Amino acid dipepetide frequency for Romboutsia sp. CE17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.179AlaAla: 3.179 ± 0.092	0.736AlaCys: 0.736 ± 0.032	2.344AlaAsp: 2.344 ± 0.054	2.813AlaGlu: 2.813 ± 0.068	2.153AlaPhe: 2.153 ± 0.055	3.413AlaGly: 3.413 ± 0.087	0.8AlaHis: 0.8 ± 0.032	5.873AlaIle: 5.873 ± 0.094	4.658AlaLys: 4.658 ± 0.093	5.42AlaLeu: 5.42 ± 0.093	1.732AlaMet: 1.732 ± 0.054	2.908AlaAsn: 2.908 ± 0.065	1.294AlaPro: 1.294 ± 0.042	1.362AlaGln: 1.362 ± 0.047	1.712AlaArg: 1.712 ± 0.045	3.298AlaSer: 3.298 ± 0.072	2.9AlaThr: 2.9 ± 0.063	3.541AlaVal: 3.541 ± 0.086	0.294AlaTrp: 0.294 ± 0.021	2.008AlaTyr: 2.008 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.628CysAla: 0.628 ± 0.033	0.199CysCys: 0.199 ± 0.02	0.741CysAsp: 0.741 ± 0.032	0.831CysGlu: 0.831 ± 0.035	0.425CysPhe: 0.425 ± 0.025	1.113CysGly: 1.113 ± 0.043	0.2CysHis: 0.2 ± 0.016	1.27CysIle: 1.27 ± 0.036	1.076CysLys: 1.076 ± 0.039	0.856CysLeu: 0.856 ± 0.037	0.353CysMet: 0.353 ± 0.021	0.789CysAsn: 0.789 ± 0.035	0.506CysPro: 0.506 ± 0.025	0.229CysGln: 0.229 ± 0.019	0.355CysArg: 0.355 ± 0.02	0.83CysSer: 0.83 ± 0.036	0.542CysThr: 0.542 ± 0.024	0.695CysVal: 0.695 ± 0.03	0.054CysTrp: 0.054 ± 0.007	0.407CysTyr: 0.407 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	2.68AspAla: 2.68 ± 0.066	0.637AspCys: 0.637 ± 0.028	3.097AspAsp: 3.097 ± 0.074	5.238AspGlu: 5.238 ± 0.082	2.699AspPhe: 2.699 ± 0.056	3.266AspGly: 3.266 ± 0.063	0.614AspHis: 0.614 ± 0.027	6.955AspIle: 6.955 ± 0.098	5.78AspLys: 5.78 ± 0.099	5.346AspLeu: 5.346 ± 0.092	1.591AspMet: 1.591 ± 0.048	3.512AspAsn: 3.512 ± 0.068	1.301AspPro: 1.301 ± 0.04	0.89AspGln: 0.89 ± 0.035	1.865AspArg: 1.865 ± 0.052	3.255AspSer: 3.255 ± 0.072	2.636AspThr: 2.636 ± 0.059	3.621AspVal: 3.621 ± 0.072	0.354AspTrp: 0.354 ± 0.024	2.77AspTyr: 2.77 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	3.795GluAla: 3.795 ± 0.083	0.763GluCys: 0.763 ± 0.034	4.927GluAsp: 4.927 ± 0.084	7.206GluGlu: 7.206 ± 0.13	3.139GluPhe: 3.139 ± 0.066	4.001GluGly: 4.001 ± 0.081	0.963GluHis: 0.963 ± 0.034	7.543GluIle: 7.543 ± 0.111	7.052GluLys: 7.052 ± 0.104	6.949GluLeu: 6.949 ± 0.091	1.837GluMet: 1.837 ± 0.052	5.723GluAsn: 5.723 ± 0.102	1.25GluPro: 1.25 ± 0.04	1.535GluGln: 1.535 ± 0.05	2.373GluArg: 2.373 ± 0.061	4.104GluSer: 4.104 ± 0.074	2.785GluThr: 2.785 ± 0.069	5.165GluVal: 5.165 ± 0.092	0.369GluTrp: 0.369 ± 0.024	3.492GluTyr: 3.492 ± 0.074	0.0GluXaa: 0.0 ± 0.0
