Amino acid dipepetide frequency for Maribacter sp. (strain HTCC2170 / KCCM 42371)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.253AlaAla: 4.253 ± 0.096
0.549AlaCys: 0.549 ± 0.024
3.338AlaAsp: 3.338 ± 0.068
3.827AlaGlu: 3.827 ± 0.069
3.178AlaPhe: 3.178 ± 0.056
4.316AlaGly: 4.316 ± 0.099
1.207AlaHis: 1.207 ± 0.037
5.321AlaIle: 5.321 ± 0.072
4.625AlaLys: 4.625 ± 0.084
6.071AlaLeu: 6.071 ± 0.091
1.681AlaMet: 1.681 ± 0.04
3.389AlaAsn: 3.389 ± 0.058
2.02AlaPro: 2.02 ± 0.056
2.29AlaGln: 2.29 ± 0.052
2.0AlaArg: 2.0 ± 0.046
4.046AlaSer: 4.046 ± 0.07
3.507AlaThr: 3.507 ± 0.085
3.981AlaVal: 3.981 ± 0.078
0.651AlaTrp: 0.651 ± 0.025
2.401AlaTyr: 2.401 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.459CysAla: 0.459 ± 0.022
0.089CysCys: 0.089 ± 0.01
0.434CysAsp: 0.434 ± 0.029
0.476CysGlu: 0.476 ± 0.027
0.408CysPhe: 0.408 ± 0.021
0.604CysGly: 0.604 ± 0.026
0.272CysHis: 0.272 ± 0.034
0.565CysIle: 0.565 ± 0.022
0.476CysLys: 0.476 ± 0.023
0.616CysLeu: 0.616 ± 0.021
0.15CysMet: 0.15 ± 0.011
0.398CysAsn: 0.398 ± 0.02
0.326CysPro: 0.326 ± 0.02
0.188CysGln: 0.188 ± 0.013
0.2CysArg: 0.2 ± 0.013
0.548CysSer: 0.548 ± 0.024
0.456CysThr: 0.456 ± 0.034
0.459CysVal: 0.459 ± 0.026
0.064CysTrp: 0.064 ± 0.008
0.309CysTyr: 0.309 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.642AspAla: 3.642 ± 0.064
0.474AspCys: 0.474 ± 0.028
3.153AspAsp: 3.153 ± 0.082
3.827AspGlu: 3.827 ± 0.062
3.78AspPhe: 3.78 ± 0.061
4.472AspGly: 4.472 ± 0.168
1.02AspHis: 1.02 ± 0.034
4.401AspIle: 4.401 ± 0.068
4.171AspLys: 4.171 ± 0.083
5.201AspLeu: 5.201 ± 0.075
1.241AspMet: 1.241 ± 0.032
3.249AspAsn: 3.249 ± 0.068
1.962AspPro: 1.962 ± 0.067
1.611AspGln: 1.611 ± 0.051
1.98AspArg: 1.98 ± 0.044
3.618AspSer: 3.618 ± 0.064
2.763AspThr: 2.763 ± 0.074
3.659AspVal: 3.659 ± 0.07
0.868AspTrp: 0.868 ± 0.031
2.85AspTyr: 2.85 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
4.053GluAla: 4.053 ± 0.066
0.343GluCys: 0.343 ± 0.019
3.744GluAsp: 3.744 ± 0.059
4.956GluGlu: 4.956 ± 0.091
2.967GluPhe: 2.967 ± 0.059
4.021GluGly: 4.021 ± 0.064
1.253GluHis: 1.253 ± 0.039
5.476GluIle: 5.476 ± 0.077
5.714GluLys: 5.714 ± 0.098
6.402GluLeu: 6.402 ± 0.092
1.755GluMet: 1.755 ± 0.043
4.65GluAsn: 4.65 ± 0.068
1.82GluPro: 1.82 ± 0.042
2.26GluGln: 2.26 ± 0.043
2.568GluArg: 2.568 ± 0.059
3.6GluSer: 3.6 ± 0.055
3.433GluThr: 3.433 ± 0.09
4.478GluVal: 4.478 ± 0.07
