LeuLys: 8.257 ± 0.12	8.138LeuLeu: 8.138 ± 0.137	2.252LeuMet: 2.252 ± 0.061	5.516LeuAsn: 5.516 ± 0.087	3.617LeuPro: 3.617 ± 0.068	3.71LeuGln: 3.71 ± 0.073	2.922LeuArg: 2.922 ± 0.062	6.354LeuSer: 6.354 ± 0.095	4.663LeuThr: 4.663 ± 0.076	5.429LeuVal: 5.429 ± 0.086	0.762LeuTrp: 0.762 ± 0.033	3.15LeuTyr: 3.15 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	1.455MetAla: 1.455 ± 0.049	0.127MetCys: 0.127 ± 0.012	1.001MetAsp: 1.001 ± 0.036	1.393MetGlu: 1.393 ± 0.037	0.942MetPhe: 0.942 ± 0.035	1.336MetGly: 1.336 ± 0.045	0.374MetHis: 0.374 ± 0.023	1.71MetIle: 1.71 ± 0.053	2.694MetLys: 2.694 ± 0.06	1.923MetLeu: 1.923 ± 0.052	0.79MetMet: 0.79 ± 0.035	1.578MetAsn: 1.578 ± 0.042	0.846MetPro: 0.846 ± 0.03	0.832MetGln: 0.832 ± 0.029	0.774MetArg: 0.774 ± 0.027	1.396MetSer: 1.396 ± 0.044	1.094MetThr: 1.094 ± 0.035	1.427MetVal: 1.427 ± 0.044	0.156MetTrp: 0.156 ± 0.014	0.675MetTyr: 0.675 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	4.254AsnAla: 4.254 ± 0.084	0.461AsnCys: 0.461 ± 0.028	2.981AsnAsp: 2.981 ± 0.062	3.759AsnGlu: 3.759 ± 0.074	4.1AsnPhe: 4.1 ± 0.082	4.034AsnGly: 4.034 ± 0.076	1.204AsnHis: 1.204 ± 0.037	5.141AsnIle: 5.141 ± 0.091	4.488AsnLys: 4.488 ± 0.077	6.502AsnLeu: 6.502 ± 0.097	1.166AsnMet: 1.166 ± 0.036	3.911AsnAsn: 3.911 ± 0.097	3.107AsnPro: 3.107 ± 0.07	2.702AsnGln: 2.702 ± 0.061	1.992AsnArg: 1.992 ± 0.049	4.032AsnSer: 4.032 ± 0.085	3.195AsnThr: 3.195 ± 0.091	3.742AsnVal: 3.742 ± 0.084	0.824AsnTrp: 0.824 ± 0.031	3.24AsnTyr: 3.24 ± 0.075	0.0AsnXaa: 0.0 ± 0.0
Pro	1.951ProAla: 1.951 ± 0.046	0.211ProCys: 0.211 ± 0.017	1.723ProAsp: 1.723 ± 0.046	3.108ProGlu: 3.108 ± 0.068	1.844ProPhe: 1.844 ± 0.045	1.642ProGly: 1.642 ± 0.046	0.631ProHis: 0.631 ± 0.029	2.594ProIle: 2.594 ± 0.06	2.94ProLys: 2.94 ± 0.063	2.703ProLeu: 2.703 ± 0.058	0.784ProMet: 0.784 ± 0.031	2.215ProAsn: 2.215 ± 0.058	0.659ProPro: 0.659 ± 0.031	1.278ProGln: 1.278 ± 0.039	0.884ProArg: 0.884 ± 0.035	1.969ProSer: 1.969 ± 0.056	1.946ProThr: 1.946 ± 0.051	2.166ProVal: 2.166 ± 0.053	0.302ProTrp: 0.302 ± 0.018	1.396ProTyr: 1.396 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.737GlnAla: 1.737 ± 0.045	0.17GlnCys: 0.17 ± 0.014	1.658GlnAsp: 1.658 ± 0.045	2.719GlnGlu: 2.719 ± 0.061	1.887GlnPhe: 1.887 ± 0.054	1.731GlnGly: 1.731 ± 0.053	0.548GlnHis: 0.548 ± 0.029	2.911GlnIle: 2.911 ± 0.059	4.065GlnLys: 4.065 ± 0.071	3.267GlnLeu: 3.267 ± 0.071	0.86GlnMet: 0.86 ± 0.03	3.113GlnAsn: 3.113 ± 0.072	1.054GlnPro: 1.054 ± 0.037	1.399GlnGln: 1.399 ± 0.047	1.207GlnArg: 1.207 ± 0.044	1.877GlnSer: 1.877 ± 0.041	1.761GlnThr: 1.761 ± 0.05	1.872GlnVal: 1.872 ± 0.05	0.335GlnTrp: 0.335 ± 0.021	1.546GlnTyr: 1.546 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	1.902ArgAla: 1.902 ± 0.057	0.21ArgCys: 0.21 ± 0.02	1.592ArgAsp: 1.592 ± 0.05	2.288ArgGlu: 2.288 ± 0.057	1.81ArgPhe: 1.81 ± 0.047	1.764ArgGly: 1.764 ± 0.052	0.529ArgHis: 0.529 ± 0.026	2.804ArgIle: 2.804 ± 0.059	3.025ArgLys: 3.025 ± 0.067	2.758ArgLeu: 2.758 ± 0.066	0.874ArgMet: 0.874 ± 0.033	2.352ArgAsn: 2.352 ± 0.055	0.944ArgPro: 0.944 ± 0.036	1.022ArgGln: 1.022 ± 0.035	1.182ArgArg: 1.182 ± 0.034	1.449ArgSer: 1.449 ± 0.048	1.715ArgThr: 1.715 ± 0.049	1.803ArgVal: 1.803 ± 0.044	0.294ArgTrp: 0.294 ± 0.018	1.213ArgTyr: 1.213 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.978SerAla: 3.978 ± 0.081	0.626SerCys: 0.626 ± 0.029	3.052SerAsp: 3.052 ± 0.062	4.613SerGlu: 4.613 ± 0.087	3.675SerPhe: 3.675 ± 0.073	4.404SerGly: 4.404 ± 0.086	1.011SerHis: 1.011 ± 0.036	4.545SerIle: 4.545 ± 0.095	4.72SerLys: 4.72 ± 0.085	5.779SerLeu: 5.779 ± 0.087	1.273SerMet: 1.273 ± 0.038	3.267SerAsn: 3.267 ± 0.087	2.03SerPro: 2.03 ± 0.054	2.312SerGln: 2.312 ± 0.058	1.896SerArg: 1.896 ± 0.047	3.781SerSer: 3.781 ± 0.089	3.319SerThr: 3.319 ± 0.076	3.956SerVal: 3.956 ± 0.077	0.695SerTrp: 0.695 ± 0.03	2.501SerTyr: 2.501 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	3.468ThrAla: 3.468 ± 0.077	0.348ThrCys: 0.348 ± 0.025	2.918ThrAsp: 2.918 ± 0.071	3.885ThrGlu: 3.885 ± 0.08	2.929ThrPhe: 2.929 ± 0.059	3.557ThrGly: 3.557 ± 0.074	0.904ThrHis: 0.904 ± 0.032	4.12ThrIle: 4.12 ± 0.073	3.981ThrLys: 3.981 ± 0.075	4.908ThrLeu: 4.908 ± 0.077	0.913ThrMet: 0.913 ± 0.037	2.974ThrAsn: 2.974 ± 0.085	2.306ThrPro: 2.306 ± 0.059	1.999ThrGln: 1.999 ± 0.048	1.458ThrArg: 1.458 ± 0.044	3.459ThrSer: 3.459 ± 0.073	3.019ThrThr: 3.019 ± 0.092	3.411ThrVal: 3.411 ± 0.072	0.566ThrTrp: 0.566 ± 0.031	2.143ThrTyr: 2.143 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	3.931ValAla: 3.931 ± 0.079	0.479ValCys: 0.479 ± 0.026	3.135ValAsp: 3.135 ± 0.071	4.473ValGlu: 4.473 ± 0.077	3.479ValPhe: 3.479 ± 0.071	3.703ValGly: 3.703 ± 0.067	0.923ValHis: 0.923 ± 0.033	4.622ValIle: 4.622 ± 0.086	5.184ValLys: 5.184 ± 0.084	5.788ValLeu: 5.788 ± 0.085	1.423ValMet: 1.423 ± 0.043	3.642ValAsn: 3.642 ± 0.087	2.044ValPro: 2.044 ± 0.051	1.779ValGln: 1.779 ± 0.049	1.851ValArg: 1.851 ± 0.049	4.104ValSer: 4.104 ± 0.084	3.171ValThr: 3.171 ± 0.073	3.863ValVal: 3.863 ± 0.084	0.581ValTrp: 0.581 ± 0.028	2.42ValTyr: 2.42 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.57TrpAla: 0.57 ± 0.025	0.077TrpCys: 0.077 ± 0.01	0.545TrpAsp: 0.545 ± 0.027	0.68TrpGlu: 0.68 ± 0.031	0.539TrpPhe: 0.539 ± 0.029	0.646TrpGly: 0.646 ± 0.034	0.185TrpHis: 0.185 ± 0.014	0.709TrpIle: 0.709 ± 0.033	0.904TrpLys: 0.904 ± 0.034	0.939TrpLeu: 0.939 ± 0.032	0.276TrpMet: 0.276 ± 0.018	0.77TrpAsn: 0.77 ± 0.032	0.158TrpPro: 0.158 ± 0.014	0.473TrpGln: 0.473 ± 0.026	0.349TrpArg: 0.349 ± 0.022	0.582TrpSer: 0.582 ± 0.032	0.486TrpThr: 0.486 ± 0.023	0.59TrpVal: 0.59 ± 0.027	0.125TrpTrp: 0.125 ± 0.014	0.412TrpTyr: 0.412 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.359TyrAla: 2.359 ± 0.058	0.33TyrCys: 0.33 ± 0.022	2.204TyrAsp: 2.204 ± 0.052	2.516TyrGlu: 2.516 ± 0.059	2.82TyrPhe: 2.82 ± 0.057	2.533TyrGly: 2.533 ± 0.066	0.833TyrHis: 0.833 ± 0.037	2.732TyrIle: 2.732 ± 0.063	3.138TyrLys: 3.138 ± 0.072	3.858TyrLeu: 3.858 ± 0.073	0.63TyrMet: 0.63 ± 0.028	2.517TyrAsn: 2.517 ± 0.071	1.375TyrPro: 1.375 ± 0.04	2.028TyrGln: 2.028 ± 0.051	1.51TyrArg: 1.51 ± 0.044	2.558TyrSer: 2.558 ± 0.071	2.071TyrThr: 2.071 ± 0.058	2.072TyrVal: 2.072 ± 0.063	0.449TyrTrp: 0.449 ± 0.025	1.932TyrTyr: 1.932 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2558 proteins (805349 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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