Phe	2.2PheAla: 2.2 ± 0.058	0.449PheCys: 0.449 ± 0.023	2.574PheAsp: 2.574 ± 0.055	2.761PheGlu: 2.761 ± 0.061	1.692PhePhe: 1.692 ± 0.052	2.861PheGly: 2.861 ± 0.07	0.449PheHis: 0.449 ± 0.026	4.776PheIle: 4.776 ± 0.1	3.621PheLys: 3.621 ± 0.071	3.674PheLeu: 3.674 ± 0.085	1.203PheMet: 1.203 ± 0.035	2.966PheAsn: 2.966 ± 0.063	0.958PhePro: 0.958 ± 0.034	0.644PheGln: 0.644 ± 0.026	1.145PheArg: 1.145 ± 0.036	2.872PheSer: 2.872 ± 0.065	2.329PheThr: 2.329 ± 0.063	2.581PheVal: 2.581 ± 0.06	0.246PheTrp: 0.246 ± 0.016	1.757PheTyr: 1.757 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	3.796GlyAla: 3.796 ± 0.093	1.062GlyCys: 1.062 ± 0.041	3.075GlyAsp: 3.075 ± 0.071	3.889GlyGlu: 3.889 ± 0.074	2.948GlyPhe: 2.948 ± 0.055	4.16GlyGly: 4.16 ± 0.096	1.015GlyHis: 1.015 ± 0.036	6.902GlyIle: 6.902 ± 0.098	5.142GlyLys: 5.142 ± 0.08	5.465GlyLeu: 5.465 ± 0.091	1.755GlyMet: 1.755 ± 0.049	3.252GlyAsn: 3.252 ± 0.059	1.329GlyPro: 1.329 ± 0.061	1.427GlyGln: 1.427 ± 0.044	1.99GlyArg: 1.99 ± 0.056	3.855GlySer: 3.855 ± 0.082	3.262GlyThr: 3.262 ± 0.081	4.702GlyVal: 4.702 ± 0.09	0.446GlyTrp: 0.446 ± 0.031	3.059GlyTyr: 3.059 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	0.659HisAla: 0.659 ± 0.032	0.201HisCys: 0.201 ± 0.016	0.716HisAsp: 0.716 ± 0.03	0.94HisGlu: 0.94 ± 0.037	0.595HisPhe: 0.595 ± 0.023	0.935HisGly: 0.935 ± 0.037	0.289HisHis: 0.289 ± 0.02	1.483HisIle: 1.483 ± 0.039	1.041HisLys: 1.041 ± 0.04	1.176HisLeu: 1.176 ± 0.039	0.335HisMet: 0.335 ± 0.021	0.776HisAsn: 0.776 ± 0.028	0.577HisPro: 0.577 ± 0.028	0.287HisGln: 0.287 ± 0.017	0.467HisArg: 0.467 ± 0.027	0.831HisSer: 0.831 ± 0.03	0.726HisThr: 0.726 ± 0.033	0.753HisVal: 0.753 ± 0.032	0.095HisTrp: 0.095 ± 0.011	0.515HisTyr: 0.515 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.739IleAla: 5.739 ± 0.097	1.352IleCys: 1.352 ± 0.043	6.861IleAsp: 6.861 ± 0.094	7.681IleGlu: 7.681 ± 0.113	4.297IlePhe: 4.297 ± 0.097	6.712IleGly: 6.712 ± 0.102	1.278IleHis: 1.278 ± 0.044	10.009IleIle: 10.009 ± 0.185	9.267IleLys: 9.267 ± 0.124	9.639IleLeu: 9.639 ± 0.138	2.425IleMet: 2.425 ± 0.058	7.125IleAsn: 7.125 ± 0.115	3.351IlePro: 3.351 ± 0.062	2.086IleGln: 2.086 ± 0.054	2.999IleArg: 2.999 ± 0.062	7.789IleSer: 7.789 ± 0.113	4.974IleThr: 4.974 ± 0.082	6.573IleVal: 6.573 ± 0.097	0.47IleTrp: 0.47 ± 0.024	4.002IleTyr: 4.002 ± 0.074	0.0IleXaa: 0.0 ± 0.0