0.74GluTrp: 0.74 ± 0.026
2.464GluTyr: 2.464 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
2.929PheAla: 2.929 ± 0.056
0.41PheCys: 0.41 ± 0.021
3.302PheAsp: 3.302 ± 0.06
3.434PheGlu: 3.434 ± 0.053
2.67PhePhe: 2.67 ± 0.061
3.742PheGly: 3.742 ± 0.071
0.831PheHis: 0.831 ± 0.03
3.804PheIle: 3.804 ± 0.066
3.558PheLys: 3.558 ± 0.068
4.685PheLeu: 4.685 ± 0.089
1.252PheMet: 1.252 ± 0.037
3.174PheAsn: 3.174 ± 0.056
1.781PhePro: 1.781 ± 0.038
1.459PheGln: 1.459 ± 0.036
1.704PheArg: 1.704 ± 0.039
3.726PheSer: 3.726 ± 0.071
2.874PheThr: 2.874 ± 0.058
3.144PheVal: 3.144 ± 0.057
0.608PheTrp: 0.608 ± 0.025
2.083PheTyr: 2.083 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
4.57GlyAla: 4.57 ± 0.131
0.644GlyCys: 0.644 ± 0.037
3.876GlyAsp: 3.876 ± 0.145
4.133GlyGlu: 4.133 ± 0.116
3.806GlyPhe: 3.806 ± 0.056
5.062GlyGly: 5.062 ± 0.124
1.371GlyHis: 1.371 ± 0.037
5.952GlyIle: 5.952 ± 0.1
5.137GlyLys: 5.137 ± 0.08
6.255GlyLeu: 6.255 ± 0.076
1.85GlyMet: 1.85 ± 0.048
3.787GlyAsn: 3.787 ± 0.082
1.726GlyPro: 1.726 ± 0.052
2.036GlyGln: 2.036 ± 0.046
2.387GlyArg: 2.387 ± 0.048
4.289GlySer: 4.289 ± 0.085
4.057GlyThr: 4.057 ± 0.129
4.57GlyVal: 4.57 ± 0.075
0.885GlyTrp: 0.885 ± 0.034
2.978GlyTyr: 2.978 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
1.051HisAla: 1.051 ± 0.033
0.183HisCys: 0.183 ± 0.013
1.001HisAsp: 1.001 ± 0.038
1.095HisGlu: 1.095 ± 0.038
1.11HisPhe: 1.11 ± 0.031
1.259HisGly: 1.259 ± 0.029
0.518HisHis: 0.518 ± 0.026
1.43HisIle: 1.43 ± 0.037
1.27HisLys: 1.27 ± 0.037
1.834HisLeu: 1.834 ± 0.046
0.411HisMet: 0.411 ± 0.02
0.958HisAsn: 0.958 ± 0.033
0.917HisPro: 0.917 ± 0.032
0.721HisGln: 0.721 ± 0.027
0.713HisArg: 0.713 ± 0.027
1.122HisSer: 1.122 ± 0.033
1.021HisThr: 1.021 ± 0.034
1.036HisVal: 1.036 ± 0.033
0.267HisTrp: 0.267 ± 0.016
0.823HisTyr: 0.823 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.379IleAla: 5.379 ± 0.076
0.623IleCys: 0.623 ± 0.024
5.011IleAsp: 5.011 ± 0.084
5.29IleGlu: 5.29 ± 0.076
3.419IlePhe: 3.419 ± 0.067
5.382IleGly: 5.382 ± 0.075
1.341IleHis: 1.341 ± 0.04
5.52IleIle: 5.52 ± 0.084
5.615IleLys: 5.615 ± 0.097
7.061IleLeu: 7.061 ± 0.097
1.557IleMet: 1.557 ± 0.042
4.363IleAsn: 4.363 ± 0.076
3.273IlePro: 3.273 ± 0.06
2.449IleGln: 2.449 ± 0.063
2.59IleArg: 2.59 ± 0.051
5.562IleSer: 5.562 ± 0.078
4.597IleThr: 4.597 ± 0.085
4.752IleVal: 4.752 ± 0.072
0.827IleTrp: 0.827 ± 0.032
2.666IleTyr: 2.666 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
4.691LysAla: 4.691 ± 0.085
0.328LysCys: 0.328 ± 0.016
4.381LysAsp: 4.381 ± 0.083
6.214LysGlu: 6.214 ± 0.094
2.921LysPhe: 2.921 ± 0.056
4.974LysGly: 4.974 ± 0.119
1.348LysHis: 1.348 ± 0.037
5.747LysIle: 5.747 ± 0.092
7.012LysLys: 7.012 ± 0.117
6.2LysLeu: 6.2 ± 0.096
2.074LysMet: 2.074 ± 0.048
4.968LysAsn: 4.968 ± 0.074
2.389LysPro: 2.389 ± 0.051
2.318LysGln: 2.318 ± 0.051
2.977LysArg: 2.977 ± 0.056
4.707LysSer: 4.707 ± 0.081
4.405LysThr: 4.405 ± 0.072
4.779LysVal: 4.779 ± 0.078
0.927LysTrp: 0.927 ± 0.03
2.898LysTyr: 2.898 ± 0.063
0.0LysXaa: 0.0 ± 0.0
Leu
5.974LeuAla: 5.974 ± 0.091
0.684LeuCys: 0.684 ± 0.025
5.402LeuAsp: 5.402 ± 0.071
6.038LeuGlu: 6.038 ± 0.092
4.796LeuPhe: 4.796 ± 0.08
6.326LeuGly: 6.326 ± 0.087
1.598LeuHis: 1.598 ± 0.042
6.671LeuIle: 6.671 ± 0.098
7.439LeuLys: 7.439 ± 0.108
8.725LeuLeu: 8.725 ± 0.124
2.27LeuMet: 2.27 ± 0.052
5.508LeuAsn: 5.508 ± 0.08
3.602LeuPro: 3.602 ± 0.05
2.916LeuGln: 2.916 ± 0.062
3.202LeuArg: 3.202 ± 0.057
6.412LeuSer: 6.412 ± 0.098
4.948LeuThr: 4.948 ± 0.084
5.74LeuVal: 5.74 ± 0.084
0.943LeuTrp: 0.943 ± 0.032
3.104LeuTyr: 3.104 ± 0.053
0.0LeuXaa: 0.0 ± 0.0
Met
1.855MetAla: 1.855 ± 0.05
0.136MetCys: 0.136 ± 0.01
1.322MetAsp: 1.322 ± 0.039
1.586MetGlu: 1.586 ± 0.04
0.98MetPhe: 0.98 ± 0.032
1.802MetGly: 1.802 ± 0.045
0.456MetHis: 0.456 ± 0.022
1.586MetIle: 1.586 ± 0.038
2.128MetLys: 2.128 ± 0.047
2.013MetLeu: 2.013 ± 0.045
0.588MetMet: 0.588 ± 0.026
1.465MetAsn: 1.465 ± 0.034
0.948MetPro: 0.948 ± 0.031
0.853MetGln: 0.853 ± 0.029
0.945MetArg: 0.945 ± 0.033
1.461MetSer: 1.461 ± 0.036
1.258MetThr: 1.258 ± 0.031
1.707MetVal: 1.707 ± 0.042
0.203MetTrp: 0.203 ± 0.013
0.724MetTyr: 0.724 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.59AsnAla: 3.59 ± 0.055
0.467AsnCys: 0.467 ± 0.025
3.415AsnAsp: 3.415 ± 0.082
3.991AsnGlu: 3.991 ± 0.062
2.76AsnPhe: 2.76 ± 0.059
4.327AsnGly: 4.327 ± 0.113
1.146AsnHis: 1.146 ± 0.035
4.518AsnIle: 4.518 ± 0.071
4.098AsnLys: 4.098 ± 0.074
5.163AsnLeu: 5.163 ± 0.074
1.341AsnMet: 1.341 ± 0.033
3.638AsnAsn: 3.638 ± 0.08
2.794AsnPro: 2.794 ± 0.055
2.048AsnGln: 2.048 ± 0.049
2.199AsnArg: 2.199 ± 0.049
3.841AsnSer: 3.841 ± 0.069
3.41AsnThr: 3.41 ± 0.066
3.454AsnVal: 3.454 ± 0.064
0.778AsnTrp: 0.778 ± 0.027
2.486AsnTyr: 2.486 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