Lys	4.247LysAla: 4.247 ± 0.08	0.924LysCys: 0.924 ± 0.043	6.103LysAsp: 6.103 ± 0.103	8.931LysGlu: 8.931 ± 0.129	3.301LysPhe: 3.301 ± 0.062	4.692LysGly: 4.692 ± 0.083	1.128LysHis: 1.128 ± 0.039	8.455LysIle: 8.455 ± 0.124	7.774LysLys: 7.774 ± 0.118	7.657LysLeu: 7.657 ± 0.102	2.371LysMet: 2.371 ± 0.052	6.892LysAsn: 6.892 ± 0.11	1.895LysPro: 1.895 ± 0.052	1.977LysGln: 1.977 ± 0.048	2.868LysArg: 2.868 ± 0.062	5.803LysSer: 5.803 ± 0.095	3.935LysThr: 3.935 ± 0.076	5.88LysVal: 5.88 ± 0.094	0.523LysTrp: 0.523 ± 0.028	4.55LysTyr: 4.55 ± 0.083	0.0LysXaa: 0.0 ± 0.0
Leu	5.035LeuAla: 5.035 ± 0.088	1.015LeuCys: 1.015 ± 0.038	5.764LeuAsp: 5.764 ± 0.089	6.823LeuGlu: 6.823 ± 0.095	3.779LeuPhe: 3.779 ± 0.084	6.286LeuGly: 6.286 ± 0.115	1.046LeuHis: 1.046 ± 0.039	8.424LeuIle: 8.424 ± 0.124	8.069LeuLys: 8.069 ± 0.107	7.691LeuLeu: 7.691 ± 0.126	2.147LeuMet: 2.147 ± 0.05	6.211LeuAsn: 6.211 ± 0.084	2.554LeuPro: 2.554 ± 0.057	1.96LeuGln: 1.96 ± 0.049	2.935LeuArg: 2.935 ± 0.055	6.78LeuSer: 6.78 ± 0.11	4.242LeuThr: 4.242 ± 0.067	5.907LeuVal: 5.907 ± 0.085	0.465LeuTrp: 0.465 ± 0.024	3.251LeuTyr: 3.251 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	1.709MetAla: 1.709 ± 0.052	0.3MetCys: 0.3 ± 0.02	1.527MetAsp: 1.527 ± 0.047	1.69MetGlu: 1.69 ± 0.043	1.042MetPhe: 1.042 ± 0.034	1.745MetGly: 1.745 ± 0.054	0.336MetHis: 0.336 ± 0.018	2.494MetIle: 2.494 ± 0.063	2.492MetLys: 2.492 ± 0.056	2.171MetLeu: 2.171 ± 0.051	0.784MetMet: 0.784 ± 0.033	1.804MetAsn: 1.804 ± 0.044	0.841MetPro: 0.841 ± 0.032	0.664MetGln: 0.664 ± 0.034	0.873MetArg: 0.873 ± 0.03	1.853MetSer: 1.853 ± 0.051	1.254MetThr: 1.254 ± 0.04	1.598MetVal: 1.598 ± 0.041	0.133MetTrp: 0.133 ± 0.012	0.953MetTyr: 0.953 ± 0.039	0.0MetXaa: 0.0 ± 0.0
Asn	2.78AsnAla: 2.78 ± 0.065	0.708AsnCys: 0.708 ± 0.033	3.293AsnAsp: 3.293 ± 0.061	4.797AsnGlu: 4.797 ± 0.08	2.533AsnPhe: 2.533 ± 0.062	3.468AsnGly: 3.468 ± 0.078	0.824AsnHis: 0.824 ± 0.036	8.287AsnIle: 8.287 ± 0.13	6.898AsnLys: 6.898 ± 0.112	6.361AsnLeu: 6.361 ± 0.103	1.802AsnMet: 1.802 ± 0.046	5.091AsnAsn: 5.091 ± 0.114	2.244AsnPro: 2.244 ± 0.054	1.517AsnGln: 1.517 ± 0.043	1.935AsnArg: 1.935 ± 0.048	3.982AsnSer: 3.982 ± 0.08	3.129AsnThr: 3.129 ± 0.061	3.542AsnVal: 3.542 ± 0.074	0.366AsnTrp: 0.366 ± 0.021	2.972AsnTyr: 2.972 ± 0.074	0.0AsnXaa: 0.0 ± 0.0
Pro	1.318ProAla: 1.318 ± 0.044	0.322ProCys: 0.322 ± 0.022	1.344ProAsp: 1.344 ± 0.044	1.98ProGlu: 1.98 ± 0.06	1.258ProPhe: 1.258 ± 0.035	1.706ProGly: 1.706 ± 0.054	0.472ProHis: 0.472 ± 0.023	2.865ProIle: 2.865 ± 0.058	2.236ProLys: 2.236 ± 0.047	2.176ProLeu: 2.176 ± 0.049	0.714ProMet: 0.714 ± 0.028	1.638ProAsn: 1.638 ± 0.046	0.541ProPro: 0.541 ± 0.028	0.71ProGln: 0.71 ± 0.031	0.846ProArg: 0.846 ± 0.033	1.757ProSer: 1.757 ± 0.05	1.518ProThr: 1.518 ± 0.042	1.829ProVal: 1.829 ± 0.057	0.199ProTrp: 0.199 ± 0.016	1.209ProTyr: 1.209 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	1.256GlnAla: 1.256 ± 0.043	0.243GlnCys: 0.243 ± 0.016	1.18GlnAsp: 1.18 ± 0.038	1.592GlnGlu: 1.592 ± 0.044	0.842GlnPhe: 0.842 ± 0.03	1.409GlnGly: 1.409 ± 0.049	0.273GlnHis: 0.273 ± 0.018	2.08GlnIle: 2.08 ± 0.045	1.875GlnLys: 1.875 ± 0.053	1.919GlnLeu: 1.919 ± 0.05	0.61GlnMet: 0.61 ± 0.026	1.371GlnAsn: 1.371 ± 0.04	0.585GlnPro: 0.585 ± 0.028	0.56GlnGln: 0.56 ± 0.028	0.89GlnArg: 0.89 ± 0.032	1.423GlnSer: 1.423 ± 0.038	0.971GlnThr: 0.971 ± 0.039	1.431GlnVal: 1.431 ± 0.044	0.146GlnTrp: 0.146 ± 0.014	0.977GlnTyr: 0.977 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	1.714ArgAla: 1.714 ± 0.045	0.382ArgCys: 0.382 ± 0.022	1.902ArgAsp: 1.902 ± 0.048	2.694ArgGlu: 2.694 ± 0.062	1.316ArgPhe: 1.316 ± 0.035	1.888ArgGly: 1.888 ± 0.055	0.476ArgHis: 0.476 ± 0.024	2.918ArgIle: 2.918 ± 0.067	2.764ArgLys: 2.764 ± 0.052	2.777ArgLeu: 2.777 ± 0.054	0.874ArgMet: 0.874 ± 0.033	1.936ArgAsn: 1.936 ± 0.05	0.88ArgPro: 0.88 ± 0.036	0.801ArgGln: 0.801 ± 0.033	1.292ArgArg: 1.292 ± 0.04	1.617ArgSer: 1.617 ± 0.048	1.432ArgThr: 1.432 ± 0.04	2.244ArgVal: 2.244 ± 0.056	0.199ArgTrp: 0.199 ± 0.014	1.455ArgTyr: 1.455 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.057SerAla: 3.057 ± 0.071	0.694SerCys: 0.694 ± 0.03	3.325SerAsp: 3.325 ± 0.062	4.128SerGlu: 4.128 ± 0.073	2.872SerPhe: 2.872 ± 0.063	4.069SerGly: 4.069 ± 0.088	0.964SerHis: 0.964 ± 0.032	7.388SerIle: 7.388 ± 0.121	6.442SerLys: 6.442 ± 0.098	6.13SerLeu: 6.13 ± 0.092	1.777SerMet: 1.777 ± 0.048	4.421SerAsn: 4.421 ± 0.085	1.589SerPro: 1.589 ± 0.043	1.683SerGln: 1.683 ± 0.054	2.118SerArg: 2.118 ± 0.045	4.608SerSer: 4.608 ± 0.093	3.401SerThr: 3.401 ± 0.084	3.84SerVal: 3.84 ± 0.072	0.378SerTrp: 0.378 ± 0.021	2.8SerTyr: 2.8 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	2.586ThrAla: 2.586 ± 0.062	0.565ThrCys: 0.565 ± 0.026	2.354ThrAsp: 2.354 ± 0.063	2.753ThrGlu: 2.753 ± 0.063	