1.879ProAla: 1.879 ± 0.051
0.221ProCys: 0.221 ± 0.018
2.252ProAsp: 2.252 ± 0.064
2.921ProGlu: 2.921 ± 0.056
1.948ProPhe: 1.948 ± 0.044
2.155ProGly: 2.155 ± 0.063
0.684ProHis: 0.684 ± 0.027
2.844ProIle: 2.844 ± 0.049
2.744ProLys: 2.744 ± 0.06
3.053ProLeu: 3.053 ± 0.055
0.874ProMet: 0.874 ± 0.029
2.333ProAsn: 2.333 ± 0.05
0.997ProPro: 0.997 ± 0.046
1.109ProGln: 1.109 ± 0.042
1.009ProArg: 1.009 ± 0.031
2.336ProSer: 2.336 ± 0.054
2.022ProThr: 2.022 ± 0.058
2.292ProVal: 2.292 ± 0.05
0.44ProTrp: 0.44 ± 0.024
1.431ProTyr: 1.431 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
1.767GlnAla: 1.767 ± 0.046
0.208GlnCys: 0.208 ± 0.014
1.628GlnAsp: 1.628 ± 0.04
2.276GlnGlu: 2.276 ± 0.045
1.562GlnPhe: 1.562 ± 0.04
2.023GlnGly: 2.023 ± 0.114
0.607GlnHis: 0.607 ± 0.021
2.548GlnIle: 2.548 ± 0.045
2.619GlnLys: 2.619 ± 0.059
3.326GlnLeu: 3.326 ± 0.067
0.896GlnMet: 0.896 ± 0.027
1.96GlnAsn: 1.96 ± 0.04
1.023GlnPro: 1.023 ± 0.03
1.189GlnGln: 1.189 ± 0.032
1.298GlnArg: 1.298 ± 0.039
1.785GlnSer: 1.785 ± 0.041
1.593GlnThr: 1.593 ± 0.039
1.891GlnVal: 1.891 ± 0.042
0.398GlnTrp: 0.398 ± 0.02
1.2GlnTyr: 1.2 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
2.092ArgAla: 2.092 ± 0.047
0.195ArgCys: 0.195 ± 0.013
1.876ArgAsp: 1.876 ± 0.051
2.124ArgGlu: 2.124 ± 0.046
1.953ArgPhe: 1.953 ± 0.046
2.098ArgGly: 2.098 ± 0.041
0.642ArgHis: 0.642 ± 0.023
2.951ArgIle: 2.951 ± 0.051
2.893ArgLys: 2.893 ± 0.051
3.424ArgLeu: 3.424 ± 0.064
0.926ArgMet: 0.926 ± 0.03
2.097ArgAsn: 2.097 ± 0.05
1.249ArgPro: 1.249 ± 0.038
1.064ArgGln: 1.064 ± 0.034
1.376ArgArg: 1.376 ± 0.037
2.031ArgSer: 2.031 ± 0.046
1.968ArgThr: 1.968 ± 0.038
2.183ArgVal: 2.183 ± 0.041
0.415ArgTrp: 0.415 ± 0.019
1.53ArgTyr: 1.53 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
3.756SerAla: 3.756 ± 0.064
0.677SerCys: 0.677 ± 0.025
3.572SerAsp: 3.572 ± 0.064
4.101SerGlu: 4.101 ± 0.06
3.742SerPhe: 3.742 ± 0.066
4.82SerGly: 4.82 ± 0.103
1.136SerHis: 1.136 ± 0.031
5.273SerIle: 5.273 ± 0.074
5.048SerLys: 5.048 ± 0.074
6.174SerLeu: 6.174 ± 0.084
1.398SerMet: 1.398 ± 0.029
3.77SerAsn: 3.77 ± 0.073
2.152SerPro: 2.152 ± 0.044
2.003SerGln: 2.003 ± 0.041
2.119SerArg: 2.119 ± 0.039
4.286SerSer: 4.286 ± 0.074
3.635SerThr: 3.635 ± 0.064
3.87SerVal: 3.87 ± 0.059
0.756SerTrp: 0.756 ± 0.03
2.554SerTyr: 2.554 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
3.596ThrAla: 3.596 ± 0.079