2.044ThrPhe: 2.044 ± 0.053	3.394ThrGly: 3.394 ± 0.076	0.821ThrHis: 0.821 ± 0.035	5.238ThrIle: 5.238 ± 0.083	3.8ThrLys: 3.8 ± 0.075	4.737ThrLeu: 4.737 ± 0.08	1.19ThrMet: 1.19 ± 0.035	2.832ThrAsn: 2.832 ± 0.057	1.744ThrPro: 1.744 ± 0.048	1.095ThrGln: 1.095 ± 0.034	1.391ThrArg: 1.391 ± 0.047	3.298ThrSer: 3.298 ± 0.075	2.652ThrThr: 2.652 ± 0.066	3.209ThrVal: 3.209 ± 0.076	0.36ThrTrp: 0.36 ± 0.026	2.116ThrTyr: 2.116 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	3.815ValAla: 3.815 ± 0.079	0.964ValCys: 0.964 ± 0.037	4.083ValAsp: 4.083 ± 0.071	4.667ValGlu: 4.667 ± 0.096	2.701ValPhe: 2.701 ± 0.06	4.507ValGly: 4.507 ± 0.092	0.791ValHis: 0.791 ± 0.03	6.295ValIle: 6.295 ± 0.082	5.236ValLys: 5.236 ± 0.085	5.864ValLeu: 5.864 ± 0.093	1.542ValMet: 1.542 ± 0.044	3.835ValAsn: 3.835 ± 0.07	1.831ValPro: 1.831 ± 0.055	1.283ValGln: 1.283 ± 0.041	1.938ValArg: 1.938 ± 0.061	4.421ValSer: 4.421 ± 0.083	3.017ValThr: 3.017 ± 0.075	4.741ValVal: 4.741 ± 0.099	0.329ValTrp: 0.329 ± 0.019	2.607ValTyr: 2.607 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.329TrpAla: 0.329 ± 0.02	0.073TrpCys: 0.073 ± 0.009	0.347TrpAsp: 0.347 ± 0.026	0.366TrpGlu: 0.366 ± 0.023	0.259TrpPhe: 0.259 ± 0.019	0.41TrpGly: 0.41 ± 0.025	0.098TrpHis: 0.098 ± 0.012	0.621TrpIle: 0.621 ± 0.027	0.427TrpLys: 0.427 ± 0.027	0.497TrpLeu: 0.497 ± 0.028	0.166TrpMet: 0.166 ± 0.014	0.359TrpAsn: 0.359 ± 0.018	0.131TrpPro: 0.131 ± 0.012	0.159TrpGln: 0.159 ± 0.014	0.181TrpArg: 0.181 ± 0.016	0.379TrpSer: 0.379 ± 0.024	0.228TrpThr: 0.228 ± 0.014	0.345TrpVal: 0.345 ± 0.018	0.075TrpTrp: 0.075 ± 0.01	0.283TrpTyr: 0.283 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.917TyrAla: 1.917 ± 0.049	0.508TyrCys: 0.508 ± 0.022	2.552TyrAsp: 2.552 ± 0.055	3.189TyrGlu: 3.189 ± 0.065	1.865TyrPhe: 1.865 ± 0.047	2.496TyrGly: 2.496 ± 0.059	0.56TyrHis: 0.56 ± 0.027	4.752TyrIle: 4.752 ± 0.103	4.257TyrLys: 4.257 ± 0.091	3.877TyrLeu: 3.877 ± 0.079	1.054TyrMet: 1.054 ± 0.033	3.09TyrAsn: 3.09 ± 0.074	1.24TyrPro: 1.24 ± 0.039	0.764TyrGln: 0.764 ± 0.028	1.384TyrArg: 1.384 ± 0.044	2.928TyrSer: 2.928 ± 0.063	2.246TyrThr: 2.246 ± 0.059	2.27TyrVal: 2.27 ± 0.05	0.232TyrTrp: 0.232 ± 0.018	1.899TyrTyr: 1.899 ± 0.062	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2826 proteins (850299 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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