0.356ThrCys: 0.356 ± 0.023
3.241ThrAsp: 3.241 ± 0.096
3.336ThrGlu: 3.336 ± 0.056
2.891ThrPhe: 2.891 ± 0.061
4.171ThrGly: 4.171 ± 0.132
1.033ThrHis: 1.033 ± 0.027
4.629ThrIle: 4.629 ± 0.08
3.809ThrLys: 3.809 ± 0.08
5.041ThrLeu: 5.041 ± 0.092
1.153ThrMet: 1.153 ± 0.032
3.201ThrAsn: 3.201 ± 0.081
2.359ThrPro: 2.359 ± 0.065
1.66ThrGln: 1.66 ± 0.044
1.652ThrArg: 1.652 ± 0.045
3.728ThrSer: 3.728 ± 0.065
3.279ThrThr: 3.279 ± 0.094
3.587ThrVal: 3.587 ± 0.097
0.635ThrTrp: 0.635 ± 0.028
2.163ThrTyr: 2.163 ± 0.057
0.0ThrXaa: 0.0 ± 0.0
Val
4.067ValAla: 4.067 ± 0.07
0.504ValCys: 0.504 ± 0.024
3.868ValAsp: 3.868 ± 0.081
3.918ValGlu: 3.918 ± 0.065
3.43ValPhe: 3.43 ± 0.063
4.121ValGly: 4.121 ± 0.063
1.155ValHis: 1.155 ± 0.028
4.741ValIle: 4.741 ± 0.07
4.187ValLys: 4.187 ± 0.071
6.276ValLeu: 6.276 ± 0.092
1.446ValMet: 1.446 ± 0.04
3.522ValAsn: 3.522 ± 0.064
2.378ValPro: 2.378 ± 0.042
1.806ValGln: 1.806 ± 0.041
2.118ValArg: 2.118 ± 0.048
4.466ValSer: 4.466 ± 0.067
3.462ValThr: 3.462 ± 0.102
4.37ValVal: 4.37 ± 0.075
0.652ValTrp: 0.652 ± 0.029
2.376ValTyr: 2.376 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
0.67TrpAla: 0.67 ± 0.028
0.097TrpCys: 0.097 ± 0.01
0.759TrpAsp: 0.759 ± 0.028
0.751TrpGlu: 0.751 ± 0.027
0.572TrpPhe: 0.572 ± 0.023
0.849TrpGly: 0.849 ± 0.032
0.293TrpHis: 0.293 ± 0.016
0.801TrpIle: 0.801 ± 0.027
0.867TrpLys: 0.867 ± 0.032
1.085TrpLeu: 1.085 ± 0.033
0.374TrpMet: 0.374 ± 0.016
0.77TrpAsn: 0.77 ± 0.03
0.333TrpPro: 0.333 ± 0.019
0.441TrpGln: 0.441 ± 0.023
0.454TrpArg: 0.454 ± 0.021
0.702TrpSer: 0.702 ± 0.026
0.571TrpThr: 0.571 ± 0.026
0.714TrpVal: 0.714 ± 0.025
0.185TrpTrp: 0.185 ± 0.016
0.484TrpTyr: 0.484 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.38TyrAla: 2.38 ± 0.05
0.311TyrCys: 0.311 ± 0.016
2.37TyrAsp: 2.37 ± 0.05
2.401TyrGlu: 2.401 ± 0.057
2.28TyrPhe: 2.28 ± 0.051
2.849TyrGly: 2.849 ± 0.045
0.829TyrHis: 0.829 ± 0.029
2.495TyrIle: 2.495 ± 0.046
2.849TyrLys: 2.849 ± 0.057
3.695TyrLeu: 3.695 ± 0.059
0.775TyrMet: 0.775 ± 0.031
2.265TyrAsn: 2.265 ± 0.043
1.495TyrPro: 1.495 ± 0.036
1.375TyrGln: 1.375 ± 0.042
1.591TyrArg: 1.591 ± 0.038
2.576TyrSer: 2.576 ± 0.052
2.264TyrThr: 2.264 ± 0.068
2.196TyrVal: 2.196 ± 0.045
0.529TyrTrp: 0.529 ± 0.023
1.677TyrTyr: 1.677 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3411 proteins (1168930 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski